--- title: "Grape Seed Extract — Evidence, Benefits & Where to Buy | Magellan" description: "Grape Seed Extract — Grape seed extract (GSE) is a polyphenol-rich preparation made from the seeds of wine grapes (Vitis vinifera), standardized…" url: "https://magellanlongevity.com/p/111.md" canonical: "https://magellanlongevity.com/p/111.html" html: "https://magellanlongevity.com/p/111.html" type: "product" section: "Nutraceuticals & Cellular Energizers" evidence_grade: "Moderate evidence" evidence_tier: "moderate" citations: 21 product_id: 111 price_usd: 16.99 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" license: "Educational content — not medical advice" --- # Grape Seed Extract [Home](https://magellanlongevity.com/) › [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) › Grape Seed Extract **HTML version:** https://magellanlongevity.com/p/111.html · **In the Magellan app:** https://magellanlongevity.com/#/product/111 ## Key facts | Field | Value | | --- | --- | | Product | Grape Seed Extract | | Category | [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) | | Evidence grade | Moderate evidence (B) | | Peer-reviewed citations | 21 | | Typical listed price | $16.99 (check the live price) | | Where to buy | [Search Amazon](https://www.amazon.com/s?k=Grape%20Seed%20Extract&tag=magellanlong-20) | | Catalog ID | 111 | ## What it is Grape seed extract (GSE) is a polyphenol-rich preparation made from the seeds of wine grapes (Vitis vinifera), standardized primarily for proanthocyanidins (oligomeric procyanidins) along with catechins and other flavonoids. Marketed as a dietary supplement, it has antioxidant and anti-inflammatory activity. Preclinical work indicates that its proanthocyanidins can increase endothelial nitric oxide synthase (eNOS) expression and nitric oxide production, in part through AMPK/SIRT1/KLF2 signaling, and can lower endothelin-1 and oxidative stress, which together support endothelial function and vascular tone. ## Its role in longevity Randomized trials and meta-analyses indicate that grape seed extract can modestly lower blood pressure — pooled systolic reductions of roughly 2–6 mmHg, larger in younger, obese, or metabolic-syndrome patients — and may improve markers of blood glucose, LDL cholesterol, triglycerides, and inflammation. Two small 2024 trials in non-alcoholic fatty liver disease reported improved insulin resistance, liver enzymes, oxidative stress, and quality of life, though both were single-center studies of about 50 people. Effects on flow-mediated dilation are inconsistent, with some trials and one large meta-analysis showing no significant change, and a 12-week trial in healthy young adults found no cognitive benefit. The literature is limited by small, heterogeneous, often short and sometimes industry-funded studies, and there is no evidence on lifespan or hard cardiovascular outcomes. This evidence characterizes the grape seed extract compound and its active proanthocyanidins in general, not this specific commercial product. ## Evidence grade: Moderate evidence - **What the grade means:** Curated grade based on the human and mechanistic evidence for this compound. - **Dose used in studies:** 150–600 mg/day in trials - **What this grade does not say:** Meta-analyses show modest blood-pressure reductions (~2–6 mmHg systolic), largest in younger or metabolically impaired people; effects on lipids and glycemia are small and inconsistent. New fatty-liver benefits rest on two small single-country trials, one trial found no cognitive benefit, and no hard cardiovascular outcomes have been tested. ## Where it comes from without a bottle Food, exercise and behaviour routes to the same pathway, each with its citation. | Natural source | How it works | Citation | | --- | --- | --- | | Grapes & red wine (whole-food polyphenols) | Grape seed extract is just a concentrate of the proanthocyanidins (oligomeric flavanols) naturally found in whole grapes, the seeds and skins, and red wine. Eating red/black grapes with seeds, or modest red wine, delivers the same polyphenol class shown to nudge blood pressure down. You'd need a lot of grapes to match a capsule dose, but the compounds are identical. | Pharmacological Research 2021 [PMID 34798267](https://pubmed.ncbi.nlm.nih.gov/34798267/) | | Colorful