--- title: "hs-CRP Inflammation Test — Evidence, Benefits & Where to Buy | Magellan" description: "hs-CRP Inflammation Test — High-sensitivity C-reactive protein (hs-CRP) is a blood test that measures very low concentrations of C-reactive protein, an…" url: "https://magellanlongevity.com/p/142.md" canonical: "https://magellanlongevity.com/p/142.html" html: "https://magellanlongevity.com/p/142.html" type: "product" section: "Diagnostics & Epigenetic Tests" evidence_grade: "Measurement tool" evidence_tier: "tool" citations: 19 product_id: 142 price_usd: 99 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" license: "Educational content — not medical advice" --- # hs-CRP Inflammation Test [Home](https://magellanlongevity.com/) › [Diagnostics & Epigenetic Tests](https://magellanlongevity.com/c/2.md) › hs-CRP Inflammation Test **HTML version:** https://magellanlongevity.com/p/142.html · **In the Magellan app:** https://magellanlongevity.com/#/product/142 ## Key facts | Field | Value | | --- | --- | | Product | hs-CRP Inflammation Test | | Category | [Diagnostics & Epigenetic Tests](https://magellanlongevity.com/c/2.md) | | Evidence grade | Measurement tool (B) | | Peer-reviewed citations | 19 | | Typical listed price | $99.00 (check the live price) | | Where to buy | [Search Amazon](https://www.amazon.com/s?k=hs-CRP%20Inflammation%20Test&tag=magellanlong-20) | | Catalog ID | 142 | ## What it is High-sensitivity C-reactive protein (hs-CRP) is a blood test that measures very low concentrations of C-reactive protein, an acute-phase protein produced by the liver in response to inflammation. Because atherosclerosis is in part an inflammatory process, hs-CRP is used as a biomarker of systemic low-grade inflammation and as an adjunct in cardiovascular risk assessment. Widely used clinical cut-points classify hs-CRP below 1, 1 to 3, and above 3 mg/L as lower, average, and higher relative cardiovascular risk. Unlike the standard CRP assay used to detect overt infection or autoimmune flares, the high-sensitivity assay resolves the small differences relevant to long-term risk stratification in otherwise healthy people. ## Its role in longevity Across large prospective cohorts and meta-analyses, higher hs-CRP is consistently associated with increased risk of coronary heart disease, stroke, cardiovascular and non-vascular mortality, and with aging-related states such as frailty and dementia; a landmark randomized trial (JUPITER) found that treating people with elevated hs-CRP but normal LDL cholesterol reduced cardiovascular events, and a second trial (CANTOS) showed that anti-inflammatory therapy targeting the pathway upstream of CRP lowered recurrent events in patients selected by elevated hs-CRP, establishing the test as a marker of targetable residual inflammatory risk. However, the evidence has important limits: Mendelian randomization studies indicate CRP itself is unlikely to be a causal factor in heart disease, and some analyses conclude it adds only modest predictive value beyond traditional risk factors for most individuals. CRP is also non-specific, rising with infection, obesity, smoking and many other conditions, so a single value cannot identify the source of inflammation and an elevated reading should be repeated once any acute illness has resolved. This body of evidence describes the C-reactive protein biomarker and the hs-CRP measurement in general, not any specific commercial testing product. ## Evidence grade: Measurement tool - **What the grade means:** Graded as an instrument: how accurately it measures, and whether measuring it changes anything. - **Dose used in studies:** Only when you are well. Check it twice, a couple of weeks apart, and take the lower value - a single high reading is far more likely to be a cold than a signal. Do not test within 2-3 weeks of any infection, injury, vaccination or hard unaccustomed exercise. - **What this