---
title: "Quercetin Capsules — Evidence, Benefits & Where to Buy | Magellan"
description: "Quercetin Capsules — Quercetin is a flavonol, a plant polyphenol found abundantly in onions, apples, berries, capers, and tea. As one of the most common…"
url: "https://magellanlongevity.com/p/105.md"
canonical: "https://magellanlongevity.com/p/105.html"
html: "https://magellanlongevity.com/p/105.html"
type: "product"
section: "Nutraceuticals & Cellular Energizers"
evidence_grade: "Moderate evidence"
evidence_tier: "moderate"
citations: 25
product_id: 105
price_usd: 21.42
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
license: "Educational content — not medical advice"
---

# Quercetin Capsules

[Home](https://magellanlongevity.com/) › [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) › Quercetin Capsules

**HTML version:** https://magellanlongevity.com/p/105.html · **In the Magellan app:** https://magellanlongevity.com/#/product/105

## Key facts

| Field | Value |
| --- | --- |
| Product | Quercetin Capsules |
| Category | [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) |
| Evidence grade | Moderate evidence (B) |
| Peer-reviewed citations | 25 |
| Typical listed price | $21.42 (check the live price) |
| Where to buy | [Search Amazon](https://www.amazon.com/s?k=Quercetin%20Capsules&tag=magellanlong-20) |
| Catalog ID | 105 |

## What it is

Quercetin is a flavonol, a plant polyphenol found abundantly in onions, apples, berries, capers, and tea. As one of the most common dietary flavonoids, it has antioxidant and anti-inflammatory properties and has been investigated for cardiovascular effects, particularly on blood pressure. Proposed mechanisms for its antihypertensive action include improved endothelial nitric-oxide-dependent vasodilation, inhibition of angiotensin-converting enzyme activity, and reduced oxidative stress. Quercetin is also one of the first-identified senolytic compounds, studied experimentally with the drug dasatinib to clear senescent cells.

## Its role in longevity

Meta-analyses of randomized trials indicate quercetin produces a small blood-pressure reduction—on the order of 2–3 mmHg—most apparent at doses of at least 500 mg/day and in people with hypertension rather than normal blood pressure; individual trials are mixed, and a rigorous trial of purified quercetin found no vascular-function effect. Meta-analyses found no meaningful effect on lipids, glucose, or insulin measures, and quercetin's poor, variable oral bioavailability likely explains the small effect sizes. Separately, quercetin is the 'Q' in the dasatinib-plus-quercetin senolytic drug combination: a first-in-human trial found the pair cleared senescent cells and lowered inflammatory factors, but the largest 2024 randomized trial was negative overall and an Alzheimer's trial showed only safety and feasibility. Those results belong to the drug combination in early trials, not to over-the-counter capsules. This body of evidence describes the compound quercetin and its mechanisms, not this specific commercial product.

## Evidence grade: Moderate evidence

- **What the grade means:** Curated grade based on the human and mechanistic evidence for this compound.
- **Dose used in studies:** ≥500 mg/day (blood-pressure effects appear mainly at 500 mg/day and above)
- **What this grade does not say:** Meta-analyses show a small (~2–3 mmHg) blood-pressure reduction, mostly in people with hypertension; lipids and glucose show no meaningful effect, and oral bioavailability is poor. The headline 'senolytic' claims come from the dasatinib+quercetin drug combination in early trials — the biggest 2024 trial was negative overall — not from quercetin capsules alone.

## Where it comes from without a bottle

Food, exercise and behaviour routes to the same pathway, each with its citation.

| Natural source | How it works | Citation |
| --- | --- | --- |
| Onions, apples & broccoli | Quercetin is the most abundant flavonol in the diet, and onions (especially red onion skin layers), apples, broccoli, and tea are its leading whole-food sources. Eating the apple peel and not over-cooking onions preserves the most quercetin. | Nutr Cancer 2008 [PMID 18584477](https://pubmed.ncbi.nlm.nih.gov/18584477/) |
| Apple & onion (cardiovascular angle) | The same quercetin studied for blood-vessel and anti-inflammatory benefits is the compound extracted from apples and onions. Building a habit around these everyday foods gives a steady dietary trickle rather than a single large dose. | Biomed Pharmacother 2016 [PMID 27919735](https://pubmed.ncbi.nlm.nih.gov/27919735/) |

### What those papers actually say

1. **Onions, apples & broccoli**
   Nutr Cancer 2008 · [PMID 18584477](https://pubmed.ncbi.nlm.nih.gov/18584477/) · [DOI 10.1080/01635580802143836](https://doi.org/10.1080/01635580802143836)

   > Other significant flavonol sources included onion (isorhamnetin and quercetin), broccoli (kaempferol and quercetin), apple (quercetin), grape (quercetin)... and beans (quercetin).

