--- title: "Glycine Powder — Evidence, Benefits & Where to Buy | Magellan" description: "Glycine Powder — Glycine is the smallest and simplest proteinogenic amino acid, synthesized endogenously but often in amounts below full metabolic…" url: "https://magellanlongevity.com/p/125.md" canonical: "https://magellanlongevity.com/p/125.html" html: "https://magellanlongevity.com/p/125.html" type: "product" section: "Nutraceuticals & Cellular Energizers" evidence_grade: "Moderate evidence" evidence_tier: "moderate" citations: 18 product_id: 125 price_usd: 18.37 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" license: "Educational content — not medical advice" --- # Glycine Powder [Home](https://magellanlongevity.com/) › [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) › Glycine Powder **HTML version:** https://magellanlongevity.com/p/125.html · **In the Magellan app:** https://magellanlongevity.com/#/product/125 ## Key facts | Field | Value | | --- | --- | | Product | Glycine Powder | | Category | [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) | | Evidence grade | Moderate evidence (B) | | Peer-reviewed citations | 18 | | Typical listed price | $18.37 (check the live price) | | Where to buy | [Search Amazon](https://www.amazon.com/s?k=Glycine%20Powder&tag=magellanlong-20) | | Catalog ID | 125 | ## What it is Glycine is the smallest and simplest proteinogenic amino acid, synthesized endogenously but often in amounts below full metabolic demand. It is a major building block of collagen, comprising roughly one-third of the collagen molecule, and serves as a substrate for glutathione, creatine, heme, and one-carbon (methylation) metabolism via glycine N-methyltransferase. In the nervous system glycine acts both as an inhibitory neurotransmitter at glycine receptors and as a co-agonist at NMDA-type glutamate receptors. Taken orally before bed, glycine lowers core body temperature through peripheral vasodilation, a change associated with the onset of sleep. ## Its role in longevity Small human trials report that about 3 g of glycine before bedtime improves subjective sleep quality and reduces next-day fatigue and sleepiness after partial sleep restriction, with mechanistic work attributing these effects to NMDA-receptor-mediated thermoregulation in the suprachiasmatic nucleus; these studies are small and several were industry-affiliated. As a precursor of glutathione, glycine combined with cysteine or N-acetylcysteine (GlyNAC) has restored glutathione synthesis and improved oxidative stress, mitochondrial function, inflammation, insulin resistance, muscle strength, and other aging hallmarks in older adults—but those placebo-controlled trials are small (about two dozen participants), come from a single research group, tested the combination rather than glycine alone, and benefits faded after supplementation stopped. Evidence for collagen-related benefits is mixed, since glycine-rich gelatin can raise collagen-synthesis markers while at least one controlled trial found no added benefit. This evidence describes glycine and its mechanisms (and, in several trials, glycine combined with other compounds), not this specific commercial product. ## Evidence grade: Moderate evidence - **What the grade means:** Curated grade based on the human and mechanistic evidence for this compound. - **Dose used in studies:** 3 g before bedtime (sleep trials) - **What this grade does not say:** Sleep benefits rest on small, partly industry-affiliated trials. The aging-hallmark improvements come from small, single-site trials of GlyNAC (glycine plus N-acetylcysteine), not glycine alone, and faded after supplementation stopped; independent replication is still needed. ## Where it comes from without a bottle Food, exercise and behaviour routes to the same pathway, each with its citation. | Natural source | How it works | Citation | | --- | --- | --- | | Gelatin / collagen-rich foods | Gelatin (and the collagen it comes from) is glycine-rich; a dose before activity raised blood glycine and boosted collagen synthesis. | The American Journal of Clinical Nutrition 2016 [PMID 27852613](https://pubmed.ncbi.nlm.nih.gov/27852613/) | | Bone broth | Simmered bone broth supplies glycine and