---
title: "Olive Leaf Extract (Oleuropein) — Evidence, Benefits & Where… | Magellan"
description: "Olive Leaf Extract (Oleuropein) — Olive leaf extract (OLE) is a botanical preparation derived from the leaves of the olive tree (Olea europaea L.),…"
url: "https://magellanlongevity.com/p/109.md"
canonical: "https://magellanlongevity.com/p/109.html"
html: "https://magellanlongevity.com/p/109.html"
type: "product"
section: "Nutraceuticals & Cellular Energizers"
evidence_grade: "Moderate evidence"
evidence_tier: "moderate"
citations: 19
product_id: 109
price_usd: 17.05
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
license: "Educational content — not medical advice"
---

# Olive Leaf Extract (Oleuropein)

[Home](https://magellanlongevity.com/) › [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) › Olive Leaf Extract (Oleuropein)

**HTML version:** https://magellanlongevity.com/p/109.html · **In the Magellan app:** https://magellanlongevity.com/#/product/109

## Key facts

| Field | Value |
| --- | --- |
| Product | Olive Leaf Extract (Oleuropein) |
| Category | [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) |
| Evidence grade | Moderate evidence (B) |
| Peer-reviewed citations | 19 |
| Typical listed price | $17.05 (check the live price) |
| Where to buy | [Search Amazon](https://www.amazon.com/s?k=Olive%20Leaf%20Extract%20%28Oleuropein%29&tag=magellanlong-20) |
| Catalog ID | 109 |

## What it is

Olive leaf extract (OLE) is a botanical preparation derived from the leaves of the olive tree (Olea europaea L.), traditionally used in Mediterranean folk medicine. Its principal bioactive constituent is the secoiridoid polyphenol oleuropein, together with related compounds such as hydroxytyrosol, oleacein and tyrosol. These polyphenols exhibit antioxidant, anti-inflammatory and anti-atherogenic activity and are thought to influence blood pressure partly by modulating angiotensin activity and improving endothelial function.

## Its role in longevity

In human trials, standardized olive leaf extract has most consistently produced modest reductions in systolic and diastolic blood pressure in people with prehypertension or hypertension, and several trials and meta-analyses also report small decreases in total and LDL cholesterol and triglycerides. Evidence for effects on glucose metabolism and inflammation is mixed, and some well-controlled trials, including studies of combination formulas, found no significant benefit, so the overall body of evidence is limited by small sample sizes and variable extract quality. Reported effects are generally small relative to prescription antihypertensives and are best viewed as adjunctive. This research characterizes the oleuropein-rich olive leaf compound and mechanism itself, not this specific commercial product.

## Evidence grade: Moderate evidence

- **What the grade means:** Curated grade based on the human and mechanistic evidence for this compound.
- **What this grade does not say:** Small, short randomized trials and a 2024 meta-analysis show modest blood-pressure (~3–4 mmHg), lipid, and insulin-sensitivity improvements, but samples are small, durations short (4–12 weeks), extracts variably standardized, and no long-term outcome trials exist. An adjunct, not a substitute for antihypertensive therapy.

## Where it comes from without a bottle

Food, exercise and behaviour routes to the same pathway, each with its citation.

| Natural source | How it works | Citation |
| --- | --- | --- |
| Extra-virgin olive oil | Oleuropein and its derivative hydroxytyrosol are the signature polyphenols of olives and good extra-virgin olive oil — the backbone of the Mediterranean diet. Using EVOO daily delivers the same radical-scavenging olive polyphenols as the leaf extract. | Rejuvenation Res 2014 [PMID 24219356](https://pubmed.ncbi.nlm.nih.gov/24219356/) |
| Olive leaf tea / whole olives | The richest natural source of oleuropein is actually the olive leaf itself — brewed as a tea it carries more, and a wider variety, of polyphenols than the oil. Table olives also contribute oleuropein. | Nutrients 2016 [PMID 27548217](https://pubmed.ncbi.nlm.nih.gov/27548217/) |

### What those papers actually say

1. **Extra-virgin olive oil**
   Rejuvenation Res 2014 · [PMID 24219356](https://pubmed.ncbi.nlm.nih.gov/24219356/) · [DOI 10.1089/rej.2013.1532](https://doi.org/10.1089/rej.2013.1532)

   > oleuropein is a radical scavenger that blocks the oxidation of low-density lipoproteins.

