--- title: "DaVinci Labs Phyto Benefits — Evidence, Benefits & Where to… | Magellan" description: "DaVinci Labs Phyto Benefits — Polyphenols are a large and diverse family of naturally occurring compounds produced by plants, characterized by multiple…" url: "https://magellanlongevity.com/p/19.md" canonical: "https://magellanlongevity.com/p/19.html" html: "https://magellanlongevity.com/p/19.html" type: "product" section: "Nutraceuticals & Cellular Energizers" evidence_grade: "Moderate evidence" evidence_tier: "moderate" citations: 23 product_id: 19 price_usd: 64.36 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" license: "Educational content — not medical advice" --- # DaVinci Labs Phyto Benefits [Home](https://magellanlongevity.com/) › [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) › DaVinci Labs Phyto Benefits **HTML version:** https://magellanlongevity.com/p/19.html · **In the Magellan app:** https://magellanlongevity.com/#/product/19 ## Key facts | Field | Value | | --- | --- | | Product | DaVinci Labs Phyto Benefits | | Category | [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) | | Evidence grade | Moderate evidence (B) | | Peer-reviewed citations | 23 | | Typical listed price | $64.36 (check the live price) | | Where to buy | [Search Amazon](https://www.amazon.com/s?k=DaVinci%20Labs%20Phyto%20Benefits&tag=magellanlong-20) | | Catalog ID | 19 | ## What it is Polyphenols are a large and diverse family of naturally occurring compounds produced by plants, characterized by multiple phenolic rings, and are abundant in fruits, vegetables, tea, coffee, cocoa, red wine, olive oil, whole grains, and legumes. Major subclasses include flavonoids (such as flavanols, flavonols, anthocyanins, and isoflavones), phenolic acids, stilbenes (such as resveratrol), and lignans. They are among the most abundant antioxidants in the human diet and are studied for anti-inflammatory, vascular, metabolic, and neuroprotective effects, though their oral bioavailability is generally low and varies widely by compound. A supplement of this type delivers a mix of such plant-derived polyphenols. ## Its role in longevity Observational cohorts consistently link higher dietary and urinary polyphenol (and flavonoid) intake to lower all-cause and cardiovascular mortality—a meta-analysis of 16 cohorts (462,194 adults) found roughly 13–15% lower mortality with higher flavonoid intake—and a 2025 UK Biobank analysis tied greater flavonoid diversity to 6–20% lower mortality and chronic-disease incidence. Polyphenol-rich foods are also a recurring feature of long-lived 'Blue Zone' diets. Trials of supplements give a more mixed picture: a meta-analysis of 281 randomized trials found modest improvements in blood pressure, lipids, and glucose markers, but the large COSMOS cocoa-flavanol trial did not reduce total cardiovascular events (only cardiovascular death), and single-compound results are inconsistent. Evidence is strongest for varied, polyphenol-rich dietary patterns; this blend itself has not been tested in human trials. This evidence describes dietary polyphenols and their component compounds generally, not this specific commercial product. ## Evidence grade: Moderate evidence - **What the grade means:** Curated grade based on the human and mechanistic evidence for this compound. - **Dose used in studies:** As a generic blend, dosing varies by formula; studied single polyphenols differ widely (e.g. resveratrol 150–500 mg/day, EGCG 300–800 mg/day). No single established dose applies to mixed blends. - **Dose from food:** Polyphenols are abundant in everyday foods: berries, dark chocolate/cocoa, green tea, coffee, red wine, olive oil, nuts and colorful produce can supply hundreds of milligrams to over a gram daily through a varied diet. - **What this grade does not say:** Large cohorts link higher and more varied flavonoid intake to