--- title: "Myo-Inositol — Evidence, Benefits & Where to Buy | Magellan" description: "Myo-Inositol — Myo-inositol is a naturally occurring sugar-like compound (a cyclitol, the most abundant of nine inositol stereoisomers) that the human…" url: "https://magellanlongevity.com/p/131.md" canonical: "https://magellanlongevity.com/p/131.html" html: "https://magellanlongevity.com/p/131.html" type: "product" section: "Nutraceuticals & Cellular Energizers" evidence_grade: "Moderate evidence" evidence_tier: "moderate" citations: 17 product_id: 131 price_usd: 32 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" license: "Educational content — not medical advice" --- # Myo-Inositol [Home](https://magellanlongevity.com/) › [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) › Myo-Inositol **HTML version:** https://magellanlongevity.com/p/131.html · **In the Magellan app:** https://magellanlongevity.com/#/product/131 ## Key facts | Field | Value | | --- | --- | | Product | Myo-Inositol | | Category | [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) | | Evidence grade | Moderate evidence (B) | | Peer-reviewed citations | 17 | | Typical listed price | $32.00 (check the live price) | | Where to buy | [Search Amazon](https://www.amazon.com/s?k=Myo-Inositol&tag=magellanlong-20) | | Catalog ID | 131 | ## What it is Myo-inositol is a naturally occurring sugar-like compound (a cyclitol, the most abundant of nine inositol stereoisomers) that the human body synthesizes and also obtains from foods such as fruits, beans, grains, and nuts. It is a structural component of cell membranes and a precursor of inositol-phosphoglycan second messengers that mediate insulin signal transduction, influencing glucose uptake and ovarian function. In insulin-resistant states such as polycystic ovary syndrome (PCOS), altered inositol metabolism is thought to contribute to impaired insulin signaling. ## Its role in longevity In randomized trials and meta-analyses, myo-inositol (often combined with D-chiro-inositol) has been associated with improved insulin sensitivity—lower fasting insulin and HOMA-IR—restoration of menstrual regularity and ovulation in PCOS, and a reduced incidence of gestational diabetes (a Cochrane review found roughly half the risk, with low certainty), with a favorable safety profile and fewer gastrointestinal effects than metformin. It has also improved metabolic-syndrome markers such as blood pressure, HOMA-IR and lipids in postmenopausal women. Evidence quality is mixed, however: the systematic review informing the 2023 international PCOS guidelines judged the overall evidence 'limited and inconclusive' and found metformin superior on several outcomes, most trials are short, many gestational-diabetes trials are small and from a single country, and aging or longevity outcomes are essentially unstudied. This evidence describes the compound myo-inositol and its mechanism, not this specific commercial product. ## Evidence grade: Moderate evidence - **What the grade means:** Curated grade based on the human and mechanistic evidence for this compound. - **Dose used in studies:** 2–4 g/day - **What this grade does not say:** Meta-analyses support lower fasting insulin and HOMA-IR in PCOS and a possible reduction in gestational diabetes (low certainty). The review behind the 2023 international PCOS guideline calls the overall evidence limited and inconclusive, with metformin better on several outcomes. Aging or longevity outcomes are essentially unstudied in humans. ## Where it comes from without a bottle Food, exercise and behaviour routes to the same pathway, each with its citation. | Natural source | How it works | Citation | | --- | --- | --- | | Fruits, beans, grains & nuts | A survey of 487 foods found these whole-plant groups carry the most myo-inositol; fresh beats frozen or canned. | The American Journal of Clinical Nutrition 1980 [PMID 7416064](https://pubmed.ncbi.nlm.nih.gov/7416064/) | | Fresh whole foods over processed | Choose fresh produce: the same food