---
title: "Nutricost NMN Capsules 500mg — Evidence, Benefits & Where to… | Magellan"
description: "Nutricost NMN Capsules 500mg — Nicotinamide mononucleotide (NMN) is a naturally occurring nucleotide and a direct biosynthetic precursor of nicotinamide…"
url: "https://magellanlongevity.com/p/3.md"
canonical: "https://magellanlongevity.com/p/3.html"
html: "https://magellanlongevity.com/p/3.html"
type: "product"
section: "Nutraceuticals & Cellular Energizers"
evidence_grade: "Moderate evidence"
evidence_tier: "moderate"
citations: 34
product_id: 3
price_usd: 19.95
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
license: "Educational content — not medical advice"
---

# Nutricost NMN Capsules 500mg

[Home](https://magellanlongevity.com/) › [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) › Nutricost NMN Capsules 500mg

**HTML version:** https://magellanlongevity.com/p/3.html · **In the Magellan app:** https://magellanlongevity.com/#/product/3

## Key facts

| Field | Value |
| --- | --- |
| Product | Nutricost NMN Capsules 500mg |
| Category | [Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md) |
| Evidence grade | Moderate evidence (B) |
| Peer-reviewed citations | 34 |
| Typical listed price | $19.95 (check the live price) |
| Where to buy | [Search Amazon](https://www.amazon.com/s?k=Nutricost%20NMN%20Capsules%20500mg&tag=magellanlong-20) |
| Catalog ID | 3 |

## What it is

Nicotinamide mononucleotide (NMN) is a naturally occurring nucleotide and a direct biosynthetic precursor of nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for cellular energy metabolism, DNA repair, and the activity of sirtuin and PARP enzymes. NAD+ levels decline with age across many tissues, a process attributed in part to increased NAD+ consumption by the NADase CD38, and this decline has been linked to metabolic and age-related dysfunction. Oral NMN is sold as a dietary supplement intended to replenish NAD+ ('NAD+ boosting'), and it is one of several vitamin B3-related NAD+ precursors alongside nicotinamide riboside and nicotinamide-plus-ribose blends, which human trials also show can raise NAD+. Human trials consistently show that supplemental NMN raises circulating NAD+ and NAD+ metabolite levels.

## Its role in longevity

In randomized controlled trials, NMN reliably increases blood NAD+ levels and has generally been well tolerated at oral doses up to roughly 900-1250 mg/day, with some trials reporting modest improvements in skeletal-muscle insulin sensitivity, walking speed, aerobic capacity, sleep quality, and diastolic blood pressure. However, the human evidence is mixed and often preliminary: several meta-analyses found no significant benefit for glucose control, blood lipids, or muscle mass and strength, and multiple individual trials were null, prompting reviewers to caution that the benefits of NMN may be exaggerated relative to the striking results seen in mice. Trials so far are small (typically 25-80 participants), short (6-12 weeks), and measure surrogate endpoints, with no lifespan or disease-prevention outcomes; formulation-specific claims also outrun the data — no published human trial has tested liposomal NMN, so enhanced-absorption claims remain unverified. Larger, longer, higher-quality trials are still needed to establish whether NAD+ repletion produces clinically meaningful anti-aging effects in people. This evidence describes the NMN compound and NAD+ biology in general, not this specific commercial product, which has not itself been tested in the cited studies.

## Evidence grade: Moderate evidence

- **What the grade means:** Curated grade based on the human and mechanistic evidence for this compound.
- **Dose used in studies:** Human RCTs used 250–1,200 mg/day orally; well-tolerated up to ~900 mg/day, with one dose-finding trial reporting benefits peaking near 600 mg/day. Most trials run 6–12 weeks.
- **Dose from food:** Only trace amounts in food: edamame, broccoli and avocado supply roughly 0.25–1.9 mg per 100 g. You'd need dozens of pounds to match a single 250–600 mg dose, so diet can't reach studied levels.
- **What this grade does not say:** Oral NMN reliably raises blood NAD⁺ and has been well tolerated in trials up to about 900–1,250 mg/day. Functional benefits so far are modest and population-specific (muscle insulin sensitivity in prediabetic women, aerobic capacity, walking speed, sleep quality), several meta-analyses are null for glucose, lipids and muscle mass, and no trial shows effects on aging, disease prevention, or lifespan.