lower mortality, and a 281-trial meta-analysis found modest improvements in blood pressure, lipids, and glucose markers. But much of the evidence is observational (healthy-eater confounding), supplement trials use heterogeneous single compounds, and this exact blend has never been tested in a human trial—expect modest effects at most. ## Where it comes from without a bottle Food, exercise and behaviour routes to the same pathway, each with its citation. | Natural source | How it works | Citation | | --- | --- | --- | | Colorful polyphenol-rich diet | Berries, dark chocolate, extra-virgin olive oil, nuts and red-purple produce all add up to total dietary polyphenols. In the PREDIMED trial, higher polyphenol intake lowered inflammatory markers and blood pressure. | British Journal of Clinical Pharmacology 2016 [PMID 27100393](https://pubmed.ncbi.nlm.nih.gov/27100393/) | | Green tea | Green tea is one of the richest everyday sources of catechin polyphenols. In a large Japanese cohort, regular green-tea drinkers had lower cardiovascular and all-cause mortality. | JAMA 2006 [PMID 16968850](https://pubmed.ncbi.nlm.nih.gov/16968850/) | | Mediterranean-style polyphenol foods | Pairing extra-virgin olive oil and tree nuts with vegetables - a polyphenol-dense Mediterranean pattern - improved endothelial function. Adherence to this diet is consistently tied to lower mortality. | British Journal of Nutrition 2011 [PMID 21736834](https://pubmed.ncbi.nlm.nih.gov/21736834/) | ### What those papers actually say 1. **Colorful polyphenol-rich diet** British Journal of Clinical Pharmacology 2016 · [PMID 27100393](https://pubmed.ncbi.nlm.nih.gov/27100393/) · [DOI 10.1111/bcp.12986](https://doi.org/10.1111/bcp.12986) > High dietary polyphenol intake is associated with reduced all-cause mortality and a lower incidence of cardiovascular events. 2. **Green tea** JAMA 2006 · [PMID 16968850](https://pubmed.ncbi.nlm.nih.gov/16968850/) · [DOI 10.1001/jama.296.10.1255](https://doi.org/10.1001/jama.296.10.1255) > Green tea consumption is associated with reduced mortality due to all causes and due to cardiovascular disease but not with reduced mortality due to cancer. 3. **Mediterranean-style polyphenol foods** British Journal of Nutrition 2011 · [PMID 21736834](https://pubmed.ncbi.nlm.nih.gov/21736834/) · [DOI 10.1017/S0007114511002078](https://doi.org/10.1017/S0007114511002078) > following an olive oil-rich MD was related to a significant reduction in all-cause mortality, and reduced the risk of mortality from CVD ## In the news - **Evidence suggests cocoa flavanols can prevent CVD mortality** — NutraIngredients 2022 [Read it](https://www.nutraingredients.com/Article/2022/04/11/evidence-suggests-cocoa-flavanols-can-prevent-cvd-mortality/) > US researchers conducting a Cocoa Supplement and Multivitamin Outcomes Study (COSMOS) observed a 27% reduction in deaths from cardiovascular disease (CVD) in older adults treated with the extract, although there was no improvement in the death rate for patients with invasive or site-specific cancer. - **Low-Flavanol Diet Drives Age-Related Memory Loss, Large Study Finds** — Columbia University Irving Medical Center 2023 [Read it](https://www.cuimc.columbia.edu/news/low-flavanol-diet-drives-age-related-memory-loss-large-study-finds) > The study found that flavanol intake among older adults tracks with scores on tests designed to detect memory loss due to normal aging and that replenishing these bioactive dietary components in mildly flavanol-deficient adults over age 60 improves performance on these tests. - **Dietary Flavanols Reverse Age-Related Memory Decline** — Columbia University Irving Medical Center 2014 [Read it](https://www.cuimc.columbia.edu/news/dietary-flavanols-reverse-age-related-memory-decline) > If a participant had the memory of a typical 60-year-old at the beginning of the study, after three months