--- title: "Fisetin Senolytic Capsules — Evidence, Benefits & Where to Buy | Magellan" description: "Fisetin Senolytic Capsules — Fisetin is a naturally occurring flavonol (a plant polyphenol) found in strawberries, apples, persimmons, onions, and other…" url: "https://magellanlongevity.com/p/101.md" canonical: "https://magellanlongevity.com/p/101.html" html: "https://magellanlongevity.com/p/101.html" type: "product" section: "Nutraceuticals & Cellular Energizers" evidence_grade: "Emerging evidence" evidence_tier: "emerging" citations: 25 product_id: 101 price_usd: 36.45 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" license: "Educational content — not medical advice" --- # Fisetin Senolytic Capsules [Home](https://magellanlongevity.com/) › [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) › Fisetin Senolytic Capsules **HTML version:** https://magellanlongevity.com/p/101.html · **In the Magellan app:** https://magellanlongevity.com/#/product/101 ## Key facts | Field | Value | | --- | --- | | Product | Fisetin Senolytic Capsules | | Category | [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) | | Evidence grade | Emerging evidence (C) | | Peer-reviewed citations | 25 | | Typical listed price | $36.45 (check the live price) | | Where to buy | [Search Amazon](https://www.amazon.com/s?k=Fisetin%20Senolytic%20Capsules&tag=magellanlong-20) | | Catalog ID | 101 | ## What it is Fisetin is a naturally occurring flavonol (a plant polyphenol) found in strawberries, apples, persimmons, onions, and other fruits and vegetables. A 2018 screen of flavonoids identified fisetin as the most potent 'senolytic' - a compound that selectively triggers death of senescent cells, damaged cells that stop dividing but persist and secrete pro-inflammatory factors termed the senescence-associated secretory phenotype (SASP). Its senolytic action is attributed to transiently disabling the anti-apoptotic survival pathways senescent cells depend on, along with prooxidant effects amplified by the copper and iron that accumulate in these cells; fisetin also has broader antioxidant and anti-inflammatory activity. ## Its role in longevity Because senescent cells accumulate with age and contribute to frailty, vascular dysfunction, inflammation, and multiple age-related diseases, selectively clearing them is a leading longevity strategy. In aged mice, intermittent fisetin has reduced senescence markers and improved endothelial function, arterial stiffness, muscle grip strength, and glucose metabolism, and one landmark 2018 study reported extended median and maximum lifespan - though the NIA Interventions Testing Program later found no significant lifespan extension at the dose and schedule it tested, so that flagship result appears dose- and schedule-dependent at best. Human evidence is early: small randomized trials show anti-inflammatory effects (100 mg/day lowered IL-8 and hs-CRP in colorectal cancer patients on chemotherapy) and better outcomes when added to stroke thrombolysis, but no published trial has demonstrated senescent-cell clearance or aging benefits in healthy older adults, and larger trials (in childhood-cancer survivors, frailty, and sepsis) are still underway. Reviewers caution that senolytics should not yet be used outside clinical trials. This evidence describes the fisetin compound and the senolytic/senescent-cell-clearance mechanism itself, not this specific commercial product. ## Evidence grade: Emerging evidence - **What the grade means:** Curated grade based on the human and mechanistic evidence for this compound. - **What this grade does not say:** Nearly all senolytic evidence is preclinical, and the 2018 mouse lifespan finding was not replicated by the NIA Interventions Testing Program in 2024. Small human RCTs show anti-inflammatory effects (for example 100 mg/day for 7 weeks in cancer patients), but no published trial has shown senescent-cell clearance or aging benefits in healthy people. Anti-aging use remains speculative pending larger trials. ## Where it comes from without a bottle Food, exercise and behaviour routes to the same pathway, each with its citation. | Natural source | How it works | Citation | | --- | --- | --- | | Strawberries (plus apples, persimmons, onions) | Fisetin is a flavonol that occurs naturally in whole fruits and vegetables; strawberries are the richest common dietary source, so a handful daily delivers small real-food amounts. | Anti-Cancer Agents in Medicinal Chemistry 2013 [PMID 23293889](https://pubmed.ncbi.nlm.nih.gov/23293889/) | | Fresh strawberries (concentrated dietary fisetin) | Among everyday foods, strawberries carry fisetin in the highest abundance, making them the practical produce-aisle way to take in this dietary polyphenol. | Food Research International 2023 [PMID 38129008](https://pubmed.ncbi.nlm.nih.gov/38129008/) | ### What those papers actually say 1. **Strawberries (plus apples, persimmons, onions)** Anti-Cancer Agents in Medicinal Chemistry 2013 · [PMID 23293889](https://pubmed.ncbi.nlm.nih.gov/23293889/) · [DOI 10.2174/18715206113139990129](https://doi.org/10.2174/18715206113139990129) > Fisetin (3,7,3',4'-tetrahydroxyflavone) belongs to the flavonol subgroup of flavonoids... and is found in several fruits and vegetables including strawberries, apples, persimmons and onions. 