---
title: "Pomegranate Ellagitannin Extract — Evidence, Benefits &… | Magellan"
description: "Pomegranate Ellagitannin Extract — Pomegranate ellagitannin extract is a concentrated source of ellagitannins (such as punicalagins) and ellagic acid,…"
url: "https://magellanlongevity.com/p/110.md"
canonical: "https://magellanlongevity.com/p/110.html"
html: "https://magellanlongevity.com/p/110.html"
type: "product"
section: "Nutraceuticals & Cellular Energizers"
evidence_grade: "Moderate evidence"
evidence_tier: "moderate"
citations: 25
product_id: 110
price_usd: 27.74
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
license: "Educational content — not medical advice"
---

# Pomegranate Ellagitannin Extract

[Home](https://magellanlongevity.com/) › [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) › Pomegranate Ellagitannin Extract

**HTML version:** https://magellanlongevity.com/p/110.html · **In the Magellan app:** https://magellanlongevity.com/#/product/110

## Key facts

| Field | Value |
| --- | --- |
| Product | Pomegranate Ellagitannin Extract |
| Category | [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) |
| Evidence grade | Moderate evidence (B) |
| Peer-reviewed citations | 25 |
| Typical listed price | $27.74 (check the live price) |
| Where to buy | [Search Amazon](https://www.amazon.com/s?k=Pomegranate%20Ellagitannin%20Extract&tag=magellanlong-20) |
| Catalog ID | 110 |

## What it is

Pomegranate ellagitannin extract is a concentrated source of ellagitannins (such as punicalagins) and ellagic acid, the polyphenols responsible for much of the pomegranate's antioxidant activity. After ingestion, these compounds are hydrolyzed to ellagic acid and then metabolized by the gut microbiota into urolithins, chiefly urolithin A. Urolithin A is a postbiotic that stimulates mitophagy, the cellular quality-control process that recycles damaged mitochondria, and the capacity to produce it varies substantially between individuals depending on gut microbiome composition.

## Its role in longevity

In human research, the ellagitannin-derived metabolite urolithin A has improved muscle strength, endurance, and biomarkers of mitochondrial function and inflammation in randomized trials of middle-aged and older adults, and a small 2025 trial found more youthful immune-cell profiles after four weeks, although several primary endpoints (e.g., peak power, maximal ATP production) were not met. Separately, pomegranate juice and extracts have modestly lowered blood pressure (a few mmHg on average) in meta-analyses of randomized trials — though at least one systematic review rates that evidence as weak — and a year-long trial found daily juice helped preserve visual memory while placebo declined. The mitophagy findings come mainly from the purified metabolite rather than the extract itself, and urolithin production varies widely between individuals. This evidence describes the ellagitannins, urolithin A, and the pomegranate polyphenols themselves, not this specific commercial extract product.

## Evidence grade: Moderate evidence

- **What the grade means:** Curated grade based on the human and mechanistic evidence for this compound.
- **What this grade does not say:** Human trials and meta-analyses support small blood-pressure reductions (a few mmHg) and one year-long trial suggests memory preservation, but at least one systematic review calls the blood-pressure evidence weak. The headline mitophagy benefits were shown mainly with purified urolithin A, not pomegranate extract, and microbiome conversion of ellagitannins varies widely — many people are low producers.

## Where it comes from without a bottle

Food, exercise and behaviour routes to the same pathway, each with its citation.

| Natural source | How it works | Citation |
| --- | --- | --- |
| Pomegranate and walnuts (ellagitannin foods) | Your gut bacteria convert the ellagitannins in pomegranate and walnuts into urolithins, the metabolites behind the benefits, so eating these whole foods is the natural precursor route. | Molecular Nutrition & Food Research 2022 [PMID 35118817](https://pubmed.ncbi.nlm.nih.gov/35118817/) |
| Walnuts or pomegranate in human trials | In people, eating walnuts or taking pomegranate extract measurably produced urolithins in urine, confirming these everyday foods actually deliver the active metabolite, though output varies by gut metabotype. | Clinical Nutrition 2017 [PMID 28347564](https://pubmed.ncbi.nlm.nih.gov/28347564/) |

### What those papers actually say

1. **Pomegranate and walnuts (ellagitannin foods)**
   Molecular Nutrition & Food Research 2022 · [PMID 35118817](https://pubmed.ncbi.nlm.nih.gov/35118817/) · [DOI 10.1002/mnfr.202101019](https://doi.org/10.1002/mnfr.202101019)

   > Urolithins, metabolites produced by the gut microbiota from the polyphenols ellagitannins and ellagic acid... health benefits after consuming ellagitannin-rich sources (pomegranates, walnuts, strawberries, etc.).