that person on average had the memory of a typical 30- or 40-year-old. ## The research Peer-reviewed studies on the active compound. Quotes are verbatim from the cited abstract. Research describes the active mechanism and is not a claim about this specific product. ### Cited studies 1. **Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases** Mechanisms of Ageing and Development 2015 · [PMID 25824609](https://pubmed.ncbi.nlm.nih.gov/25824609/) · [DOI 10.1016/j.mad.2015.03.008](https://doi.org/10.1016/j.mad.2015.03.008) > Caloric restriction has been shown repeatedly to prolong the lifespan in laboratory animals, with its benefits dependent on molecular targets... including the NAD-dependent deacetylase SIRT1. 2. **Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial** The Journals of Gerontology: Series A 2022 · [PMID 35975308](https://pubmed.ncbi.nlm.nih.gov/35975308/) · [DOI 10.1093/gerona/glac135](https://doi.org/10.1093/gerona/glac135) > GlyNAC supplementation in older adults improved glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, and multiple hallmarks of aging. 3. **Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial.** Am J Clin Nutr 2022 · [PMID 35294962](https://pubmed.ncbi.nlm.nih.gov/35294962/) · [DOI 10.1093/ajcn/nqac055](https://doi.org/10.1093/ajcn/nqac055) > Cocoa extract supplementation did not significantly reduce total cardiovascular events among older adults but reduced CVD death by 27%. 4. **Dietary flavanols restore hippocampal-dependent memory in older adults with lower diet quality and lower habitual flavanol consumption.** Proc Natl Acad Sci U S A 2023 · [PMID 37252983](https://pubmed.ncbi.nlm.nih.gov/37252983/) · [DOI 10.1073/pnas.2216932120](https://doi.org/10.1073/pnas.2216932120) > the flavanol intervention restored memory among participants in lower tertiles of habitual diet quality or habitual flavanol consumption. 5. **The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS).** Am J Clin Nutr 2022 · [PMID 35021194](https://pubmed.ncbi.nlm.nih.gov/35021194/) · [DOI 10.1093/ajcn/nqac001](https://doi.org/10.1093/ajcn/nqac001) > A Green-MED (high-polyphenol) diet, rich in Mankai, green tea, and walnuts and low in red/processed meat, is potentially neuroprotective for age-related brain atrophy. 6. **High concentrations of a urinary biomarker of polyphenol intake are associated with decreased mortality in older adults.** J Nutr 2013 · [PMID 23803472](https://pubmed.ncbi.nlm.nih.gov/23803472/) · [DOI 10.3945/jn.113.177121](https://doi.org/10.3945/jn.113.177121) > TUP is an independent risk factor for mortality among community-dwelling older adults, suggesting that high dietary intake of polyphenols may be associated with longevity. 7. **Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort.** Nat Commun 2019 · [PMID 31409784](https://pubmed.ncbi.nlm.nih.gov/31409784/) · [DOI 10.1038/s41467-019-11622-x](https://doi.org/10.1038/s41467-019-11622-x) > A moderate habitual intake of flavonoids is inversely associated with all-cause, cardiovascular- and cancer-related mortality. This strong association plateaus at intakes of approximately 500 mg/day. 8. **Reduced mortality risk by a polyphenol-rich diet: An analysis from the Moli-sani study.** Nutrition 2017 · [PMID 29469027](https://pubmed.ncbi.nlm.nih.gov/29469027/) · [DOI 10.1016/j.nut.2017.11.012](https://doi.org/10.1016/j.nut.2017.11.012) > The polyphenol content of the diet was associated with reduced mortality risk in a Mediterranean population, possibly through an antiinflammatory mechanism. 9. **Dietary polyphenols as geroprotective compounds: From Blue Zones to hallmarks of ageing.** Ageing Res Rev 2025 · [PMID 40120947](https://pubmed.ncbi.nlm.nih.gov/40120947/) · [DOI 10.1016/j.arr.2025.102733](https://doi.org/10.1016/j.arr.2025.102733) > A significant body of evidence suggests that polyphenols, a large family of compounds ubiquitously found in plant-based foods, may exhibit geroprotective activity by influencing underlying biological mechanisms of ageing and promoting optimal longevity. 