--- title: "NOVOS Core All-In-One Sachets — Evidence, Benefits & Where… | Magellan" description: "NOVOS Core All-In-One Sachets — NOVOS Core is a multi-ingredient dietary supplement marketed for longevity that combines about a dozen compounds intended…" url: "https://magellanlongevity.com/p/12.md" canonical: "https://magellanlongevity.com/p/12.html" html: "https://magellanlongevity.com/p/12.html" type: "product" section: "Nutraceuticals & Cellular Energizers" evidence_grade: "Emerging evidence" evidence_tier: "emerging" citations: 26 product_id: 12 price_usd: 109 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" license: "Educational content — not medical advice" --- # NOVOS Core All-In-One Sachets [Home](https://magellanlongevity.com/) › [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) › NOVOS Core All-In-One Sachets **HTML version:** https://magellanlongevity.com/p/12.html · **In the Magellan app:** https://magellanlongevity.com/#/product/12 ## Key facts | Field | Value | | --- | --- | | Product | NOVOS Core All-In-One Sachets | | Category | [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) | | Evidence grade | Emerging evidence (C) | | Peer-reviewed citations | 26 | | Typical listed price | $109.00 (check the live price) | | Where to buy | [Search Amazon](https://www.amazon.com/s?k=NOVOS%20Core%20All-In-One%20Sachets&tag=magellanlong-20) | | Catalog ID | 12 | ## What it is NOVOS Core is a multi-ingredient dietary supplement marketed for longevity that combines about a dozen compounds intended to target several biological 'hallmarks of aging.' Its ingredients include calcium alpha-ketoglutarate (a Krebs-cycle metabolite), the senolytic flavonoid fisetin, pterostilbene (a methylated resveratrol analog), glycine, glucosamine sulfate, magnesium malate, L-theanine, Rhodiola rosea, a microdose of lithium, hyaluronic acid, ginger, and vitamin C. Rather than acting through a single pathway, the formula is designed so that different components address distinct aging processes such as cellular senescence, mitochondrial and metabolic function, epigenetic regulation, and oxidative stress. The evidence below concerns these individual active ingredients and their mechanisms, since the finished multi-ingredient product has not itself been tested in controlled human trials. ## Its role in longevity Several of NOVOS Core's ingredients have genuine, though mostly early-stage, human or animal evidence relevant to aging: trials of GlyNAC (glycine plus N-acetylcysteine) improved oxidative stress, mitochondrial function, strength and walking performance in older adults — though at glycine doses far above what the sachets provide and paired with NAC, which the formula lacks; a small retrospective analysis linked an alpha-ketoglutarate formulation to reduced DNA-methylation age, with a proper randomized trial still underway; regular glucosamine use was associated with about 15% lower all-cause mortality in the 495,000-person UK Biobank cohort, an observational finding that cannot prove cause; low-dose lithium correlated with lower all-cause mortality in a large population; and fisetin extended lifespan and reduced senescent-cell burden in mice, with human senolytic trials still in progress. Magnesium modestly lowers blood pressure in pooled trials, but pterostilbene is a weak spot: it raised LDL cholesterol by about 17 mg/dL in one randomized trial, and pterostilbene combined with nicotinamide riboside did not improve muscle recovery in elderly volunteers. The specific doses, combination, and long-term safety of this exact stack have not been validated. This evidence describes the individual compounds and their mechanisms, not this specific commercial multi-ingredient product, which has not been tested as a whole in controlled human studies. ## Evidence grade: Emerging evidence - **What the grade means:** Curated grade based on the human and mechanistic evidence for this compound. - **Dose used in studies:** As an all-in-one blend, there is no single studied dose; each ingredient has its own evidence and the combination as a whole is rarely tested in humans. Review the per-ingredient label amounts. - **Dose from