--- title: "Luteolin Capsules — Evidence, Benefits & Where to Buy | Magellan" description: "Luteolin Capsules — Luteolin is a naturally occurring flavone (a class of flavonoid) found in celery, parsley, green pepper, chamomile and various other…" url: "https://magellanlongevity.com/p/115.md" canonical: "https://magellanlongevity.com/p/115.html" html: "https://magellanlongevity.com/p/115.html" type: "product" section: "Nutraceuticals & Cellular Energizers" evidence_grade: "Emerging evidence" evidence_tier: "emerging" citations: 21 product_id: 115 price_usd: 19.95 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" license: "Educational content — not medical advice" --- # Luteolin Capsules [Home](https://magellanlongevity.com/) › [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) › Luteolin Capsules **HTML version:** https://magellanlongevity.com/p/115.html · **In the Magellan app:** https://magellanlongevity.com/#/product/115 ## Key facts | Field | Value | | --- | --- | | Product | Luteolin Capsules | | Category | [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) | | Evidence grade | Emerging evidence (C) | | Peer-reviewed citations | 21 | | Typical listed price | $19.95 (check the live price) | | Where to buy | [Search Amazon](https://www.amazon.com/s?k=Luteolin%20Capsules&tag=magellanlong-20) | | Catalog ID | 115 | ## What it is Luteolin is a naturally occurring flavone (a class of flavonoid) found in celery, parsley, green pepper, chamomile and various other fruits, vegetables and medicinal herbs. In laboratory and animal studies it acts mainly as an antioxidant and anti-inflammatory agent, inhibiting microglial and astrocyte activation and the release of pro-inflammatory cytokines such as TNF-α, IL-1β and IL-6, and it can modulate endoplasmic reticulum (ER) stress and signaling pathways including JNK/AP-1, NF-κB and mTOR. Because it is poorly water-soluble, luteolin has limited oral bioavailability, so it is often delivered in lipid-based or co-micronized formulations (for example combined with palmitoylethanolamide, PEA) to improve absorption. ## Its role in longevity Preclinical studies consistently show that luteolin reduces neuroinflammation and can ameliorate memory and learning deficits in rodent models of Alzheimer's disease, cerebral hypoperfusion and LPS-induced cognitive impairment, in part by inhibiting ER stress and cytokine release. Human evidence is more limited and often uses luteolin combined with other agents: randomized trials of palmitoylethanolamide-luteolin (PEA-LUT) plus olfactory training markedly improved recovery of smell after COVID-19 (in one multicenter trial about 89% of patients improved versus 37% with training alone) and reported benefits for subjective cognition; a chlorogenic acid plus luteolin nutraceutical improved weight, glycemic and vascular markers over six months in pre-obesity; and open-label studies of a luteolin-containing formulation in children with autism reported behavioral improvement and lower serum TNF/IL-6. On the other hand, a placebo-controlled trial in Gulf War Illness found luteolin no better than placebo. Overall the data support an anti-neuroinflammatory mechanism with promising but indication-specific, not yet definitive clinical benefit; standalone luteolin is not an established anti-aging supplement, and larger rigorous trials are needed. This evidence describes the compound luteolin (and its formulations) and its mechanisms, not this specific commercial product. ## Evidence grade: Emerging evidence - **What the grade means:** Curated grade based on the human and mechanistic evidence for this compound. - **What this grade does not say:** Human evidence is indication-specific and mostly for combination products, not standalone luteolin. PEA-luteolin improved post-COVID smell recovery in randomized trials, but luteolin alone was no better than placebo in a Gulf War Illness crossover trial. Oral bioavailability is poor and the mast-cell/neuroinflammation promise remains largely preclinical. ## Where it comes from without a bottle Food, exercise and behaviour routes to the same pathway, each with its citation. | Natural source | How it works | Citation | | --- | --- | --- | | Celery and parsley (top flavone foods) | In dietary surveys, celery and parsley are identified as the leading whole-food sources of the flavone luteolin, so soups, salads and herb garnishes supply it directly. | Nutrition and Cancer 2008 [PMID 