---
title: "Apigenin Capsules — Evidence, Benefits & Where to Buy | Magellan"
description: "Apigenin Capsules — Apigenin (4',5,7-trihydroxyflavone) is a naturally occurring flavone abundant in chamomile, parsley, celery, and other plants. It is…"
url: "https://magellanlongevity.com/p/114.md"
canonical: "https://magellanlongevity.com/p/114.html"
html: "https://magellanlongevity.com/p/114.html"
type: "product"
section: "Nutraceuticals & Cellular Energizers"
evidence_grade: "Emerging evidence"
evidence_tier: "emerging"
citations: 18
product_id: 114
price_usd: 24.95
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
license: "Educational content — not medical advice"
---

# Apigenin Capsules

[Home](https://magellanlongevity.com/) › [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) › Apigenin Capsules

**HTML version:** https://magellanlongevity.com/p/114.html · **In the Magellan app:** https://magellanlongevity.com/#/product/114

## Key facts

| Field | Value |
| --- | --- |
| Product | Apigenin Capsules |
| Category | [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) |
| Evidence grade | Emerging evidence (C) |
| Peer-reviewed citations | 18 |
| Typical listed price | $24.95 (check the live price) |
| Where to buy | [Search Amazon](https://www.amazon.com/s?k=Apigenin%20Capsules&tag=magellanlong-20) |
| Catalog ID | 114 |

## What it is

Apigenin (4',5,7-trihydroxyflavone) is a naturally occurring flavone abundant in chamomile, parsley, celery, and other plants. It is a pharmacological inhibitor of CD38, the principal NAD+-consuming (NADase) enzyme in mammalian tissues, and this activity underlies its ability to raise intracellular NAD+ levels. By preserving NAD+, apigenin supports the activity of NAD+-dependent sirtuins such as SIRT1 and the mitochondrial deacetylase SIRT3. It also modulates additional targets, including GABA-A receptors and NF-kappaB-driven inflammatory pathways. Human pharmacokinetic studies show the free aglycone is poorly absorbed—only about 0.5% of an oral dose is recovered in urine as metabolites—whereas the glycoside forms found in chamomile are absorbed far better.

## Its role in longevity

CD38 activity rises with age and drives the tissue decline of NAD+ that is linked to mitochondrial dysfunction, inflammation, and cellular senescence, so inhibiting CD38 is a plausible strategy to preserve NAD+ during aging. In animal and cell studies, apigenin lowers CD38 activity, raises the NAD+/NADH ratio, restores SIRT3-dependent mitochondrial antioxidant defenses, and improves metabolic, vascular, senescence, and neuroinflammatory endpoints. Human data, however, come largely from chamomile extracts standardized to apigenin: a randomized trial in mild-to-moderate generalized anxiety disorder found chamomile modestly outperformed placebo, but such extracts deliver far less apigenin than dedicated capsules, and no published trial has tested isolated apigenin at typical supplement doses for sleep, NAD+, or aging outcomes. Whether apigenin supplements raise NAD+ or slow aging in people remains unproven; most mechanistic evidence is preclinical. This evidence describes the compound apigenin and the CD38/NAD+ mechanism itself, not this specific commercial product.

## Evidence grade: Emerging evidence

- **What the grade means:** Curated grade based on the human and mechanistic evidence for this compound.
- **What this grade does not say:** The CD38/NAD⁺ longevity mechanism is demonstrated in cells and mice, not people. Human efficacy data come from chamomile-extract trials delivering far less apigenin than capsules, showing modest anxiety relief, and free apigenin is poorly absorbed in human pharmacokinetic studies. No trial has tested isolated apigenin for sleep, NAD⁺, or aging outcomes.

## Where it comes from without a bottle

Food, exercise and behaviour routes to the same pathway, each with its citation.

| Natural source | How it works | Citation |
| --- | --- | --- |
| Parsley & celery | Fresh parsley and celery are the richest everyday food sources of the flavone apigenin; eat them raw or lightly cooked to preserve it. | Nutrition and Cancer 2008 [PMID 18584477](https://pubmed.ncbi.nlm.nih.gov/18584477/) |
| Chamomile tea | Brew dried chamomile flower heads; apigenin is one of the primary flavonoids that steeps out into the tea. | Phytotherapy Research 2006 [PMID 16628544](https://pubmed.ncbi.nlm.nih.gov/16628544/) |
| Celery, parsley & chamomile (diet-wide) | Apigenin is spread across common plant foods; regular dietary intake is the recommended way to get it rather than isolated supplements. | Expert Opinion on Drug Metabolism & Toxicology 2016 [PMID 27766890](https://pubmed.ncbi.nlm.nih.gov/27766890/) |

### What those papers actually say

1. **Parsley & celery**
   Nutrition and Cancer 2008 · [PMID 18584477](https://pubmed.ncbi.nlm.nih.gov/18584477/) · [DOI 10.1080/01635580802143836](https://doi.org/10.1080/01635580802143836)

   > Parsley (apigenin), celery (apigenin and luteolin), and English spinach (luteolin) were the major flavone sources.

