--- title: "Therapeutic potential of beetroot juice in peripheral artery…" description: "Beetroot juice may improve several markers of cardiovascular health and exercise performance relevant to peripheral artery disease." url: "https://magellanlongevity.com/study/beet_no.md" canonical: "https://magellanlongevity.com/study/beet_no.html" html: "https://magellanlongevity.com/study/beet_no.html" type: "study" study_key: "beet_no" journal: "Nitric Oxide" year: 2025 pmid: "40139306" doi: "10.1016/j.niox.2025.03.003" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # Therapeutic potential of beetroot juice in peripheral artery disease (review of the nitrate–nitrite–NO pathway) [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Therapeutic potential of beetroot juice in peripheral… **HTML version:** https://magellanlongevity.com/study/beet_no.html · **In the Magellan app:** https://magellanlongevity.com/#/study/beet_no ## Citation | Field | Value | | --- | --- | | Journal | Nitric Oxide | | Year | 2025 | | PMID | [40139306](https://pubmed.ncbi.nlm.nih.gov/40139306/) | | DOI | [10.1016/j.niox.2025.03.003](https://doi.org/10.1016/j.niox.2025.03.003) | | Study key | beet_no | ## Takeaway Beetroot juice may improve several markers of cardiovascular health and exercise performance relevant to peripheral artery disease. ## The question What are the potential therapeutic effects of beetroot juice (BRJ) in the management of peripheral artery disease (PAD)? ## Hypothesis Beetroot juice, rich in nitrate and betaine, may offer therapeutic benefits for PAD by increasing nitric oxide (NO) bioavailability through the nitrate-nitrite-NO pathway, thereby improving blood flow and other physiological functions. ## Methods This is a review article that explores the potential therapeutic effects of beetroot juice in PAD management by examining existing evidence related to its bioactive compounds and their mechanisms of action, particularly the nitrate-nitrite-NO pathway. ## Results The review indicates that beetroot juice can improve exercise performance, lower blood pressure, improve endothelial function, enhance skeletal muscle microvascular function, and improve central autonomic nervous system function. ## Conclusion Beetroot and its rich bioactive compounds show promise as a novel supportive therapy for improving peripheral artery disease. ## Limitations The abstract does not explicitly state any limitations of the review itself, but rather focuses on the potential benefits of beetroot juice. ## Verbatim from the abstract > Beetroot nitrate is metabolized via the nitrate–nitrite–nitric oxide pathway, increasing NO bioavailability; NO is a vasodilator that improves blood flow, lowers blood pressure and improves endothelial function. ## Where this study is used on Magellan This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions. | Compound or device | Evidence grade | Graded pages | | --- | --- | --- | | Beetroot / Dietary Nitrate | Moderate evidence | [Beetroot / Dietary Nitrate](https://magellanlongevity.com/p/202.md) | ## Reference 1. **Therapeutic potential of beetroot juice in peripheral artery disease (review of the nitrate–nitrite–NO pathway)** Nitric Oxide 2025 · [PMID 40139306](https://pubmed.ncbi.nlm.nih.gov/40139306/) · [DOI 10.1016/j.niox.2025.03.003](https://doi.org/10.1016/j.niox.2025.03.003) > Beetroot nitrate is metabolized via the nitrate–nitrite–nitric oxide pathway, increasing NO bioavailability; NO is a vasodilator that improves blood flow, lowers blood pressure and improves endothelial function. ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/beet_no.html#page","url":"https://magellanlongevity.com/study/beet_no.html","name":"Therapeutic potential of beetroot juice in peripheral artery disease (review of the nitrate–nitrite–NO…","description":"Beetroot juice may improve several markers of cardiovascular health and exercise performance relevant to peripheral artery disease.","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/beet_no.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"Therapeutic potential of beetroot juice in peripheral…","item":"https://magellanlongevity.com/study/beet_no.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/beet_no.html#study","name":"Therapeutic potential of beetroot juice in peripheral artery disease (review of the nitrate–nitrite–NO pathway)","headline":"Therapeutic potential of beetroot juice in peripheral artery disease (review of the nitrate–nitrite–NO…","datePublished":"2025","isPartOf":{"@type":"Periodical","name":"Nitric Oxide"},"identifier":"PMID:40139306","url":"https://pubmed.ncbi.nlm.nih.gov/40139306/","sameAs":"https://doi.org/10.1016/j.niox.2025.03.003","abstract":"Beetroot juice may improve several markers of cardiovascular health and exercise performance relevant to peripheral artery disease."}]} ``` ## Related on Magellan Longevity - [Beetroot / Dietary Nitrate](https://magellanlongevity.com/p/202.md) — product graded on this and related evidence - [Beetroot Juice and Exercise Capacity: A Systematic Review and Meta-Analysis](https://magellanlongevity.com/study/beet_bp.md) - [Impact of dietary nitrate supplementation on exercise capacity and cardiovascular…](https://magellanlongevity.com/study/beet_meta2.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).