grade does not say:** hs-CRP has earned its place: it separated risk independently of LDL cholesterol in the classic NEJM prediction work, and in 30-year follow-up of the Women's Health Study it was still carrying predictive information decades after a single measurement. The measurement travels better than most on this list - CRP has been validated from finger-stick dried blood spots against automated analysers, with stability, haematocrit and precision formally checked, and remote self-collection in older adults has been shown to be reliable. The weakness is not the assay, it is the biology: CRP is an acute-phase protein that swings enormously with any infection or inflammation, so one number in isolation is close to meaningless and this product bundles it with vitamin D rather than selling it alone. Also worth saying plainly - a genuinely raised hs-CRP in a well person has no specific consumer fix attached to it; it is information you take to a clinician, not an instruction. ## In the news - **C-Reactive Protein test to screen for heart disease: Why do we need another test?** — Harvard Health Publishing 2017 [Read it](https://www.health.harvard.edu/heart-health/c-reactive-protein-test-to-screen-for-heart-disease) > Less than 1 milligram per liter of blood corresponds to a low risk for heart attack or other cardiovascular problems; 1-3 milligrams per liter corresponds to moderate risk; and over 3 milligrams, to high risk. - **C-Reactive Protein (CRP) Test: MedlinePlus Medical Test** — MedlinePlus (U.S. National Library of Medicine) 2025 [Read it](https://medlineplus.gov/lab-tests/c-reactive-protein-crp-test/) > An hs-CRP test measures very tiny increases in your CRP levels. It is used to estimate your risk of heart disease. - **Prioritizing Health \| hsCRP: A Promising Risk Assessment Tool** — American College of Cardiology 2025 [Read it](https://www.acc.org/latest-in-cardiology/articles/2025/12/01/01/prioritizing-health-hscrp) > Elevated hsCRP is associated with future MI, stroke and cardiovascular disease death in both primary and secondary prevention populations, based on evidence from randomized controlled trials (RCTs) and observational studies. ## The research Peer-reviewed studies on the active compound. Quotes are verbatim from the cited abstract. Research describes the active mechanism and is not a claim about this specific product. ### Cited studies 1. **Evidence: High-sensitivity C-reactive protein** Cardiovasc Diabetol 2025 · [PMID 40750895](https://pubmed.ncbi.nlm.nih.gov/40750895/) · [DOI 10.1186/s12933-025-02835-0](https://doi.org/10.1186/s12933-025-02835-0) > elevated inflammatory index was significantly associated with cardiovascular disease incidence and mortality 2. **C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women** N Engl J Med 2000 · [PMID 10733371](https://pubmed.ncbi.nlm.nih.gov/10733371/) · [DOI 10.1056/NEJM200003233421202](https://doi.org/10.1056/NEJM200003233421202) > hs-CRP was the strongest univariate predictor of the risk of cardiovascular events 3. **Inflammation, Cholesterol, Lipoprotein(a), and 30-Year Cardiovascular Outcomes in Women** N Engl J Med 2024 · [PMID 39216091](https://pubmed.ncbi.nlm.nih.gov/39216091/) · [DOI 10.1056/NEJMoa2405182](https://doi.org/10.1056/NEJMoa2405182) > adjusted hazard ratio 1.70 for high-sensitivity CRP over 30 years 4. **Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.** N Engl J Med 2008 · [PMID 18997196](https://pubmed.ncbi.nlm.nih.gov/18997196/) · [DOI 10.1056/NEJMoa0807646](https://doi.org/10.1056/NEJMoa0807646) > In this trial of apparently healthy persons without hyperlipidemia but with elevated high-sensitivity C-reactive protein levels, rosuvastatin significantly reduced the incidence of major cardiovascular events. 5. **C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis.** Lancet 2009 · [PMID 20031199](https://pubmed.ncbi.nlm.nih.gov/20031199/) · [DOI 10.1016/S0140-6736(09)61717-7](https://doi.org/10.1016/S0140-6736%2809%2961717-7) > CRP concentration has continuous associations with the risk of coronary heart disease, ischaemic stroke, vascular mortality, and death from several cancers and lung disease that are each of broadly similar size. 6. **C-reactive protein gene polymorphisms, C-reactive protein blood levels, and cardiovascular disease risk.** J Am Coll Cardiol 2007 · [PMID 17868801](https://pubmed.ncbi.nlm.nih.gov/17868801/) · [DOI 10.1016/j.jacc.2007.06.012](https://doi.org/10.1016/j.jacc.2007.06.012) > C-reactive protein (CRP), a blood marker of inflammation and a hallmark of the acute-phase response, has been shown to be a powerful and specific predictor of cardiovascular event risk in populations of otherwise healthy persons. 7. **High-sensitivity C-reactive protein: clinical importance.** Curr Probl Cardiol 2004 · [PMID 15258556](https://pubmed.ncbi.nlm.nih.gov/15258556/) > hsCRP levels of less than 1, 1 to 3, and greater than 3 mg/L are associated with lower, moderate, and higher cardiovascular risks, respectively. 8. **C-reactive protein and cardiovascular disease: a review of risk prediction and interventions.** Clin Chim Acta 2002 · [PMID 11814453](https://pubmed.ncbi.nlm.nih.gov/11814453/) · [DOI 10.1016/s0009-8981(01)00797-5](https://doi.org/10.1016/s0009-8981%2801%2900797-5) > CRP correlates with risk of CVD in patients who have a history of acute coronary disease, stable angina, and in those who have never been diagnosed with CVD. CRP imparts risk that is independent of hyperlipidemia. 9. **High-sensitivity C-reactive protein as a risk assessment tool for cardiovascular disease.** Clin Cardiol 2005 · [PMID 16250263](https://pubmed.ncbi.nlm.nih.gov/16250263/) · [DOI 10.1002/clc.4960280905](https://doi.org/10.1002/clc.4960280905) > C-reactive protein is an index of inflammation that is now believed to promote directly all stages of atherosclerosis, including plaque rupture. As measured by high-sensitivity assays, high-sensitivity CRP (hs-CRP) also independently predicts recurrent events in patients with known coronary artery diseases. 10. **Narrative review: Assessment of C-reactive protein in risk prediction for cardiovascular disease.** Ann Intern Med 2006 · [PMID 16818927](https://pubmed.ncbi.nlm.nih.gov/16818927/) · [DOI 10.7326/0003-4819-145-1-200607040-00129](https://doi.org/10.7326/0003-4819-145-1-200607040-00129) > They find no definitive evidence that, for most individuals, CRP adds substantial predictive value above that provided by risk estimation using traditional risk factors for CVD. 11. **Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data.** BMJ 2011 · [PMID 21325005](https://pubmed.ncbi.nlm.nih.gov/21325005/) · [DOI 10.1136/bmj.d548](https://doi.org/10.1136/bmj.d548) > Human genetic data indicate that C reactive protein concentration itself is unlikely to be even a modest causal factor in coronary heart disease. 12. **Cardiac troponin and C-reactive protein for predicting all-cause and cardiovascular mortality in patients with chronic kidney disease: a meta-analysis.** Clinics (Sao Paulo) 2015 · [PMID 26017799](https://pubmed.ncbi.nlm.nih.gov/26017799/) · [DOI 10.6061/clinics/2015(04)14](https://doi.org/10.6061/clinics/2015%2804%2914) > Elevated serum levels of cardiac troponin and C-reactive protein are significant associated with higher risks of all-cause and cardiovascular mortality in patients with chronic kidney disease. 13. **C-reactive protein for predicting all-cause mortality in patients with acute ischemic stroke: a meta-analysis.** Biosci Rep 2019 · [PMID 30718369](https://pubmed.ncbi.nlm.nih.gov/30718369/) · [DOI 10.1042/BSR20181135](https://doi.org/10.1042/BSR20181135) > Acute ischemic stroke patients with the highest CRP level were independently associated with an increased risk of all-cause mortality (HR: 2.07; 95% CI: 1.60-2.68) compared with the lowest CRP category. 