18584477](https://pubmed.ncbi.nlm.nih.gov/18584477/) | | Vegetables and fruits (dietary luteolin) | Luteolin is a widespread dietary flavone obtained from many vegetables and fruits, and it engages the same Nrf2 antioxidant defense pathway targeted by the supplement. | Journal of Molecular Neuroscience 2018 [PMID 30083786](https://pubmed.ncbi.nlm.nih.gov/30083786/) | ### What those papers actually say 1. **Celery and parsley (top flavone foods)** Nutrition and Cancer 2008 · [PMID 18584477](https://pubmed.ncbi.nlm.nih.gov/18584477/) · [DOI 10.1080/01635580802143836](https://doi.org/10.1080/01635580802143836) > Parsley (apigenin), celery (apigenin and luteolin), and English spinach (luteolin) were the major flavone sources. 2. **Vegetables and fruits (dietary luteolin)** Journal of Molecular Neuroscience 2018 · [PMID 30083786](https://pubmed.ncbi.nlm.nih.gov/30083786/) · [DOI 10.1007/s12031-018-1094-2](https://doi.org/10.1007/s12031-018-1094-2) > Dietary flavonoids... are bioactive products, extracted from several types of vegetables and fruits. Luteolin... is a widespread flavone known to have antioxidant and cytoprotective properties related to... (Nrf2) pathway. ## In the news - **Plant flavonoid found to reduce inflammatory response in the brain** — EurekAlert! (University of Illinois) 2008 [Read it](https://www.eurekalert.org/news-releases/551787) > Those mice that were fed luteolin had significantly lower levels of IL-6 in their blood plasma four hours after injection with the LPS. Luteolin also decreased LPS-induced transcription of IL-6 in the hippocampus, a brain region that is critical to spatial learning and memory. ## The research Peer-reviewed studies on the active compound. Quotes are verbatim from the cited abstract. Research describes the active mechanism and is not a claim about this specific product. ### Cited studies 1. **Evidence: inhibits neuroinflammation, ER stress** Acta Pharmacol Sin 2021 · [PMID 34267346](https://pubmed.ncbi.nlm.nih.gov/34267346/) · [DOI 10.1038/s41401-021-00702-8](https://doi.org/10.1038/s41401-021-00702-8) > Luteolin alleviates cognitive impairment via inhibiting neuroinflammation 2. **Dietary Luteolin Reduces Proinflammatory Microglia in the Brain of Senescent Mice** Rejuvenation Res 2016 · [PMID 26918466](https://pubmed.ncbi.nlm.nih.gov/26918466/) · [DOI 10.1089/rej.2015.1708](https://doi.org/10.1089/rej.2015.1708) > a diet supplemented with luteolin inhibited brain microglia activity during aging 3. **Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma** Biofactors 2020 · [PMID 33098588](https://pubmed.ncbi.nlm.nih.gov/33098588/) · [DOI 10.1002/biof.1687](https://doi.org/10.1002/biof.1687) > luteolin can suppress neuroinflammatory response, microglia activation, and oxidative stress 4. **Luteolin: A promising natural agent in management of pain in chronic conditions.** Front Pain Res (Lausanne) 2023 · [PMID 36937566](https://pubmed.ncbi.nlm.nih.gov/36937566/) · [DOI 10.3389/fpain.2023.1114428](https://doi.org/10.3389/fpain.2023.1114428) > The data reviewed strongly support luteolin's promising benefits in pain management and raise the need for further clinical trials that can establish its role in clinical practice. 5. **Luteolin Could Improve Cognitive Dysfunction by Inhibiting Neuroinflammation.** Neurochem Res 2018 · [PMID 29392519](https://pubmed.ncbi.nlm.nih.gov/29392519/) · [DOI 10.1007/s11064-018-2482-2](https://doi.org/10.1007/s11064-018-2482-2) > luteolin prevented the increase of TNF-α and IL-1β, IL-6, and MDA, improved the activity of SOD and GPx, inhibited microglia over-activation and astrogliosis (particularly in the hippocampus and cortex), and ameliorated learning and short-term memory dysfunction, and LTP deficit. 6. **Luteolin and Exercise Combination Therapy Ameliorates Amyloid-β1-42 Oligomers-Induced Cognitive Impairment in AD Mice by Mediating Neuroinflammation and Autophagy.** J Alzheimers Dis 2023 · [PMID 36710678](https://pubmed.ncbi.nlm.nih.gov/36710678/) · [DOI 10.3233/JAD-220904](https://doi.org/10.3233/JAD-220904) > Luteolin (100 mg/kg/d) combined with exercise could significantly improve the performance of AD model mice in novel object recognition test, and the improvement was greater than that of monotherapy. 7. **Luteolin Suppresses Microglia Neuroinflammatory Responses and Relieves Inflammation-Induced Cognitive Impairments.