10. **Hormetic Effects of Phytochemicals on Health and Longevity.** Trends Endocrinol Metab 2019 · [PMID 31060881](https://pubmed.ncbi.nlm.nih.gov/31060881/) · [DOI 10.1016/j.tem.2019.04.001](https://doi.org/10.1016/j.tem.2019.04.001) > Phytochemicals such as alkaloids, polyphenols, and terpenoids found in plants and fungi activate the same cellular processes as caloric restriction, fasting, and exercise. 11. **Resveratrol supplementation efficiently improves endothelial health: A systematic review and meta-analysis of randomized controlled trials.** Phytother Res 2022 · [PMID 35833325](https://pubmed.ncbi.nlm.nih.gov/35833325/) · [DOI 10.1002/ptr.7562](https://doi.org/10.1002/ptr.7562) > The meta-analysis results showed that resveratrol significantly change the concentrations of FMD (WMD: 1.43%; 95% CI: 0.98 to 1.88, p < .001) and ICAM-1 (WMD: -7.09 ng/ml, 95% CI: -7.45 to -6.73, p < .001). 12. **Effect of Resveratrol on Endothelial Function in Patients with CKD and Diabetes: A Randomized Controlled Trial.** Clin J Am Soc Nephrol 2023 · [PMID 37843843](https://pubmed.ncbi.nlm.nih.gov/37843843/) · [DOI 10.2215/CJN.0000000000000337](https://doi.org/10.2215/CJN.0000000000000337) > Resveratrol supplementation improved endothelial function in patients with CKD and diabetes. 13. **Effect of resveratrol supplementation on hepatic steatosis and cardiovascular indices in overweight subjects with type 2 diabetes: a double-blind, randomized controlled trial.** BMC Cardiovasc Disord 2022 · [PMID 35538431](https://pubmed.ncbi.nlm.nih.gov/35538431/) · [DOI 10.1186/s12872-022-02637-2](https://doi.org/10.1186/s12872-022-02637-2) > Resveratrol supplementation had no effect on hepatic steatosis and cardiovascular indices. 14. **Sex May Modulate the Effects of Combined Polyphenol Extract and L-citrulline Supplementation on Ambulatory Blood Pressure in Adults with Prehypertension: A Randomized Controlled Trial.** Nutrients 2021 · [PMID 33513929](https://pubmed.ncbi.nlm.nih.gov/33513929/) · [DOI 10.3390/nu13020399](https://doi.org/10.3390/nu13020399) > supplementation with polyphenol extract and L-citrulline for 6 weeks has no impact on ambulatory BP, blood lipids and CRP in adults with prehypertension. However, the polyphenol extract/L-citrulline supplement may reduce ambulatory SBP in women, but not in men. 15. **Minor effects of green tea catechin supplementation on cardiovascular risk markers in active older people: a randomized controlled trial.** Geriatr Gerontol Int 2012 · [PMID 23035743](https://pubmed.ncbi.nlm.nih.gov/23035743/) · [DOI 10.1111/j.1447-0594.2012.00952.x](https://doi.org/10.1111/j.1447-0594.2012.00952.x) > the present randomized control trial suggests that GTC supplementation in active older participants did not significantly affect cardiovascular risk markers. 16. **Polyphenols and Their Impact on the Prevention of Neurodegenerative Diseases and Development.** Nutrients 2023 · [PMID 37571391](https://pubmed.ncbi.nlm.nih.gov/37571391/) · [DOI 10.3390/nu15153454](https://doi.org/10.3390/nu15153454) > Dietary supplementation with neuroprotective plant-derived polyphenols might be considered an important element of healthy aging. Some polyphenols improve cognition, mood, visual functions, language, and verbal memory functions. 17. **Diet, nutrition and the ageing brain: current evidence and new directions.** Proc Nutr Soc 2018 · [PMID 29316987](https://pubmed.ncbi.nlm.nih.gov/29316987/) · [DOI 10.1017/S0029665117004177](https://doi.org/10.1017/S0029665117004177) > Specific dietary components have also been investigated in relation to brain health, with emerging evidence supporting protective roles for n-3 PUFA, polyphenols, vitamin D and B-vitamins. 