2. **Chamomile tea**
   Phytotherapy Research 2006 · [PMID 16628544](https://pubmed.ncbi.nlm.nih.gov/16628544/) · [DOI 10.1002/ptr.1900](https://doi.org/10.1002/ptr.1900)

   > The main constituents of the flowers include several phenolic compounds, primarily the flavonoids apigenin, quercetin, patuletin, luteolin and their glucosides.

3. **Celery, parsley & chamomile (diet-wide)**
   Expert Opinion on Drug Metabolism & Toxicology 2016 · [PMID 27766890](https://pubmed.ncbi.nlm.nih.gov/27766890/) · [DOI 10.1080/17425255.2017.1251903](https://doi.org/10.1080/17425255.2017.1251903)

   > Apigenin, a natural flavone, is widely distributed in plants such as celery, parsley and chamomile.

## In the news

- **Apigenin: Benefits And Side Effects** — Lifespan.io (Lifespan Research Institute) 2025 [Read it](https://lifespan.io/topic/apigenin-benefits-side-effects/)
  > Despite there being a number of interesting animal studies with apigenin, there is currently a lack of human data.

## The research

Peer-reviewed studies on the active compound. Quotes are verbatim from the cited abstract. Research describes the active mechanism and is not a claim about this specific product.

### Cited studies

1. **Evidence: inhibits CD38, raises NAD/Sirt3**
   Aging 2020 · [PMID 32507768](https://pubmed.ncbi.nlm.nih.gov/32507768/) · [DOI 10.18632/aging.103410](https://doi.org/10.18632/aging.103410)

   > CD38 inhibition by apigenin restored the intracellular NAD ratio and Sirt3 activity

2. **Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism**
   Diabetes 2013 · [PMID 23172919](https://pubmed.ncbi.nlm.nih.gov/23172919/) · [DOI 10.2337/db12-1139](https://doi.org/10.2337/db12-1139)

   > apigenin increases NAD+ levels by inhibiting CD38

3. **Inhibition of CD38 and nicotinamide riboside ameliorate neuroinflammation by increasing NAD**
   J Neurochem 2021 · [PMID 33871064](https://pubmed.ncbi.nlm.nih.gov/33871064/) · [DOI 10.1111/jnc.15367](https://doi.org/10.1111/jnc.15367)

   > apigenin, a flavonoid with CD38 inhibitory activity, increased NAD level and suppressed neuroinflammation

4. **Apigenin Alleviates Oxidative Stress-Induced Cellular Senescence via Modulation of the SIRT1-NAD+-CD38 Axis.**
   Am J Chin Med 2021 · [PMID 34049472](https://pubmed.ncbi.nlm.nih.gov/34049472/) · [DOI 10.1142/S0192415X21500592](https://doi.org/10.1142/S0192415X21500592)

   > Our findings suggest that apigenin is a promising phytochemical for reducing the impact of senescent cells in age-related lung diseases such as COPD.

5. **CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism.**
   Cell Metab 2016 · [PMID 27304511](https://pubmed.ncbi.nlm.nih.gov/27304511/) · [DOI 10.1016/j.cmet.2016.05.006](https://doi.org/10.1016/j.cmet.2016.05.006)

   > Here we demonstrate that expression and activity of the NADase CD38 increase with aging and that CD38 is required for the age-related NAD decline and mitochondrial dysfunction via a pathway mediated at least in part by regulation of SIRT3 activity.

6. **Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages.**
   Nat Metab 2020 · [PMID 33199924](https://pubmed.ncbi.nlm.nih.gov/33199924/) · [DOI 10.1038/s42255-020-00305-3](https://doi.org/10.1038/s42255-020-00305-3)

   > These M1-like macrophages express high levels of the NAD-consuming enzyme CD38 and have enhanced CD38-dependent NADase activity, thereby reducing tissue NAD levels.

7. **CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD and NMN levels.**
   Nat Metab 2020 · [PMID 33199925](https://pubmed.ncbi.nlm.nih.gov/33199925/) · [DOI 10.1038/s42255-020-00298-z](https://doi.org/10.1038/s42255-020-00298-z)

   > Our findings demonstrate that senescence-induced inflammation promotes accumulation of CD38 in immune cells that, through its ecto-enzymatic activity, decreases levels of NMN and NAD.

8. **NAD+ and sirtuins in aging and disease.**
   Trends Cell Biol 2014 · [PMID 24786309](https://pubmed.ncbi.nlm.nih.gov/24786309/) · [DOI 10.1016/j.tcb.2014.04.002](https://doi.org/10.1016/j.tcb.2014.04.002)

   > NAD(+) levels decline during the aging process and may be an Achilles' heel, causing defects in nuclear and mitochondrial functions and resulting in many age-associated pathologies.