analysis showed processing strips inositol, so fresh fruit and vegetables deliver more than packaged versions. | The American Journal of Clinical Nutrition 1980 [PMID 7416064](https://pubmed.ncbi.nlm.nih.gov/7416064/) | ### What those papers actually say 1. **Fruits, beans, grains & nuts** The American Journal of Clinical Nutrition 1980 · [PMID 7416064](https://pubmed.ncbi.nlm.nih.gov/7416064/) · [DOI 10.1093/ajcn/33.9.1954](https://doi.org/10.1093/ajcn/33.9.1954) > We observed that the greatest amounts of myo-inositol were present in fruits, beans, grains, and nuts. 2. **Fresh whole foods over processed** The American Journal of Clinical Nutrition 1980 · [PMID 7416064](https://pubmed.ncbi.nlm.nih.gov/7416064/) · [DOI 10.1093/ajcn/33.9.1954](https://doi.org/10.1093/ajcn/33.9.1954) > Fresh vegetables and fruits were found to contain more myo-inositol than did frozen, canned, or salt-free products. ## In the news - **Myo-inositol shows promise for PCOS therapy** — Contemporary OB/GYN 2024 [Read it](https://www.contemporaryobgyn.net/view/myo-inositol-shows-promise-for-pcos-therapy) > Myo-inositol significantly improves the hormonal and metabolic profiles of patients with polycystic ovary syndrome (PCOS), according to a recent study published in Cureus. - **Inositol: Uses, benefits, and risks** — Medical News Today 2023 [Read it](https://www.medicalnewstoday.com/articles/inositol) > Inositol is a type of sugar that helps make cell membranes and regulate insulin levels. Inositol may be beneficial for people with conditions like polycystic ovary syndrome (PCOS) and metabolic syndrome. - **Can inositol help manage PCOS symptoms? Here's what the research says** — Allara Health 2025 [Read it](https://www.allarahealth.com/blog/inositol-pcos) > For people with PCOS, taking myo-inositol and d-chiro-inositol can improve insulin resistance, improve hormone levels, regulate periods, and reduce symptoms of PCOS associated with high levels of testosterone. ## The research Peer-reviewed studies on the active compound. Quotes are verbatim from the cited abstract. Research describes the active mechanism and is not a claim about this specific product. ### Cited studies 1. **Evidence: insulin second-messenger** Reprod Biol Endocrinol 2023 · [PMID 36703143](https://pubmed.ncbi.nlm.nih.gov/36703143/) · [DOI 10.1186/s12958-023-01055-z](https://doi.org/10.1186/s12958-023-01055-z) > Inositol is an effective and safe treatment in PCOS 2. **A randomized controlled trial comparing myoinositol with metformin versus metformin monotherapy in PCOS** Clin Endocrinol (Oxf) 2023 · [PMID 37265016](https://pubmed.ncbi.nlm.nih.gov/37265016/) · [DOI 10.1111/cen.14931](https://doi.org/10.1111/cen.14931) > myoinositol acts as an insulin sensitizer and exerts beneficial effects in PCOS 3. **Comparison of two insulin sensitizers, metformin and myo-inositol, in women with PCOS** Gynecol Endocrinol 2016 · [PMID 27808588](https://pubmed.ncbi.nlm.nih.gov/27808588/) · [DOI 10.1080/09513590.2016.1236078](https://doi.org/10.1080/09513590.2016.1236078) > The insulin sensitivity improved in both treatment groups 4. **Inositol for Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis to Inform the 2023 Update of the International Evidence-based PCOS Guidelines.** J Clin Endocrinol Metab 2024 · [PMID 38163998](https://pubmed.ncbi.nlm.nih.gov/38163998/) · [DOI 10.1210/clinem/dgad762](https://doi.org/10.1210/clinem/dgad762) > Evidence suggests benefits for myo-inositol or D-chiro-inositol (DCI) for some metabolic measures and potential benefits from DCI for ovulation, but inositol may have no effect on other outcomes. 5. **Efficacy of myo-inositol and d-chiro-inositol combination on menstrual cycle regulation and improving insulin resistance in young women with polycystic ovary syndrome: A randomized open-label study.** Int J Gynaecol Obstet 2021 · [PMID 34624138](https://pubmed.ncbi.nlm.nih.gov/34624138/) · [DOI 10.1002/ijgo.13971](https://doi.org/10.1002/ijgo.13971) > Myo-inositol and d-chiro-inositol in combination (3.6:1 ratio) are effective in regularizing menstrual cycles and improving insulin resistance. 