--- title: "Broccoli Sprout Sulforaphane — Evidence, Benefits & Where to… | Magellan" description: "Broccoli Sprout Sulforaphane — Sulforaphane is an isothiocyanate phytochemical formed when the plant enzyme myrosinase acts on glucoraphanin, a…" url: "https://magellanlongevity.com/p/103.md" canonical: "https://magellanlongevity.com/p/103.html" html: "https://magellanlongevity.com/p/103.html" type: "product" section: "Nutraceuticals & Cellular Energizers" evidence_grade: "Moderate evidence" evidence_tier: "moderate" citations: 19 product_id: 103 price_usd: 11.19 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" license: "Educational content — not medical advice" --- # Broccoli Sprout Sulforaphane [Home](https://magellanlongevity.com/) › [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) › Broccoli Sprout Sulforaphane **HTML version:** https://magellanlongevity.com/p/103.html · **In the Magellan app:** https://magellanlongevity.com/#/product/103 ## Key facts | Field | Value | | --- | --- | | Product | Broccoli Sprout Sulforaphane | | Category | [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) | | Evidence grade | Moderate evidence (B) | | Peer-reviewed citations | 19 | | Typical listed price | $11.19 (check the live price) | | Where to buy | [Search Amazon](https://www.amazon.com/s?k=Broccoli%20Sprout%20Sulforaphane&tag=magellanlong-20) | | Catalog ID | 103 | ## What it is Sulforaphane is an isothiocyanate phytochemical formed when the plant enzyme myrosinase acts on glucoraphanin, a glucosinolate concentrated in cruciferous vegetables such as broccoli and especially young broccoli sprouts. In the body it is a potent activator of the NRF2 (NF-E2-related factor 2) transcription factor, which induces phase-2 antioxidant and detoxification enzymes. In diabetes research it has been shown to suppress hepatic glucose production by promoting NRF2 nuclear translocation and downregulating key gluconeogenic enzymes. It is commonly delivered as a standardized broccoli sprout extract. ## Its role in longevity Human trials indicate that concentrated broccoli-sprout sulforaphane can modestly lower fasting blood glucose and glycated hemoglobin, most clearly in obese or dysregulated type 2 diabetes and in a subset of people with prediabetes; a 2025 randomized placebo-controlled trial found a small average reduction in fasting glucose (about 0.2 mmol/L), with substantially larger effects in participants whose gut microbiota and metabolic profile predicted response. A separate line of randomized trials shows sulforaphane-rich preparations enhance the detoxification and excretion of airborne and tobacco-derived carcinogens, and early trials report improved insulin resistance and liver enzymes, with a generally good safety and tolerability profile aside from mild gastrointestinal effects. Benefits so far are biomarker-level rather than proven disease-outcome reductions, and supplement bioavailability varies widely unless the preparation retains active myrosinase. This evidence concerns the sulforaphane compound and broccoli-sprout extracts in general, not this specific commercial product. ## Evidence grade: Moderate evidence - **What the grade means:** Curated grade based on the human and mechanistic evidence for this compound. - **What this grade does not say:** Randomized trials show real biomarker effects — enhanced carcinogen detoxification and a modest glucose-lowering signal in prediabetes — but these are surrogate markers, not proven disease-outcome reductions. Actual sulforaphane delivery varies widely between supplements unless active myrosinase is retained. Mild gastrointestinal upset is the main side effect. ## Where it comes from without a bottle Food, exercise and behaviour routes to the same pathway, each with its citation. | Natural source | How it works | Citation | | --- | --- | --- | | Cruciferous vegetables (broccoli, sprouts, kale) | Eating cruciferous vegetables is the traditional way to obtain sulforaphane: they carry glucoraphanin, which your chewing and gut enzymes convert into active sulforaphane. | Journal