food:** Varies by formula. Some ingredients (vitamins, minerals, polyphenols) are common in foods, while others (NMN, CoQ10, specific botanical extracts) aren't meaningfully obtained from diet at supplemental levels. - **What this grade does not say:** Human data exist only for individual ingredients, not this product: GlyNAC improved oxidative stress and physical function in older adults at doses far above what the sachets provide (and includes NAC, which the formula lacks), glucosamine's mortality link is observational, and the fisetin and alpha-ketoglutarate anti-aging claims rest on animal data with human trials still underway. Pterostilbene raised LDL cholesterol by about 17 mg/dL in one randomized trial. The finished stack has never been tested in a human trial. ## Where it comes from without a bottle Food, exercise and behaviour routes to the same pathway, each with its citation. | Natural source | How it works | Citation | | --- | --- | --- | | A Mediterranean dietary pattern | Rather than any single capsule, the plant-forward Mediterranean pattern - vegetables, fruit, legumes, whole grains, olive oil and fish - is the most evidence-backed 'all-in-one' for longevity. Adherence is repeatedly tied to lower mortality. | BMJ 2005 [PMID 15820966](https://pubmed.ncbi.nlm.nih.gov/15820966/) | | Healthy plant-forward eating patterns | Across large cohorts, several healthy patterns - Mediterranean, plant-based and DASH - each add years of life expectancy, independent of your genes. The diet itself is the broadest longevity 'stack'. | Science Advances 2026 [PMID 41686892](https://pubmed.ncbi.nlm.nih.gov/41686892/) | | Fruit- and vegetable-forward eating | Within the Mediterranean pattern, the produce itself carries much of the benefit: above-median fruit and vegetable intake show the strongest individual links to lower mortality. | British Journal of Nutrition 2018 [PMID 30401007](https://pubmed.ncbi.nlm.nih.gov/30401007/) | ### What those papers actually say 1. **A Mediterranean dietary pattern** BMJ 2005 · [PMID 15820966](https://pubmed.ncbi.nlm.nih.gov/15820966/) · [DOI 10.1136/bmj.38415.644155.8F](https://doi.org/10.1136/bmj.38415.644155.8F) > An increase in the modified Mediterranean diet score was associated with lower overall mortality 2. **Healthy plant-forward eating patterns** Science Advances 2026 · [PMID 41686892](https://pubmed.ncbi.nlm.nih.gov/41686892/) · [DOI 10.1126/sciadv.ads7559](https://doi.org/10.1126/sciadv.ads7559) > achieving the top quintile of dietary scores was associated with 1.9 to 3.0 years of life gained at 45 years in men and 1.5 to 2.3 years in women. 3. **Fruit- and vegetable-forward eating** British Journal of Nutrition 2018 · [PMID 30401007](https://pubmed.ncbi.nlm.nih.gov/30401007/) · [DOI 10.1017/S0007114518002593](https://doi.org/10.1017/S0007114518002593) > Our meta-analyses confirm the inverse association of MedDiet with mortality and highlight the dietary components that influence mostly this association. ## In the news - **GlyNAC improves multiple defects in aging to boost strength and cognition in older humans** — EurekAlert! (Baylor College of Medicine) 2021 [Read it](https://www.eurekalert.org/news-releases/864962) > A pilot human clinical trial conducted by researchers at Baylor College of Medicine reveals that supplementation with GlyNAC - a combination of glycine and N-acetylcysteine as precursors of the natural antioxidant glutathione - could improve many age-associated defects in older humans to improve muscle strength and cognition, and promote healthy aging. ## The research Peer-reviewed studies on the active compound. Quotes are verbatim from the cited abstract. Research describes the active mechanism and is not a claim about this specific product. ### Cited studies 1. **The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, double-blind, placebo-controlled, dose-dependent clinical trial** GeroScience 2022 · [PMID 36482258](https://pubmed.ncbi.nlm.nih.gov/36482258/) · [DOI 10.1007/s11357-022-00705-1](https://doi.org/10.1007/s11357-022-00705-1) > In animal studies, β-nicotinamide mononucleotide (NMN) supplementation increases nicotinamide adenine dinucleotide (NAD) concentrations and improves healthspan and lifespan with great safety. 