--- title: "NOVOS Vital Organ Support — Evidence, Benefits & Where to Buy | Magellan" description: "NOVOS Vital Organ Support — NOVOS Vital is a multi-ingredient gummy supplement marketed for whole-body organ support, combining seven food-derived…" url: "https://magellanlongevity.com/p/14.md" canonical: "https://magellanlongevity.com/p/14.html" html: "https://magellanlongevity.com/p/14.html" type: "product" section: "Nutraceuticals & Cellular Energizers" evidence_grade: "Emerging evidence" evidence_tier: "emerging" citations: 25 product_id: 14 price_usd: 69 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" license: "Educational content — not medical advice" --- # NOVOS Vital Organ Support [Home](https://magellanlongevity.com/) › [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) › NOVOS Vital Organ Support **HTML version:** https://magellanlongevity.com/p/14.html · **In the Magellan app:** https://magellanlongevity.com/#/product/14 ## Key facts | Field | Value | | --- | --- | | Product | NOVOS Vital Organ Support | | Category | [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) | | Evidence grade | Emerging evidence (C) | | Peer-reviewed citations | 25 | | Typical listed price | $69.00 (check the live price) | | Where to buy | [Search Amazon](https://www.amazon.com/s?k=NOVOS%20Vital%20Organ%20Support&tag=magellanlong-20) | | Catalog ID | 14 | ## What it is NOVOS Vital is a multi-ingredient gummy supplement marketed for whole-body organ support, combining seven food-derived compounds: lutein and zeaxanthin (xanthophyll carotenoids concentrated in the retina and brain), nattokinase (a fibrinolytic enzyme from fermented soybeans/natto), inulin (a prebiotic fermentable fiber), apple cider vinegar (a source of acetic acid), rutin (a flavonoid), and trehalose (a disaccharide that can induce autophagy). Each ingredient acts through a distinct, well-characterized mechanism rather than a single shared pathway. The formulation is aimed at organs that commonly decline with age, including the eyes, brain, heart, kidneys, liver, muscles, and gut. ## Its role in longevity The individual ingredients carry uneven levels of human evidence. Lutein and zeaxanthin are the best supported, with large trials (AREDS2) and RCTs linking them to eye and cognitive health, though some endpoints were null (the AREDS2 primary AMD endpoint and macular-pigment change in the LIMPIA trial). Nattokinase and vinegar/acetic acid show mixed results: a large 3-year RCT found no effect of nattokinase on subclinical atherosclerosis, while smaller trials and meta-analyses report modest blood-pressure reductions (a 2023 meta-analysis of six RCTs found about 3 mmHg systolic) and improved post-meal glucose; inulin has meta-analytic support for glycemic control in prediabetes and type 2 diabetes. Rutin and trehalose are supported mainly by mechanistic and preclinical (endothelial, autophagy) data, and trehalose - the formulation's flagship brain-health ingredient - was well tolerated but showed no efficacy in its largest human test to date, the HEALEY ALS platform trial. No trial has tested this exact seven-ingredient combination, and gummy doses may sit below studied doses, so benefits are inferred from each compound separately. This evidence describes the underlying compounds and mechanisms, not this specific commercial product. ## Evidence grade: Emerging evidence - **What the grade means:** Curated grade based on the human and mechanistic evidence for this compound. - **Dose used in studies:** A multi-ingredient blend, so there is no single human dose; effective amounts depend on each component and the specific formula. Check the individual ingredients and their label amounts. - **Dose from food:** Varies by formula. Many organ-support nutrients (choline, omega-3s, antioxidants, B vitamins) come from foods like fish, eggs, leafy greens and organ meats, but concentrated supplement amounts often exceed typical dietary intake. - **What this grade does not say:** Evidence is ingredient-by-ingredient: modest human RCT support for nattokinase (blood pressure), lutein/zeaxanthin (eye health), and inulin (glycemia), but rutin and trehalose rest mainly on preclinical data, and trehalose showed no efficacy in the large HEALEY ALS platform trial. No trial has tested the finished seven-ingredient product, gummy doses may fall below studied amounts, and