---
title: "Nutraceuticals & Cellular Energizers — Evidence-Graded Longevity Products | Magellan"
description: "Evidence-graded nutraceuticals & cellular energizers — 65 products, each linked to peer-reviewed research and PubMed citations."
url: "https://magellanlongevity.com/c/1.md"
canonical: "https://magellanlongevity.com/c/1.html"
html: "https://magellanlongevity.com/c/1.html"
type: "category"
section: "Nutraceuticals & Cellular Energizers"
products: 65
citations: 1199
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Nutraceuticals & Cellular Energizers

[Home](https://magellanlongevity.com/) › Nutraceuticals & Cellular Energizers

**HTML version:** https://magellanlongevity.com/c/1.html · **In the Magellan app:** https://magellanlongevity.com/#/cat/1

## What this category is

Every product below is graded on the strength of the human and mechanistic research behind it and linked to its primary PubMed citations — independent of affiliate commissions. 65 products, 1199 distinct peer-reviewed citations in total.

## Evidence grade distribution

| Evidence grade | Products |
| --- | --- |
| Emerging evidence | 11 |
| Moderate evidence | 50 |
| Preliminary | 1 |
| Strong evidence | 3 |

## Every product in Nutraceuticals & Cellular Energizers

| Product | Evidence grade | Citations | Typical price | Role |
| --- | --- | --- | --- | --- |
| [Omega-3 EPA/DHA Fish Oil](https://magellanlongevity.com/p/128.md) | Moderate evidence | 22 | $33.75 | Across large randomized trials and meta-analyses, marine omega-3s reliably reduce serum triglycerides (roughly 15% at… |
| [Creatine Monohydrate](https://magellanlongevity.com/p/123.md) | Strong evidence | 23 | $44.00 | Across meta-analyses and randomized trials, creatine monohydrate combined with resistance training modestly increases… |
| [Astaxanthin Softgels](https://magellanlongevity.com/p/107.md) | Moderate evidence | 22 | $26.95 | In humans, randomized trials and meta-analyses most consistently show that astaxanthin lowers the lipid-peroxidation… |
| [Zinc Picolinate](https://magellanlongevity.com/p/133.md) | Moderate evidence | 23 | $9.95 | Multiple meta-analyses of randomized trials indicate that oral zinc, started soon after symptom onset, can modestly… |
| [Vitamin K2 (MK-7)](https://magellanlongevity.com/p/138.md) | Moderate evidence | 20 | $13.99 | In humans, MK-7 supplementation consistently improves vitamin K-status biomarkers — lowering circulating… |
| [Silymarin (Milk Thistle)](https://magellanlongevity.com/p/112.md) | Moderate evidence | 18 | $25.00 | In non-alcoholic fatty liver disease (NAFLD/MASLD), multiple meta-analyses of randomized trials find that silymarin… |
| [Green Tea EGCG Extract](https://magellanlongevity.com/p/106.md) | Moderate evidence | 20 | $19.08 | For weight and metabolic syndrome, meta-analyses of randomized trials indicate that green tea catechins produce small,… |
| [Olive Leaf Extract (Oleuropein)](https://magellanlongevity.com/p/109.md) | Moderate evidence | 19 | $17.05 | In human trials, standardized olive leaf extract has most consistently produced modest reductions in systolic and… |
| [Alpha-Lipoic Acid (ALA)](https://magellanlongevity.com/p/129.md) | Moderate evidence | 23 | $16.99 | The best-supported clinical use of ALA is for symptomatic diabetic peripheral neuropathy: randomized trials and… |
| [Ubiquinol (Reduced CoQ10)](https://magellanlongevity.com/p/121.md) | Moderate evidence | 27 | $46.49 | In human trials CoQ10 has been studied mainly as an adjunct in cardiovascular disease: the Q-SYMBIO randomized trial… |
| [Urolithin A (Mitopure)](https://magellanlongevity.com/p/102.md) | Moderate evidence | 20 | $50.00 | In human research, urolithin A supplementation is safe and bioavailable and improves markers of mitochondrial health.… |
| [Magnesium L-Threonate](https://magellanlongevity.com/p/127.md) | Emerging evidence | 19 | $30.78 | In small randomized trials, magnesium-L-threonate improved composite cognition versus placebo in older adults with… |