2. **Fresh strawberries (concentrated dietary fisetin)** Food Research International 2023 · [PMID 38129008](https://pubmed.ncbi.nlm.nih.gov/38129008/) · [DOI 10.1016/j.foodres.2023.113783](https://doi.org/10.1016/j.foodres.2023.113783) > Fisetin, a dietary polyphenol abundantly found in strawberries, exhibits a broad spectrum of health-promoting activities, including antihyperlipidemic effects. ## In the news - **Mayo Clinic researchers uncover new agents that eliminate cells associated with age-related diseases** — Mayo Clinic News Network 2017 [Read it](https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-researchers-uncover-new-agents-that-eliminate-cells-associated-with-age-related-diseases/) > At Mayo Clinic, we discovered the first senolytic drugs – agents that selectively eliminate senescent cells while leaving normal cells unaffected. These senolytic agents alleviated a range of age- and disease-related problems in mice. - **Mayo Clinic are testing Fisetin as a senescent cell therapy** — Lifespan.io 2022 [Read it](https://www.lifespan.io/road-maps/the-rejuvenation-roadmap/mayo-clinic-fisetin) > Fisetin is undergoing human clinical trials to test its ability to remove harmful senescent cells which accumulate with age. A Phase 2 study to address age-related frailty was conducted from February 2018 to December 2019 with some positive initial results. ## The research Peer-reviewed studies on the active compound. Quotes are verbatim from the cited abstract. Research describes the active mechanism and is not a claim about this specific product. ### Cited studies 1. **Evidence: clears senescent cells (flavonol)** EBioMedicine 2018 · [PMID 30279143](https://pubmed.ncbi.nlm.nih.gov/30279143/) · [DOI 10.1016/j.ebiom.2018.09.015](https://doi.org/10.1016/j.ebiom.2018.09.015) > fisetin was the most potent senolytic 2. **Senolytic drugs: from discovery to translation** J Intern Med 2020 · [PMID 32686219](https://pubmed.ncbi.nlm.nih.gov/32686219/) · [DOI 10.1111/joim.13141](https://doi.org/10.1111/joim.13141) > The first senolytic drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis-driven approach 3. **Cellular Senescence: A Translational Perspective** EBioMedicine 2017 · [PMID 28416161](https://pubmed.ncbi.nlm.nih.gov/28416161/) · [DOI 10.1016/j.ebiom.2017.04.013](https://doi.org/10.1016/j.ebiom.2017.04.013) > we discover pro-survival Senescent Cell Anti-apoptotic Pathways and the first senolytic agents 4. **Use of kersetin and fisetin flavonoids in combination with pregabalin and gabapentin in the treatment of neuropathic pain.** J Pharm Pharmacol 2024 · [PMID 38588462](https://pubmed.ncbi.nlm.nih.gov/38588462/) · [DOI 10.1093/jpp/rgae034](https://doi.org/10.1093/jpp/rgae034) > Based on these findings; it is possible to say that quercetin and fisetin are potential agents that can be used alone or in combination with other effective treatments to alleviate neuropathic pain. 5. **Analgesic Effects of Fisetin, Peimine, Astaxanthin, Artemisinin, Bardoxolone Methyl and 740 Y-P and Their Influence on Opioid Analgesia in a Mouse Model of Neuropathic Pain.** Int J Mol Sci 2023 · [PMID 37240346](https://pubmed.ncbi.nlm.nih.gov/37240346/) · [DOI 10.3390/ijms24109000](https://doi.org/10.3390/ijms24109000) > The results of our research clearly indicate that substances that inhibit all three MAPKs provide pain relief and improve opioid effectiveness, especially if they additionally block NF-κB, such as peimine, inhibit NF-κB and activate PI3K, such as fisetin, or activate Nrf2, such as astaxanthin. 6. **Prospective Selective Mechanism of Emerging Senolytic Agents Derived from Flavonoids.** J Agric Food Chem 2021 · [PMID 34662116](https://pubmed.ncbi.nlm.nih.gov/34662116/) · [DOI 10.1021/acs.jafc.1c04379](https://doi.org/10.1021/acs.jafc.1c04379) > Among senolytic candidates, only dasatinib with quercetin and fisetin meet the rigorous criteria for senolytic drugs, according to a modified version of Koch's postulates. 