proline, but the honest caveat is the amounts are variable and lower than a standardized collagen dose. | International Journal of Sport Nutrition and Exercise Metabolism 2018 [PMID 29893587](https://pubmed.ncbi.nlm.nih.gov/29893587/) | | Collagen-peptide foods | Eating collagen/gelatin delivers glycine-containing peptides into the blood that feed skin and connective-tissue collagen. | Journal of the Science of Food and Agriculture 2016 [PMID 26840887](https://pubmed.ncbi.nlm.nih.gov/26840887/) | ### What those papers actually say 1. **Gelatin / collagen-rich foods** The American Journal of Clinical Nutrition 2016 · [PMID 27852613](https://pubmed.ncbi.nlm.nih.gov/27852613/) · [DOI 10.3945/ajcn.116.138594](https://doi.org/10.3945/ajcn.116.138594) > Supplementation with increasing amounts of gelatin increased circulating glycine, proline, hydroxyproline, and hydroxylysine, peaking 1 h after the supplement was given. 2. **Bone broth** International Journal of Sport Nutrition and Exercise Metabolism 2018 · [PMID 29893587](https://pubmed.ncbi.nlm.nih.gov/29893587/) · [DOI 10.1123/ijsnem.2018-0139](https://doi.org/10.1123/ijsnem.2018-0139) > It is unlikely that BB can provide a consistently reliable source of key amino acids. 3. **Collagen-peptide foods** Journal of the Science of Food and Agriculture 2016 · [PMID 26840887](https://pubmed.ncbi.nlm.nih.gov/26840887/) · [DOI 10.1002/jsfa.7606](https://doi.org/10.1002/jsfa.7606) > Several human studies have demonstrated occurrence of two major collagen peptides, prolyl-hydroxyproline (Pro-Hyp) and hydroxyprolyl-glycine (Hyp-Gly), in human peripheral blood. ## In the news - **GlyNAC improves multiple defects in aging to boost strength and cognition in older humans** — EurekAlert! (Baylor College of Medicine) 2021 [Read it](https://www.eurekalert.org/news-releases/864962) > older humans taking GlyNAC for 24 weeks saw improvements in many characteristic defects of aging, including glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, body fat, genomic toxicity, muscle strength, gait speed, exercise capacity and cognitive function. - **GlyNAC improves multiple defects in aging to boost strength and cognition in older humans** — ScienceDaily 2021 [Read it](https://www.sciencedaily.com/releases/2021/03/210329122746.htm) > After taking GlyNAC for 24 weeks, all these defects in older adults improved and some reversed to the levels found in young adults. ## The research Peer-reviewed studies on the active compound. Quotes are verbatim from the cited abstract. Research describes the active mechanism and is not a claim about this specific product. ### Cited studies 1. **Evidence: collagen and methylation substrate** Front Neurol 2012 · [PMID 22529837](https://pubmed.ncbi.nlm.nih.gov/22529837/) · [DOI 10.3389/fneur.2012.00061](https://doi.org/10.3389/fneur.2012.00061) > glycine improves daytime sleepiness and fatigue induced by acute sleep restriction 2. **New Functions and Potential Applications of Amino Acids** Adv Biochem Eng Biotechnol 2017 · [PMID 27872968](https://pubmed.ncbi.nlm.nih.gov/27872968/) · [DOI 10.1007/10_2016_35](https://doi.org/10.1007/10_2016_35) > glycine ingestion before bedtime significantly improved subjective sleep quality 3. **New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep.** J Pharmacol Sci 2012 · [PMID 22293292](https://pubmed.ncbi.nlm.nih.gov/22293292/) · [DOI 10.1254/jphs.11r04fm](https://doi.org/10.1254/jphs.11r04fm) > We recently reported that glycine ingestion before bedtime significantly ameliorated subjective sleep quality in individuals with insomniac tendencies. 4. **The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus.** Neuropsychopharmacology 2014 · [PMID 25533534](https://pubmed.ncbi.nlm.nih.gov/25533534/) · [DOI 10.1038/npp.2014.326](https://doi.org/10.1038/npp.2014.326) > These data suggest that exogenous glycine promotes sleep via peripheral vasodilatation through the activation of NMDA receptors in the SCN shell. 5. **Collagen peptide supplementation before bedtime reduces sleep fragmentation and improves cognitive function in physically active males with sleep complaints.