---
title: "Supplementation with Akkermansia muciniphila in overweight and…"
description: "Pasteurized Akkermansia muciniphila supplementation is safe and may improve insulin sensitivity, cholesterol, and other metabolic markers in…"
url: "https://magellanlongevity.com/study/akk_human.md"
canonical: "https://magellanlongevity.com/study/akk_human.html"
html: "https://magellanlongevity.com/study/akk_human.html"
type: "study"
study_key: "akk_human"
journal: "Nature Medicine"
year: 2019
pmid: "31263284"
doi: "10.1038/s41591-019-0495-2"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

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## Citation

| Field | Value |
| --- | --- |
| Journal | Nature Medicine |
| Year | 2019 |
| PMID | [31263284](https://pubmed.ncbi.nlm.nih.gov/31263284/) |
| DOI | [10.1038/s41591-019-0495-2](https://doi.org/10.1038/s41591-019-0495-2) |
| Study key | akk_human |

## Takeaway

Pasteurized Akkermansia muciniphila supplementation is safe and may improve insulin sensitivity, cholesterol, and other metabolic markers in overweight/obese insulin-resistant individuals.

## The question

Can daily oral supplementation with Akkermansia muciniphila improve metabolic parameters in overweight/obese insulin-resistant human volunteers?

## Hypothesis

Supplementation with A. muciniphila will be safe, well-tolerated, and improve metabolic parameters in overweight/obese insulin-resistant individuals, given its negative correlation with obesity-related disorders in previous studies.

## Methods

This was a randomized, double-blind, placebo-controlled pilot study. 40 overweight/obese insulin-resistant volunteers were enrolled, with 32 completing the trial. Participants received daily oral supplementation of 10^10 A. muciniphila bacteria (either live or pasteurized) or a placebo for three months. Primary endpoints included safety, tolerability, and metabolic parameters (insulin resistance, circulating lipids, visceral adiposity, body mass), while secondary outcomes were gut barrier function (plasma lipopolysaccharides) and gut microbiota composition.

## Results

Daily oral supplementation of 10^10 A. muciniphila (live or pasteurized) for three months was safe and well tolerated. Compared to placebo, pasteurized A. muciniphila improved insulin sensitivity by 28.62%, reduced insulinemia by 34.08%, and decreased plasma total cholesterol by 8.68%. Pasteurized A. muciniphila also slightly decreased body weight by 2.27 kg, fat mass by 1.37 kg, and hip circumference by 2.63 cm compared to baseline. Additionally, A. muciniphila reduced blood markers for liver dysfunction and inflammation, while the overall gut microbiome structure remained unaffected.

## Conclusion

This proof-of-concept study demonstrates that supplementation with A. muciniphila is safe, well-tolerated, and improves several metabolic parameters in overweight/obese insulin-resistant individuals.

## Limitations

The study was a single-center pilot study with a relatively small number of participants completing the trial (32 out of 40 enrolled).

## Verbatim from the abstract

> Akkermansia muciniphila supplementation was safe and well tolerated and improved insulin sensitivity and markers of metabolic health in overweight, insulin-resistant adults.

## Impact of Pasteurized A. muciniphila on Metabolic Parameters (vs. Placebo)

| Measure | Percentage Change (%) |
| --- | --- |
| Insulin Sensitivity Improvement | 28.62 |
| Insulinemia Reduction | -34.08 |
| Plasma Total Cholesterol Reduction | -8.68 |

*Pasteurized A. muciniphila significantly improved insulin sensitivity and reduced insulinemia and plasma total cholesterol compared to placebo.*

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| Probiotics | Moderate evidence | [Probiotic Multi-Strain (50B CFU)](https://magellanlongevity.com/p/199.md) |
| Akkermansia muciniphila | Emerging evidence | [Akkermansia muciniphila Probiotic](https://magellanlongevity.com/p/200.md) |

## Reference

1. **Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study**
   Nature Medicine 2019 · [PMID 31263284](https://pubmed.ncbi.nlm.nih.gov/31263284/) · [DOI 10.1038/s41591-019-0495-2](https://doi.org/10.1038/s41591-019-0495-2)

   > Akkermansia muciniphila supplementation was safe and well tolerated and improved insulin sensitivity and markers of metabolic health in overweight, insulin-resistant adults.

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## Related on Magellan Longevity

- [Probiotic Multi-Strain (50B CFU)](https://magellanlongevity.com/p/199.md) — product graded on this and related evidence
- [Akkermansia muciniphila Probiotic](https://magellanlongevity.com/p/200.md) — product graded on this and related evidence
- [Potential Modulation of Inflammation by Probiotic and Omega-3 Supplementation in Elderly…](https://magellanlongevity.com/study/prob_rct.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).