7. **Emerging senolytic agents derived from natural products.** Mech Ageing Dev 2019 · [PMID 31077707](https://pubmed.ncbi.nlm.nih.gov/31077707/) · [DOI 10.1016/j.mad.2019.05.001](https://doi.org/10.1016/j.mad.2019.05.001) > In recent years, emerging natural compounds have been discovered to be effective senolytic agents, such as quercetin, fisetin, piperlongumine and the curcumin analog. 8. **Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence.** Aging Cell 2023 · [PMID 38062873](https://pubmed.ncbi.nlm.nih.gov/38062873/) · [DOI 10.1111/acel.14060](https://doi.org/10.1111/acel.14060) > The findings from this study identify fisetin as promising therapy for clinical translation to target excess cell senescence to treat age-related arterial dysfunction. 9. **Intermittent Supplementation With Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle With Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic Senolytic Approaches.** Aging Cell 2025 · [PMID 40437670](https://pubmed.ncbi.nlm.nih.gov/40437670/) · [DOI 10.1111/acel.70114](https://doi.org/10.1111/acel.70114) > We found that fisetin mitigated the adverse changes in frailty and grip strength with aging. Fisetin had no effects in young mice. 10. **Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice.** Cell Metab 2025 · [PMID 41270738](https://pubmed.ncbi.nlm.nih.gov/41270738/) · [DOI 10.1016/j.cmet.2025.10.009](https://doi.org/10.1016/j.cmet.2025.10.009) > the senolytic, fisetin, which targets senescent endothelial cells among other senescent cell types, reduced adipose tissue senescent endothelial cell abundance and improved glucose metabolism in obese mice or mice transplanted with senescent mouse endothelial cells. 11. **IL-23R is a senescence-linked circulating and tissue biomarker of aging.** Nat Aging 2024 · [PMID 39658621](https://pubmed.ncbi.nlm.nih.gov/39658621/) · [DOI 10.1038/s43587-024-00752-7](https://doi.org/10.1038/s43587-024-00752-7) > We discovered that age-dependent changes in plasma proteins, including IL-23R, CCL5 and CA13, were reversed by senotherapeutics, which corresponded to expression differences in tissues, particularly in the kidney. In plasma from humans across the lifespan, IL-23R increased with age. 12. **Fisetin, potential flavonoid with multifarious targets for treating neurological disorders: An updated review.** Eur J Pharmacol 2021 · [PMID 34516952](https://pubmed.ncbi.nlm.nih.gov/34516952/) · [DOI 10.1016/j.ejphar.2021.174492](https://doi.org/10.1016/j.ejphar.2021.174492) > Fisetin has manifested several health benefits in preclinical models of neurodegenerative diseases such as Alzheimer's disease, Vascular dementia, and Schizophrenia. 13. **Recent advances in potential of Fisetin in the management of myocardial ischemia-reperfusion injury-A systematic review.** Phytomedicine 2022 · [PMID 35533608](https://pubmed.ncbi.nlm.nih.gov/35533608/) · [DOI 10.1016/j.phymed.2022.154123](https://doi.org/10.1016/j.phymed.2022.154123) > Fisetin is reported to be effective in attenuating IR injury by delaying the clotting time, preserving the mitochondrial function, reducing oxidative stress, and inhibiting GSK 3β. But it failed to protect diseased cardiomyocytes challenged to IR. 14. **Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle.** Aging (Albany NY) 2022 · [PMID 36084954](https://pubmed.ncbi.nlm.nih.gov/36084954/) · [DOI 10.18632/aging.204275](https://doi.org/10.18632/aging.204275) > the senolytic ablation of these senescent cells with fisetin can be an effective therapeutic strategy for improving function of muscle stem cells and phenotypes of dystrophic muscles. 15. **Anticancer Potential of Selected Flavonols: Fisetin, Kaempferol, and Quercetin on Head and Neck Cancers.** Nutrients 2021 · [PMID 33807530](https://pubmed.ncbi.nlm.nih.gov/33807530/) · [DOI 10.3390/nu13030845](https://doi.org/10.3390/nu13030845) > Study results prove antiproliferative and proapoptotic properties of flavonols with regard to head and neck cancer. 16. **Fisetin for COVID-19 in skilled nursing facilities: Senolytic trials in the COVID era.** J Am Geriatr Soc 2021 · [PMID 34375437](https://pubmed.ncbi.nlm.nih.gov/34375437/) · [DOI 10.1111/jgs.17416](https://doi.org/10.1111/jgs.17416) > Senolytic agents, such as Fisetin, selectively eliminate SnCs and delay, prevent, or alleviate multiple disorders in aged experimental animals and animal models of human chronic diseases, including obesity, diabetes, and respiratory diseases. 17. **Senolytics To slOw Progression of Sepsis (STOP-Sepsis) in elderly patients: Study protocol for a multicenter, randomized, adaptive allocation clinical trial.