## Where it comes from without a bottle

Food, exercise and behaviour routes to the same pathway, each with its citation.

| Natural source | How it works | Citation |
| --- | --- | --- |
| NMN-containing produce (edamame, broccoli, avocado) | NMN occurs naturally in foods and is the direct NAD+ precursor; oral NMN is rapidly turned into NAD+ in tissues, the same pathway food feeds. | Cell Metabolism 2016 [PMID 28068222](https://pubmed.ncbi.nlm.nih.gov/28068222/) |
| Exercise (the NAD+ pathway, no supplement needed) | You don't have to buy NMN to raise NAD+: boosting the NAD+ metabolome lowers inflammation, and physical activity and the precursors in food drive the same system. | Cell Reports 2019 [PMID 31412242](https://pubmed.ncbi.nlm.nih.gov/31412242/) |

### What those papers actually say

1. **NMN-containing produce (edamame, broccoli, avocado)**
   Cell Metabolism 2016 · [PMID 28068222](https://pubmed.ncbi.nlm.nih.gov/28068222/) · [DOI 10.1016/j.cmet.2016.09.013](https://doi.org/10.1016/j.cmet.2016.09.013)

   > Orally administered NMN was quickly utilized to synthesize NAD in tissues. Remarkably, NMN effectively mitigates age-associated physiological decline in mice.

2. **Exercise (the NAD+ pathway, no supplement needed)**
   Cell Reports 2019 · [PMID 31412242](https://pubmed.ncbi.nlm.nih.gov/31412242/) · [DOI 10.1016/j.celrep.2019.07.043](https://doi.org/10.1016/j.celrep.2019.07.043)

   > NR elevated the muscle NAD metabolome... NR also depressed levels of circulating inflammatory cytokines.

## In the news

- **Anti-aging compound that improves metabolic health in mice improves muscle glucose metabolism in people** — WashU Medicine 2021 [Read it](https://medicine.washu.edu/news/anti-aging-compound-that-improves-metabolic-health-in-mice-improves-muscle-glucose-metabolism-in-people/)
  > Although our study shows a beneficial effect of NMN in skeletal muscle, it is premature to make any clinical recommendations based on the results from our study
- **Anti-aging compound improves muscle glucose metabolism in people** — ScienceDaily 2021 [Read it](https://www.sciencedaily.com/releases/2021/04/210422150349.htm)
  > However, the treatment did not lower blood glucose or blood pressure, improve blood lipid profile, increase insulin sensitivity in the liver, reduce fat in the liver or decrease circulating markers of inflammation as seen in mice.
- **Recent research into nicotinamide mononucleotide and ageing** — Nature Research Custom Media (nature.com) 2022 [Read it](https://www.nature.com/articles/d42473-022-00002-7)
  > This has led to NMN being sold worldwide as a diet supplement, with very little data to support that it has beneficial effects in people.
- **FDA declares NMN lawful in dietary supplements** — NutraIngredients 2025 [Read it](https://www.nutraingredients.com/Article/2025/09/30/fda-declares-nmn-lawful-in-dietary-supplements/)
  > NMN (beta-nicotinamide mononucleotide) is one of the forms of vitamin B3, or niacin, that has been shown to enhance the levels of nicotinamide adenine dinucleotide (NAD+) in the cells of the body.
- **Do NAD+ supplements work to promote longevity? Here's what the experts say.** — National Geographic 2025 [Read it](https://www.nationalgeographic.com/health/article/what-is-nad)
  > However, while NAD+ supplements and therapy are often touted to support “longevity,” there is no evidence that it does so.
- **Anti-aging compound that improves metabolic health in mice improves muscle glucose metabolism in people** — WashU Medicine (The Source) 2021 [Read it](https://source.washu.edu/2021/04/anti-aging-compound-that-improves-metabolic-health-in-mice-improves-muscle-glucose-metabolism-in-people/)
  > A small clinical trial of postmenopausal women with prediabetes shows that the compound NMN (nicotinamide mononucleotide) improved the ability of insulin to increase glucose uptake in skeletal muscle, which often is abnormal in people with obesity, prediabetes or Type 2 diabetes.