| [Beta-Alanine](https://magellanlongevity.com/p/137.md) | Moderate evidence | 21 | $23.63 | Meta-analyses of controlled trials indicate that beta-alanine produces a small but statistically significant overall… |
| [Lutein and Zeaxanthin](https://magellanlongevity.com/p/120.md) | Strong evidence | 21 | $22.95 | The best human evidence concerns eye health in aging: in the landmark AREDS2 randomized trial, adding… |
| [Quercetin Capsules](https://magellanlongevity.com/p/105.md) | Moderate evidence | 25 | $21.42 | Meta-analyses of randomized trials indicate quercetin produces a small blood-pressure reduction—on the order of 2–3… |
| [Magnesium Glycinate](https://magellanlongevity.com/p/136.md) | Moderate evidence | 19 | $26.00 | Pooled analyses of randomized trials indicate oral magnesium lowers blood pressure by a small amount—about 2 mmHg in a… |
| [Cocoa Flavanol Extract](https://magellanlongevity.com/p/116.md) | Moderate evidence | 21 | $49.99 | In the large COSMOS randomized trial of older adults, daily cocoa extract did not significantly reduce the primary… |
| [Apigenin Capsules](https://magellanlongevity.com/p/114.md) | Emerging evidence | 18 | $24.95 | CD38 activity rises with age and drives the tissue decline of NAD+ that is linked to mitochondrial dysfunction,… |
| [Glycine Powder](https://magellanlongevity.com/p/125.md) | Moderate evidence | 18 | $18.37 | Small human trials report that about 3 g of glycine before bedtime improves subjective sleep quality and reduces… |
| [Myo-Inositol](https://magellanlongevity.com/p/131.md) | Moderate evidence | 17 | $32.00 | In randomized trials and meta-analyses, myo-inositol (often combined with D-chiro-inositol) has been associated with… |
| [Double Wood NMN Capsules](https://magellanlongevity.com/p/2.md) | Moderate evidence | 34 | $27.95 | In randomized controlled trials, NMN reliably increases blood NAD+ levels and has generally been well tolerated at… |
| [Carnosine](https://magellanlongevity.com/p/139.md) | Moderate evidence | 24 | $32.49 | Meta-analyses of randomized trials indicate that carnosine or beta-alanine supplementation modestly improves glycemic… |
| [Pycnogenol Pine Bark Extract](https://magellanlongevity.com/p/117.md) | Moderate evidence | 25 | $49.99 | In human trials, Pycnogenol has improved flow-mediated dilation and other measures of endothelial function in people… |
| [Grape Seed Extract](https://magellanlongevity.com/p/111.md) | Moderate evidence | 21 | $16.99 | Randomized trials and meta-analyses indicate that grape seed extract can modestly lower blood pressure — pooled… |
| [Hesperidin Citrus Flavonoid](https://magellanlongevity.com/p/113.md) | Moderate evidence | 22 | $15.99 | In human trials, hesperidin or hesperidin-rich orange juice has improved endothelial function and postprandial… |
| [Betaine (TMG)](https://magellanlongevity.com/p/132.md) | Strong evidence | 23 | $17.14 | Human trials and meta-analyses consistently show that oral betaine lowers fasting and post-methionine-load plasma… |
| [PQQ (Pyrroloquinoline Quinone)](https://magellanlongevity.com/p/122.md) | Moderate evidence | 23 | $17.94 | In human aging and health, PQQ is studied mainly for cognitive function, mitochondrial and energy support, antioxidant… |
| [Acetyl-L-Carnitine (ALCAR)](https://magellanlongevity.com/p/126.md) | Moderate evidence | 26 | $14.99 | Randomized trials and meta-analyses report modest benefits on cognition in mild cognitive impairment and mild… |
| [L-Methylfolate (5-MTHF)](https://magellanlongevity.com/p/130.md) | Moderate evidence | 21 | $22.00 | In human trials, both L-5-MTHF and folic acid raise blood folate and lower total homocysteine, an amino acid whose… |
| [Fisetin Senolytic Capsules](https://magellanlongevity.com/p/101.md) | Emerging evidence | 25 | $36.45 | Because senescent cells accumulate with age and contribute to frailty, vascular dysfunction, inflammation, and… |