no organ-function, healthspan, or lifespan benefit has been demonstrated. ## Where it comes from without a bottle Food, exercise and behaviour routes to the same pathway, each with its citation. | Natural source | How it works | Citation | | --- | --- | --- | | Green leafy vegetables | Spinach, kale and collards deliver folate, lutein, vitamin K and nitrate that support brain and vascular health - core 'organ-support' nutrients. Roughly one serving a day tracked with markedly slower cognitive decline. | Neurology 2017 [PMID 29263222](https://pubmed.ncbi.nlm.nih.gov/29263222/) | | Nuts (walnuts, almonds) | A daily handful of nuts supplies unsaturated fats, magnesium and vitamin E that support the heart and metabolism. Higher nut intake tracks with lower cardiovascular, cancer and all-cause mortality. | BMC Medicine 2016 [PMID 27916000](https://pubmed.ncbi.nlm.nih.gov/27916000/) | | Oily fish (omega-3) | Salmon, sardines and mackerel provide EPA and DHA that support heart, brain and eye tissue. Honest caveat: pooled trials show only a slight reduction in coronary events, not a large all-cause-mortality effect. | Cochrane Database of Systematic Reviews 2020 [PMID 32114706](https://pubmed.ncbi.nlm.nih.gov/32114706/) | ### What those papers actually say 1. **Green leafy vegetables** Neurology 2017 · [PMID 29263222](https://pubmed.ncbi.nlm.nih.gov/29263222/) · [DOI 10.1212/WNL.0000000000004815](https://doi.org/10.1212/WNL.0000000000004815) > consumption of green leafy vegetables was associated with slower cognitive decline 2. **Nuts (walnuts, almonds)** BMC Medicine 2016 · [PMID 27916000](https://pubmed.ncbi.nlm.nih.gov/27916000/) · [DOI 10.1186/s12916-016-0730-3](https://doi.org/10.1186/s12916-016-0730-3) > Higher nut intake is associated with reduced risk of cardiovascular disease, total cancer and all-cause mortality, and mortality from respiratory disease, diabetes, and infections. 3. **Oily fish (omega-3)** Cochrane Database of Systematic Reviews 2020 · [PMID 32114706](https://pubmed.ncbi.nlm.nih.gov/32114706/) · [DOI 10.1002/14651858.CD003177.pub5](https://doi.org/10.1002/14651858.CD003177.pub5) > increasing LCn3 slightly reduces risk of coronary heart disease mortality and events, and reduces serum triglycerides ## In the news - **Research upholds use of supplements to slow macular degeneration** — Harvard Health 2022 [Read it](https://www.health.harvard.edu/diseases-and-conditions/research-upholds-use-of-supplements-to-slow-macular-degeneration) > Leaving beta carotene out of eye supplements and adding lutein and zeaxanthin still appears to be the safest and most effective formula for slowing the progression of age-related macular degeneration (AMD), the most common cause of blindness after age 50. - **What Apple Cider Vinegar Can (and Can't) Do for You** — Cleveland Clinic 2025 [Read it](https://health.clevelandclinic.org/exploring-the-health-benefits-of-apple-cider-vinegar) > An analysis of studies shows evidence that apple cider vinegar may decrease fasting plasma glucose levels when taken with a meal full of complex carbohydrates. ## The research Peer-reviewed studies on the active compound. Quotes are verbatim from the cited abstract. Research describes the active mechanism and is not a claim about this specific product. ### Cited studies 1. **Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial** The Journals of Gerontology: Series A 2022 · [PMID 35975308](https://pubmed.ncbi.nlm.nih.gov/35975308/) · [DOI 10.1093/gerona/glac135](https://doi.org/10.1093/gerona/glac135) > GlyNAC supplementation in older adults improved glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, and multiple hallmarks of aging. 2. **Association between vitamin D supplementation and mortality: systematic review and meta-analysis** BMJ 2019 · [PMID 31405892](https://pubmed.ncbi.nlm.nih.gov/31405892/) · [DOI 10.1136/bmj.l4673](https://doi.org/10.1136/bmj.l4673) > Vitamin D supplementation was associated with a reduction in cancer mortality but not all-cause or cardiovascular mortality in this meta-analysis of randomised controlled trials. 3. **Efficacy of vitamin D supplementation on cancer mortality: systematic review and individual patient data meta-analysis** Ageing Res Rev 2023 · [PMID 37004841](https://pubmed.ncbi.nlm.nih.gov/37004841/) · [DOI 10.1016/j.arr.2023.101923](https://doi.org/10.1016/j.arr.2023.101923) > vitamin D administered daily reduced cancer mortality by 12 percent 4. **Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial.** JAMA 2013 · [PMID 23644932](https://pubmed.ncbi.nlm.nih.gov/23644932/) · [DOI 10.1001/jama.2013.4997](https://doi.org/10.1001/jama.2013.4997) > Addition of lutein + zeaxanthin, DHA + EPA, or both to the AREDS formulation in primary analyses did not further reduce risk of progression to advanced AMD. However, because of potential increased incidence of lung cancer in former smokers, lutein + zeaxanthin could be an appropriate carotenoid substitute in the AREDS formulation. 5. **Improvement of retinal function in early age-related macular degeneration after lutein and zeaxanthin supplementation: a randomized, double-masked, placebo-controlled trial.** Am J Ophthalmol 2012 · [PMID 22835510](https://pubmed.ncbi.nlm.nih.gov/22835510/) · [DOI 10.1016/j.ajo.2012.04.014](https://doi.org/10.1016/j.ajo.2012.04.014) > Early functional abnormalities of the central retina in the early AMD patients could be improved by lutein and zeaxanthin supplementation. These improvements may be potentially attributed to the elevations in MPOD. 6. **Dietary Nutrient Intake and Progression to Late Age-Related Macular Degeneration in the Age-Related Eye Disease Studies 1 and 2.** Ophthalmology 2020 · [PMID 32858063](https://pubmed.ncbi.nlm.nih.gov/32858063/) · [DOI 10.1016/j.ophtha.2020.08.018](https://doi.org/10.1016/j.ophtha.2020.08.018) > Higher dietary intake of multiple nutrients, including minerals, vitamins, and carotenoids, is associated with decreased risk of progression to late AMD. 7. **Effect of Dietary Supplementation With Lutein, Zeaxanthin, and ω-3 on Macular Pigment: A Randomized Clinical Trial.** JAMA Ophthalmol 2017 · [PMID 28973076](https://pubmed.ncbi.nlm.nih.gov/28973076/) · [DOI 10.1001/jamaophthalmol.2017.3398](https://doi.org/10.1001/jamaophthalmol.2017.3398) > Among first-generation offspring of parents with neovascular AMD in the LIMPIA trial, MPOD as measured with the modified HRA and the MPD-Visucam was not modified after 6 months of lutein and zeaxanthin dietary supplementation despite plasma levels showing continuous exposure to lutein and zeaxanthin. 8. **Lutein and Zeaxanthin Influence Brain Function in Older Adults: A Randomized Controlled Trial.** J Int Neuropsychol Soc 2017 · [PMID 28695791](https://pubmed.ncbi.nlm.nih.gov/28695791/) · [DOI 10.1017/S1355617717000534](https://doi.org/10.1017/S1355617717000534) > L and Z supplementation appears to benefit neurocognitive function by enhancing cerebral perfusion, even if consumed for a discrete period of time in late life. 9. **The Effects of Lutein and Zeaxanthin Supplementation on Cognitive Function in Adults With Self-Reported Mild Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Study.** Front Nutr 2022 · [PMID 35252311](https://pubmed.ncbi.nlm.nih.gov/35252311/) · [DOI 10.3389/fnut.2022.843512](https://doi.org/10.3389/fnut.2022.843512) > The results from this trial suggest that 6-months of supplementation with lutein and zeaxanthin may improve visual memory and learning in community-dwelling adults with self-reported cognitive complaints. 10. **Effects of a Lutein and Zeaxanthin Intervention on Cognitive Function: A Randomized, Double-Masked, Placebo-Controlled Trial** Nutrients 2017 · [PMID 29135938](https://pubmed.ncbi.nlm.nih.gov/29135938/) · [DOI 10.3390/nu9111246](https://doi.org/10.3390/nu9111246) > Supplementation with L + Z improves CNS xanthophyll levels and cognitive function in young, healthy adults 11. **Nattokinase atherothrombotic prevention study: A randomized controlled trial.** Clin Hemorheol Microcirc 2021 · [PMID 33843667](https://pubmed.ncbi.nlm.nih.gov/33843667/) · [DOI 10.3233/CH-211147](https://doi.org/10.3233/CH-211147) > Results of this trial show that nattokinase supplementation has a null effect on subclinical atherosclerosis progression in healthy individuals at low risk for CVD. 12. **Consumption of nattokinase is associated with reduced blood pressure and von Willebrand factor, a cardiovascular risk marker: results from a randomized, double-blind, placebo-controlled, multicenter North American clinical trial.