18. **The role of curcumin in aging and senescence: Molecular mechanisms.** Biomed Pharmacother 2020 · [PMID 33360051](https://pubmed.ncbi.nlm.nih.gov/33360051/) · [DOI 10.1016/j.biopha.2020.111119](https://doi.org/10.1016/j.biopha.2020.111119) > curcumin and its metabolites, prolong the mean lifespan of some aging model organisms such as C. elegans, D. melanogaster, yeast, and mouse. 19. **Pre-diagnostic polyphenol intake and breast cancer survival: the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.** Breast Cancer Res Treat 2015 · [PMID 26531755](https://pubmed.ncbi.nlm.nih.gov/26531755/) · [DOI 10.1007/s10549-015-3595-9](https://doi.org/10.1007/s10549-015-3595-9) > Intake of lignans before breast cancer diagnosis may be related to improved survival among postmenopausal women, but may on the contrary worsen the survival for premenopausal women. 20. **A Greater Flavonoid Intake Is Associated with Lower Total and Cause-Specific Mortality: A Meta-Analysis of Cohort Studies.** Nutrients 2020 · [PMID 32781562](https://pubmed.ncbi.nlm.nih.gov/32781562/) > Across 16 cohorts and 462,194 adults, higher flavonoid intake was associated with 13% lower all-cause and 15% lower cardiovascular mortality; the cancer-mortality association was not significant. 21. **High diversity of dietary flavonoid intake is associated with a lower risk of all-cause mortality and major chronic diseases.** Nature food 2025 · [PMID 40456886](https://pubmed.ncbi.nlm.nih.gov/40456886/) > In 124,805 UK Biobank participants, the widest flavonoid diversity was associated with 6–20% lower all-cause mortality and lower incidence of several major chronic diseases. 22. **The Effect of Antioxidant Polyphenol Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis.** Nutrients 2024 · [PMID 39683599](https://pubmed.ncbi.nlm.nih.gov/39683599/) > Across 281 RCTs (17,126 participants), polyphenol supplements modestly improved cardiometabolic markers—catechins lowered systolic blood pressure ~1.6 mmHg, anthocyanins improved lipids, curcumin improved glucose handling. 23. **Polyphenol Health Effects on Cardiovascular and Neurodegenerative Disorders: A Review and Meta-Analysis.** International journal of molecular sciences 2019 · [PMID 30654461](https://pubmed.ncbi.nlm.nih.gov/30654461/) > Some polyphenols improved specific cardiovascular-risk and cognitive markers, but the authors judged the data too inconsistent for definitive prevention recommendations. ## Where to buy [Search Amazon for DaVinci Labs Phyto Benefits](https://www.amazon.com/s?k=DaVinci%20Labs%20Phyto%20Benefits&tag=magellanlong-20) — affiliate search link. ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"ItemPage","@id":"https://magellanlongevity.com/p/19.html#page","url":"https://magellanlongevity.com/p/19.html","name":"DaVinci Labs Phyto Benefits","description":"Polyphenols are a large and diverse family of naturally occurring compounds produced by plants, characterized by multiple phenolic rings, and are…","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/p/19.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Nutraceuticals & Cellular Energizers","item":"https://magellanlongevity.com/c/1.html"},{"@type":"ListItem","position":3,"name":"DaVinci Labs Phyto Benefits","item":"https://magellanlongevity.com/p/19.html"}]},{"@type":"Product","@id":"https://magellanlongevity.com/p/19.html#product","name":"DaVinci Labs Phyto Benefits","category":"Nutraceuticals & Cellular Energizers","url":"https://magellanlongevity.com/p/19.html","description":"Polyphenols are a large and diverse family of naturally occurring compounds produced by plants, characterized by multiple phenolic rings, and are abundant in fruits, vegetables, tea, coffee, cocoa, red wine, olive oil, whole grains, and legumes. 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Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).