| [Luteolin Capsules](https://magellanlongevity.com/p/115.md) | Emerging evidence | 21 | $19.95 | Preclinical studies consistently show that luteolin reduces neuroinflammation and can ameliorate memory and learning… |
| [Ergothioneine (L-Ergo)](https://magellanlongevity.com/p/108.md) | Moderate evidence | 16 | $34.95 | In humans, blood ergothioneine levels tend to fall with age, particularly after 60, and multiple observational and… |
| [Pomegranate Ellagitannin Extract](https://magellanlongevity.com/p/110.md) | Moderate evidence | 25 | $27.74 | In human research, the ellagitannin-derived metabolite urolithin A has improved muscle strength, endurance, and… |
| [Nutricost NMN Capsules 500mg](https://magellanlongevity.com/p/3.md) | Moderate evidence | 34 | $19.95 | In randomized controlled trials, NMN reliably increases blood NAD+ levels and has generally been well tolerated at… |
| [Broccoli Sprout Sulforaphane](https://magellanlongevity.com/p/103.md) | Moderate evidence | 19 | $11.19 | Human trials indicate that concentrated broccoli-sprout sulforaphane can modestly lower fasting blood glucose and… |
| [Tart Cherry Sleep Extract](https://magellanlongevity.com/p/118.md) | Emerging evidence | 20 | $12.99 | In small randomized and crossover trials, tart cherry juice or concentrate has modestly increased total sleep time (by… |
| [L-Carnitine](https://magellanlongevity.com/p/135.md) | Moderate evidence | 20 | $19.95 | Older and mostly small randomized trials, pooled in meta-analyses, suggest that L-carnitine given around the time of… |
| [Saffron Extract](https://magellanlongevity.com/p/119.md) | Moderate evidence | 24 | $19.95 | Multiple randomized controlled trials and meta-analyses report that saffron (commonly about 20-30 mg/day for mood and… |
| [NOVOS Vital Organ Support](https://magellanlongevity.com/p/14.md) | Emerging evidence | 25 | $69.00 | The individual ingredients carry uneven levels of human evidence. Lutein and zeaxanthin are the best supported, with… |
| [NOVOS Boost NMN](https://magellanlongevity.com/p/13.md) | Moderate evidence | 34 | $44.00 | In randomized controlled trials, NMN reliably increases blood NAD+ levels and has generally been well tolerated at… |
| [DaVinci Labs Phyto Benefits](https://magellanlongevity.com/p/19.md) | Moderate evidence | 23 | $64.36 | Observational cohorts consistently link higher dietary and urinary polyphenol (and flavonoid) intake to lower… |
| [Taurine](https://magellanlongevity.com/p/124.md) | Moderate evidence | 19 | $10.40 | A landmark 2023 study reported that taurine declines with age in mice, monkeys, and humans and that supplementation… |
| [NOVOS Core All-In-One Sachets](https://magellanlongevity.com/p/12.md) | Emerging evidence | 26 | $109.00 | Several of NOVOS Core's ingredients have genuine, though mostly early-stage, human or animal evidence relevant to… |
| [NMN Complex 1000 mg (Micro Ingredients)](https://magellanlongevity.com/p/1.md) | Moderate evidence | 34 | $34.95 | In randomized controlled trials, NMN reliably increases blood NAD+ levels and has generally been well tolerated at… |
| [Purovitalis Liposomal β-NMN](https://magellanlongevity.com/p/5.md) | Moderate evidence | 34 | $47.99 | In randomized controlled trials, NMN reliably increases blood NAD+ levels and has generally been well tolerated at… |
| [Purovitalis Liposomal Trans-Resveratrol](https://magellanlongevity.com/p/6.md) | Moderate evidence | 26 | $29.99 | In human health, the best-supported effects of resveratrol come from randomized trials and meta-analyses in people… |
| [Spermidine (Wheat-Germ Extract)](https://magellanlongevity.com/p/7.md) | Moderate evidence | 22 | $44.95 | In model organisms (yeast, worms, flies and mice) spermidine induces autophagy and extends lifespan, and in rodents it… |
| [Berberine HCl 500 mg (AMPK)](https://magellanlongevity.com/p/9.md) | Moderate evidence | 18 | $18.95 | In randomized trials and their meta-analyses in type 2 diabetes, berberine has produced significant reductions in… |