berries & dark grapes (dietary flavanols) | The blood-pressure benefit tracks the proanthocyanidin/flavanol dose, and these same flavanols are concentrated in dark grapes, blueberries, cranberries, and other deeply pigmented berries. A flavanol-rich diet is the realistic everyday route; grape seed extract simply standardizes the dose. | Medicine (Baltimore) 2016 [PMID 27537554](https://pubmed.ncbi.nlm.nih.gov/27537554/) | ### What those papers actually say 1. **Grapes & red wine (whole-food polyphenols)** Pharmacological Research 2021 · [PMID 34798267](https://pubmed.ncbi.nlm.nih.gov/34798267/) · [DOI 10.1016/j.phrs.2021.105905](https://doi.org/10.1016/j.phrs.2021.105905) > GSE supplementation significantly reduced DBP (WMD: -2.20 mmHg) and HR but had no significant effects on FMD and SBP. 2. **Colorful berries & dark grapes (dietary flavanols)** Medicine (Baltimore) 2016 · [PMID 27537554](https://pubmed.ncbi.nlm.nih.gov/27537554/) · [DOI 10.1097/MD.0000000000004247](https://doi.org/10.1097/MD.0000000000004247) > Overall analyses found significant reductions for SBP and DBP after grape seed extract treatment. ## In the news - **Study Shows Grape Seed Extract May Be Effective In Reducing Blood Pressure** — ScienceDaily (University of California, Davis - Health System) 2006 [Read it](https://www.sciencedaily.com/releases/2006/03/060327084242.htm) > Participants in the two groups receiving grape seed extract experienced an equal degree of reduced blood pressure. The average drop in systolic pressure was 12 millimeters. - **Grape Seed Extract: Usefulness and Safety** — NCCIH (National Center for Complementary and Integrative Health) 2025 [Read it](https://www.nccih.nih.gov/health/grape-seed-extract) > A 2022 review of 19 studies (1,080 participants) showed that grape seed extract reduced diastolic blood pressure (the lower number in a blood pressure reading) but not systolic blood pressure (the higher number). ## The research Peer-reviewed studies on the active compound. Quotes are verbatim from the cited abstract. Research describes the active mechanism and is not a claim about this specific product. ### Cited studies 1. **Evidence: improves endothelial function, lowers BP** Nutrients 2021 · [PMID 33671310](https://pubmed.ncbi.nlm.nih.gov/33671310/) · [DOI 10.3390/nu13020654](https://doi.org/10.3390/nu13020654) > both supplementations significantly modulated blood pressure 2. **Effects of Grape Seed Proanthocyanidin Extract on Vascular Endothelial Function in Prehypertension: a Randomized Controlled Study** Nutrients 2019 · [PMID 31757033](https://pubmed.ncbi.nlm.nih.gov/31757033/) · [DOI 10.3390/nu11122844](https://doi.org/10.3390/nu11122844) > mean SBP in the high-dose group significantly decreased by 13 mmHg after 12 weeks 3. **The impact of grape seed extract treatment on blood pressure changes: A meta-analysis of 16 randomized controlled trials.** Medicine (Baltimore) 2016 · [PMID 27537554](https://pubmed.ncbi.nlm.nih.gov/27537554/) · [DOI 10.1097/MD.0000000000004247](https://doi.org/10.1097/MD.0000000000004247) > Overall analyses found significant reductions for SBP (WMD = -6.077; 95% CI: -10.736 to -1.419; P = 0.011) and DBP (WMD = -2.803; 95% CI: -4.417 to -1.189; P = 0.001) after grape seed extract treatment. 4. **The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials.** J Am Diet Assoc 2011 · [PMID 21802563](https://pubmed.ncbi.nlm.nih.gov/21802563/) · [DOI 10.1016/j.jada.2011.05.015](https://doi.org/10.1016/j.jada.2011.05.015) > Based on the currently available literature, grape seed extract appears to significantly lower systolic blood pressure and heart rate, with no effect on lipid or CRP levels. 5. **The effect of grape (Vitis vinifera) seed extract supplementation on flow-mediated dilation, blood pressure, and heart rate: A systematic review and meta-analysis of controlled trials with duration- and dose-response analysis.** Pharmacol Res 2021 · [PMID 34798267](https://pubmed.ncbi.nlm.nih.gov/34798267/) · [DOI 10.1016/j.phrs.2021.105905](https://doi.org/10.1016/j.phrs.2021.105905) > In conclusion, GSE may be beneficial for individuals with or at risk of cardiovascular disease because it may have hypotensive and HR-lowering properties. 