2. **Walnuts or pomegranate in human trials**
   Clinical Nutrition 2017 · [PMID 28347564](https://pubmed.ncbi.nlm.nih.gov/28347564/) · [DOI 10.1016/j.clnu.2017.03.012](https://doi.org/10.1016/j.clnu.2017.03.012)

   > Urolithins are microbial metabolites produced after consumption of ellagitannin-containing foods such as pomegranates and walnuts.

## In the news

- **Study: Daily intake of Urolithin A improves muscle strength by 12% after four months** — News-Medical 2022 [Read it](https://www.news-medical.net/news/20220517/Study-Daily-intake-of-Urolithin-A-improves-muscle-strength-by-1225-after-four-months.aspx)
  > A new milestone study published today in Cell Reports Medicine showed that daily intake of Amazentis' proprietary Urolithin A, Mitopure, significantly improved muscle strength by 12% after four months.
- **Urolithin A may counteract age-related immune decline and inflammaging** — NutraIngredients 2025 [Read it](https://www.nutraingredients.com/Article/2025/11/05/urolithin-a-may-counteract-age-related-immune-decline-and-inflammaging/)
  > Preliminary data published in Nature Medicine indicated that urolithin A may improve mitochondrial function by stimulating mitophagy, a process by which damaged mitochondria are recycled to permit a renewal with healthy mitochondria.

## The research

Peer-reviewed studies on the active compound. Quotes are verbatim from the cited abstract. Research describes the active mechanism and is not a claim about this specific product.

### Cited studies

1. **Evidence: precursor to urolithins, mitophagy**
   Phytother Res 2021 · [PMID 34542202](https://pubmed.ncbi.nlm.nih.gov/34542202/) · [DOI 10.1002/ptr.7290](https://doi.org/10.1002/ptr.7290)

   > urolithin A is safe and can improve mitochondrial biomarkers in elderly patients

2. **Clustering according to urolithin metabotype explains variability in cardiovascular risk biomarkers in individuals consuming pomegranate: a randomized clinical trial**
   Mol Nutr Food Res 2017 · [PMID 27879044](https://pubmed.ncbi.nlm.nih.gov/27879044/) · [DOI 10.1002/mnfr.201600830](https://doi.org/10.1002/mnfr.201600830)

   > LDL-cholesterol and oxidized LDL dose-dependently decreased, correlated with urolithin production

3. **Gene expression changes in colon tissues following intake of an ellagitannin-containing pomegranate extract: a randomized clinical trial**
   J Nutr Biochem 2017 · [PMID 28183047](https://pubmed.ncbi.nlm.nih.gov/28183047/) · [DOI 10.1016/j.jnutbio.2017.01.014](https://doi.org/10.1016/j.jnutbio.2017.01.014)

   > Ellagitannins and their gut-derived metabolites, the urolithins, modify gene expression in colon

4. **Pomegranate extract alleviates disease activity and some blood biomarkers of inflammation and oxidative stress in Rheumatoid Arthritis patients.**
   Eur J Clin Nutr 2017 · [PMID 27577177](https://pubmed.ncbi.nlm.nih.gov/27577177/) · [DOI 10.1038/ejcn.2016.151](https://doi.org/10.1038/ejcn.2016.151)

   > Compared with the placebo group, POMx supplement significantly reduced the score of DAS28 (P<0.001) which could be related to the decrease in swollen (P<0.001) and tender joints (P=0.001) count, pain intensity (P=0.003) and ESR levels (P= 0.03).

5. **The effect of pomegranate juice on clinical signs, matrix metalloproteinases and antioxidant status in patients with knee osteoarthritis.**
   J Sci Food Agric 2016 · [PMID 26804926](https://pubmed.ncbi.nlm.nih.gov/26804926/) · [DOI 10.1002/jsfa.7647](https://doi.org/10.1002/jsfa.7647)

   > Significant decreases in Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) total score (P = 0.01), stiffness score (P = 0.00) and physical function score (P = 0.01) were observed in PJ group after the intervention.

6. **Pomegranate use to attenuate bone loss in major musculoskeletal diseases: an evidence-based review.**
   Curr Drug Targets 2013 · [PMID 24200293](https://pubmed.ncbi.nlm.nih.gov/24200293/) · [DOI 10.2174/1389450114666131108155039](https://doi.org/10.2174/1389450114666131108155039)

   > This evidence-based review highlighted the potential of pomegranate extract being used for treating bone loss in osteoporosis, osteoarthritis and rheumatoid arthritis.

