--- title: "Urolithin A (Mitopure) — Evidence, Benefits & Where to Buy | Magellan" description: "Urolithin A (Mitopure) — Urolithin A is a natural compound produced by gut bacteria from ellagitannins and ellagic acid, dietary polyphenols found in…" url: "https://magellanlongevity.com/p/102.md" canonical: "https://magellanlongevity.com/p/102.html" html: "https://magellanlongevity.com/p/102.html" type: "product" section: "Nutraceuticals & Cellular Energizers" evidence_grade: "Moderate evidence" evidence_tier: "moderate" citations: 20 product_id: 102 price_usd: 50 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" license: "Educational content — not medical advice" --- # Urolithin A (Mitopure) [Home](https://magellanlongevity.com/) › [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) › Urolithin A (Mitopure) **HTML version:** https://magellanlongevity.com/p/102.html · **In the Magellan app:** https://magellanlongevity.com/#/product/102 ## Key facts | Field | Value | | --- | --- | | Product | Urolithin A (Mitopure) | | Category | [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) | | Evidence grade | Moderate evidence (B) | | Peer-reviewed citations | 20 | | Typical listed price | $50.00 (check the live price) | | Where to buy | [Search Amazon](https://www.amazon.com/s?k=Urolithin%20A%20%28Mitopure%29&tag=magellanlong-20) | | Catalog ID | 102 | ## What it is Urolithin A is a natural compound produced by gut bacteria from ellagitannins and ellagic acid, dietary polyphenols found in pomegranates, walnuts, and berries. It is not present directly in food but is generated during digestion, and the capacity to produce it varies widely between individuals depending on gut microbiome composition. Mechanistically, urolithin A stimulates mitophagy (the cellular recycling of damaged mitochondria) and promotes mitochondrial biogenesis and function. ## Its role in longevity In human research, urolithin A supplementation is safe and bioavailable and improves markers of mitochondrial health. Randomized trials report better muscle endurance in adults 65-90, roughly 12% strength gains with improved aerobic endurance in middle-aged adults, lower inflammatory markers (C-reactive protein, acylcarnitines), and, after just four weeks in a 2025 trial, a shift toward younger immune profiles with expanded naive-like, less-exhausted CD8+ T cells. Honest caveats: nearly all trials are small (about 50-100 people), short (up to 4 months), and manufacturer-funded; several primary endpoints were missed (peak power, maximal ATP production, and, in one trial, 6-minute walk distance); and no long-term disease or mortality data exist. This evidence describes the urolithin A compound and its mechanism rather than any specific commercial product. ## Evidence grade: Moderate evidence - **What the grade means:** Curated grade based on the human and mechanistic evidence for this compound. - **Dose used in studies:** 1,000 mg/day in most trials (500–1,000 mg/day studied) - **What this grade does not say:** Several small, well-controlled randomized trials show improved muscle endurance and strength, lower inflammatory markers, and younger-looking immune-cell profiles, with an excellent safety record. But nearly all are short (4 months or less) and manufacturer-funded, some missed their primary endpoints, and there is no long-term disease or lifespan data. Most people cannot reliably make urolithin A from food — the rationale for direct supplementation. ## Where it comes from without a bottle Food, exercise and behaviour routes to the same pathway, each with its citation. | Natural source | How it works | Citation | | --- | --- | --- | | Pomegranate, walnuts & berries (your gut makes urolithin A) | You can't eat urolithin A directly — it's made in your gut. Eating ellagitannin-rich foods (pomegranate, walnuts, strawberries, raspberries) feeds gut bacteria that convert those polyphenols into urolithin A inside your colon. | Clin Nutr 2017 [PMID 28347564](https://pubmed.ncbi.nlm.nih.gov/28347564/) | | Walnuts, tea & berries (the ellagitannin pathway) | Beyond pomegranate, the same precursor ellagitannins are abundant in walnuts, tea, strawberries, raspberries, blackberries and cloudberries — all of which your microbiota can ferment into urolithin A, the driver of mitophagy and mitochondrial renewal. | Phytother Res 2021 [PMID 34542202](https://pubmed.ncbi.nlm.nih.gov/34542202/) | | Honest