--- title: "GlyNAC (Glycine + NAC) — Evidence, Benefits & Where to Buy | Magellan" description: "GlyNAC (Glycine + NAC) — GlyNAC is a nutritional supplement combining two amino acids, glycine and N-acetylcysteine (NAC, a precursor of cysteine), that…" url: "https://magellanlongevity.com/p/198.md" canonical: "https://magellanlongevity.com/p/198.html" html: "https://magellanlongevity.com/p/198.html" type: "product" section: "Nutraceuticals & Cellular Energizers" evidence_grade: "Emerging evidence" evidence_tier: "emerging" citations: 15 product_id: 198 price_usd: 34 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" license: "Educational content — not medical advice" --- # GlyNAC (Glycine + NAC) [Home](https://magellanlongevity.com/) › [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) › GlyNAC (Glycine + NAC) **HTML version:** https://magellanlongevity.com/p/198.html · **In the Magellan app:** https://magellanlongevity.com/#/product/198 ## Key facts | Field | Value | | --- | --- | | Product | GlyNAC (Glycine + NAC) | | Category | [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) | | Evidence grade | Emerging evidence (C) | | Peer-reviewed citations | 15 | | Typical listed price | $34.00 (check the live price) | | Where to buy | [Search Amazon](https://www.amazon.com/s?k=GlyNAC%20%28Glycine%20%2B%20NAC%29&tag=magellanlong-20) | | Catalog ID | 198 | ## What it is GlyNAC is a nutritional supplement combining two amino acids, glycine and N-acetylcysteine (NAC, a precursor of cysteine), that together supply the building blocks the body needs to synthesize glutathione, its most abundant intracellular antioxidant. Glutathione levels and synthesis decline with age, and this deficiency has been linked to elevated oxidative stress and mitochondrial dysfunction, two proposed drivers of aging. By providing both precursor amino acids, GlyNAC is intended to restore glutathione production and, through it, counter oxidative stress and support mitochondrial function. Most of the human research on GlyNAC has been conducted by a single group at Baylor College of Medicine. ## Its role in longevity In small clinical trials, mostly pilot and open-label studies plus one randomized placebo-controlled trial of 24 older adults from the same laboratory, GlyNAC supplementation corrected glutathione deficiency and improved markers of oxidative stress, mitochondrial function, inflammation, insulin resistance, muscle strength, gait speed and cognition, and in mice it extended lifespan by about 24%. However, the human evidence base is limited by small samples, short duration and reliance on one research group, and an independent randomized dose-ranging trial in 114 healthy older adults found glutathione and oxidative-damage benefits mainly in participants with elevated baseline oxidative stress, so effects may be context-dependent; measured benefits also reversed after supplementation stopped. This evidence describes the glycine/NAC/glutathione mechanism and the GlyNAC combination studied in research settings, not this specific commercial product. ## Evidence grade: Emerging evidence - **What the grade means:** Curated grade based on the human and mechanistic evidence for this compound. - **Dose used in studies:** In the Baylor/Sekhar trials, older adults took glycine 1.33 mmol/kg and N-acetylcysteine 0.83 mmol/kg daily (~100 mg/kg of each, roughly 7 g + 7 g for a 70 kg adult) for 16 weeks. - **Dose from food:** Glutathione itself isn't absorbed intact from food; the body builds it from precursors. Glycine is plentiful in collagen, meat and gelatin, but NAC is synthetic and not a food component, so trial-level intake is hard to reach by diet alone. - **What this grade does not say:** Small human trials show GlyNAC restores glutathione and improves oxidative-stress, mitochondrial and physical-function markers, but nearly all come from one research group, the largest placebo-controlled trial enrolled 24 