7. **Evidence: activates mitophagy, recycles mitochondria**
   Cell Rep Med 2022 · [PMID 35584623](https://pubmed.ncbi.nlm.nih.gov/35584623/) · [DOI 10.1016/j.xcrm.2022.100633](https://doi.org/10.1016/j.xcrm.2022.100633)

   > significant improvements in muscle strength with intake of Urolithin A

8. **Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial**
   JAMA Netw Open 2022 · [PMID 35050355](https://pubmed.ncbi.nlm.nih.gov/35050355/) · [DOI 10.1001/jamanetworkopen.2021.44279](https://doi.org/10.1001/jamanetworkopen.2021.44279)

   > Urolithin A is a gut microbiome-derived metabolite shown to stimulate mitophagy and improve muscle function

9. **The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans.**
   Nat Metab 2019 · [PMID 32694802](https://pubmed.ncbi.nlm.nih.gov/32694802/) · [DOI 10.1038/s42255-019-0073-4](https://doi.org/10.1038/s42255-019-0073-4)

   > These observed effects on mitochondrial biomarkers show that UA induces a molecular signature of improved mitochondrial and cellular health following regular oral consumption in humans.

10. **Evaluating the Impact of Urolithin A Supplementation on Running Performance, Recovery, and Mitochondrial Biomarkers**
    Sports Med 2025 · [PMID 40839339](https://pubmed.ncbi.nlm.nih.gov/40839339/) · [DOI 10.1007/s40279-025-02292-5](https://doi.org/10.1007/s40279-025-02292-5)

    > UA upregulated pathways associated with mitochondria, led to a medium effect for increased markers of mitophagy

11. **Consumption of Watermelon Juice Enriched in l-Citrulline and Pomegranate Ellagitannins Enhanced Metabolism during Physical Exercise.**
    J Agric Food Chem 2017 · [PMID 28513179](https://pubmed.ncbi.nlm.nih.gov/28513179/) · [DOI 10.1021/acs.jafc.7b00586](https://doi.org/10.1021/acs.jafc.7b00586)

    > the antioxidant pomegranate ellagitannins are precursors of urolithin A, which has been associated with mitophagy and increased muscle function.

12. **Targeting aging with urolithin A in humans: A systematic review.**
    Ageing Res Rev 2024 · [PMID 39002645](https://pubmed.ncbi.nlm.nih.gov/39002645/) · [DOI 10.1016/j.arr.2024.102406](https://doi.org/10.1016/j.arr.2024.102406)

    > UA increased muscle strength and endurance, however, had no effect on anthropometrics, cardiovascular outcomes, and physical function.

13. **Urolithin A: A Novel Postbiotic for inflammation, aging, and cancer: A Journey from Dietary ellagitannins to clinical use.**
    Mol Biol Rep 2026 · [PMID 42118217](https://pubmed.ncbi.nlm.nih.gov/42118217/) · [DOI 10.1007/s11033-026-11950-4](https://doi.org/10.1007/s11033-026-11950-4)

    > UA enhances muscle endurance, mitochondrial function indicators, and cardiometabolic health without side effects or adverse reactions in preliminary human trials, primarily including the elderly and sedentary individuals.

14. **Ellagic acid and intestinal microflora metabolite urolithin A: A review on its sources, metabolic distribution, health benefits, and biotransformation.**
    Crit Rev Food Sci Nutr 2022 · [PMID 35142569](https://pubmed.ncbi.nlm.nih.gov/35142569/) · [DOI 10.1080/10408398.2022.2036693](https://doi.org/10.1080/10408398.2022.2036693)

    > Foods rich in ellagic tannins are first hydrolyzed into ellagic acid in the stomach and small intestine, and then converted into urolithins with high bioavailability by the intestinal flora.

15. **Crosstalk between dietary pomegranate and gut microbiota: evidence of health benefits.**
    Crit Rev Food Sci Nutr 2023 · [PMID 37335106](https://pubmed.ncbi.nlm.nih.gov/37335106/) · [DOI 10.1080/10408398.2023.2219763](https://doi.org/10.1080/10408398.2023.2219763)

    > Uro contributes to strengthening intestinal barrier and reducing inflammatory processes. Yet, Uro production varies greatly among individuals and depend on GM composition.

16. **Urolithins, gut microbiota-derived metabolites of ellagitannins, inhibit LPS-induced inflammation in RAW 264.7 murine macrophages.**
    Mol Nutr Food Res 2015 · [PMID 26202092](https://pubmed.ncbi.nlm.nih.gov/26202092/) · [DOI 10.1002/mnfr.201500264](https://doi.org/10.1002/mnfr.201500264)

    > Urolithins A, B, and C decreased NO production via inhibition of the iNOS protein and mRNA expression. They decreased the expression of IL-1β, TNF-α, and IL-6 mRNA in LPS challenged RAW 264.7 murine macrophages.