2. **Olive leaf tea / whole olives**
   Nutrients 2016 · [PMID 27548217](https://pubmed.ncbi.nlm.nih.gov/27548217/) · [DOI 10.3390/nu8080513](https://doi.org/10.3390/nu8080513)

   > Olive leaf extract (OLE) contains a higher quantity and variety of polyphenols than those found in EVOO.

## In the news

- **Olive leaf extract shows promise in lowering blood pressure** — NutraIngredients 2025 [Read it](https://www.nutraingredients.com/Article/2025/05/15/olive-leaf-extract-may-support-healthy-blood-pressure/)
  > The bioactive compounds in olive leaf, such as oleuropein, oleacein, tyrosol and hydroxytyrosol, have previously shown anti-inflammatory, antioxidant and anti-atherogenic properties. They may inhibit angiotensin and promote an antihypertensive effect.
- **Olive leaf extract: Health benefits, dosage, and side effects** — Medical News Today 2019 [Read it](https://www.medicalnewstoday.com/articles/324878)
  > Preliminary studies suggest that olive leaf extract may have several health benefits. These include lowering blood pressure, improving cholesterol levels, and reducing the risk of weight gain and type 2 diabetes.

## The research

Peer-reviewed studies on the active compound. Quotes are verbatim from the cited abstract. Research describes the active mechanism and is not a claim about this specific product.

### Cited studies

1. **Evidence: oleuropein lowers BP and LDL**
   Eur J Nutr 2016 · [PMID 26951205](https://pubmed.ncbi.nlm.nih.gov/26951205/) · [DOI 10.1007/s00394-016-1188-y](https://doi.org/10.1007/s00394-016-1188-y)

   > hypotensive and lipid-lowering effects in vivo

2. **Olive leaf extract effect on cardiometabolic profile among adults with prehypertension and hypertension: a meta-analysis**
   PeerJ 2021 · [PMID 33868820](https://pubmed.ncbi.nlm.nih.gov/33868820/) · [DOI 10.7717/peerj.11173](https://doi.org/10.7717/peerj.11173)

   > 500 mg olive leaf extract showed a significant reduction in systolic BP

3. **Impact of olive leaf extract on pain management and functional improvement in elderly patients with knee osteoarthritis: A randomized controlled trial.**
   Explore (NY) 2025 · [PMID 39955806](https://pubmed.ncbi.nlm.nih.gov/39955806/) · [DOI 10.1016/j.explore.2025.103136](https://doi.org/10.1016/j.explore.2025.103136)

   > The intervention groups showed significantly more significant reductions in mean pain scores than the control group (p < 0.05).

4. **Double-blind placebo-controlled trial of hydroxytyrosol of Olea europaea on pain in gonarthrosis.**
   Phytomedicine 2013 · [PMID 23746949](https://pubmed.ncbi.nlm.nih.gov/23746949/) · [DOI 10.1016/j.phymed.2013.03.021](https://doi.org/10.1016/j.phymed.2013.03.021)

   > The group administered hydroxytyrosol showed significant improvement in the Japanese Orthopedic Association score (pain measurement index) and the visual analog scale score compared to the placebo group.

5. **Efficacy of olive leaf extracts in controlling blood pressure in hypertensive patients: a double-blind randomized clinical trial.**
   J Hypertens 2025 · [PMID 40990594](https://pubmed.ncbi.nlm.nih.gov/40990594/) · [DOI 10.1097/HJH.0000000000004141](https://doi.org/10.1097/HJH.0000000000004141)

   > OLE can decrease 24-h BP, BPL, and diastolic BPV with improvement of lipid profile, systemic inflammation, and body weight in hypertensive patients.