6. **Myoinositol/metformin pretreatment in GnRH-antagonist cycle for women with PCOS undergoing IVF: a double-blinded randomized controlled study.** Gynecol Endocrinol 2021 · [PMID 34590929](https://pubmed.ncbi.nlm.nih.gov/34590929/) · [DOI 10.1080/09513590.2021.1981282](https://doi.org/10.1080/09513590.2021.1981282) > Myo had improvement in fasting insulin, HOMA, Sr.AMH, and SHBG suggesting decreased insulin resistance. 7. **Comparison of metformin plus myoinositol vs metformin alone in PCOS women undergoing ovulation induction cycles: randomized controlled trial.** Gynecol Endocrinol 2019 · [PMID 30614289](https://pubmed.ncbi.nlm.nih.gov/30614289/) · [DOI 10.1080/09513590.2018.1549656](https://doi.org/10.1080/09513590.2018.1549656) > Live birth rate was significantly higher in the Group I as compared to Group II [55% (33/60); 26.67% (16/60); p = .002]. 8. **Inositols in PCOS.** Molecules 2020 · [PMID 33260918](https://pubmed.ncbi.nlm.nih.gov/33260918/) · [DOI 10.3390/molecules25235566](https://doi.org/10.3390/molecules25235566) > The available clinical data suggest that MI, DCI, and their combination in physiological ratio 40:1 with or without other compound could be beneficial for improving metabolic, hormonal, and reproductive aspects of PCOS. 9. **Myo-Inositol and D-Chiro-Inositol as Modulators of Ovary Steroidogenesis: A Narrative Review.** Nutrients 2023 · [PMID 37111094](https://pubmed.ncbi.nlm.nih.gov/37111094/) · [DOI 10.3390/nu15081875](https://doi.org/10.3390/nu15081875) > Noticeably, experimental data have shown that myo-inositol and its most relevant epimer D-chiro-inositol are both necessary to permit a faithful transduction of insulin and of other molecular factors. 10. **Lifestyle management in polycystic ovary syndrome - beyond diet and physical activity.** BMC Endocr Disord 2023 · [PMID 36647089](https://pubmed.ncbi.nlm.nih.gov/36647089/) · [DOI 10.1186/s12902-022-01208-y](https://doi.org/10.1186/s12902-022-01208-y) > Research investigating inositol supplementation have produced the most promising findings, showing improved metabolic profiles and reduced hyperandrogenism. 11. **Myo-inositol supplementation for the prevention of gestational diabetes: A meta-analysis of randomized controlled trials.** Eur J Obstet Gynecol Reprod Biol 2022 · [PMID 35460931](https://pubmed.ncbi.nlm.nih.gov/35460931/) · [DOI 10.1016/j.ejogrb.2022.04.009](https://doi.org/10.1016/j.ejogrb.2022.04.009) > Compared with control group in pregnant women, myo-inositol supplementation could lead to remarkably reduced incidence of gestational diabetes (OR = 0.32; 95% CI = 0.15 to 0.72; P = 0.005) 12. **Inositol for the prevention of gestational diabetes: a systematic review and meta-analysis of randomized controlled trials.** Arch Gynecol Obstet 2018 · [PMID 30564926](https://pubmed.ncbi.nlm.nih.gov/30564926/) · [DOI 10.1007/s00404-018-5005-0](https://doi.org/10.1007/s00404-018-5005-0) > ISL supplementation was associated with lower rate of GDM (OR 0.49, 95% CI 0.24-1.03, p = 0.01) and lower preterm delivery rate (OR 0.35, 95% CI 0.17-0.74, p = 0.006). 13. **Inositol supplementation for the prevention and treatment of gestational diabetes mellitus: a meta-analysis of randomized controlled trials.** Arch Gynecol Obstet 2023 · [PMID 37308791](https://pubmed.ncbi.nlm.nih.gov/37308791/) · [DOI 10.1007/s00404-023-07100-x](https://doi.org/10.1007/s00404-023-07100-x) > The meta-analysis found that inositol supplementation resulted in a significantly lower incidence of GDM in the inositol versus the control group (odds ratio [OR] 0.40; 95% confidence interval [CI] 0.24-0.67; P = 0.0005). 14. **The efficacy of myo-inositol supplementation to reduce the incidence of gestational diabetes: a meta-analysis.