2. **Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases** Mechanisms of Ageing and Development 2015 · [PMID 25824609](https://pubmed.ncbi.nlm.nih.gov/25824609/) · [DOI 10.1016/j.mad.2015.03.008](https://doi.org/10.1016/j.mad.2015.03.008) > Caloric restriction has been shown repeatedly to prolong the lifespan in laboratory animals, with its benefits dependent on molecular targets... including the NAD-dependent deacetylase SIRT1. 3. **Induction of autophagy by spermidine promotes longevity** Nature Cell Biology 2009 · [PMID 19801973](https://pubmed.ncbi.nlm.nih.gov/19801973/) · [DOI 10.1038/ncb1975](https://doi.org/10.1038/ncb1975) > Administration of spermidine, a natural polyamine, markedly extended the lifespan of yeast, flies and worms, and human immune cells, by triggering autophagy. 4. **Krebs cycle intermediates regulate DNA and histone methylation: epigenetic impact on the aging process** Ageing Research Reviews 2014 · [PMID 24910305](https://pubmed.ncbi.nlm.nih.gov/24910305/) · [DOI 10.1016/j.arr.2014.05.004](https://doi.org/10.1016/j.arr.2014.05.004) > Krebs cycle intermediates can shape the epigenetic landscape of chromatin by regulating DNA and histone methylation. 5. **Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial** The Journals of Gerontology: Series A 2022 · [PMID 35975308](https://pubmed.ncbi.nlm.nih.gov/35975308/) · [DOI 10.1093/gerona/glac135](https://doi.org/10.1093/gerona/glac135) > GlyNAC supplementation in older adults improved glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, and multiple hallmarks of aging. 6. **Rejuvant, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging** Aging 2021 · [PMID 34847066](https://pubmed.ncbi.nlm.nih.gov/34847066/) · [DOI 10.18632/aging.203736](https://doi.org/10.18632/aging.203736) > individuals showed an average decrease in biological aging of 8 years 7. **Alpha-Ketoglutarate dietary supplementation to improve health in humans** Trends in Endocrinology & Metabolism 2021 · [PMID 34952764](https://pubmed.ncbi.nlm.nih.gov/34952764/) · [DOI 10.1016/j.tem.2021.11.003](https://doi.org/10.1016/j.tem.2021.11.003) > As an antioxidant, AKG interferes in nitrogen and ammonia balance, and affects epigenetic and immune regulation — pleiotropic functions relevant to healthy aging. 8. **Alpha-ketoglutarate supplementation and BiologicaL agE in middle-aged adults (ABLE)-intervention study protocol.** Geroscience 2023 · [PMID 37217632](https://pubmed.ncbi.nlm.nih.gov/37217632/) · [DOI 10.1007/s11357-023-00813-6](https://doi.org/10.1007/s11357-023-00813-6) > ABLE is a double blinded placebo-controlled randomized trial (RCT) of 1 g sustained release Ca-AKG versus placebo for 6 months of intervention and 3 months follow up including 120 40-60-year-old healthy individuals with a higher DNA methylation age compared to their chronological age. 9. **Alpha-Ketoglutarate Ameliorates Synaptic Plasticity Deficits in APP/PS1 Mice Model of Alzheimer's Disease.** Aging Cell 2025 · [PMID 40959937](https://pubmed.ncbi.nlm.nih.gov/40959937/) · [DOI 10.1111/acel.70235](https://doi.org/10.1111/acel.70235) > Our previous research found that dietary supplementation with calcium alpha-ketoglutarate (CaAKG), a calcium derivative of AKG, enhances both lifespan and healthspan in mice. 10. **Low-dose lithium uptake promotes longevity in humans and metazoans** Eur J Nutr 2011 · [PMID 21301855](https://pubmed.ncbi.nlm.nih.gov/21301855/) · [DOI 10.1007/s00394-011-0171-x](https://doi.org/10.1007/s00394-011-0171-x) > We find an inverse correlation between drinking water lithium concentrations and all-cause mortality in 18 neighbouring Japanese municipalities (1,206,174 individuals)... a comparably low concentration of lithium extends lifespan of C. elegans. 11. **Evidence: clears senescent cells (flavonol)** EBioMedicine 2018 · [PMID 30279143](https://pubmed.ncbi.nlm.nih.gov/30279143/) · [DOI 10.1016/j.ebiom.2018.09.015](https://doi.org/10.1016/j.ebiom.2018.09.015) > fisetin was the most potent senolytic 12. **Senolytic drugs: from discovery to translation** J Intern Med 2020 · [PMID 32686219](https://pubmed.ncbi.nlm.nih.gov/32686219/) · [DOI 10.1111/joim.13141](https://doi.org/10.1111/joim.13141) > The first senolytic drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis-driven approach 13. **Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence.** Aging Cell 2023 · [PMID 38062873](https://pubmed.ncbi.nlm.nih.gov/38062873/) · [DOI 10.1111/acel.14060](https://doi.org/10.1111/acel.14060) > The findings from this study identify fisetin as promising therapy for clinical translation to target excess cell senescence to treat age-related arterial dysfunction. 14. **Increased cellular senescence in doxorubicin-induced murine ovarian injury: effect of senolytics.** Geroscience 2023 · [PMID 36648735](https://pubmed.ncbi.nlm.nih.gov/36648735/) · [DOI 10.1007/s11357-023-00728-2](https://doi.org/10.1007/s11357-023-00728-2) > Short-term intervention with the classic senolytic combination dasatinib and quercetin (DQ) or fisetin significantly reduced the load of senescent cells in ovaries after doxorubicin treatment. However, neither DQ nor fisetin alleviated doxorubicin-related ovarian dysfunction. 15. **Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double-blind, placebo-controlled clinical trial.** Hepatology 2022 · [PMID 36082508](https://pubmed.ncbi.nlm.nih.gov/36082508/) · [DOI 10.1002/hep.32778](https://doi.org/10.1002/hep.32778) > This study demonstrates that NRPT at the recommended dose is safe and may hold promise in lowering markers of hepatic inflammation in patients with NAFLD. 16. **A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals.** JCI Insight 2022 · [PMID 35998039](https://pubmed.ncbi.nlm.nih.gov/35998039/) · [DOI 10.1172/jci.insight.158314](https://doi.org/10.1172/jci.insight.158314) > Daily supplementation with 1,000 mg NR and 200 mg PT is safe but does not improve recruitment of the MuSC pool or other measures of muscle recovery in response to injury or subsequent regeneration in elderly individuals. 17. **GlyNAC supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation and insulin resistance** Clin Transl Med 2021 · [PMID 33783984](https://pubmed.ncbi.nlm.nih.gov/33783984/) · [DOI 10.1002/ctm2.372](https://doi.org/10.1002/ctm2.372) > GlyNAC corrected glutathione deficiency, oxidative stress and mitochondrial dysfunction 18. **Evidence: collagen and methylation substrate** Front Neurol 2012 · [PMID 22529837](https://pubmed.ncbi.nlm.nih.gov/22529837/) · [DOI 10.3389/fneur.2012.00061](https://doi.org/10.3389/fneur.2012.00061) > glycine improves daytime sleepiness and fatigue induced by acute sleep restriction 19. **A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue.** Planta Med 2008 · [PMID 19016404](https://pubmed.ncbi.nlm.nih.gov/19016404/) · [DOI 10.1055/s-0028-1088346](https://doi.org/10.1055/s-0028-1088346) > It is concluded that repeated administration of R. ROSEA extract SHR-5 exerts an anti-fatigue effect that increases mental performance, particularly the ability to concentrate, and decreases cortisol response to awakening stress in burnout patients with fatigue syndrome. 20. **Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty.** Phytomedicine 2000 · [PMID 11081987](https://pubmed.ncbi.nlm.nih.gov/11081987/) · [DOI 10.1016/S0944-7113(00)80055-0](https://doi.org/10.1016/S0944-7113%2800%2980055-0) > These results suggest that RRE can reduce general fatigue under certain stressful conditions. 21. **Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.** Nutrients 2019 · [PMID 31623400](https://pubmed.ncbi.nlm.nih.gov/31623400/) · [DOI 10.3390/nu11102362](https://doi.org/10.3390/nu11102362) > Our findings suggest that L-theanine has the potential to promote mental health in the general population with stress-related ailments and cognitive impairments. 22. **Anti-Stress, Behavioural and Magnetoencephalography Effects of an L-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial.** Nutrients 2016 · [PMID 26797633](https://pubmed.ncbi.nlm.nih.gov/26797633/) · [DOI 10.3390/nu8010053](https://doi.org/10.3390/nu8010053) > The primary outcome measure, subjective stress response to a multitasking cognitive stressor, was significantly reduced one hour after administration of the L-theanine drink when compared to placebo. 