of Agricultural and Food Chemistry 2004 [PMID 14969551](https://pubmed.ncbi.nlm.nih.gov/14969551/) | | Fresh broccoli florets and sprouts | Both broccoli florets and young sprouts supply glucoraphanin, which the plant enzyme myrosinase hydrolyzes into sulforaphane when the vegetable is chopped or chewed raw. | Critical Reviews in Food Science and Nutrition 2023 [PMID 37129118](https://pubmed.ncbi.nlm.nih.gov/37129118/) | ### What those papers actually say 1. **Cruciferous vegetables (broccoli, sprouts, kale)** Journal of Agricultural and Food Chemistry 2004 · [PMID 14969551](https://pubmed.ncbi.nlm.nih.gov/14969551/) · [DOI 10.1021/jf0307189](https://doi.org/10.1021/jf0307189) > In addition to the traditional avenue for obtaining sulforaphane, namely, the consumption of appropriate cruciferous vegetables... glucoraphanin, the natural precursor to sulforaphane. 2. **Fresh broccoli florets and sprouts** Critical Reviews in Food Science and Nutrition 2023 · [PMID 37129118](https://pubmed.ncbi.nlm.nih.gov/37129118/) · [DOI 10.1080/10408398.2023.2195493](https://doi.org/10.1080/10408398.2023.2195493) > Sulforaphane, an isothiocyanate produced as a result of hydrolysis of precursor glucosinolates called glucoraphanin... the specific role of fresh florets and sprouts of broccoli. ## In the news - **Daily Dose of Broccoli Sprout Extract Helps Blood Sugar, Study Shows** — ScienceAlert 2025 [Read it](https://www.sciencealert.com/daily-dose-of-broccoli-sprout-extract-helps-blood-sugar-study-shows) > Volunteers were given either a compound commonly found in cruciferous vegetables known as sulforaphane or a placebo every day for 12 weeks. Those given sulforaphane showed a significant reduction in blood sugar, report the researchers, led by a team from the University of Gothenburg in Sweden. - **Concentrated broccoli sprout extract may reduce fasting blood glucose in type 2 diabetes, obesity** — Healio (Endocrine Today) 2017 [Read it](https://www.healio.com/news/endocrinology/20170622/concentrated-broccoli-sprout-extract-may-reduce-fasting-blood-glucose-in-type-2-diabetes-obesity) > A small group of Scandinavian adults with poorly controlled type 2 diabetes and obesity saw a reduction in both HbA1c and fasting plasma glucose with a daily supplement of broccoli sprout extract over 12 weeks when compared with similar adults assigned to placebo. - **Reduced prediabetes in people who ate broccoli compound** — ScienceDaily 2025 [Read it](https://www.sciencedaily.com/releases/2025/02/250214003212.htm) > The chemical compound sulforaphane found in broccoli sprouts can be linked to improved blood sugar levels in prediabetes, a precursor to type 2 diabetes. ## The research Peer-reviewed studies on the active compound. Quotes are verbatim from the cited abstract. Research describes the active mechanism and is not a claim about this specific product. ### Cited studies 1. **Evidence: sulforaphane reduces hepatic gluconeogenesis** Nat Microbiol 2025 · [PMID 39929977](https://pubmed.ncbi.nlm.nih.gov/39929977/) · [DOI 10.1038/s41564-025-01932-w](https://doi.org/10.1038/s41564-025-01932-w) > reduction in fasting blood glucose compared with placebo 2. **Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes** Sci Transl Med 2017 · [PMID 28615356](https://pubmed.ncbi.nlm.nih.gov/28615356/) · [DOI 10.1126/scitranslmed.aah4477](https://doi.org/10.1126/scitranslmed.aah4477) > Sulforaphane suppressed glucose production; reduced fasting blood glucose and HbA1c 3. **Sulforaphane Delays Fibroblast Senescence by Curbing Cellular Glucose Uptake, Increased Glycolysis, and Oxidative Damage** Oxid Med Cell Longev 2018 · [PMID 30595796](https://pubmed.ncbi.nlm.nih.gov/30595796/) · [DOI 10.1155/2018/5642148](https://doi.org/10.1155/2018/5642148) > sulforaphane activates Nrf2 and delays senescence by decreasing glucose metabolism and oxidative damage 4. **Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial.** Int J Food Sci Nutr 2012 · [PMID 22537070](https://pubmed.ncbi.nlm.nih.gov/22537070/) · [DOI 10.3109/09637486.2012.665043](https://doi.org/10.3109/09637486.2012.665043) > After 4 weeks, consumption of 10 g/d BSP resulted in a significant decrease in serum insulin concentration and HOMA-IR (p = 0.05 for treatment effect). Therefore, broccoli sprouts may improve IR in type 2 diabetic patients. 5. **Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study.** Nutr Cancer 2006 · [PMID 16965241](https://pubmed.ncbi.nlm.nih.gov/16965241/) · [DOI 10.1207/s15327914nc5501_7](https://doi.org/10.1207/s15327914nc5501_7) > No significant or consistent subjective or objective abnormal events (toxicities) associated with any of the sprout extract ingestions were observed. 6. **Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects.** World J Gastroenterol 2015 · [PMID 26604653](https://pubmed.ncbi.nlm.nih.gov/26604653/) · [DOI 10.3748/wjg.v21.i43.12457](https://doi.org/10.3748/wjg.v21.i43.12457) > Dietary supplementation with BS extract containing the SF precursor GR is likely to be highly effective in improving liver function through reduction of oxidative stress. 7. **Dose-dependent detoxication of the airborne pollutant benzene in a randomized trial of broccoli sprout beverage in Qidong, China.** Am J Clin Nutr 2019 · [PMID 31268126](https://pubmed.ncbi.nlm.nih.gov/31268126/) · [DOI 10.1093/ajcn/nqz122](https://doi.org/10.1093/ajcn/nqz122) > A statistically significant increase in benzene mercapturic acids in urine was found for the high-dose group (+63.2%) during the 10-d period. 8. **Sulforaphane reprograms the metabolomic landscape of chronic kidney disease: insights from NMR-based metabolomics.** Food Funct 2026 · [PMID 42200637](https://pubmed.ncbi.nlm.nih.gov/42200637/) · [DOI 10.1039/d6fo00047a](https://doi.org/10.1039/d6fo00047a) > SFN supplementation tended to reduce 2-hydroxyisovalerate and glycerol levels, metabolites associated with insulin resistance and oxidative stress, and attenuated methanol elevation. 9. **Potential efficacy of broccoli sprouts as a unique supplement for management of type 2 diabetes and its complications.** J Med Food 2013 · [PMID 23631497](https://pubmed.ncbi.nlm.nih.gov/23631497/) · [DOI 10.1089/jmf.2012.2559](https://doi.org/10.1089/jmf.2012.2559) > In hyperglycemic and oxidative conditions, sulforaphane has the potential to activate the NF-E2-related factor-2 (Nrf2)-dependent antioxidant response-signaling pathway, induces phase 2 enzymes, attenuates oxidative stress, and inactivates nuclear factor kappa-B (NF-κB), a key modulator of inflammatory pathways. 10. **A mechanistic overview of sulforaphane and its derivatives application in diabetes and its complications.** Inflammopharmacology 2023 · [PMID 37955784](https://pubmed.ncbi.nlm.nih.gov/37955784/) · [DOI 10.1007/s10787-023-01373-z](https://doi.org/10.1007/s10787-023-01373-z) > Sulforaphane has been demonstrated to activate the PIK/AKT and AMP-activated protein kinase pathways and the glucose transporter type 4 to increase insulin production and reduce insulin resistance. 11. **Sulforaphane alleviates high fat diet-induced insulin resistance via AMPK/Nrf2/GPx4 axis.** Biomed Pharmacother 2022 · [PMID 35709656](https://pubmed.ncbi.nlm.nih.gov/35709656/) · [DOI 10.1016/j.biopha.2022.113273](https://doi.org/10.1016/j.biopha.2022.113273) > SFN was found to effectively reduce body weight, fasting blood glucose and hyperlipidemia, and improve liver function in HFD-fed mice. 12. **Oral Sulforaphane Intervention Protects Against Diabetic Cardiomyopathy in db/db Mice: Focus on Cardiac Lipotoxicity and Substrate Metabolism.** Antioxidants (Basel) 2025 · [PMID 40427484](https://pubmed.ncbi.nlm.nih.gov/40427484/) · [DOI 10.3390/antiox14050603](https://doi.org/10.3390/antiox14050603) > SFN intervention (SFN-I) alleviated hyperglycemia, dyslipidemia, HOMA-IR, serum MDA levels, and liver inflammation. 13. **Sulforaphane attenuates aldose reductase-mediated platelet dysfunction in high glucose-stimulated human platelets via downregulation of the Src/ROS/p53 signaling pathway.