## The research

Peer-reviewed studies on the active compound. Quotes are verbatim from the cited abstract. Research describes the active mechanism and is not a claim about this specific product.

### Cited studies

1. **The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, double-blind, placebo-controlled, dose-dependent clinical trial**
   GeroScience 2022 · [PMID 36482258](https://pubmed.ncbi.nlm.nih.gov/36482258/) · [DOI 10.1007/s11357-022-00705-1](https://doi.org/10.1007/s11357-022-00705-1)

   > In animal studies, β-nicotinamide mononucleotide (NMN) supplementation increases nicotinamide adenine dinucleotide (NAD) concentrations and improves healthspan and lifespan with great safety.

2. **The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update**
   Advances in Nutrition 2023 · [PMID 37619764](https://pubmed.ncbi.nlm.nih.gov/37619764/) · [DOI 10.1016/j.advnut.2023.08.008](https://doi.org/10.1016/j.advnut.2023.08.008)

   > As the NAD concentration in human skin, blood, liver, muscle, and brain are thought to decrease with age, finding ways to increase NAD status could possibly influence the aging process.

3. **Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases**
   Mechanisms of Ageing and Development 2015 · [PMID 25824609](https://pubmed.ncbi.nlm.nih.gov/25824609/) · [DOI 10.1016/j.mad.2015.03.008](https://doi.org/10.1016/j.mad.2015.03.008)

   > Caloric restriction has been shown repeatedly to prolong the lifespan in laboratory animals, with its benefits dependent on molecular targets... including the NAD-dependent deacetylase SIRT1.

4. **NAD metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized controlled trial**
   Sci Rep 2023 · [PMID 36797393](https://pubmed.ncbi.nlm.nih.gov/36797393/) · [DOI 10.1038/s41598-023-29787-3](https://doi.org/10.1038/s41598-023-29787-3)

   > NMN supplementation showed potential in alleviating arterial stiffness

5. **Towards personalized NMN supplementation: nicotinamide adenine dinucleotide (NAD) concentration**
   Frontiers in Aging 2024 · [PMID 38430946](https://pubmed.ncbi.nlm.nih.gov/38430946/)

   > Physical-performance improvements from NMN tracked the rise in blood NAD+, with benefit maximized around 600 mg/day in a dose-dependent trial.

6. **Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women.**
   Science 2021 · [PMID 33888596](https://pubmed.ncbi.nlm.nih.gov/33888596/) · [DOI 10.1126/science.abe9985](https://doi.org/10.1126/science.abe9985)

   > Insulin-stimulated glucose disposal, assessed by using the hyperinsulinemic-euglycemic clamp, and skeletal muscle insulin signaling [phosphorylation of protein kinase AKT and mechanistic target of rapamycin (mTOR)] increased after NMN supplementation but did not change after placebo treatment.

7. **Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men.**
   npj Aging 2022 · [PMID 35927255](https://pubmed.ncbi.nlm.nih.gov/35927255/) · [DOI 10.1038/s41514-022-00084-z](https://doi.org/10.1038/s41514-022-00084-z)

   > There were nominally significant improvements in gait speed and performance in the left grip test, which should be validated in larger studies; however, NMN exerted no significant effect on body composition.

8. **Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study.**
   J Int Soc Sports Nutr 2021 · [PMID 34238308](https://pubmed.ncbi.nlm.nih.gov/34238308/) · [DOI 10.1186/s12970-021-00442-4](https://doi.org/10.1186/s12970-021-00442-4)

   > NMN increases the aerobic capacity of humans during exercise training

9. **Ingestion of β-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled study.**
   Geroscience 2024 · [PMID 38789831](https://pubmed.ncbi.nlm.nih.gov/38789831/) · [DOI 10.1007/s11357-024-01204-1](https://doi.org/10.1007/s11357-024-01204-1)

   > At secondary outcomes, after 12 weeks of NMN intake, the NMN group had a significantly shorter 4-m walking time than the placebo group as well as significantly higher blood levels of NAD + and its metabolites.

10. **Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study.**
    Nutrients 2022 · [PMID 35215405](https://pubmed.ncbi.nlm.nih.gov/35215405/) · [DOI 10.3390/nu14040755](https://doi.org/10.3390/nu14040755)

    > Overall, NMN intake in the afternoon effectively improved lower limb function and reduced drowsiness in older adults. These findings suggest the potential of NMN in preventing loss of physical performance and improving fatigue in older adults.