9. **Dietary apigenin ameliorates obesity-related hypertension through TRPV4-dependent vasorelaxation and TRPV4-independent adiponectin secretion.**
   Biochim Biophys Acta Mol Basis Dis 2024 · [PMID 39218272](https://pubmed.ncbi.nlm.nih.gov/39218272/) · [DOI 10.1016/j.bbadis.2024.167488](https://doi.org/10.1016/j.bbadis.2024.167488)

   > Apigenin downregulated Cluster of differentiation 38 (CD38), restoring Nicotinamide adenine dinucleotide+ (NAD+) levels and activating the NAD+/Sirtuin 1 (SIRT1) pathway, enhancing adiponectin expression.

10. **The NADase CD38 is a central regulator in gouty inflammation and a novel druggable therapeutic target.**
    Inflamm Res 2024 · [PMID 38493256](https://pubmed.ncbi.nlm.nih.gov/38493256/) · [DOI 10.1007/s00011-024-01863-y](https://doi.org/10.1007/s00011-024-01863-y)

    > Mouse air pouch inflammatory responses to MSU crystals were blunted by CD38 KO and apigenin.

11. **Targeting CD38 to Suppress Osteoarthritis Development and Associated Pain After Joint Injury in Mice.**
    Arthritis Rheumatol 2023 · [PMID 36103412](https://pubmed.ncbi.nlm.nih.gov/36103412/) · [DOI 10.1002/art.42351](https://doi.org/10.1002/art.42351)

    > CD38 deficiency exerts OA disease-modifying effects. Inhibition of CD38 has the potential to be a novel therapeutic approach for OA treatment.

12. **CD38 Coordinates with NF-kappaB to Promote Cochlear Inflammation in Noise-Induced Hearing Loss: the Protective Effect of Apigenin.**
    Mol Neurobiol 2024 · [PMID 39725836](https://pubmed.ncbi.nlm.nih.gov/39725836/) · [DOI 10.1007/s12035-024-04675-7](https://doi.org/10.1007/s12035-024-04675-7)

    > apigenin significantly reduce the threshold shift of hearing by inhibiting the expression of NF-κB and CD38 can be a promising target for protecting against noise-induced hearing loss.

13. **Apigenin: a natural molecule at the intersection of sleep and aging.**
    Front Nutr 2024 · [PMID 38476603](https://pubmed.ncbi.nlm.nih.gov/38476603/) · [DOI 10.3389/fnut.2024.1359176](https://doi.org/10.3389/fnut.2024.1359176)

    > Cumulatively, a large body of evidence positions apigenin as a unique molecule capable of influencing both aging and sleep.

14. **Efficacy and safety of Matricaria chamomilla intervention in managing menopausal symptoms: a triple-blind clinical trial.**
    Menopause 2025 · [PMID 39836709](https://pubmed.ncbi.nlm.nih.gov/39836709/) · [DOI 10.1097/GME.0000000000002496](https://doi.org/10.1097/GME.0000000000002496)

    > Notable differences were found between the intervention and control groups in the overall scores on the symptom scorecard from baseline to 12 weeks' postintervention (-10.36; 95% confidence interval [CI], -13.84 to -6.92; P < 0.001).

15. **Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo.**
    Int J Mol Med 2016 · [PMID 27279007](https://pubmed.ncbi.nlm.nih.gov/27279007/) · [DOI 10.3892/ijmm.2016.2626](https://doi.org/10.3892/ijmm.2016.2626)

    > we found that the apigenin-containing cream increased dermal density and elasticity, and reduced fine wrinkle length.

16. **Apigenin potentiates glucose-stimulated insulin secretion through the PKA-MEK kinase signaling pathway independent of K-ATP channels.**
    Biomed Pharmacother 2024 · [PMID 38906017](https://pubmed.ncbi.nlm.nih.gov/38906017/) · [DOI 10.1016/j.biopha.2024.116986](https://doi.org/10.1016/j.biopha.2024.116986)

    > Apigenin exerts glucose-stimulated insulin secretion by modulating the PKA-MEK kinase signaling cascade independent of K-ATP channels.

17. **A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder.**
    Journal of clinical psychopharmacology 2009 · [PMID 19593179](https://pubmed.ncbi.nlm.nih.gov/19593179/)

    > In 57 adults with mild-to-moderate generalized anxiety disorder, 8 weeks of apigenin-standardized chamomile extract reduced anxiety scores significantly more than placebo (p = 0.047)—the main human efficacy signal for apigenin, at far lower doses than capsules provide.

18. **Absorption, distribution, metabolism and excretion of apigenin and its glycosides in healthy male adults.**
    Free radical biology & medicine 2022 · [PMID 35452808](https://pubmed.ncbi.nlm.nih.gov/35452808/)

    > Human pharmacokinetic study: free apigenin was poorly absorbed (about 0.5% of intake recovered in urine as metabolites), while chamomile-type glycoside forms were absorbed far better (up to about 34%).

## Where to buy

[Search Amazon for Apigenin Capsules](https://www.amazon.com/s?k=Apigenin%20Capsules&tag=magellanlong-20) — affiliate search link.

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## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).