** Integr Blood Press Control 2016 · [PMID 27785095](https://pubmed.ncbi.nlm.nih.gov/27785095/) · [DOI 10.2147/IBPC.S99553](https://doi.org/10.2147/IBPC.S99553) > The data suggest that nattokinase consumption in a North American population is associated with beneficial changes to BP in a hypertensive population, indicating sex-specific mechanisms of action of nattokinase's effect on vWF and hypertension. 13. **Nattospes as Effective and Safe Functional Supplements in Management of Stroke.** J Med Food 2020 · [PMID 31934821](https://pubmed.ncbi.nlm.nih.gov/31934821/) · [DOI 10.1089/jmf.2019.0183](https://doi.org/10.1089/jmf.2019.0183) > This study indicated that Nattospes as nutraceutical supplement can be applied safely and effectively in the management of subacute stage ischemic stroke. 14. **Vinegar consumption can attenuate postprandial glucose and insulin responses; a systematic review and meta-analysis of clinical trials.** Diabetes Res Clin Pract 2017 · [PMID 28292654](https://pubmed.ncbi.nlm.nih.gov/28292654/) · [DOI 10.1016/j.diabres.2017.01.021](https://doi.org/10.1016/j.diabres.2017.01.021) > The findings suggest that vinegar can be effective in reducing postprandial glucose and insulin levels, indicating it could be considered as an adjunctive tool for improving glycemic control. 15. **The effects of SCFAs on glycemic control in humans: a systematic review and meta-analysis.** Am J Clin Nutr 2022 · [PMID 35388874](https://pubmed.ncbi.nlm.nih.gov/35388874/) · [DOI 10.1093/ajcn/nqac085](https://doi.org/10.1093/ajcn/nqac085) > Vinegar decreased the glucose response acutely in healthy and metabolically unhealthy individuals. Acetate, propionate, butyrate, and mixed SCFAs had no effect on blood glucose and insulin in humans. 16. **Prebiotic inulin-type fructans induce specific changes in the human gut microbiota.** Gut 2017 · [PMID 28213610](https://pubmed.ncbi.nlm.nih.gov/28213610/) · [DOI 10.1136/gutjnl-2016-313271](https://doi.org/10.1136/gutjnl-2016-313271) > Ecosystem-wide analysis of the effect of a dietary intervention with prebiotic inulin-type fructans on the colon microbiota revealed that this effect is specifically associated with three genera 17. **Prebiotic effect of inulin-type fructans on faecal microbiota and short-chain fatty acids in type 2 diabetes: a randomised controlled trial.** Eur J Nutr 2020 · [PMID 32440730](https://pubmed.ncbi.nlm.nih.gov/32440730/) · [DOI 10.1007/s00394-020-02282-5](https://doi.org/10.1007/s00394-020-02282-5) > Six weeks supplementation with inulin-type fructans had a significant bifidogenic effect and induced increased concentrations of faecal SCFA, without changing faecal microbial diversity. 18. **Inulin-type prebiotics reduce serum uric acid levels via gut microbiota modulation: a randomized, controlled crossover trial in peritoneal dialysis patients.** Eur J Nutr 2021 · [PMID 34491388](https://pubmed.ncbi.nlm.nih.gov/34491388/) · [DOI 10.1007/s00394-021-02669-y](https://doi.org/10.1007/s00394-021-02669-y) > Inulin-type prebiotics is a promising therapeutic candidate to reduce serum UA levels in renal failure patients, and this urate-lowering effect could possibly be attributed to intestinal microbial degradation of UA. 19. **Current insights and future perspectives of flavonoids: A promising antihypertensive approach.** Phytother Res 2024 · [PMID 38616386](https://pubmed.ncbi.nlm.nih.gov/38616386/) · [DOI 10.1002/ptr.8199](https://doi.org/10.1002/ptr.8199) > This comprehensive review summarizes the antihypertensive activity of specific flavonoids, including quercetin, luteolin, rutin, troxerutin, apigenin, and chrysin, in L-NAME-induced hypertension models. 20. **Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.** Autophagy 2018 · [PMID 30335591](https://pubmed.ncbi.nlm.nih.gov/30335591/) · [DOI 10.1080/15548627.2018.1535292](https://doi.org/10.1080/15548627.2018.1535292) > The natural compound trehalose promotes autophagy via TFEB (transcription factor EB), ameliorating disease phenotype in multiple ND models, but its mechanism is still obscure. 21. **Treatment with Autophagy Inducer Trehalose Alleviates Memory and Behavioral Impairments and Neuroinflammatory Brain Processes in db/db Mice.** Cells 2021 · [PMID 34685538](https://pubmed.ncbi.nlm.nih.gov/34685538/) · [DOI 10.3390/cells10102557](https://doi.org/10.3390/cells10102557) > Trehalose caused a slight reduction in increased blood glucose concentration, considerable autophagy activation, and a decrease in the neuroinflammatory response in the brain along with improvements of exploration, locomotor activity, anxiety, depressive-like behavior, and fear learning and memory in db/db mice. 22. **Effects of nattokinase on blood pressure: a randomized, controlled trial.