6. **The effects of grape seed extract on glycemic control, serum lipoproteins, inflammation, and body weight: A systematic review and meta-analysis of randomized controlled trials.** Phytother Res 2019 · [PMID 31880030](https://pubmed.ncbi.nlm.nih.gov/31880030/) · [DOI 10.1002/ptr.6518](https://doi.org/10.1002/ptr.6518) > This meta-analysis demonstrated that GSE intake significantly reduced FPG, TC, LDL cholesterol, triglycerides, and CRP levels. 7. **The effect of grape seed extract supplementation on oxidative stress and inflammation: A systematic review and meta-analysis of controlled trials.** Int J Clin Pract 2021 · [PMID 34107109](https://pubmed.ncbi.nlm.nih.gov/34107109/) · [DOI 10.1111/ijcp.14469](https://doi.org/10.1111/ijcp.14469) > It appears that GSE supplementation can remarkably modulate the body's redox system, particularly through the inhibition of lipid peroxidation, but has neutral or mildly beneficial effects on inflammatory responses. 8. **Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial.** Br J Nutr 2015 · [PMID 26568249](https://pubmed.ncbi.nlm.nih.gov/26568249/) · [DOI 10.1017/S0007114515004328](https://doi.org/10.1017/S0007114515004328) > GSE was found to be safe and to improve BP in people with pre-hypertension, supporting the use of GSE as a functional ingredient in a low-energy beverage for BP control. 9. **A grape seed and bilberry extract reduces blood pressure in individuals at risk of developing type 2 diabetes: the PRECISE study, a double-blind placebo-controlled cross-over intervention study.** Front Nutr 2023 · [PMID 37351191](https://pubmed.ncbi.nlm.nih.gov/37351191/) · [DOI 10.3389/fnut.2023.1139880](https://doi.org/10.3389/fnut.2023.1139880) > Long-term supplementation with bilberry and grape seed extract can improve systolic and diastolic blood pressure in individuals at risk of T2DM. 10. **Effects of Acute Grape Seed Extract Supplementation on Hemodynamics in Normal Body Weight and Obese Males.** J Nutr Sci Vitaminol (Tokyo) 2020 · [PMID 33132345](https://pubmed.ncbi.nlm.nih.gov/33132345/) · [DOI 10.3177/jnsv.66.427](https://doi.org/10.3177/jnsv.66.427) > Our study suggests that acute supplementation with GSE reduced both SBP and MAP via a reduction in CO in obese individuals and decreased peripheral vasoconstriction in NBW group. 11. **Effects of Grape Seed Extract Supplementation on Endothelial Function and Endurance Performance in Basketball Players.** Int J Environ Res Public Health 2022 · [PMID 36361103](https://pubmed.ncbi.nlm.nih.gov/36361103/) · [DOI 10.3390/ijerph192114223](https://doi.org/10.3390/ijerph192114223) > We demonstrated that chronic supplementation with GSE improved endurance performance and these effects may partially be due to vasodilation in active skeletal muscle mediated by enhanced endothelial function. 12. **Effect of Grape Seed Extract and Quercetin on Cardiovascular and Endothelial Parameters in High-Risk Subjects.** J Biomed Biotechnol 2004 · [PMID 15577189](https://pubmed.ncbi.nlm.nih.gov/15577189/) · [DOI 10.1155/S1110724304403088](https://doi.org/10.1155/S1110724304403088) > Thus sufficient polyphenols from GSE appear to be absorbed to influence endothelial nitric oxide production, and GSE has the potential to favourably influence vascular function. 13. **Grape Seed Extract Supplementation Attenuates the Blood Pressure Response to Exercise in Prehypertensive Men.** J Med Food 2018 · [PMID 29683391](https://pubmed.ncbi.nlm.nih.gov/29683391/) · [DOI 10.1089/jmf.2017.0133](https://doi.org/10.1089/jmf.2017.0133) > FMD was augmented by GSE (18.9 ± 2.0 vs. 12.4% ± 2.0%). 14. **Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity.** Diabet Med 2009 · [PMID 19646193](https://pubmed.ncbi.nlm.nih.gov/19646193/) · [DOI 10.1111/j.1464-5491.2009.02727.x](https://doi.org/10.1111/j.1464-5491.2009.02727.x) > GSE significantly improved markers of inflammation and glycaemia and a sole marker of oxidative stress in obese Type 2 diabetic subjects at high risk of cardiovascular events over a 4-week period, which suggests it may have a therapeutic role in decreasing cardiovascular risk. 15. **Grape seed proanthocyanidin extracts enhance endothelial nitric oxide synthase expression through 5'-AMP activated protein kinase/Surtuin 1-Krüpple like factor 2 pathway and modulate blood pressure in ouabain induced hypertensive rats.