| [Dr. Mercola Liposomal Vitamin D3](https://magellanlongevity.com/p/10.md) | Moderate evidence | 17 | $16.97 | Large randomized trials and meta-analyses give a mixed picture. In generally healthy, vitamin-D-replete adults the two… |
| [DaVinci Labs NAD+ ACTIVATE](https://magellanlongevity.com/p/17.md) | Moderate evidence | 34 | $27.12 | In randomized controlled trials, NMN reliably increases blood NAD+ levels and has generally been well tolerated at… |
| [DaVinci Labs Glutathione Bright](https://magellanlongevity.com/p/20.md) | Moderate evidence | 17 | $71.76 | Randomized trials show that oral glutathione supplementation can genuinely raise body stores — a well-run 6-month… |
| [D-Glucosamine Sulfate](https://magellanlongevity.com/p/197.md) | Moderate evidence | 24 | $18.95 | Evidence on glucosamine for aging-related joint health is genuinely mixed: in the landmark 3-year randomized trial of… |
| [GlyNAC (Glycine + NAC)](https://magellanlongevity.com/p/198.md) | Emerging evidence | 16 | $34.00 | In small clinical trials, mostly pilot and open-label studies plus one randomized placebo-controlled trial of 24 older… |
| [Probiotic Multi-Strain (50B CFU)](https://magellanlongevity.com/p/199.md) | Moderate evidence | 24 | $16.99 | The strongest human evidence is indication-specific: a Cochrane review of 31 trials (8,672 participants) found… |
| [Akkermansia muciniphila Probiotic](https://magellanlongevity.com/p/200.md) | Emerging evidence | 14 | $64.00 | In a randomized, double-blind proof-of-concept trial in overweight or obese insulin-resistant adults, three months of… |
| [Inulin Prebiotic Fiber](https://magellanlongevity.com/p/201.md) | Moderate evidence | 21 | $27.99 | Randomized trials and meta-analyses indicate that inulin-type fructans reliably increase stool frequency and improve… |
| [Beetroot / Dietary Nitrate](https://magellanlongevity.com/p/202.md) | Moderate evidence | 24 | $9.99 | Meta-analyses of randomized trials show that beetroot juice and dietary nitrate lower blood pressure—about 5 mmHg… |
| [Palmitoylethanolamide (PEA)](https://magellanlongevity.com/p/206.md) | Moderate evidence | 18 | $76.99 | Across randomized trials and several meta-analyses, oral PEA has been associated with reductions in chronic pain of… |
| [Boswellia Serrata Extract](https://magellanlongevity.com/p/207.md) | Moderate evidence | 17 | $19.95 | The best-studied use of Boswellia serrata relevant to human aging is knee and hand osteoarthritis, where multiple… |
| [MSM (Methylsulfonylmethane)](https://magellanlongevity.com/p/208.md) | Moderate evidence | 21 | $11.62 | Across human studies, MSM has been evaluated mainly for osteoarthritis, exercise recovery, and seasonal allergic… |
| [Lithium Orotate (5 mg)](https://magellanlongevity.com/p/210.md) | Emerging evidence | 22 | $19.95 | The most firmly established human benefit of lithium is a reduction in suicide and all-cause mortality among people… |
| [Osteo Bi-Flex Triple Strength (Glucosamine Chondroitin + Joint Shield)](https://magellanlongevity.com/p/217.md) | Moderate evidence | 24 | $13.79 | Evidence on glucosamine and chondroitin for osteoarthritis is large but genuinely mixed. The pivotal NIH-funded GAIT… |
| [Glucosamine Chondroitin MSM (with OptiMSM)](https://magellanlongevity.com/p/218.md) | Moderate evidence | 25 | $32.99 | The evidence for glucosamine and chondroitin in human osteoarthritis is genuinely mixed. The landmark GAIT trial found… |
| [MSM with OptiMSM (1,500 mg)](https://magellanlongevity.com/p/219.md) | Emerging evidence | 21 | $13.98 | MSM has been studied chiefly for knee osteoarthritis, where small, short-term randomized trials report modest… |
| [Phosphatidylcholine (PC) Complex](https://magellanlongevity.com/p/220.md) | Preliminary | 25 | $16.00 | In human health, phosphatidylcholine's most encouraging evidence is in ulcerative colitis, where several randomized… |