older adults for 16 weeks, and benefits faded after stopping. The ~24% lifespan extension was shown only in mice; there are no human data on disease or mortality outcomes. ## Where it comes from without a bottle Food, exercise and behaviour routes to the same pathway, each with its citation. | Natural source | How it works | Citation | | --- | --- | --- | | Glycine + NAC together | GlyNAC simply combines two dietary amino acids — glycine and cysteine (as NAC). Supplying both restored glutathione and improved aging markers in older adults. | J Gerontol A Biol Sci Med Sci 2023 [PMID 35975308](https://pubmed.ncbi.nlm.nih.gov/35975308/) | | Collagen / gelatin (glycine) | The glycine half of GlyNAC is abundant in collagen and gelatin — glycine makes up roughly a third of the collagen molecule. Bone broth and gelatin are rich sources. | Journal of Nutrition 2008 [PMID 18806118](https://pubmed.ncbi.nlm.nih.gov/18806118/) | | Cysteine-rich foods (eggs, garlic) | The NAC half supplies cysteine — the sulfur amino acid that feeds glutathione and is in high demand for skin and tissue repair. Eggs, garlic and allium veg are dietary sources. | Eur J Clin Invest 1987 [PMID 3108003](https://pubmed.ncbi.nlm.nih.gov/3108003/) | ### What those papers actually say 1. **Glycine + NAC together** J Gerontol A Biol Sci Med Sci 2023 · [PMID 35975308](https://pubmed.ncbi.nlm.nih.gov/35975308/) · [DOI 10.1093/gerona/glac135](https://doi.org/10.1093/gerona/glac135) > GlyNAC is an effective nutritional supplement that improves and reverses multiple age-associated abnormalities to promote health in aging humans 2. **Collagen / gelatin (glycine)** Journal of Nutrition 2008 · [PMID 18806118](https://pubmed.ncbi.nlm.nih.gov/18806118/) · [DOI 10.1093/jn/138.10.2021S](https://doi.org/10.1093/jn/138.10.2021S) > Biochemically, one-third of the collagen molecule is composed of glycine 3. **Cysteine-rich foods (eggs, garlic)** Eur J Clin Invest 1987 · [PMID 3108003](https://pubmed.ncbi.nlm.nih.gov/3108003/) · [DOI 10.1111/j.1365-2362.1987.tb02392.x](https://doi.org/10.1111/j.1365-2362.1987.tb02392.x) > The episode of limited availability of sulphur amino acids coincides with the period of most intensive collagen and keratin resynthesis of burned skin tissue ## In the news - **Supplement Reverses Hallmarks Of Old Age And Promotes Healthier Aging** — IFLScience 2022 [Read it](https://www.iflscience.com/supplement-reverses-hallmarks-of-old-age-and-promotes-healthier-aging-64948) > New research has found that supplementing older people with GlyNAC – a combination of glycine and N-acetylcysteine – wards off several key indicators of aging and keeps people healthier as they age. - **Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Benefits both Health Span and Lifespan** — USC Longevity Institute 2024 [Read it](https://gero.usc.edu/longevity-institute/supplementing-glycine-and-n-acetylcysteine-glynac-in-older-adults-benefits-both-health-span-and-lifespan/) > In summary, this RCT found that GlyNAC supplementation in older adults significantly improved/corrected GSH deficiency, OxS, mitochondrial dysfunction, physical function, waist circumference, and 7 hallmarks of aging affecting mitochondria, inflammation, IR, mitophagy, genomic damage, cellular senescence, and stem cells. ## The research Peer-reviewed studies on the active compound. Quotes are verbatim from the cited abstract. Research describes the active mechanism and is not a claim about this specific product. ### Cited studies 1. **Glycine and N-Acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, physical function, and aging hallmarks: A randomized clinical trial** The Journals of Gerontology: Series A 2022 · [PMID 35975308](https://pubmed.ncbi.nlm.nih.gov/35975308/) > GlyNAC supplementation improved glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, physical function and multiple hallmarks of aging in older adults. 