2. **Apple & onion (cardiovascular angle)**
   Biomed Pharmacother 2016 · [PMID 27919735](https://pubmed.ncbi.nlm.nih.gov/27919735/) · [DOI 10.1016/j.biopha.2016.11.077](https://doi.org/10.1016/j.biopha.2016.11.077)

   > Quercetin is a dietary flavonoid compound extracted from various plants, such as apple and onions.

## In the news

- **Senolytics improve health, extend life: Preclinical research findings** — Mayo Clinic News Network 2018 [Read it](https://newsnetwork.mayoclinic.org/discussion/senolytics-improve-health-extend-life-preclinical-research-findings/)
  > The senolytics used in this study are a cocktail of dasatinib, which promotes cancer cell death, and quercetin, an antioxidant found in apples and other foods.
- **Mayo researchers demonstrate senescent cell burden is reduced in humans by senolytic drugs** — Mayo Clinic News Network 2019 [Read it](https://newsnetwork.mayoclinic.org/discussion/mayo-researchers-demonstrate-senescent-cell-burden-is-reduced-in-humans-by-senolytic-drugs/)
  > For three days the nine participants received a combination dose of dasatinab and quercetin. Though the drugs cleared the body in a couple of days, effects on reducing senescent cells were evident for at least 11 days.

## The research

Peer-reviewed studies on the active compound. Quotes are verbatim from the cited abstract. Research describes the active mechanism and is not a claim about this specific product.

### Cited studies

1. **Evidence: lowers systolic/diastolic blood pressure**
   Curr Probl Cardiol 2022 · [PMID 35948195](https://pubmed.ncbi.nlm.nih.gov/35948195/) · [DOI 10.1016/j.cpcardiol.2022.101350](https://doi.org/10.1016/j.cpcardiol.2022.101350)

   > quercetin supplementation significantly decreased systolic blood pressure

2. **Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials**
   J Am Heart Assoc 2016 · [PMID 27405810](https://pubmed.ncbi.nlm.nih.gov/27405810/) · [DOI 10.1161/JAHA.115.002713](https://doi.org/10.1161/JAHA.115.002713)

   > significant reductions both in systolic BP and diastolic BP following supplementation with quercetin

3. **Effect of quercetin supplementation on plasma lipid profiles, blood pressure, and glucose levels: a meta-analysis**
   Nutr Rev 2020 · [PMID 31940027](https://pubmed.ncbi.nlm.nih.gov/31940027/) · [DOI 10.1093/nutrit/nuz071](https://doi.org/10.1093/nutrit/nuz071)

   > quercetin significantly lowered both systolic BP and diastolic BP

4. **Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial**
   Urology 1999 · [PMID 10604689](https://pubmed.ncbi.nlm.nih.gov/10604689/) · [DOI 10.1016/s0090-4295(99)00358-1](https://doi.org/10.1016/s0090-4295%2899%2900358-1)

   > In a double-blind placebo-controlled trial, the bioflavonoid quercetin was well tolerated and provided significant symptomatic improvement in most men with chronic pelvic pain syndrome.

5. **The Adjunctive Effect of Quercetin on Postoperative Pain Management Following Cesarean Section: A Randomized Controlled Study.**
   Drug Des Devel Ther 2025 · [PMID 40687903](https://pubmed.ncbi.nlm.nih.gov/40687903/) · [DOI 10.2147/DDDT.S526188](https://doi.org/10.2147/DDDT.S526188)

   > These findings suggest Quercetin may serve as a safe, effective adjunct in multimodal pain management protocols for cesarean delivery.

6. **Therapeutic potential of senolytic agent quercetin in osteoarthritis: A systematic review and meta-analysis of preclinical studies.**
   Ageing Res Rev 2023 · [PMID 37442369](https://pubmed.ncbi.nlm.nih.gov/37442369/) · [DOI 10.1016/j.arr.2023.101989](https://doi.org/10.1016/j.arr.2023.101989)

   > A random-effects meta-analysis was performed on six studies using the Osteoarthritis Research Society International (OARSI) scoring system, revealing that quercetin significantly improved OA cartilage OARSI scores (SMD, -6.30 [95% CI, -9.59 to -3.01]; P = 0.0002; heterogeneity: I2 = 86%).

7. **Use of kersetin and fisetin flavonoids in combination with pregabalin and gabapentin in the treatment of neuropathic pain.**
   J Pharm Pharmacol 2024 · [PMID 38588462](https://pubmed.ncbi.nlm.nih.gov/38588462/) · [DOI 10.1093/jpp/rgae034](https://doi.org/10.1093/jpp/rgae034)

   > Based on these findings; it is possible to say that quercetin and fisetin are potential agents that can be used alone or in combination with other effective treatments to alleviate neuropathic pain.