6. **Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with Captopril.**
   Phytomedicine 2010 · [PMID 21036583](https://pubmed.ncbi.nlm.nih.gov/21036583/) · [DOI 10.1016/j.phymed.2010.08.016](https://doi.org/10.1016/j.phymed.2010.08.016)

   > In conclusion, Olive (Olea europaea) leaf extract, at the dosage regimen of 500 mg twice daily, was similarly effective in lowering systolic and diastolic blood pressures in subjects with stage-1 hypertension as Captopril, given at its effective dose of 12.5-25 mg twice daily.

7. **Effects of a combination of olive leaf extract and potassium on blood pressure in participants with mild to moderate hypertension: A double blind, randomized, placebo-controlled trial.**
   Phytomedicine 2026 · [PMID 41935461](https://pubmed.ncbi.nlm.nih.gov/41935461/) · [DOI 10.1016/j.phymed.2026.158138](https://doi.org/10.1016/j.phymed.2026.158138)

   > Supplementation also reduced total cholesterol by 11.1 mg/dL, LDL-cholesterol by 6.9 mg/dL, and triglycerides by approximately 22 mg/dL at Week 6, while HDL-cholesterol remained stable.

8. **Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men: a randomized, placebo-controlled, crossover trial.**
   PLoS One 2013 · [PMID 23516412](https://pubmed.ncbi.nlm.nih.gov/23516412/) · [DOI 10.1371/journal.pone.0057622](https://doi.org/10.1371/journal.pone.0057622)

   > OLE supplementation was associated with a 15% improvement in insulin sensitivity (p = 0.024) compared to placebo. There was also a 28% improvement in pancreatic β-cell responsiveness (p = 0.013).

9. **Olive leaf extract as a hypoglycemic agent in both human diabetic subjects and in rats.**
   J Med Food 2012 · [PMID 22512698](https://pubmed.ncbi.nlm.nih.gov/22512698/) · [DOI 10.1089/jmf.2011.0243](https://doi.org/10.1089/jmf.2011.0243)

   > In the randomized clinical trial, the subjects treated with olive leaf extract exhibited significantly lower HbA1c and fasting plasma insulin levels; however, postprandial plasma insulin levels did not differ significantly by treatment group.

10. **Effects of Olive Leaf Extract on Metabolic Response, Liver and Kidney Functions and Inflammatory Biomarkers in Hypertensive Patients.**
    Pak J Biol Sci 2019 · [PMID 31930845](https://pubmed.ncbi.nlm.nih.gov/31930845/) · [DOI 10.3923/pjbs.2019.342.348](https://doi.org/10.3923/pjbs.2019.342.348)

    > The OLE tablets did not have significant effect on liver enzymes, total protein, albumin, urea and creatinine (p>0.05), but significantly decreased interleukin-6, interleukin-8 and tumor necrosis factor alpha as inflammatory biomarkers (p<0.05) in OLE group compared to the placebo group.

11. **The effect of olive leaf extract on cardiovascular health markers: a randomized placebo-controlled clinical trial.**
    Eur J Nutr 2020 · [PMID 33034707](https://pubmed.ncbi.nlm.nih.gov/33034707/) · [DOI 10.1007/s00394-020-02397-9](https://doi.org/10.1007/s00394-020-02397-9)

    > Blood lipid profiles were not significantly affected by 8 weeks OLE supplementation in overweight/obese subjects with mildly elevated cholesterol levels.

12. **Antihypertensive potential of combined extracts of olive leaf, green coffee bean and beetroot: a randomized, double-blind, placebo-controlled crossover trial.**
    Nutrients 2014 · [PMID 25379688](https://pubmed.ncbi.nlm.nih.gov/25379688/) · [DOI 10.3390/nu6114881](https://doi.org/10.3390/nu6114881)

    > There was no significant effect of treatment on ABP or any other outcome measure. The failure to confirm prior evidence of the antihypertensive benefits of these extracts emphasises the importance of placebo control and the value of ABP monitoring.