23. **A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage.** Frontiers in aging 2022 · [PMID 35821844](https://pubmed.ncbi.nlm.nih.gov/35821844/) > In healthy older adults, glycine plus N-acetylcysteine (GlyNAC) restored glutathione redox status and reduced oxidative damage—support for the combination, not glycine alone. 24. **Associations of regular glucosamine use with all-cause and cause-specific mortality: a large prospective cohort study.** Annals of the rheumatic diseases 2020 · [PMID 32253185](https://pubmed.ncbi.nlm.nih.gov/32253185/) > Regular glucosamine use was associated with 15% lower all-cause mortality (HR 0.85) and 18% lower cardiovascular mortality among 495,077 UK Biobank participants — observational, so it cannot prove cause. 25. **Pterostilbene on metabolic parameters: a randomized, double-blind, and placebo-controlled trial.** Evidence-based complementary and alternative medicine : eCAM 2014 · [PMID 25057276](https://pubmed.ncbi.nlm.nih.gov/25057276/) > High-dose pterostilbene lowered blood pressure by 7.8/7.3 mmHg but raised LDL cholesterol by 17.1 mg/dL on monotherapy — a safety signal for this formula's resveratrol analog. 26. **Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials.** Hypertension (Dallas, Tex. : 1979) 2016 · [PMID 27402922](https://pubmed.ncbi.nlm.nih.gov/27402922/) > Across 34 double-blind RCTs, magnesium at about 368 mg/day lowered systolic blood pressure by 2.0 mmHg and diastolic by 1.8 mmHg. ## Where to buy [Search Amazon for NOVOS Core All-In-One Sachets](https://www.amazon.com/s?k=NOVOS%20Core%20All-In-One%20Sachets&tag=magellanlong-20) — affiliate search link. ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"ItemPage","@id":"https://magellanlongevity.com/p/12.html#page","url":"https://magellanlongevity.com/p/12.html","name":"NOVOS Core All-In-One Sachets","description":"NOVOS Core is a multi-ingredient dietary supplement marketed for longevity that combines about a dozen compounds intended to target several biological…","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/p/12.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Nutraceuticals & Cellular Energizers","item":"https://magellanlongevity.com/c/1.html"},{"@type":"ListItem","position":3,"name":"NOVOS Core All-In-One Sachets","item":"https://magellanlongevity.com/p/12.html"}]},{"@type":"Product","@id":"https://magellanlongevity.com/p/12.html#product","name":"NOVOS Core All-In-One Sachets","category":"Nutraceuticals & Cellular Energizers","url":"https://magellanlongevity.com/p/12.html","description":"NOVOS Core is a multi-ingredient dietary supplement marketed for longevity that combines about a dozen compounds intended to target several biological 'hallmarks of aging.' Its ingredients include calcium alpha-ketoglutarate (a Krebs-cycle metabolite), the senolytic flavonoid fisetin,…","additionalProperty":[{"@type":"PropertyValue","name":"Evidence grade","value":"Emerging evidence"}],"offers":{"@type":"Offer","priceCurrency":"USD","price":"109.00","url":"https://www.amazon.com/s?k=NOVOS%20Core%20All-In-One%20Sachets&tag=magellanlong-20","availability":"https://schema.org/InStock"}}]} ``` ## Related on Magellan Longevity - [Omega-3 EPA/DHA Fish Oil](https://magellanlongevity.com/p/128.md) — Across large randomized trials and meta-analyses, marine omega-3s reliably reduce serum triglycerides… - [Creatine Monohydrate](https://magellanlongevity.com/p/123.md) — Across meta-analyses and randomized trials, creatine monohydrate combined with resistance training modestly… - [Astaxanthin Softgels](https://magellanlongevity.com/p/107.md) — In humans, randomized trials and meta-analyses most consistently show that astaxanthin lowers the… - [Zinc Picolinate](https://magellanlongevity.com/p/133.md) — Multiple meta-analyses of randomized trials indicate that oral zinc, started soon after symptom onset, can… - [Vitamin K2 (MK-7)](https://magellanlongevity.com/p/138.md) — In humans, MK-7 supplementation consistently improves vitamin K-status biomarkers — lowering circulating… - [All Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).