8. **The Effects of Quercetin Supplementation on Blood Pressures and Endothelial Function Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials.**
   Curr Pharm Des 2019 · [PMID 31092175](https://pubmed.ncbi.nlm.nih.gov/31092175/) · [DOI 10.2174/1381612825666190513095352](https://doi.org/10.2174/1381612825666190513095352)

   > We found a significant reduction in systolic blood pressure (SBP) (WMD: -1.69; 95% CI: -3.22, -0.17) following the intake of quercetin supplements.

9. **The effects of Quercetin supplementation on cardiometabolic outcomes: An umbrella review of meta-analyses of randomized controlled trials.**
   Phytother Res 2023 · [PMID 37654199](https://pubmed.ncbi.nlm.nih.gov/37654199/) · [DOI 10.1002/ptr.7971](https://doi.org/10.1002/ptr.7971)

   > Quercetin supplementation could significantly reduce systolic blood pressure (SBP) (weighted mean difference (WMD): -1.9, 95% CI = -3.2 to -0.6, I = 88.3%) and insulin level (WMD: -1.07, 95% CI = -1.9 to -0.1, I = 75.0%).

10. **Quercetin reduces blood pressure in hypertensive subjects.**
    J Nutr 2007 · [PMID 17951477](https://pubmed.ncbi.nlm.nih.gov/17951477/) · [DOI 10.1093/jn/137.11.2405](https://doi.org/10.1093/jn/137.11.2405)

    > Blood pressure was not altered in prehypertensive patients after quercetin supplementation. In contrast, reductions in (P < 0.01) systolic (-7 +/- 2 mm Hg), diastolic (-5 +/- 2 mm Hg), and mean arterial pressures (-5 +/- 2 mm Hg) were observed in stage 1 hypertensive patients after quercetin treatment.

11. **Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study.**
    Br J Nutr 2009 · [PMID 19402938](https://pubmed.ncbi.nlm.nih.gov/19402938/) · [DOI 10.1017/S0007114509359127](https://doi.org/10.1017/S0007114509359127)

    > In contrast to placebo, quercetin decreased systolic blood pressure (SBP) by 2.6 mmHg (P < 0.01) in the entire study group, by 2.9 mmHg (P < 0.01) in the subgroup of hypertensive subjects and by 3.7 mmHg (P < 0.001) in the subgroup of younger adults aged 25-50 years.

12. **Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-)hypertension: a randomised double-blinded placebo-controlled cross-over trial.**
    Br J Nutr 2015 · [PMID 26328470](https://pubmed.ncbi.nlm.nih.gov/26328470/) · [DOI 10.1017/S0007114515002950](https://doi.org/10.1017/S0007114515002950)

    > In the subgroup of hypertensives, quercetin decreased 24 h systolic BP by -3·6 mmHg (P=0·022) when compared with placebo (mean treatment difference, -3·9 mmHg; P=0·049).

13. **Acute intake of quercetin from onion skin extract does not influence postprandial blood pressure and endothelial function in overweight-to-obese adults with hypertension: a randomized, double-blind, placebo-controlled, crossover trial.**
    Eur J Nutr 2016 · [PMID 26924303](https://pubmed.ncbi.nlm.nih.gov/26924303/) · [DOI 10.1007/s00394-016-1185-1](https://doi.org/10.1007/s00394-016-1185-1)

    > Systolic and diastolic blood pressure increased significantly over time, but were not affected by treatment (placebo or quercetin).

14. **Enzymatically modified isoquercitrin improves endothelial function in volunteers at risk of cardiovascular disease.**
    Br J Nutr 2019 · [PMID 31870463](https://pubmed.ncbi.nlm.nih.gov/31870463/) · [DOI 10.1017/S0007114519002137](https://doi.org/10.1017/S0007114519002137)

    > EMIQ® treatment resulted in a significantly higher FMD response compared with the placebo (1·80 (95 % CI 0·23, 3·37) %; P = 0·025).

15. **Effect of onion peel extract on endothelial function and endothelial progenitor cells in overweight and obese individuals.**
    Nutrition 2015 · [PMID 26233871](https://pubmed.ncbi.nlm.nih.gov/26233871/) · [DOI 10.1016/j.nut.2015.04.020](https://doi.org/10.1016/j.nut.2015.04.020)

    > Compared with baseline values, the OPE group showed significantly improved FMD at 12 wk (from 12.5 ± 5.2 to 15.2 ± 6.1; P = 0.002), whereas the placebo group showed no difference.