** Gynecol Endocrinol 2022 · [PMID 35575290](https://pubmed.ncbi.nlm.nih.gov/35575290/) · [DOI 10.1080/09513590.2022.2071865](https://doi.org/10.1080/09513590.2022.2071865) > Myo-inositol supplementation is effective to reduce the incidence of gestational diabetes, 2-h glucose OGTT, HOMA-IR and preterm delivery, which suggested that myo-inositol supplementation should be recommended to prevent gestational diabetes. 15. **Effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome: a perspective, randomized, placebo-controlled study.** Menopause 2011 · [PMID 20811299](https://pubmed.ncbi.nlm.nih.gov/20811299/) · [DOI 10.1097/gme.0b013e3181e8e1b1](https://doi.org/10.1097/gme.0b013e3181e8e1b1) > Myo-inositol plus diet improved systolic and diastolic blood pressure, HOMA index, cholesterol, and triglyceride serum levels with highly significant differences, compared with the groups treated only with diet and placebo. 16. **Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials.** Endocrine connections 2017 · [PMID 29042448](https://pubmed.ncbi.nlm.nih.gov/29042448/) > Meta-analysis of 9 RCTs (247 cases, 249 controls) found myo-inositol lowered fasting insulin (SMD −1.02 µU/mL, p = 0.009) and HOMA-IR (SMD −0.585, p = 0.041) versus control in PCOS. 17. **Antenatal dietary supplementation with myo-inositol for preventing gestational diabetes.** The Cochrane database of systematic reviews 2023 · [PMID 36790138](https://pubmed.ncbi.nlm.nih.gov/36790138/) > Cochrane review of 7 RCTs (1,319 pregnant women): antenatal myo-inositol may reduce gestational diabetes (RR 0.53, 95% CI 0.31–0.90) and hypertensive disorders of pregnancy (RR 0.34), but evidence certainty was low. ## Where to buy [Search Amazon for Myo-Inositol](https://www.amazon.com/s?k=Myo-Inositol&tag=magellanlong-20) — affiliate search link. ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"ItemPage","@id":"https://magellanlongevity.com/p/131.html#page","url":"https://magellanlongevity.com/p/131.html","name":"Myo-Inositol","description":"Myo-inositol is a naturally occurring sugar-like compound (a cyclitol, the most abundant of nine inositol stereoisomers) that the human body synthesizes…","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/p/131.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Nutraceuticals & Cellular Energizers","item":"https://magellanlongevity.com/c/1.html"},{"@type":"ListItem","position":3,"name":"Myo-Inositol","item":"https://magellanlongevity.com/p/131.html"}]},{"@type":"Product","@id":"https://magellanlongevity.com/p/131.html#product","name":"Myo-Inositol","category":"Nutraceuticals & Cellular Energizers","url":"https://magellanlongevity.com/p/131.html","description":"Myo-inositol is a naturally occurring sugar-like compound (a cyclitol, the most abundant of nine inositol stereoisomers) that the human body synthesizes and also obtains from foods such as fruits, beans, grains, and nuts. It is a structural component of cell membranes and a precursor of…","additionalProperty":[{"@type":"PropertyValue","name":"Evidence grade","value":"Moderate evidence"}],"offers":{"@type":"Offer","priceCurrency":"USD","price":"32.00","url":"https://www.amazon.com/s?k=Myo-Inositol&tag=magellanlong-20","availability":"https://schema.org/InStock"}}]} ``` ## Related on Magellan Longevity - [Omega-3 EPA/DHA Fish Oil](https://magellanlongevity.com/p/128.md) — Across large randomized trials and meta-analyses, marine omega-3s reliably reduce serum triglycerides… - [Creatine Monohydrate](https://magellanlongevity.com/p/123.md) — Across meta-analyses and randomized trials, creatine monohydrate combined with resistance training modestly… - [Astaxanthin Softgels](https://magellanlongevity.com/p/107.md) — In humans, randomized trials and meta-analyses most consistently show that astaxanthin lowers the… - [Zinc Picolinate](https://magellanlongevity.com/p/133.md) — Multiple meta-analyses of randomized trials indicate that oral zinc, started soon after symptom onset, can… - [Vitamin K2 (MK-7)](https://magellanlongevity.com/p/138.md) — In humans, MK-7 supplementation consistently improves vitamin K-status biomarkers — lowering circulating… - [All Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).