--- title: "C-reactive protein and other markers of inflammation in the…" description: "Adding C-reactive protein to standard lipid screening can better identify postmenopausal women at risk for cardiovascular events." url: "https://magellanlongevity.com/study/d10733371.md" canonical: "https://magellanlongevity.com/study/d10733371.html" html: "https://magellanlongevity.com/study/d10733371.html" type: "study" study_key: "d10733371" journal: "N Engl J Med" year: 2000 pmid: "10733371" doi: "10.1056/NEJM200003233421202" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › C-reactive protein and other markers of inflammation in… **HTML version:** https://magellanlongevity.com/study/d10733371.html · **In the Magellan app:** https://magellanlongevity.com/#/study/d10733371 ## Citation | Field | Value | | --- | --- | | Journal | N Engl J Med | | Year | 2000 | | PMID | [10733371](https://pubmed.ncbi.nlm.nih.gov/10733371/) | | DOI | [10.1056/NEJM200003233421202](https://doi.org/10.1056/NEJM200003233421202) | | Study key | d10733371 | ## Takeaway Adding C-reactive protein to standard lipid screening can better identify postmenopausal women at risk for cardiovascular events. ## The question Can measuring markers of inflammation improve the prediction of cardiovascular event risk? ## Hypothesis Measurement of markers of inflammation, in addition to traditional risk factors, will improve the prediction of cardiovascular event risk. ## Methods A prospective, nested case-control study was conducted among 28,263 apparently healthy postmenopausal women over a mean follow-up of three years. Researchers assessed the risk of cardiovascular events associated with baseline levels of various markers, including high-sensitivity C-reactive protein (hs-CRP), serum amyloid A, interleukin-6, soluble intercellular adhesion molecule type 1 (sICAM-1), homocysteine, and lipid measurements. Cardiovascular events included death from coronary heart disease, nonfatal myocardial infarction or stroke, or the need for coronary-revascularization procedures. ## Results Hs-CRP was the strongest univariate predictor of cardiovascular events, with a relative risk of 4.4 for women in the highest versus lowest quartile. Other significant univariate predictors included serum amyloid A (3.0), sICAM-1 (2.6), interleukin-6 (2.2), homocysteine (2.0), total cholesterol (2.4), LDL cholesterol (2.4), apolipoprotein B-100 (3.4), HDL cholesterol (0.3), and the ratio of total cholesterol to HDL cholesterol (3.4). Prediction models incorporating inflammation markers and lipids were significantly better than lipid-only models (P<0.001). Hs-CRP and serum amyloid A were significant predictors even in women with LDL cholesterol below 130 mg/dL. In multivariate analyses, only hs-CRP (relative risk 1.5) and the ratio of total cholesterol to HDL cholesterol (relative risk 1.4) independently predicted risk. ## Conclusion Adding C-reactive protein measurement to lipid-based screening may improve the identification of individuals at risk for cardiovascular events. ## Limitations The study was conducted in apparently healthy postmenopausal women, which may limit generalizability to other populations. The follow-up period was a mean of three years, which might not capture long-term risks. ## Verbatim from the abstract > hs-CRP was the strongest univariate predictor of the risk of cardiovascular events ## Univariate Relative Risk of Cardiovascular Events (Highest vs. Lowest Quartile) | Measure | Relative Risk | | --- | --- | | hs-CRP | 4.4 | | Serum Amyloid A | 3 | | sICAM-1 | 2.6 | | Interleukin-6 | 2.2 | | Homocysteine | 2 | | Total Cholesterol | 2.4 | | LDL Cholesterol | 2.4 | | Apolipoprotein B-100 | 3.4 | | HDL Cholesterol | 0.3 | | Total Chol/HDL Chol Ratio | 3.4 | *This chart shows the univariate relative risk of cardiovascular events for women in the highest quartile compared to the lowest quartile for various markers.* ## Where this study is used on Magellan This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions. | Compound or device | Evidence grade | Graded pages | | --- | --- | --- | | hs-CRP Inflammation Test | Measurement tool | [hs-CRP Inflammation Test](https://magellanlongevity.com/p/142.md) | ## Reference 1. **C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women** N Engl J Med 2000 · [PMID 10733371](https://pubmed.ncbi.nlm.nih.gov/10733371/) · [DOI 10.1056/NEJM200003233421202](https://doi.org/10.1056/NEJM200003233421202) > hs-CRP was the strongest univariate predictor of the risk of cardiovascular events ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/d10733371.html#page","url":"https://magellanlongevity.com/study/d10733371.html","name":"C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women","description":"Adding C-reactive protein to standard lipid screening can better identify postmenopausal women at risk for cardiovascular events.","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/d10733371.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"C-reactive protein and other markers of inflammation in…","item":"https://magellanlongevity.com/study/d10733371.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/d10733371.html#study","name":"C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women","headline":"C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women","datePublished":"2000","isPartOf":{"@type":"Periodical","name":"N Engl J Med"},"identifier":"PMID:10733371","url":"https://pubmed.ncbi.nlm.nih.gov/10733371/","sameAs":"https://doi.org/10.1056/NEJM200003233421202","abstract":"Adding C-reactive protein to standard lipid screening can better identify postmenopausal women at risk for cardiovascular events."}]} ``` ## Related on Magellan Longevity - [hs-CRP Inflammation Test](https://magellanlongevity.com/p/142.md) — product graded on this and related evidence - [Evidence: High-sensitivity C-reactive protein](https://magellanlongevity.com/study/s142.md) - [Inflammation, Cholesterol, Lipoprotein(a), and 30-Year Cardiovascular Outcomes in Women](https://magellanlongevity.com/study/d39216091.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).