caveat: you need the right gut bacteria | Whether eating these foods actually yields urolithin A depends on your personal microbiome — people fall into metabotypes (UM-A, UM-B, UM-0), and UM-0 individuals make little or none. That gut-dependence is exactly why a direct supplement exists. | Mol Nutr Food Res 2022 [PMID 35118817](https://pubmed.ncbi.nlm.nih.gov/35118817/) | ### What those papers actually say 1. **Pomegranate, walnuts & berries (your gut makes urolithin A)** Clin Nutr 2017 · [PMID 28347564](https://pubmed.ncbi.nlm.nih.gov/28347564/) · [DOI 10.1016/j.clnu.2017.03.012](https://doi.org/10.1016/j.clnu.2017.03.012) > Urolithins are microbial metabolites produced after consumption of ellagitannin-containing foods such as pomegranates and walnuts. 2. **Walnuts, tea & berries (the ellagitannin pathway)** Phytother Res 2021 · [PMID 34542202](https://pubmed.ncbi.nlm.nih.gov/34542202/) · [DOI 10.1002/ptr.7290](https://doi.org/10.1002/ptr.7290) > Urolithins are the gut metabolites produced from ellagitannin-rich foods such as pomegranates, tea, walnuts. 3. **Honest caveat: you need the right gut bacteria** Mol Nutr Food Res 2022 · [PMID 35118817](https://pubmed.ncbi.nlm.nih.gov/35118817/) · [DOI 10.1002/mnfr.202101019](https://doi.org/10.1002/mnfr.202101019) > Urolithins, metabolites produced by the gut microbiota from the polyphenols ellagitannins and ellagic acid. ## In the news - **Urolithin A recharges aging immune cells and boosts mitochondrial fitness in midlife adults** — News-Medical 2025 [Read it](https://www.news-medical.net/news/20251103/Urolithin-A-recharges-aging-immune-cells-and-boosts-mitochondrial-fitness-in-midlife-adults.aspx) > A month of Urolithin A supplementation restored youthful energy metabolism in immune cells, hinting at a safe nutritional strategy to counter immune aging and improve resilience to infections. - **First Human Clinical Trial Results on the Anti-Aging Compound, Urolithin A, Published by Amazentis and Researchers From the EPFL and SIB** — BioSpace 2019 [Read it](https://www.biospace.com/first-human-clinical-trial-results-on-the-anti-aging-compound-urolithin-a-published-by-amazentis-and-researchers-from-the-epfl-and-sib) > There are currently no effective solutions to treat age-related decline in muscle function other than months of exercise. This is an important first clinical validation that shows Urolithin A could be a promising solution for the management of healthy muscle function during aging. - **New Study Showing Urolithin A Significantly Improves Muscle Endurance in Older Adults Published in JAMA Network Open** — PR Newswire 2022 [Read it](https://www.prnewswire.com/news-releases/new-study-showing-urolithin-a-significantly-improves-muscle-endurance-in-older-adults-published-in-jama-network-open-301465521.html) > results from the study showed that after just two months, those who received a daily Mitopure supplement experienced significant improvement in hand and leg muscle endurance (the ability to repeatedly contract a muscle over an extended period of time) compared to those who received a placebo - **New Study: Urolithin A Revitalizes an Aging Immune System** — Timeline 2025 [Read it](https://www.timeline.com/blog/new-study-urolithin-a-revitalizes-an-aging-immune-system) > A new clinical trial in Nature Aging shows that Urolithin A can rejuvenate the aging immune system by improving mitochondrial health. ## The research Peer-reviewed studies on the active compound. Quotes are verbatim from the cited abstract. Research describes the active mechanism and is not a claim about this specific product. ### Cited studies 1. **Evidence: activates mitophagy, recycles mitochondria** Cell Rep Med 2022 · [PMID 35584623](https://pubmed.ncbi.nlm.nih.gov/35584623/) · [DOI 10.1016/j.xcrm.2022.100633](https://doi.org/10.1016/j.xcrm.2022.100633) > significant improvements in muscle strength with intake of Urolithin A 2. **Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial** JAMA Netw Open 2022 · [PMID 35050355](https://pubmed.ncbi.nlm.nih.gov/35050355/) · [DOI 10.1001/jamanetworkopen.2021.44279](https://doi.org/10.1001/jamanetworkopen.2021.44279) > Urolithin A is a gut microbiome-derived metabolite shown to stimulate mitophagy and improve muscle function 3. **Evaluating the Impact of Urolithin A Supplementation on Running Performance, Recovery, and Mitochondrial Biomarkers** Sports Med 2025 · [PMID 40839339](https://pubmed.ncbi.nlm.nih.gov/40839339/) · [DOI 10.1007/s40279-025-02292-5](https://doi.org/10.1007/s40279-025-02292-5) > UA upregulated pathways associated with mitochondria, led to a medium effect for increased markers of mitophagy 4. **Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis.** Aging Cell 2022 · [PMID 35778837](https://pubmed.ncbi.nlm.nih.gov/35778837/) · [DOI 10.1111/acel.13662](https://doi.org/10.1111/acel.13662) > Furthermore, Urolithin A reduced disease progression in a mouse model of OA, decreasing cartilage degeneration, synovial inflammation, and pain. 5. **Urolithin A alleviates neuropathic pain and activates mitophagy.** Mol Pain 2023 · [PMID 37464536](https://pubmed.ncbi.nlm.nih.gov/37464536/) · [DOI 10.1177/17448069231190815](https://doi.org/10.1177/17448069231190815) > We showed that the autophagy flow was blocked in the spinal dorsal horn of the chronic constriction injury (CCI) mice when the most obvious pain behavior occurs. 6. **The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans.** Nat Metab 2019 · [PMID 32694802](https://pubmed.ncbi.nlm.nih.gov/32694802/) · [DOI 10.1038/s42255-019-0073-4](https://doi.org/10.1038/s42255-019-0073-4) > These observed effects on mitochondrial biomarkers show that UA induces a molecular signature of improved mitochondrial and cellular health following regular oral consumption in humans. 7. **Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial.** Nat Aging 2025 · [PMID 41174221](https://pubmed.ncbi.nlm.nih.gov/41174221/) · [DOI 10.1038/s43587-025-00996-x](https://doi.org/10.1038/s43587-025-00996-x) > These findings indicate that short-term UA supplementation modulates human immune cell composition and function, supporting its potential to counteract age-related immune decline and inflammaging. 8. **Assessment of Urolithin A effects on muscle endurance, strength, inflammation, oxidative stress, and protein metabolism in male athletes with resistance training: an 8-week randomized, double-blind, placebo-controlled study.** J Int Soc Sports Nutr 2024 · [PMID 39487653](https://pubmed.ncbi.nlm.nih.gov/39487653/) · [DOI 10.1080/15502783.2024.2419388](https://doi.org/10.1080/15502783.2024.2419388) > After 8 weeks of UA supplementation at 1 g/day, resistance-trained male athletes showed improvements in muscle strength and endurance. Additionally, UA supplementation was also associated with reduced oxidative stress levels and a decrease in inflammation response levels. 9. **Evaluation of Urolithin A Efficacy in Heart Failure Patients with Reduced Ejection Fraction: A Randomized, Double-blind, Crossover, Placebo-controlled Clinical Trial.** Rev Recent Clin Trials 2024 · [PMID 38415449](https://pubmed.ncbi.nlm.nih.gov/38415449/) · [DOI 10.2174/0115748871279354240209101604](https://doi.org/10.2174/0115748871279354240209101604) > The results of the present study do not support any positive effect of UA supplementation in improving echocardiographic and biochemical indices of HFrEF. 10. **Targeting aging with urolithin A in humans: A systematic review.** Ageing Res Rev 2024 · [PMID 39002645](https://pubmed.ncbi.nlm.nih.gov/39002645/) · [DOI 10.1016/j.arr.2024.102406](https://doi.org/10.1016/j.arr.2024.102406) > UA increased muscle strength and endurance, however, had no effect on anthropometrics, cardiovascular outcomes, and physical function. 11. **Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents.** Nat Med 2016 · [PMID 27400265](https://pubmed.ncbi.nlm.nih.gov/27400265/) · [DOI 10.1038/nm.4132](https://doi.org/10.1038/nm.4132) > We identified urolithin A (UA) as a first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption. In C. elegans, UA prevented the accumulation of dysfunctional mitochondria with age and extended lifespan. 12. **Impact of the Natural Compound Urolithin A on Health, Disease, and Aging.** Trends Mol Med 2021 · [PMID 34030963](https://pubmed.ncbi.nlm.nih.gov/34030963/) · [DOI 10.1016/j.molmed.2021.04.009](https://doi.org/10.1016/j.molmed.2021.04.009) > UA enhances cellular health by increasing mitophagy and mitochondrial function and reducing detrimental inflammation. 13. **Evidence: precursor to urolithins, mitophagy** Phytother Res 2021 · [PMID 34542202](https://pubmed.ncbi.nlm.nih.gov/34542202/) · [DOI 10.1002/ptr.7290](https://doi.org/10.1002/ptr.7290) > urolithin A is safe and can improve mitochondrial biomarkers in elderly patients 14. **Mitophagy Activation by Urolithin A to Target Muscle Aging.