## The research behind this category

The studies cited most often across the 65 products above. Quotes are verbatim from the cited abstract.

### Most-cited studies

1. **Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases**
   Mechanisms of Ageing and Development 2015 · [PMID 25824609](https://pubmed.ncbi.nlm.nih.gov/25824609/) · [DOI 10.1016/j.mad.2015.03.008](https://doi.org/10.1016/j.mad.2015.03.008)

   > Caloric restriction has been shown repeatedly to prolong the lifespan in laboratory animals, with its benefits dependent on molecular targets... including the NAD-dependent deacetylase SIRT1.

2. **Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis**
   Br J Sports Med 2018 · [PMID 29018060](https://pubmed.ncbi.nlm.nih.gov/29018060/) · [DOI 10.1136/bjsports-2016-097333](https://doi.org/10.1136/bjsports-2016-097333)

   > Of 20 supplements investigated in 69 studies, seven demonstrated large and clinically important effects for [osteoarthritis] pain reduction at short term.

3. **The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, double-blind, placebo-controlled, dose-dependent clinical trial**
   GeroScience 2022 · [PMID 36482258](https://pubmed.ncbi.nlm.nih.gov/36482258/) · [DOI 10.1007/s11357-022-00705-1](https://doi.org/10.1007/s11357-022-00705-1)

   > In animal studies, β-nicotinamide mononucleotide (NMN) supplementation increases nicotinamide adenine dinucleotide (NAD) concentrations and improves healthspan and lifespan with great safety.

4. **CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism.**
   Cell Metab 2016 · [PMID 27304511](https://pubmed.ncbi.nlm.nih.gov/27304511/) · [DOI 10.1016/j.cmet.2016.05.006](https://doi.org/10.1016/j.cmet.2016.05.006)

   > Here we demonstrate that expression and activity of the NADase CD38 increase with aging and that CD38 is required for the age-related NAD decline and mitochondrial dysfunction via a pathway mediated at least in part by regulation of SIRT3 activity.

5. **CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD and NMN levels.**
   Nat Metab 2020 · [PMID 33199925](https://pubmed.ncbi.nlm.nih.gov/33199925/) · [DOI 10.1038/s42255-020-00298-z](https://doi.org/10.1038/s42255-020-00298-z)

   > Our findings demonstrate that senescence-induced inflammation promotes accumulation of CD38 in immune cells that, through its ecto-enzymatic activity, decreases levels of NMN and NAD.

6. **Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD(+) in healthy middle-aged and older adults.**
   Nature communications 2018 · [PMID 29599478](https://pubmed.ncbi.nlm.nih.gov/29599478/)

   > Nicotinamide riboside (1,000 mg/day for 6 weeks) raised blood NAD+ by about 60% and was well tolerated, with exploratory signals for lower blood pressure and aortic stiffness.

7. **A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD(+) Metabolome in Healthy Middle-Aged Adults: A Randomized, Triple-Blind, Placebo-Controlled, Cross-Over Pilot Clinical Trial.**
   Nutrients 2022 · [PMID 35684021](https://pubmed.ncbi.nlm.nih.gov/35684021/)

   > A small placebo-controlled crossover trial found a nicotinamide-plus-D-ribose blend safely raised the blood NAD+ metabolome in healthy middle-aged adults; endpoints were biomarkers only.

8. **DMPC-Based Liposomal Vesicles for Encapsulation and Controlled Release of NMN and Matrigel in Sarcopenia Therapy.**
   International journal of molecular sciences 2025 · [PMID 40565060](https://pubmed.ncbi.nlm.nih.gov/40565060/)

   > Liposomal NMN delivery has been demonstrated only in cell and animal models; human pharmacokinetic superiority over plain NMN remains unverified.

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```

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## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).