2. **GlyNAC supplementation in mice increases length of life by correcting glutathione deficiency, oxidative stress, mitochondrial dysfunction, abnormalities in mitophagy and nutrient sensing, and genomic damage** The Journals of Gerontology: Series A 2022 · [PMID 35268089](https://pubmed.ncbi.nlm.nih.gov/35268089/) > GlyNAC supplementation increased length of life in mice by 24% while correcting glutathione deficiency and multiple defects of aging. 3. **GlyNAC supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation and insulin resistance** Clin Transl Med 2021 · [PMID 33783984](https://pubmed.ncbi.nlm.nih.gov/33783984/) · [DOI 10.1002/ctm2.372](https://doi.org/10.1002/ctm2.372) > GlyNAC corrected glutathione deficiency, oxidative stress and mitochondrial dysfunction 4. **Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation.** Am J Clin Nutr 2011 · [PMID 21795440](https://pubmed.ncbi.nlm.nih.gov/21795440/) · [DOI 10.3945/ajcn.110.003483](https://doi.org/10.3945/ajcn.110.003483) > Dietary supplementation with the glutathione precursors cysteine and glycine fully restores glutathione synthesis and concentrations and lowers levels of oxidative stress and oxidant damages. 5. **GlyNAC (Glycine and-Acetylcysteine) Supplementation Improves Impaired Mitochondrial Fuel Oxidation and Lowers Insulin Resistance in Patients with Type 2 Diabetes: Results of a Pilot Study.** Antioxidants (Basel) 2022 · [PMID 35052658](https://pubmed.ncbi.nlm.nih.gov/35052658/) · [DOI 10.3390/antiox11010154](https://doi.org/10.3390/antiox11010154) > GlyNAC supplementation significantly improved fasted MFO by 30% (< 0.001), lowered MGO by 47% (< 0.01), decreased IR by 22% (< 0.01) and lowered FFA by 25% (< 0.01). 6. **Supplementing Glycine and N-acetylcysteine (GlyNAC) in Aging HIV Patients Improves Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Endothelial Dysfunction, Insulin Resistance, Genotoxicity, Strength, and Cognition: Results of an Open-Label Clinical Trial.** Biomedicines 2020 · [PMID 33007928](https://pubmed.ncbi.nlm.nih.gov/33007928/) · [DOI 10.3390/biomedicines8100390](https://doi.org/10.3390/biomedicines8100390) > Nutritional supplementation with GlyNAC improves comorbidities suggestive of premature aging in PWH including functional and cognitive decline, and warrants additional investigation. 7. **A Randomized Controlled Clinical Trial in Healthy Older Adults to Determine Efficacy of Glycine and N-Acetylcysteine Supplementation on Glutathione Redox Status and Oxidative Damage.** Front Aging 2022 · [PMID 35821844](https://pubmed.ncbi.nlm.nih.gov/35821844/) · [DOI 10.3389/fragi.2022.852569](https://doi.org/10.3389/fragi.2022.852569) > In summary GlyNAC supplementation is safe, well tolerated, and may increase glutathione levels in older adults with high glutathione demand. 8. **GlyNAC Supplementation Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Aging Hallmarks, Metabolic Defects, Muscle Strength, Cognitive Decline, and Body Composition: Implications for Healthy Aging.** J Nutr 2021 · [PMID 34587244](https://pubmed.ncbi.nlm.nih.gov/34587244/) · [DOI 10.1093/jn/nxab309](https://doi.org/10.1093/jn/nxab309) > It is particularly exciting that GlyNAC supplementation appears to reverse multiple aging hallmarks, and if confirmed in a randomized clinical trial, it could introduce a transformative paradigm shift in aging and geriatrics. 9. **Glutathione and glutathione-dependent enzymes: From biochemistry to gerontology and successful aging.** Ageing Res Rev 2023 · [PMID 37683986](https://pubmed.ncbi.nlm.nih.gov/37683986/) · [DOI 10.1016/j.arr.2023.102066](https://doi.org/10.1016/j.arr.2023.102066) > Notably, GSH levels decline during aging, an alteration generally related to impaired GSH biosynthesis and leading to cell dysfunction. 10. **Oral supplementation with glycine reduces oxidative stress in patients with metabolic syndrome, improving their systolic blood pressure.