11. **Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study.**
    J Clin Endocrinol Metab 2023 · [PMID 36740954](https://pubmed.ncbi.nlm.nih.gov/36740954/) · [DOI 10.1210/clinem/dgad027](https://doi.org/10.1210/clinem/dgad027)

    > MIB-626 administration in overweight or obese, middle-aged and older adults safely increased circulating NAD levels, and significantly reduced total LDL and non-HDL cholesterol, body weight, and diastolic blood pressure.

12. **Effects of nicotinamide mononucleotide on older patients with diabetes and impaired physical performance: A prospective, placebo-controlled, double-blind study.**
    Geriatr Gerontol Int 2022 · [PMID 36443648](https://pubmed.ncbi.nlm.nih.gov/36443648/) · [DOI 10.1111/ggi.14513](https://doi.org/10.1111/ggi.14513)

    > In older male patients with diabetes and impaired physical performance, NMN supplementation for 24 weeks was safe, but did not improve grip strength and walking speed.

13. **Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women.**
    Sci Rep 2022 · [PMID 36002548](https://pubmed.ncbi.nlm.nih.gov/36002548/) · [DOI 10.1038/s41598-022-18272-y](https://doi.org/10.1038/s41598-022-18272-y)

    > Our results indicate that β-NMN is safe and well-tolerated in healthy adult men and women an oral dose of 1250 mg once daily for up to 4 weeks.

14. **Low-dose oral nicotinamide mononucleotide for immune thrombocytopenia: a phase 1/2 trial.**
    Nat Med 2026 · [PMID 42056497](https://pubmed.ncbi.nlm.nih.gov/42056497/) · [DOI 10.1038/s41591-026-04366-x](https://doi.org/10.1038/s41591-026-04366-x)

    > Among 25 enrolled patients, no dose-limiting toxicities or treatment-related serious adverse events occurred; NMN was well tolerated, with only mild treatment-related adverse events in 12% and non-severe infections (grade 1) in 8% of patients

15. **Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled Trials.**
    Curr Diab Rep 2024 · [PMID 39531138](https://pubmed.ncbi.nlm.nih.gov/39531138/) · [DOI 10.1007/s11892-024-01557-z](https://doi.org/10.1007/s11892-024-01557-z)

    > Based on the small number of RCTs involving mainly relatively healthy adults, short-term supplementation of NMN of 250-2000 mg/d did not show significantly positive impacts on glucose control and lipid profile.

16. **Efficacy of oral nicotinamide mononucleotide supplementation on glucose and lipid metabolism for adults: a systematic review with meta-analysis on randomized controlled trials.**
    Crit Rev Food Sci Nutr 2024 · [PMID 39116016](https://pubmed.ncbi.nlm.nih.gov/39116016/) · [DOI 10.1080/10408398.2024.2387324](https://doi.org/10.1080/10408398.2024.2387324)

    > Together, our findings suggest that an exaggeration of the benefits of NMN supplementation may exist in the field.

17. **Effects of Nicotinamide Mononucleotide Supplementation on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.**
    Nutrients 2026 · [PMID 41901064](https://pubmed.ncbi.nlm.nih.gov/41901064/) · [DOI 10.3390/nu18060890](https://doi.org/10.3390/nu18060890)

    > Compared with the placebo, NMN supplementation was associated with a statistically significant but modest reduction in resting DBP (WMD, -2.15 mmHg; 95% CI: -3.68 to -0.61). In contrast, the reduction in resting SBP was not statistically significant.

18. **The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-Analysis.**
    J Cachexia Sarcopenia Muscle 2025 · [PMID 40275690](https://pubmed.ncbi.nlm.nih.gov/40275690/) · [DOI 10.1002/jcsm.13799](https://doi.org/10.1002/jcsm.13799)

    > Current evidence does not support NMN and NR supplementation for preserving muscle mass and function in adults with mean age of over 60 years.