16. **Effects of the pure flavonoids epicatechin and quercetin on vascular function and cardiometabolic health: a randomized, double-blind, placebo-controlled, crossover trial.**
    Am J Clin Nutr 2015 · [PMID 25934864](https://pubmed.ncbi.nlm.nih.gov/25934864/) · [DOI 10.3945/ajcn.114.098590](https://doi.org/10.3945/ajcn.114.098590)

    > Quercetin-3-glucoside supplementation had no effect on flow-mediated dilation, insulin resistance, or other CVD risk factors.

17. **Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis.**
    Clin Nutr 2011 · [PMID 21324570](https://pubmed.ncbi.nlm.nih.gov/21324570/) · [DOI 10.1016/j.clnu.2011.01.010](https://doi.org/10.1016/j.clnu.2011.01.010)

    > Quercetin supplementation improved the antioxidant defence, indicated by the increased total plasma antioxidant capacity. Moreover, quercetin supplementation also reduced markers of oxidative stress and inflammation in the blood of sarcoidosis patients.

18. **Randomised clinical trial to determine the safety of quercetin supplementation in patients with chronic obstructive pulmonary disease.**
    BMJ Open Respir Res 2020 · [PMID 32071149](https://pubmed.ncbi.nlm.nih.gov/32071149/) · [DOI 10.1136/bmjresp-2018-000392](https://doi.org/10.1136/bmjresp-2018-000392)

    > Quercetin was safely tolerated up to 2000 mg/day as assessed by lung function, blood profile and COPD assessment test questionnaire.

19. **Senolytics improve physical function and increase lifespan in old age.**
    Nat Med 2018 · [PMID 29988130](https://pubmed.ncbi.nlm.nih.gov/29988130/) · [DOI 10.1038/s41591-018-0092-9](https://doi.org/10.1038/s41591-018-0092-9)

    > The senolytic cocktail, dasatinib plus quercetin, which causes selective elimination of senescent cells, decreased the number of naturally occurring senescent cells and their secretion of frailty-related proinflammatory cytokines in explants of human adipose tissue.

20. **Senolytic drugs: from discovery to translation**
    J Intern Med 2020 · [PMID 32686219](https://pubmed.ncbi.nlm.nih.gov/32686219/) · [DOI 10.1111/joim.13141](https://doi.org/10.1111/joim.13141)

    > The first senolytic drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis-driven approach

21. **Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease.**
    EBioMedicine 2019 · [PMID 31542391](https://pubmed.ncbi.nlm.nih.gov/31542391/)

    > First-in-human senolytic trial: dasatinib+quercetin cleared senescent cells in adipose tissue and skin within 11 days and lowered circulating SASP factors (IL-1α, IL-6, MMP-9/-12) in diabetic kidney disease.

22. **Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial.**
    Nature medicine 2024 · [PMID 38956196](https://pubmed.ncbi.nlm.nih.gov/38956196/)

    > Phase 2 RCT: intermittent dasatinib+quercetin did not reduce bone resorption overall in postmenopausal women (CTx −4.1% vs −7.7% control); exploratory benefit was confined to the high-senescent-cell-burden subgroup.

23. **Effects of quercetin supplementation on lipid profile: A systematic review and meta-analysis of randomized controlled trials.**
    Critical reviews in food science and nutrition 2017 · [PMID 25897620](https://pubmed.ncbi.nlm.nih.gov/25897620/)

    > Meta-analysis of RCTs found no clinically relevant lipid effects overall; only the ≥500 mg/day for ≥4 weeks subgroup showed triglyceride reduction (−24.5 mg/dL) alongside a slight total-cholesterol rise (+3.6 mg/dL).

24. **Senolytic therapy in mild Alzheimer's disease: a phase 1 feasibility trial.**
    Nature medicine 2023 · [PMID 37679434](https://pubmed.ncbi.nlm.nih.gov/37679434/)

    > Phase 1 trial (n=5): intermittent dasatinib+quercetin was safe and feasible in early Alzheimer's disease, with exploratory biomarker signals only.

25. **Effects of quercetin supplementation on glycemic control among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials.**
    Phytotherapy research : PTR 2019 · [PMID 30848564](https://pubmed.ncbi.nlm.nih.gov/30848564/)

    > Meta-analysis in metabolic-syndrome populations found no significant effect of quercetin on fasting glucose, insulin, or HOMA-IR at usual doses.

## Where to buy

[Search Amazon for Quercetin Capsules](https://www.amazon.com/s?k=Quercetin%20Capsules&tag=magellanlong-20) — affiliate search link.

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## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).