** Trials 2024 · [PMID 39434114](https://pubmed.ncbi.nlm.nih.gov/39434114/) · [DOI 10.1186/s13063-024-08474-2](https://doi.org/10.1186/s13063-024-08474-2) > We are conducting a multi-center, randomized, double-blinded, adaptive allocation phase 2 clinical trial to assess the efficacy of the senolytic drug fisetin in preventing clinical deterioration of elderly patients diagnosed with sepsis. 18. **Polyphenols and Diets as Current and Potential Nutrition Senotherapeutics in Alzheimer's Disease: Findings from Clinical Trials.** J Alzheimers Dis 2024 · [PMID 38875032](https://pubmed.ncbi.nlm.nih.gov/38875032/) · [DOI 10.3233/JAD-231222](https://doi.org/10.3233/JAD-231222) > Promising results with neuroprotective effects of senotherapeutic agents such as quercetin, resveratrol, Epigallocatechin-gallate, curcumin and fisetin were reported from preclinical studies. However, in-human trials remain limited, and findings were inconclusive. 19. **Vascular Niches Are the Primary Hotspots in Cardiac Aging.** Circ Res 2025 · [PMID 41090219](https://pubmed.ncbi.nlm.nih.gov/41090219/) · [DOI 10.1161/CIRCRESAHA.125.327060](https://doi.org/10.1161/CIRCRESAHA.125.327060) > We treated mice with broad-spectrum senolytics dasatinib and quercetin, and endothelial-specific senolytic fisetin and studied their effects on senescence and macrophage populations. 20. **Emerging Therapeutic Potential of Fisetin for Nephrotoxicity, Kidney Injury, and Nephropathy: A Systematic Review.** Curr Diabetes Rev 2026 · [PMID 40464183](https://pubmed.ncbi.nlm.nih.gov/40464183/) · [DOI 10.2174/0115733998369114250512094027](https://doi.org/10.2174/0115733998369114250512094027) > Preclinical studies revealed that FIS demonstrates promising protective effects against kidney toxicity, renal injury, diabetes, and lupus-induced nephropathy. However, more clinical studies are needed in this field to determine effective and safe doses. 21. **Targeting the FOXO4-p53 axis by retro-inverso peptide senolytic agents: a pharmacological strategy to mitigate brain aging and cognitive decline.** Naunyn Schmiedebergs Arch Pharmacol 2026 · [PMID 42024235](https://pubmed.ncbi.nlm.nih.gov/42024235/) · [DOI 10.1007/s00210-026-05309-6](https://doi.org/10.1007/s00210-026-05309-6) > Preliminary human studies involving FOXO4-axis modulators, such as high-dose fisetin, show a reduction in the senescence-associated secretory phenotype (SASP) and enhancements in cognitive and physical measures among older adults. 22. **Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used.** GeroScience 2024 · [PMID 38041783](https://pubmed.ncbi.nlm.nih.gov/38041783/) > The NIA Interventions Testing Program's rigorous multi-site mouse lifespan study found fisetin did not significantly extend lifespan at the dose and schedule tested - a key non-replication of the 2018 lifespan finding. 23. **Effect of fisetin supplementation on inflammatory factors and matrix metalloproteinase enzymes in colorectal cancer patients.** Food & function 2018 · [PMID 29541713](https://pubmed.ncbi.nlm.nih.gov/29541713/) > In a double-blind RCT of 37 colorectal cancer patients on chemotherapy, fisetin 100 mg/day for 7 weeks significantly lowered plasma IL-8 and hs-CRP versus placebo. 24. **Fisetin Prolongs Therapy Window of Brain Ischemic Stroke Using Tissue Plasminogen Activator: A Double-Blind Randomized Placebo-Controlled Clinical Trial.** Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2019 · [PMID 31434498](https://pubmed.ncbi.nlm.nih.gov/31434498/) > Adding fisetin to delayed rt-PA stroke treatment in a double-blind RCT improved neurological scores and reduced MMP-2, MMP-9 and CRP. 25. **New agents that target senescent cells: the flavone, fisetin, and the BCL-X(L) inhibitors, A1331852 and A1155463.** Aging 2017 · [PMID 28273655](https://pubmed.ncbi.nlm.nih.gov/28273655/) > The 2017 mechanistic study that identified fisetin as a senolytic, showing it selectively induces apoptosis in senescent murine and human cells. ## Where to buy [Search Amazon for Fisetin Senolytic Capsules](https://www.amazon.com/s?k=Fisetin%20Senolytic%20Capsules&tag=magellanlong-20) — affiliate search link. ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"ItemPage","@id":"https://magellanlongevity.com/p/101.html#page","url":"https://magellanlongevity.com/p/101.html","name":"Fisetin Senolytic Capsules","description":"Fisetin is a naturally occurring flavonol (a plant polyphenol) found in strawberries, apples, persimmons, onions, and other fruits and vegetables. 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Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).