** Can J Physiol Pharmacol 2013 · [PMID 24144057](https://pubmed.ncbi.nlm.nih.gov/24144057/) · [DOI 10.1139/cjpp-2012-0341](https://doi.org/10.1139/cjpp-2012-0341) > Individuals treated with glycine showed a 25% decrease in TBARS compared with the placebo-treated group. 11. **Medical and Dietary Uses of N-Acetylcysteine.** Antioxidants (Basel) 2019 · [PMID 31035402](https://pubmed.ncbi.nlm.nih.gov/31035402/) · [DOI 10.3390/antiox8050111](https://doi.org/10.3390/antiox8050111) > Although NAC is considered a safe substance, the results among clinical trials are sometimes controversial or incomplete, like for many other antioxidants. 12. **Overview on the Effects of-Acetylcysteine in Neurodegenerative Diseases.** Molecules 2018 · [PMID 30551603](https://pubmed.ncbi.nlm.nih.gov/30551603/) · [DOI 10.3390/molecules23123305](https://doi.org/10.3390/molecules23123305) > NAC is a glutathione precursor and shows antioxidant and anti-inflammatory activities. In addition to the uses quoted in the literature, NAC may be considered helpful in therapies to counteract neurodegenerative and mental health diseases. 13. **Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise.** Free Radic Biol Med 2001 · [PMID 11557312](https://pubmed.ncbi.nlm.nih.gov/11557312/) · [DOI 10.1016/s0891-5849(01)00640-2](https://doi.org/10.1016/s0891-5849%2801%2900640-2) > This acute human inflammatory model strongly suggests that vitamin C and NAC supplementation immediately post-injury, transiently increases tissue damage and oxidative stress. 14. **Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults.** Front Nutr 2026 · [PMID 42232577](https://pubmed.ncbi.nlm.nih.gov/42232577/) · [DOI 10.3389/fnut.2026.1775264](https://doi.org/10.3389/fnut.2026.1775264) > Evidence on NAC suggests context-dependent effects, with supplementation improving glutathione availability, fatigue resistance, and exercise performance in individuals with low baseline glutathione, while results remain inconsistent in healthy populations. 15. **Efficacy and Safety of Glutathione Supplementation in Patients with HIV Infection and HIV-Tuberculosis Co-Infection.** Nutrients 2026 · [PMID 41754089](https://pubmed.ncbi.nlm.nih.gov/41754089/) · [DOI 10.3390/nu18040571](https://doi.org/10.3390/nu18040571) > These interventions have shown consistent safety and tolerability across diverse populations, including individuals receiving complex antiretroviral and antitubercular regimens, with gastrointestinal discomfort being the most commonly reported adverse effect and serious toxicities remaining rare. ## Where to buy [Search Amazon for GlyNAC (Glycine + NAC)](https://www.amazon.com/s?k=GlyNAC%20%28Glycine%20%2B%20NAC%29&tag=magellanlong-20) — affiliate search link. ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"ItemPage","@id":"https://magellanlongevity.com/p/198.html#page","url":"https://magellanlongevity.com/p/198.html","name":"GlyNAC (Glycine + NAC)","description":"GlyNAC is a nutritional supplement combining two amino acids, glycine and N-acetylcysteine (NAC, a precursor of cysteine), that together supply the…","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/p/198.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Nutraceuticals & Cellular Energizers","item":"https://magellanlongevity.com/c/1.html"},{"@type":"ListItem","position":3,"name":"GlyNAC (Glycine + NAC)","item":"https://magellanlongevity.com/p/198.html"}]},{"@type":"Product","@id":"https://magellanlongevity.com/p/198.html#product","name":"GlyNAC (Glycine + NAC)","category":"Nutraceuticals & Cellular Energizers","url":"https://magellanlongevity.com/p/198.html","description":"GlyNAC is a nutritional supplement combining two amino acids, glycine and N-acetylcysteine (NAC, a precursor of cysteine), that together supply the building blocks the body needs to synthesize glutathione, its most abundant intracellular antioxidant. 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Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).