19. **Effects of Nicotinamide Mononucleotide Supplementation on Muscle and Liver Functions Among the Middle-aged and Elderly: A Systematic Review and Meta-analysis of Randomized Controlled Trials.**
    Curr Pharm Biotechnol 2025 · [PMID 39185644](https://pubmed.ncbi.nlm.nih.gov/39185644/) · [DOI 10.2174/0113892010306242240808094303](https://doi.org/10.2174/0113892010306242240808094303)

    > NMN has positive efficacy in enhancing muscle function, reducing insulin resistance and lowering aminotransferase levels in middle-aged and elderly individuals.

20. **CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism.**
    Cell Metab 2016 · [PMID 27304511](https://pubmed.ncbi.nlm.nih.gov/27304511/) · [DOI 10.1016/j.cmet.2016.05.006](https://doi.org/10.1016/j.cmet.2016.05.006)

    > Here we demonstrate that expression and activity of the NADase CD38 increase with aging and that CD38 is required for the age-related NAD decline and mitochondrial dysfunction via a pathway mediated at least in part by regulation of SIRT3 activity.

21. **Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes.**
    Cell Rep 2020 · [PMID 32755581](https://pubmed.ncbi.nlm.nih.gov/32755581/) · [DOI 10.1016/j.celrep.2020.107987](https://doi.org/10.1016/j.celrep.2020.107987)

    > in vivo supplementation of nicotinamide mononucleotide (NMN) efficaciously improves the quality of oocytes from naturally aged mice by recovering nicotinamide adenine dinucleotide (NAD) levels.

22. **Nicotinamide mononucleotide (NMN) as an anti-aging health product - Promises and safety concerns.**
    J Adv Res 2021 · [PMID 35499054](https://pubmed.ncbi.nlm.nih.gov/35499054/) · [DOI 10.1016/j.jare.2021.08.003](https://doi.org/10.1016/j.jare.2021.08.003)

    > As there is a large influx of NMN based anti-aging products on the market, proper clinical investigations are urgently needed to find out the effectiveness and safety of NMN supplementation.

23. **Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions.**
    J Gerontol A Biol Sci Med Sci 2023 · [PMID 37068054](https://pubmed.ncbi.nlm.nih.gov/37068054/) · [DOI 10.1093/gerona/glad106](https://doi.org/10.1093/gerona/glad106)

    > Supplementation with these compounds is safe, tolerable, and can increase the abundance of NAD+ and related metabolites in multiple tissues. Dosing regimens and study durations vary greatly across interventions, and small sample sizes limit data interpretation of physiological outcomes.

24. **Effects of NAD+ precursor supplementation on glucose and lipid metabolism in humans: a meta-analysis.**
    Nutr Metab (Lond) 2022 · [PMID 35303905](https://pubmed.ncbi.nlm.nih.gov/35303905/) · [DOI 10.1186/s12986-022-00653-9](https://doi.org/10.1186/s12986-022-00653-9)

    > supplementation with NAD+ precursors improved TG, TC, LDL, and HDL levels in humans, but resulted in hyperglycemia, compared with placebo or no treatment.

25. **Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men.**
    Endocr J 2019 · [PMID 31685720](https://pubmed.ncbi.nlm.nih.gov/31685720/) · [DOI 10.1507/endocrj.EJ19-0313](https://doi.org/10.1507/endocrj.EJ19-0313)

    > The single oral administration of NMN was safe and effectively metabolized in healthy men without causing any significant deleterious effects.

26. **Association between blood nicotinamide adenine dinucleotide levels and blood laboratory parameters at baseline and after nicotinamide mononucleotide supplementation in middle-aged healthy individuals: post hoc analysis of a randomized, double-blinded, placebo-controlled clinical trial.**
    Geroscience 2025 · [PMID 41162813](https://pubmed.ncbi.nlm.nih.gov/41162813/) · [DOI 10.1007/s11357-025-01968-0](https://doi.org/10.1007/s11357-025-01968-0)

    > NMN-induced increases in blood NAD are associated with an increase in RBC parameters, potentially indicating enhanced oxygen-carrying capacity.

27. **Human trials exploring anti-aging medicines.**
    Cell Metab 2024 · [PMID 38181790](https://pubmed.ncbi.nlm.nih.gov/38181790/) · [DOI 10.1016/j.cmet.2023.12.007](https://doi.org/10.1016/j.cmet.2023.12.007)

    > Multiple clinical trials have commenced to evaluate the efficacy of such agents against age-associated diseases including diabetes, cardiovascular disease, cancer, and neurodegenerative diseases.