** Eur J Nutr 2023 · [PMID 37874350](https://pubmed.ncbi.nlm.nih.gov/37874350/) · [DOI 10.1007/s00394-023-03267-w](https://doi.org/10.1007/s00394-023-03267-w) > CP supplementation did not influence sleep quantity, latency, or efficiency, but reduced awakenings and improved cognitive function in physically active males with sleep complaints. 6. **Nutritional Modulation of Sleep Latency, Duration, and Efficiency: A Randomized, Repeated-Measures, Double-Blind Deception Study.** Med Sci Sports Exerc 2022 · [PMID 36094342](https://pubmed.ncbi.nlm.nih.gov/36094342/) · [DOI 10.1249/MSS.0000000000003040](https://doi.org/10.1249/MSS.0000000000003040) > The intervention trial reduced sleep onset latency (-24 ± 25 min; P = 0.002), increased total sleep time (22 ± 32 min; P = 0.01), and increased sleep efficiency (2.4% ± 3.9%; P = 0.03), while also reducing morning sleepiness ( P = 0.02). 7. **Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation.** Am J Clin Nutr 2011 · [PMID 21795440](https://pubmed.ncbi.nlm.nih.gov/21795440/) · [DOI 10.3945/ajcn.110.003483](https://doi.org/10.3945/ajcn.110.003483) > Dietary supplementation with the glutathione precursors cysteine and glycine fully restores glutathione synthesis and concentrations and lowers levels of oxidative stress and oxidant damages. 8. **Glutathione synthesis is diminished in patients with uncontrolled diabetes and restored by dietary supplementation with cysteine and glycine.** Diabetes Care 2010 · [PMID 20929994](https://pubmed.ncbi.nlm.nih.gov/20929994/) · [DOI 10.2337/dc10-1006](https://doi.org/10.2337/dc10-1006) > Dietary supplementation with GSH precursor amino acids can restore GSH synthesis and lower oxidative stress and oxidant damage in the face of persistent hyperglycemia. 9. **Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial** The Journals of Gerontology: Series A 2022 · [PMID 35975308](https://pubmed.ncbi.nlm.nih.gov/35975308/) · [DOI 10.1093/gerona/glac135](https://doi.org/10.1093/gerona/glac135) > GlyNAC supplementation in older adults improved glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, and multiple hallmarks of aging. 10. **GlyNAC supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation and insulin resistance** Clin Transl Med 2021 · [PMID 33783984](https://pubmed.ncbi.nlm.nih.gov/33783984/) · [DOI 10.1002/ctm2.372](https://doi.org/10.1002/ctm2.372) > GlyNAC corrected glutathione deficiency, oxidative stress and mitochondrial dysfunction 11. **GlyNAC Supplementation Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Aging Hallmarks, Metabolic Defects, Muscle Strength, Cognitive Decline, and Body Composition: Implications for Healthy Aging.** J Nutr 2021 · [PMID 34587244](https://pubmed.ncbi.nlm.nih.gov/34587244/) · [DOI 10.1093/jn/nxab309](https://doi.org/10.1093/jn/nxab309) > It is particularly exciting that GlyNAC supplementation appears to reverse multiple aging hallmarks, and if confirmed in a randomized clinical trial, it could introduce a transformative paradigm shift in aging and geriatrics. 12. **Glutathione and glutathione-dependent enzymes: From biochemistry to gerontology and successful aging.** Ageing Res Rev 2023 · [PMID 37683986](https://pubmed.ncbi.nlm.nih.gov/37683986/) · [DOI 10.1016/j.arr.2023.102066](https://doi.org/10.1016/j.arr.2023.102066) > Notably, GSH levels decline during aging, an alteration generally related to impaired GSH biosynthesis and leading to cell dysfunction. 13. **Effects of glycine on metabolic syndrome components: a review.** J Endocrinol Invest 2022 · [PMID 35013990](https://pubmed.ncbi.nlm.nih.gov/35013990/) · [DOI 10.1007/s40618-021-01720-3](https://doi.org/10.1007/s40618-021-01720-3) > Glycine supplementation improves various components of metabolic syndrome including diabetes, obesity, hyperlipidemia and hypertension. 14. **Vitamin C-enriched gelatin supplementation before intermittent activity augments collagen synthesis.** Am J Clin Nutr 2016 · [PMID 27852613](https://pubmed.ncbi.nlm.nih.gov/27852613/) · [DOI 10.3945/ajcn.116.138594](https://doi.org/10.3945/ajcn.116.138594) > Subjects who took 15 g gelatin 1 h before exercise showed double the amino-terminal propeptide of collagen I in their blood, indicating increased collagen synthesis. 15. **Collagen Peptide Supplementation during Training Does Not Further Increase Connective Tissue Protein Synthesis Rates.