** Neurotox Res 2021 · [PMID 34655374](https://pubmed.ncbi.nlm.nih.gov/34655374/) · [DOI 10.1007/s12640-021-00426-x](https://doi.org/10.1007/s12640-021-00426-x) > these results demonstrated luteolin was effective in alleviating cognitive impairment and limited neuronal damage via inhibiting the release of inflammatory mediators, suggesting luteolin is potential for further therapeutic research of neuroinflammation-related neurodegenerative diseases. 8. **Co-ultraPEALut in Subjective Cognitive Impairment Following SARS-CoV-2 Infection: An Exploratory Retrospective Study.** Brain Sci 2024 · [PMID 38539680](https://pubmed.ncbi.nlm.nih.gov/38539680/) · [DOI 10.3390/brainsci14030293](https://doi.org/10.3390/brainsci14030293) > Neuro-post-COVID-19 patients treated with co-ultraPEALut scored better than controls in MoCA and PRMQ questionnaires after 10 months: this may support the importance of neuroinflammation modulation for neuro-long-COVID-19. 9. **Treatment of COVID-19 olfactory dysfunction with olfactory training, palmitoylethanolamide with luteolin, or combined therapy: a blinded controlled multicenter randomized trial.** Eur Arch Otorhinolaryngol 2023 · [PMID 37380908](https://pubmed.ncbi.nlm.nih.gov/37380908/) · [DOI 10.1007/s00405-023-08085-8](https://doi.org/10.1007/s00405-023-08085-8) > At 90 days, odor identification scores improved by > 3 points in 89.2% of patients receiving combined therapy vs. 36.8% receiving olfactory training with placebo, 40% receiving twice daily um-PEA-LUT alone, and 41.6% receiving once daily um-PEA-LUT alone (p < 0.00001). 10. **Ultramicronized Palmitoylethanolamide and Luteolin Supplement Combined with Olfactory Training to Treat Post-COVID-19 Olfactory Impairment: A Multi-Center Double-Blinded Randomized Placebo- Controlled Clinical Trial.** Curr Neuropharmacol 2022 · [PMID 35450527](https://pubmed.ncbi.nlm.nih.gov/35450527/) · [DOI 10.2174/1570159X20666220420113513](https://doi.org/10.2174/1570159X20666220420113513) > The intervention group showed significantly greater improvement in olfactory threshold, discrimination, and identification scores compared to controls (p=0.0001). Overall, 92% of patients in the intervention group improved versus 42% of controls. 11. **Efficacy of Palmitoylethanolamide and Luteolin Association on Post-Covid Olfactory Dysfunction: A Systematic Review and Meta-Analysis of Clinical Studies.** Biomedicines 2023 · [PMID 37626685](https://pubmed.ncbi.nlm.nih.gov/37626685/) · [DOI 10.3390/biomedicines11082189](https://doi.org/10.3390/biomedicines11082189) > CoUltraPEALut demonstrated significant efficacy in the overall recovery of the olfactory function, compared to the conventional therapy, suggesting that it could represent a possible future adjuvant treatment for PCOD. 12. **A Placebo-Controlled, Pseudo-Randomized, Crossover Trial of Botanical Agents for Gulf War Illness: Resveratrol (), Luteolin, and Fisetin ().** Int J Environ Res Public Health 2021 · [PMID 33802381](https://pubmed.ncbi.nlm.nih.gov/33802381/) · [DOI 10.3390/ijerph18052483](https://doi.org/10.3390/ijerph18052483) > Luteolin did not decrease symptom severity more than placebo at either the lower (= 0.718) or higher dosages (= 0.492). 13. **An open-label pilot study of a formulation containing the anti-inflammatory flavonoid luteolin and its effects on behavior in children with autism spectrum disorders.** Clin Ther 2013 · [PMID 23688534](https://pubmed.ncbi.nlm.nih.gov/23688534/) · [DOI 10.1016/j.clinthera.2013.04.006](https://doi.org/10.1016/j.clinthera.2013.04.006) > There was a significant improvement in adaptive functioning as measured by using the VABS age-equivalent scores (8.43 months in the communication domain, 7.17 months in daily living skills, and 8 months in the social domain; P < 0.005) 14. **Children with autism spectrum disorders, who improved with a luteolin-containing dietary formulation, show reduced serum levels of TNF and IL-6.** Transl Psychiatry 2015 · [PMID 26418275](https://pubmed.ncbi.nlm.nih.gov/26418275/) · [DOI 10.1038/tp.2015.142](https://doi.org/10.1038/tp.2015.142) > the mean serum IL-6 and TNF levels decreased significantly (P=0.036 and P=0.015, respectively) at the end of the treatment period (26 weeks) as compared with levels at the beginning 15. **Luteolin prevents liver from tunicamycin-induced endoplasmic reticulum stress via nuclear factor erythroid 2-related factor 2-dependent sestrin 2 induction.