** Biol Pharm Bull 2012 · [PMID 22987017](https://pubmed.ncbi.nlm.nih.gov/22987017/) · [DOI 10.1248/bpb.b12-00598](https://doi.org/10.1248/bpb.b12-00598) > In conclusion, GSPE increase eNOS expression and NO production in an AMPK/SIRT1 dependent manner through KLF2 induction, and attenuate ouabain induced hypertension. 16. **Beneficial effects of grape seed proanthocyanidin extract on arterial remodeling in spontaneously hypertensive rats via protecting against oxidative stress.** Mol Med Rep 2016 · [PMID 27601315](https://pubmed.ncbi.nlm.nih.gov/27601315/) · [DOI 10.3892/mmr.2016.5699](https://doi.org/10.3892/mmr.2016.5699) > ET-1 production was reduced, while NO production was increased in the GSPE group, which exhibited improved endothelial function. 17. **Effects of oligomeric grape seed proanthocyanidins on heart, aorta, kidney in DOCA-salt mice: role of oxidative stress.** Phytother Res 2012 · [PMID 22903376](https://pubmed.ncbi.nlm.nih.gov/22903376/) · [DOI 10.1002/ptr.4793](https://doi.org/10.1002/ptr.4793) > These findings suggest that administration of GSPs has the potential to attenuate DOCA-salt induced CR and KH and preserve NO activity and endothelial function, which mechanism may contribute to its antioxidant characteristic, at least in part. 18. **The effects of grape seed extract supplementation on cardiovascular risk factors, liver enzymes and hepatic steatosis in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled study.** BMC complementary medicine and therapies 2024 · [PMID 38755622](https://pubmed.ncbi.nlm.nih.gov/38755622/) > In 50 NAFLD patients, 520 mg/day for 2 months significantly improved insulin resistance, lipids, liver enzymes, and blood pressure versus placebo. 19. **Grape seed extract supplementation in non-alcoholic fatty liver disease.** International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 2024 · [PMID 38419408](https://pubmed.ncbi.nlm.nih.gov/38419408/) > 500 mg/day of proanthocyanidins for 2 months lowered IL-6 and malondialdehyde and raised antioxidant enzymes and quality-of-life scores in 50 NAFLD patients. 20. **Grape seed polyphenol extract and cognitive function in healthy young adults: a randomised, placebo-controlled, parallel-groups acute-on-chronic trial.** Nutritional neuroscience 2022 · [PMID 31942838](https://pubmed.ncbi.nlm.nih.gov/31942838/) > 400 mg/day for 12 weeks produced no consistent cognitive benefit, acute or chronic, in 60 healthy young adults — an honest null. 21. **Vitis Vinifera Seed Extract Versus Micronized Purified Flavonoid Fraction for Patients with Chronic Venous Disease: A Randomized Noninferiority Trial.** Annals of vascular surgery 2024 · [PMID 39009117](https://pubmed.ncbi.nlm.nih.gov/39009117/) > A head-to-head randomized trial tested grape seed extract against the standard venoactive drug MPFF in chronic venous disease. ## Where to buy [Search Amazon for Grape Seed Extract](https://www.amazon.com/s?k=Grape%20Seed%20Extract&tag=magellanlong-20) — affiliate search link. ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"ItemPage","@id":"https://magellanlongevity.com/p/111.html#page","url":"https://magellanlongevity.com/p/111.html","name":"Grape Seed Extract","description":"Grape seed extract (GSE) is a polyphenol-rich preparation made from the seeds of wine grapes (Vitis vinifera), standardized primarily for…","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/p/111.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Nutraceuticals & Cellular Energizers","item":"https://magellanlongevity.com/c/1.html"},{"@type":"ListItem","position":3,"name":"Grape Seed Extract","item":"https://magellanlongevity.com/p/111.html"}]},{"@type":"Product","@id":"https://magellanlongevity.com/p/111.html#product","name":"Grape Seed Extract","category":"Nutraceuticals & Cellular Energizers","url":"https://magellanlongevity.com/p/111.html","description":"Grape seed extract (GSE) is a polyphenol-rich preparation made from the seeds of wine grapes (Vitis vinifera), standardized primarily for proanthocyanidins (oligomeric procyanidins) along with catechins and other flavonoids. 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Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).