** Med Sci Sports Exerc 2024 · [PMID 39086044](https://pubmed.ncbi.nlm.nih.gov/39086044/) · [DOI 10.1249/MSS.0000000000003519](https://doi.org/10.1249/MSS.0000000000003519) > Collagen peptide supplementation (2 × 15 g daily) does not increase myofibrillar or muscle connective protein synthesis rates during 1 wk of intense resistance exercise training in young, recreational athletes. 16. **Improvement of nitrogen retention by arginine and glycine supplementation and its relation to collagen synthesis in traumatized mature and aged rats.** J Nutr 1984 · [PMID 6470827](https://pubmed.ncbi.nlm.nih.gov/6470827/) · [DOI 10.1093/jn/114.9.1697](https://doi.org/10.1093/jn/114.9.1697) > The beneficial effect of arginine and glycine supplementation on improving N retention in traumatized rats appears to be due, at least in part, to increased collagen synthesis in wounds. 17. **Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction.** Mol Metab 2022 · [PMID 35121169](https://pubmed.ncbi.nlm.nih.gov/35121169/) · [DOI 10.1016/j.molmet.2022.101452](https://doi.org/10.1016/j.molmet.2022.101452) > One-carbon metabolism is routinely dysregulated in nonalcoholic fatty liver disease. This includes decreased glycine N-methyltransferase (GNMT), a critical regulator of s-adenosylmethionine (SAM). 18. **A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage.** Frontiers in aging 2022 · [PMID 35821844](https://pubmed.ncbi.nlm.nih.gov/35821844/) > In healthy older adults, glycine plus N-acetylcysteine (GlyNAC) restored glutathione redox status and reduced oxidative damage—support for the combination, not glycine alone. ## Where to buy [Search Amazon for Glycine Powder](https://www.amazon.com/s?k=Glycine%20Powder&tag=magellanlong-20) — affiliate search link. ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"ItemPage","@id":"https://magellanlongevity.com/p/125.html#page","url":"https://magellanlongevity.com/p/125.html","name":"Glycine Powder","description":"Glycine is the smallest and simplest proteinogenic amino acid, synthesized endogenously but often in amounts below full metabolic demand. It is a major…","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/p/125.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Nutraceuticals & Cellular Energizers","item":"https://magellanlongevity.com/c/1.html"},{"@type":"ListItem","position":3,"name":"Glycine Powder","item":"https://magellanlongevity.com/p/125.html"}]},{"@type":"Product","@id":"https://magellanlongevity.com/p/125.html#product","name":"Glycine Powder","category":"Nutraceuticals & Cellular Energizers","url":"https://magellanlongevity.com/p/125.html","description":"Glycine is the smallest and simplest proteinogenic amino acid, synthesized endogenously but often in amounts below full metabolic demand. It is a major building block of collagen, comprising roughly one-third of the collagen molecule, and serves as a substrate for glutathione, creatine, heme, and…","additionalProperty":[{"@type":"PropertyValue","name":"Evidence grade","value":"Moderate evidence"}],"offers":{"@type":"Offer","priceCurrency":"USD","price":"18.37","url":"https://www.amazon.com/s?k=Glycine%20Powder&tag=magellanlong-20","availability":"https://schema.org/InStock"}}]} ``` ## Related on Magellan Longevity - [Omega-3 EPA/DHA Fish Oil](https://magellanlongevity.com/p/128.md) — Across large randomized trials and meta-analyses, marine omega-3s reliably reduce serum triglycerides… - [Creatine Monohydrate](https://magellanlongevity.com/p/123.md) — Across meta-analyses and randomized trials, creatine monohydrate combined with resistance training modestly… - [Astaxanthin Softgels](https://magellanlongevity.com/p/107.md) — In humans, randomized trials and meta-analyses most consistently show that astaxanthin lowers the… - [Zinc Picolinate](https://magellanlongevity.com/p/133.md) — Multiple meta-analyses of randomized trials indicate that oral zinc, started soon after symptom onset, can… - [Vitamin K2 (MK-7)](https://magellanlongevity.com/p/138.md) — In humans, MK-7 supplementation consistently improves vitamin K-status biomarkers — lowering circulating… - [All Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).