28. **CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD and NMN levels.**
    Nat Metab 2020 · [PMID 33199925](https://pubmed.ncbi.nlm.nih.gov/33199925/) · [DOI 10.1038/s42255-020-00298-z](https://doi.org/10.1038/s42255-020-00298-z)

    > Our findings demonstrate that senescence-induced inflammation promotes accumulation of CD38 in immune cells that, through its ecto-enzymatic activity, decreases levels of NMN and NAD.

29. **NAD+ Repletion Rescues Female Fertility during Reproductive Aging.**
    Cell Rep 2020 · [PMID 32049001](https://pubmed.ncbi.nlm.nih.gov/32049001/) · [DOI 10.1016/j.celrep.2020.01.058](https://doi.org/10.1016/j.celrep.2020.01.058)

    > Here, we show that this loss of oocyte quality with age accompanies declining levels of the prominent metabolic cofactor nicotinamide adenine dinucleotide (NAD).

30. **Supplementation with NAD+ Precursors for Treating Alzheimer's Disease: A Metabolic Approach.**
    J Alzheimers Dis 2024 · [PMID 39422945](https://pubmed.ncbi.nlm.nih.gov/39422945/) · [DOI 10.3233/JAD-231277](https://doi.org/10.3233/JAD-231277)

    > Results of preclinical and clinical studies confirm the potential benefits of NAD+ precursors for the treatment of AD. However, further clinical studies are required to confirm the increasingly important value of NAD+ precursors as effective pharmacological interventions in the clinic.

31. **MIB-626, an Oral Formulation of a Microcrystalline Unique Polymorph of β-Nicotinamide Mononucleotide, Increases Circulating Nicotinamide Adenine Dinucleotide and its Metabolome in Middle-Aged and Older Adults.**
    J Gerontol A Biol Sci Med Sci 2023 · [PMID 35182418](https://pubmed.ncbi.nlm.nih.gov/35182418/) · [DOI 10.1093/gerona/glac049](https://doi.org/10.1093/gerona/glac049)

    > MIB-626 1 000 mg once-daily or twice-daily regimens were safe and associated with substantial dose-related increases in blood NAD levels and its metabolome.

32. **A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD(+) Metabolome in Healthy Middle-Aged Adults: A Randomized, Triple-Blind, Placebo-Controlled, Cross-Over Pilot Clinical Trial.**
    Nutrients 2022 · [PMID 35684021](https://pubmed.ncbi.nlm.nih.gov/35684021/)

    > A small placebo-controlled crossover trial found a nicotinamide-plus-D-ribose blend safely raised the blood NAD+ metabolome in healthy middle-aged adults; endpoints were biomarkers only.

33. **Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD(+) in healthy middle-aged and older adults.**
    Nature communications 2018 · [PMID 29599478](https://pubmed.ncbi.nlm.nih.gov/29599478/)

    > Nicotinamide riboside (1,000 mg/day for 6 weeks) raised blood NAD+ by about 60% and was well tolerated, with exploratory signals for lower blood pressure and aortic stiffness.

34. **DMPC-Based Liposomal Vesicles for Encapsulation and Controlled Release of NMN and Matrigel in Sarcopenia Therapy.**
    International journal of molecular sciences 2025 · [PMID 40565060](https://pubmed.ncbi.nlm.nih.gov/40565060/)

    > Liposomal NMN delivery has been demonstrated only in cell and animal models; human pharmacokinetic superiority over plain NMN remains unverified.

## Where to buy

[Search Amazon for Nutricost NMN Capsules 500mg](https://www.amazon.com/s?k=Nutricost%20NMN%20Capsules%20500mg&tag=magellanlong-20) — affiliate search link.

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- [Zinc Picolinate](https://magellanlongevity.com/p/133.md) — Multiple meta-analyses of randomized trials indicate that oral zinc, started soon after symptom onset, can…
- [Vitamin K2 (MK-7)](https://magellanlongevity.com/p/138.md) — In humans, MK-7 supplementation consistently improves vitamin K-status biomarkers — lowering circulating…
- [All Nutraceuticals & Cellular Energizers](https://magellanlongevity.com/c/1.md)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).