14. **Sleep Disturbance, Sleep Duration, and Inflammation: A Systematic Review and Meta-Analysis of Cohort Studies and Experimental Sleep Deprivation.** Biol Psychiatry 2015 · [PMID 26140821](https://pubmed.ncbi.nlm.nih.gov/26140821/) · [DOI 10.1016/j.biopsych.2015.05.014](https://doi.org/10.1016/j.biopsych.2015.05.014) > Sleep disturbance was associated with higher levels of CRP (ES .12; 95% CI = .05-.19) and IL-6 (ES .20; 95% CI = .08-.31). 15. **The role of nutrition in inflammaging.** Ageing Res Rev 2022 · [PMID 35219904](https://pubmed.ncbi.nlm.nih.gov/35219904/) · [DOI 10.1016/j.arr.2022.101596](https://doi.org/10.1016/j.arr.2022.101596) > healthy diets, including the Mediterranean diet, are associated with lower concentrations of inflammatory mediators, like C-reactive protein (CRP) and Tumor Necrosis Factor-α (TNF-α), that are hallmarks of inflammaging. 16. **Association of inflammatory mediators with frailty status in older adults: results from a systematic review and meta-analysis.** Geroscience 2020 · [PMID 32803650](https://pubmed.ncbi.nlm.nih.gov/32803650/) · [DOI 10.1007/s11357-020-00247-4](https://doi.org/10.1007/s11357-020-00247-4) > This work established strong association between inflammatory biomarkers and frailty, confirming the role of age-related chronic inflammation in frailty development. 17. **Risk Factors for Young-Onset Dementia in the UK Biobank.** JAMA Neurol 2024 · [PMID 38147328](https://pubmed.ncbi.nlm.nih.gov/38147328/) · [DOI 10.1001/jamaneurol.2023.4929](https://doi.org/10.1001/jamaneurol.2023.4929) > 15 factors were significantly associated with a higher YOD risk, namely lower formal education, lower socioeconomic status, carrying 2 apolipoprotein ε4 allele, no alcohol use, alcohol use disorder, social isolation, vitamin D deficiency, high C-reactive protein levels 18. **Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease.** The New England journal of medicine 2017 · [PMID 28845751](https://pubmed.ncbi.nlm.nih.gov/28845751/) > In 10,061 post-MI patients with hs-CRP ≥2 mg/L, canakinumab 150 mg reduced recurrent cardiovascular events (HR 0.85) but caused more fatal infections, with no difference in all-cause mortality. 19. **Biomarkers of Vascular Inflammation for Cardiovascular Risk Prognostication: A Meta-Analysis.** JACC. Cardiovascular imaging 2022 · [PMID 34801448](https://pubmed.ncbi.nlm.nih.gov/34801448/) > A meta-analysis found that vascular-inflammation biomarkers including hs-CRP improve cardiovascular risk prognostication. ## Where to buy [Search Amazon for hs-CRP Inflammation Test](https://www.amazon.com/s?k=hs-CRP%20Inflammation%20Test&tag=magellanlong-20) — affiliate search link. ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"ItemPage","@id":"https://magellanlongevity.com/p/142.html#page","url":"https://magellanlongevity.com/p/142.html","name":"hs-CRP Inflammation Test","description":"High-sensitivity C-reactive protein (hs-CRP) is a blood test that measures very low concentrations of C-reactive protein, an acute-phase protein produced…","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/p/142.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Diagnostics & Epigenetic Tests","item":"https://magellanlongevity.com/c/2.html"},{"@type":"ListItem","position":3,"name":"hs-CRP Inflammation Test","item":"https://magellanlongevity.com/p/142.html"}]},{"@type":"Product","@id":"https://magellanlongevity.com/p/142.html#product","name":"hs-CRP Inflammation Test","category":"Diagnostics & Epigenetic Tests","url":"https://magellanlongevity.com/p/142.html","description":"High-sensitivity C-reactive protein (hs-CRP) is a blood test that measures very low concentrations of C-reactive protein, an acute-phase protein produced by the liver in response to inflammation. 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Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).