** Calcif Tissue Int 2023 · [PMID 37925671](https://pubmed.ncbi.nlm.nih.gov/37925671/) · [DOI 10.1007/s00223-023-01145-5](https://doi.org/10.1007/s00223-023-01145-5) > The natural postbiotic Urolithin A has been shown to promote mitophagy, mitochondrial function and improved muscle function across species in different experimental models and across multiple clinical studies. 15. **Mitophagy inhibits amyloid-beta and tau pathology and reverses cognitive deficits in models of Alzheimer's disease.** Nat Neurosci 2019 · [PMID 30742114](https://pubmed.ncbi.nlm.nih.gov/30742114/) · [DOI 10.1038/s41593-018-0332-9](https://doi.org/10.1038/s41593-018-0332-9) > mitophagy stimulation (through NAD supplementation, urolithin A, and actinonin) reverses memory impairment 16. **Urolithin A promotes p62-dependent lysophagy to prevent acute retinal neurodegeneration.** Mol Neurodegener 2024 · [PMID 38890703](https://pubmed.ncbi.nlm.nih.gov/38890703/) · [DOI 10.1186/s13024-024-00739-3](https://doi.org/10.1186/s13024-024-00739-3) > UA alleviated neurodegeneration and preserved visual function in SI-treated mice. 17. **Urolithin A Inactivation of TLR3/TRIF Signaling to Block the NF-kB/STAT1 Axis Reduces Inflammation and Enhances Antioxidant Defense in Poly(I:C)-Induced RAW264.7 Cells.** Int J Mol Sci 2022 · [PMID 35563088](https://pubmed.ncbi.nlm.nih.gov/35563088/) · [DOI 10.3390/ijms23094697](https://doi.org/10.3390/ijms23094697) > our results suggest that urolithin A inhibits TLR3-activated inflammatory and oxidative-associated pathways in macrophages, and that this inhibition is induced by poly(I:C). 18. **Protective effect of urolithin a on cisplatin-induced nephrotoxicity in mice via modulation of inflammation and oxidative stress.** Food Chem Toxicol 2019 · [PMID 31014901](https://pubmed.ncbi.nlm.nih.gov/31014901/) · [DOI 10.1016/j.fct.2019.04.031](https://doi.org/10.1016/j.fct.2019.04.031) > Urolithin A pretreatment reduced all the above renal damage parameters in a significant way. 19. **Multi-Species Synbiotic Supplementation Enhances Gut Microbial Diversity, Increases Urolithin A and Butyrate Production, and Reduces Inflammation in Healthy Adults: A Randomized, Placebo-Controlled Trial.** Nutrients 2025 · [PMID 40944126](https://pubmed.ncbi.nlm.nih.gov/40944126/) · [DOI 10.3390/nu17172734](https://doi.org/10.3390/nu17172734) > This multi-species synbiotic significantly increases diversity and abundance of key beneficial bacteria, enhances UroA production and butyrate levels, and is associated with lowered systemic inflammation. 20. **A double-blind, randomized, neoadjuvant study of the tissue effects of POMx pills in men with prostate cancer before radical prostatectomy.** Cancer Prev Res (Phila) 2013 · [PMID 23985577](https://pubmed.ncbi.nlm.nih.gov/23985577/) · [DOI 10.1158/1940-6207.CAPR-12-0423](https://doi.org/10.1158/1940-6207.CAPR-12-0423) > Urolithin A was detected in 21 of the 33 patients in the POMx group versus 12 of the 35 in the placebo group (P = 0.031). ## Where to buy [Search Amazon for Urolithin A (Mitopure)](https://www.amazon.com/s?k=Urolithin%20A%20%28Mitopure%29&tag=magellanlong-20) — affiliate search link. ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"ItemPage","@id":"https://magellanlongevity.com/p/102.html#page","url":"https://magellanlongevity.com/p/102.html","name":"Urolithin A (Mitopure)","description":"Urolithin A is a natural compound produced by gut bacteria from ellagitannins and ellagic acid, dietary polyphenols found in pomegranates, walnuts, and…","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/p/102.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Nutraceuticals & Cellular Energizers","item":"https://magellanlongevity.com/c/1.html"},{"@type":"ListItem","position":3,"name":"Urolithin A (Mitopure)","item":"https://magellanlongevity.com/p/102.html"}]},{"@type":"Product","@id":"https://magellanlongevity.com/p/102.html#product","name":"Urolithin A (Mitopure)","category":"Nutraceuticals & Cellular Energizers","url":"https://magellanlongevity.com/p/102.html","description":"Urolithin A is a natural compound produced by gut bacteria from ellagitannins and ellagic acid, dietary polyphenols found in pomegranates, walnuts, and berries. 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Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).