** Toxicol Appl Pharmacol 2020 · [PMID 32407927](https://pubmed.ncbi.nlm.nih.gov/32407927/) · [DOI 10.1016/j.taap.2020.115036](https://doi.org/10.1016/j.taap.2020.115036) > luteolin significantly decreased Tm- or thapsigargin-mediated C/EBP homologous protein (CHOP) expression. In addition, luteolin reduced the activation of three canonical signaling pathways related to the unfolded protein response 16. **Preclinical evidence for luteolin in ulcerative colitis: a meta-analysis and systematic review.** Front Pharmacol 2025 · [PMID 40808687](https://pubmed.ncbi.nlm.nih.gov/40808687/) · [DOI 10.3389/fphar.2025.1639644](https://doi.org/10.3389/fphar.2025.1639644) > The meta-analysis revealed that LUT significantly ameliorated colon length, reduced the disease activity index, alleviated body weight loss, and decreased histological scores. 17. **Cardioprotective Effects and Possible Mechanisms of Luteolin for Myocardial Ischemia-Reperfusion Injury: A Systematic Review and Meta-Analysis of Preclinical Evidence.** Front Cardiovasc Med 2022 · [PMID 35548432](https://pubmed.ncbi.nlm.nih.gov/35548432/) · [DOI 10.3389/fcvm.2022.685998](https://doi.org/10.3389/fcvm.2022.685998) > Pooling of the data demonstrated that luteolin exerts cardioprotective effects against MIRI through different signaling pathways. As possible mechanisms, luteolin exerts anti-apoptosis, anti-oxidation, and anti-inflammation effects against MIRI. 18. **Focal brain inflammation and autism.** J Neuroinflammation 2013 · [PMID 23570274](https://pubmed.ncbi.nlm.nih.gov/23570274/) · [DOI 10.1186/1742-2094-10-46](https://doi.org/10.1186/1742-2094-10-46) > The natural flavonoid luteolin inhibits mTOR, mast cells and microglia and could have a significant benefit in ASD. 19. **The role of natural flavonoids on neuroinflammation as a therapeutic target for Alzheimer's disease: a narrative review.** Neural Regen Res 2023 · [PMID 37449593](https://pubmed.ncbi.nlm.nih.gov/37449593/) · [DOI 10.4103/1673-5374.373680](https://doi.org/10.4103/1673-5374.373680) > Previous research found that multiple natural flavonoids could exert satisfactory treatment effects on the neuroinflammation associated with Alzheimer's disease. 20. **Paving Luteolin Therapeutic Potentialities and Agro-Food-Pharma Applications: Emphasis on Pharmacological Effects and Bioavailability Traits.** Oxid Med Cell Longev 2021 · [PMID 34594472](https://pubmed.ncbi.nlm.nih.gov/34594472/) · [DOI 10.1155/2021/1987588](https://doi.org/10.1155/2021/1987588) > luteolin has a very limited bioavailability, which consequently affects its biological properties and efficacy. Several drug delivery strategies have been developed to raise its bioavailability, with nanoformulations and lipid carriers, such as liposomes, being the most intensively explored. 21. **A Nutraceutical Containing Chlorogenic Acid and Luteolin Improves Cardiometabolic Parameters in Subjects with Pre-Obesity: A 6-Month Randomized, Double-Blind, Placebo-Controlled Study.** Nutrients 2023 · [PMID 36678333](https://pubmed.ncbi.nlm.nih.gov/36678333/) > In a 6-month double-blind RCT in pre-obesity, a chlorogenic acid + luteolin nutraceutical (150 mg/day) improved weight, HbA1c/HOMA-IR, lipids, carotid intima-media thickness and endothelial function. ## Where to buy [Search Amazon for Luteolin Capsules](https://www.amazon.com/s?k=Luteolin%20Capsules&tag=magellanlong-20) — affiliate search link. ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"ItemPage","@id":"https://magellanlongevity.com/p/115.html#page","url":"https://magellanlongevity.com/p/115.html","name":"Luteolin Capsules","description":"Luteolin is a naturally occurring flavone (a class of flavonoid) found in celery, parsley, green pepper, chamomile and various other fruits, vegetables…","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/p/115.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Nutraceuticals & Cellular Energizers","item":"https://magellanlongevity.com/c/1.html"},{"@type":"ListItem","position":3,"name":"Luteolin Capsules","item":"https://magellanlongevity.com/p/115.html"}]},{"@type":"Product","@id":"https://magellanlongevity.com/p/115.html#product","name":"Luteolin Capsules","category":"Nutraceuticals & Cellular Energizers","url":"https://magellanlongevity.com/p/115.html","description":"Luteolin is a naturally occurring flavone (a class of flavonoid) found in celery, parsley, green pepper, chamomile and various other fruits, vegetables and medicinal herbs. 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Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).