13. **Efficacy and safety of olive leaf extract (Olea europaea L.) for glycaemic control in adults with type 2 diabetes mellitus (ESOLED): A pilot randomised controlled trial.**
    Complement Ther Clin Pract 2025 · [PMID 39818111](https://pubmed.ncbi.nlm.nih.gov/39818111/) · [DOI 10.1016/j.ctcp.2025.101949](https://doi.org/10.1016/j.ctcp.2025.101949)

    > The ESOLED trial has provided preliminary evidence on the tolerability of OLE in adults with type 2 diabetes, but was inconclusive in determining whether OLE is effective at improving glycaemic control, insulin sensitivity, diabetes-related distress and quality of life.

14. **No effect of fenugreek, bergamot and olive leaf extract on glucose homeostasis in patients with prediabetes: a randomized double-blind placebo-controlled study.**
    Arch Med Sci Atheroscler Dis 2019 · [PMID 31448348](https://pubmed.ncbi.nlm.nih.gov/31448348/) · [DOI 10.5114/amsad.2019.86756](https://doi.org/10.5114/amsad.2019.86756)

    > The administration of an agent containing fenugreek, olive leaf polyphenols and bergamot extract for 6 months did not improve glycemia or lipid parameters in patients with prediabetes.

15. **Olive leaf extract effect on cardiometabolic risk factors: a systematic review and meta-analysis of randomized clinical trials.**
    Nutr Rev 2024 · [PMID 38287654](https://pubmed.ncbi.nlm.nih.gov/38287654/) · [DOI 10.1093/nutrit/nuad164](https://doi.org/10.1093/nutrit/nuad164)

    > The outcomes demonstrated a positive correlation between the intervention group and glucose metabolism (4 RCTs), blood pressure (2 RCTs), lipid profile (2 RCTs), and inflammatory markers (2 RCTs).

16. **The effects of olive leaf extract on cardiovascular risk factors in the general adult population: a systematic review and meta-analysis of randomized controlled trials.**
    Diabetol Metab Syndr 2022 · [PMID 36271405](https://pubmed.ncbi.nlm.nih.gov/36271405/) · [DOI 10.1186/s13098-022-00920-y](https://doi.org/10.1186/s13098-022-00920-y)

    > The present study revealed that supplementation with OLE yielded beneficial effects for blood pressure and lipid profile in adults, especially in patients with hypertension.

17. **Efficacy of Olive Leaf Extract in Improving Blood Pressure in Pre-Hypertensive and Hypertensive Individuals: A Systematic Review and Meta-Analysis.**
    Phytother Res 2025 · [PMID 40325976](https://pubmed.ncbi.nlm.nih.gov/40325976/) · [DOI 10.1002/ptr.8509](https://doi.org/10.1002/ptr.8509)

    > Olive leaf extract (1000 mg/day) may reduce systolic and diastolic blood pressure by -11.45 and -4.65 mmHg, respectively.

18. **Cardioprotective potential of oleuropein, hydroxytyrosol, oleocanthal and their combination: Unravelling complementary effects on acute myocardial infarction and metabolic syndrome.**
    Redox Biol 2024 · [PMID 39153251](https://pubmed.ncbi.nlm.nih.gov/39153251/) · [DOI 10.1016/j.redox.2024.103311](https://doi.org/10.1016/j.redox.2024.103311)

    > Conclusively, OL-HT-OC combination therapy exerts potent cardioprotective, antihyperglycemic and anti-atherosclerotic properties in vivo, with remarkable and clinically translatable cardiovascular benefits in high-risk patients.

19. **Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases.**
    J Transl Med 2014 · [PMID 25086598](https://pubmed.ncbi.nlm.nih.gov/25086598/) · [DOI 10.1186/s12967-014-0219-9](https://doi.org/10.1186/s12967-014-0219-9)

    > Thus, a protective action has been demonstrated in preclinical studies against several diseases, especially cardiovascular and metabolic disorders.

## Where to buy

[Search Amazon for Olive Leaf Extract (Oleuropein)](https://www.amazon.com/s?k=Olive%20Leaf%20Extract%20%28Oleuropein%29&tag=magellanlong-20) — affiliate search link.

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## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).