17. **Impacts of supplementation with pomegranate on cardiometabolic risk factors: A systematic review and dose-response meta-analysis.**
    Nutr Metab Cardiovasc Dis 2025 · [PMID 40617711](https://pubmed.ncbi.nlm.nih.gov/40617711/) · [DOI 10.1016/j.numecd.2025.104154](https://doi.org/10.1016/j.numecd.2025.104154)

    > PO supplementation substantially reduced body weight (standardized mean difference (SMD): -0.14 kg, 95 % CI: -0.25, -0.03; P = 0.01), diastolic blood pressure (DBP) (SMD: -0.39 mmHg, 95 % CI: -0.59, -0.18; P < 0.001)

18. **Effects of pomegranate juice on blood pressure: A systematic review and meta-analysis of randomized controlled trials.**
    Pharmacol Res 2016 · [PMID 27888156](https://pubmed.ncbi.nlm.nih.gov/27888156/) · [DOI 10.1016/j.phrs.2016.11.018](https://doi.org/10.1016/j.phrs.2016.11.018)

    > Quantitative data synthesis from 8 RCTs showed significant reductions in both systolic [weighed mean difference (WMD): -4.96mmHg, 95% CI: -7.67 to -2.25, p<0.001) and diastolic BP (WMD: -2.01mmHg, 95% CI: -3.71 to -0.31, p=0.021) after pomegranate juice consumption.

19. **Effects of pomegranate juice consumption on blood pressure and lipid profile in patients with type 2 diabetes: A single-blind randomized clinical trial.**
    Clin Nutr ESPEN 2018 · [PMID 30661697](https://pubmed.ncbi.nlm.nih.gov/30661697/) · [DOI 10.1016/j.clnesp.2018.11.013](https://doi.org/10.1016/j.clnesp.2018.11.013)

    > It is concluded that PJ consumption could decrease systolic and diastolic blood pressure in patients with diabetes while having no effect on lipid profile.

20. **Does Pomegranate intake attenuate cardiovascular risk factors in hemodialysis patients?**
    Nutr J 2014 · [PMID 24593225](https://pubmed.ncbi.nlm.nih.gov/24593225/) · [DOI 10.1186/1475-2891-13-18](https://doi.org/10.1186/1475-2891-13-18)

    > Regular PJ consumption by HD patients reduced systolic blood pressure and improved lipid profile. These favorable changes may reduce the accelerated atherosclerosis and high incidence of CVD among HD patients.

21. **Effects of pomegranate juice consumption on myocardial perfusion in patients with coronary heart disease.**
    Am J Cardiol 2005 · [PMID 16169367](https://pubmed.ncbi.nlm.nih.gov/16169367/) · [DOI 10.1016/j.amjcard.2005.05.026](https://doi.org/10.1016/j.amjcard.2005.05.026)

    > After 3 months, the extent of stress-induced ischemia decreased in the pomegranate group (SDS -0.8 +/- 2.7) but increased in the control group (SDS 1.2 +/- 3.1, p <0.05).

22. **Influence of gut microbiota-derived ellagitannins' metabolites urolithins on pro-inflammatory activities of human neutrophils.**
    Planta Med 2014 · [PMID 24995502](https://pubmed.ncbi.nlm.nih.gov/24995502/) · [DOI 10.1055/s-0034-1368615](https://doi.org/10.1055/s-0034-1368615)

    > Urolithins can specifically modulate inflammatory functions of neutrophils, and thus could contribute to the beneficial health effects of ellagitannin-rich medicinal plant materials and food products.

23. **Randomized placebo-controlled study of the memory effects of pomegranate juice in middle-aged and older adults.**
    The American journal of clinical nutrition 2020 · [PMID 31711104](https://pubmed.ncbi.nlm.nih.gov/31711104/)

    > In 261 adults aged 50–75, daily pomegranate juice for 12 months kept visual memory performance stable while the placebo group declined.

24. **Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial.**
    Nature aging 2025 · [PMID 41174221](https://pubmed.ncbi.nlm.nih.gov/41174221/)

    > In 50 adults, 1,000 mg/day of urolithin A for 4 weeks expanded naive-like CD8+ T cells and remodeled immune-cell metabolism, countering markers of age-related immune decline — using the purified metabolite, not pomegranate extract.

25. **Evidence for the effectiveness of pomegranate supplementation for blood pressure management is weak: A systematic review of randomized clinical trials.**
    Nutrition research (New York, N.Y.) 2017 · [PMID 29173650](https://pubmed.ncbi.nlm.nih.gov/29173650/)

    > A counterpoint systematic review judged the evidence that pomegranate supplementation lowers blood pressure to be weak and low-quality.

## Where to buy

[Search Amazon for Pomegranate Ellagitannin Extract](https://www.amazon.com/s?k=Pomegranate%20Ellagitannin%20Extract&tag=magellanlong-20) — affiliate search link.

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## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).