** Hypertension research : official journal of the Japanese Society of Hypertension 2008 · [PMID 18971533](https://pubmed.ncbi.nlm.nih.gov/18971533/) > In 86 adults with pre-hypertension or stage-1 hypertension, nattokinase 2,000 FU/day for 8 weeks lowered systolic blood pressure by 5.6 mmHg and diastolic by 2.8 mmHg versus placebo. 23. **Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.** Reviews in cardiovascular medicine 2023 · [PMID 39076715](https://pubmed.ncbi.nlm.nih.gov/39076715/) > Meta-analysis of 6 RCTs (n=546) found nattokinase reduced systolic blood pressure by about 3.5 mmHg and diastolic by 2.3 mmHg, with mixed lipid signals at low doses. 24. **Inulin-type fructans supplementation improves glycemic control for the prediabetes and type 2 diabetes populations: results from a GRADE-assessed systematic review and dose-response meta-analysis of 33 randomized controlled trials.** Journal of translational medicine 2019 · [PMID 31805963](https://pubmed.ncbi.nlm.nih.gov/31805963/) > Meta-analysis of 33 RCTs (n=1,346) found inulin-type fructans lowered fasting glucose by about 0.60 mmol/L and HbA1c by 0.58% in prediabetes and type 2 diabetes subgroups. 25. **Safety and efficacy of trehalose in amyotrophic lateral sclerosis (HEALEY ALS Platform Trial): an adaptive, phase 2/3, double-blind, randomised, placebo-controlled trial.** The Lancet. Neurology 2025 · [PMID 40409314](https://pubmed.ncbi.nlm.nih.gov/40409314/) > In the HEALEY ALS platform trial - the largest human test of trehalose to date - trehalose was well tolerated but showed no evidence of efficacy. ## Where to buy [Search Amazon for NOVOS Vital Organ Support](https://www.amazon.com/s?k=NOVOS%20Vital%20Organ%20Support&tag=magellanlong-20) — affiliate search link. ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"ItemPage","@id":"https://magellanlongevity.com/p/14.html#page","url":"https://magellanlongevity.com/p/14.html","name":"NOVOS Vital Organ Support","description":"NOVOS Vital is a multi-ingredient gummy supplement marketed for whole-body organ support, combining seven food-derived compounds: lutein and zeaxanthin…","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/p/14.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Nutraceuticals & Cellular Energizers","item":"https://magellanlongevity.com/c/1.html"},{"@type":"ListItem","position":3,"name":"NOVOS Vital Organ Support","item":"https://magellanlongevity.com/p/14.html"}]},{"@type":"Product","@id":"https://magellanlongevity.com/p/14.html#product","name":"NOVOS Vital Organ Support","category":"Nutraceuticals & Cellular Energizers","url":"https://magellanlongevity.com/p/14.html","description":"NOVOS Vital is a multi-ingredient gummy supplement marketed for whole-body organ support, combining seven food-derived compounds: lutein and zeaxanthin (xanthophyll carotenoids concentrated in the retina and brain), nattokinase (a fibrinolytic enzyme from fermented soybeans/natto), inulin (a…","additionalProperty":[{"@type":"PropertyValue","name":"Evidence grade","value":"Emerging evidence"}],"offers":{"@type":"Offer","priceCurrency":"USD","price":"69.00","url":"https://www.amazon.com/s?k=NOVOS%20Vital%20Organ%20Support&tag=magellanlong-20","availability":"https://schema.org/InStock"}}]} ``` ## Related on Magellan Longevity - [Omega-3 EPA/DHA Fish Oil](https://magellanlongevity.com/p/128.md) — Across large randomized trials and meta-analyses, marine omega-3s reliably reduce serum triglycerides… - [Creatine Monohydrate](https://magellanlongevity.com/p/123.md) — Across meta-analyses and randomized trials, creatine monohydrate combined with resistance training modestly… - [Astaxanthin Softgels](https://magellanlongevity.com/p/107.md) — In humans, randomized trials and meta-analyses most consistently show that astaxanthin lowers the… - [Zinc Picolinate](https://magellanlongevity.com/p/133.md) — Multiple meta-analyses of randomized trials indicate that oral zinc, started soon after symptom onset, can… - [Vitamin K2 (MK-7)](https://magellanlongevity.com/p/138.md) — In humans, MK-7 supplementation consistently improves vitamin K-status biomarkers — lowering circulating… - [All Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).