** Front Nutr 2025 · [PMID 40823012](https://pubmed.ncbi.nlm.nih.gov/40823012/) · [DOI 10.3389/fnut.2025.1663245](https://doi.org/10.3389/fnut.2025.1663245) > These findings suggest that by inhibiting the Src/ROS/p53 signaling pathway and mitigating AR-mediated platelet dysfunction, SFN may confer significant protection against atherothrombosis during hyperglycemia. 14. **Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress.** Autophagy 2020 · [PMID 32138578](https://pubmed.ncbi.nlm.nih.gov/32138578/) · [DOI 10.1080/15548627.2020.1739442](https://doi.org/10.1080/15548627.2020.1739442) > by simultaneously activating macroautophagy/autophagy and detoxifying pathways, natural compound SFN may trigger a self-defense cellular mechanism that can effectively mitigate oxidative stress commonly associated with many metabolic and age-related diseases. 15. **Efficacy and safety of sulforaphane in schizophrenia: a systematic review and meta-analysis of randomized controlled trials.** BMC Psychiatry 2025 · [PMID 41184790](https://pubmed.ncbi.nlm.nih.gov/41184790/) · [DOI 10.1186/s12888-025-07515-7](https://doi.org/10.1186/s12888-025-07515-7) > Sulforaphane led to significant reductions in metabolic markers, including LDL, triglycerides, and cholesterol. Discontinuation rates were lower in the sulforaphane group (RR = 0.68; 95% CI: 0.49 to 0.95; p = 0.02). 16. **Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers.** Cancers 2022 · [PMID 35565256](https://pubmed.ncbi.nlm.nih.gov/35565256/) > A broccoli seed and sprout extract increased detoxication of tobacco-derived carcinogens in current smokers in a randomized crossover trial. 17. **Protective effects of sulforaphane against toxic substances and contaminants: A systematic review.** Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 · [PMID 38824824](https://pubmed.ncbi.nlm.nih.gov/38824824/) > A systematic review found sulforaphane consistently upregulates detoxication and antioxidant-response pathways, supporting protection against toxic substances and contaminants. 18. **Randomized Phase II Clinical Trial of Sulforaphane in Former Smokers at High Risk for Lung Cancer.** Cancer prevention research (Philadelphia, Pa.) 2025 · [PMID 40041932](https://pubmed.ncbi.nlm.nih.gov/40041932/) > A Phase II randomized trial moved sulforaphane into a cancer-prevention setting, testing it in former smokers at high risk for lung cancer. 19. **Efficacy and tolerability of sulforaphane in the therapeutic management of cancers: a systematic review of randomized controlled trials.** Frontiers in oncology 2023 · [PMID 38074675](https://pubmed.ncbi.nlm.nih.gov/38074675/) > A systematic review of randomized trials in oncology settings found sulforaphane generally tolerable, with supportive but not definitive efficacy signals. ## Where to buy [Search Amazon for Broccoli Sprout Sulforaphane](https://www.amazon.com/s?k=Broccoli%20Sprout%20Sulforaphane&tag=magellanlong-20) — affiliate search link. ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"ItemPage","@id":"https://magellanlongevity.com/p/103.html#page","url":"https://magellanlongevity.com/p/103.html","name":"Broccoli Sprout Sulforaphane","description":"Sulforaphane is an isothiocyanate phytochemical formed when the plant enzyme myrosinase acts on glucoraphanin, a glucosinolate concentrated in…","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/p/103.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Nutraceuticals & Cellular Energizers","item":"https://magellanlongevity.com/c/1.html"},{"@type":"ListItem","position":3,"name":"Broccoli Sprout Sulforaphane","item":"https://magellanlongevity.com/p/103.html"}]},{"@type":"Product","@id":"https://magellanlongevity.com/p/103.html#product","name":"Broccoli Sprout Sulforaphane","category":"Nutraceuticals & Cellular Energizers","url":"https://magellanlongevity.com/p/103.html","description":"Sulforaphane is an isothiocyanate phytochemical formed when the plant enzyme myrosinase acts on glucoraphanin, a glucosinolate concentrated in cruciferous vegetables such as broccoli and especially young broccoli sprouts. 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Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).