---
title: "Selenium and coenzyme Q10 interrelationship in cardiovascular…"
description: "Supplementing with selenium and coenzyme Q10 may improve cardiovascular outcomes in elderly individuals, potentially by enhancing antioxidant capacity."
url: "https://magellanlongevity.com/study/d25511910.md"
canonical: "https://magellanlongevity.com/study/d25511910.html"
html: "https://magellanlongevity.com/study/d25511910.html"
type: "study"
study_key: "d25511910"
journal: "J Trace Elem Med Biol"
year: 2014
pmid: "25511910"
doi: "10.1016/j.jtemb.2014.11.006"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Selenium and coenzyme Q10 interrelationship in cardiovascular diseases

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## Citation

| Field | Value |
| --- | --- |
| Journal | J Trace Elem Med Biol |
| Year | 2014 |
| PMID | [25511910](https://pubmed.ncbi.nlm.nih.gov/25511910/) |
| DOI | [10.1016/j.jtemb.2014.11.006](https://doi.org/10.1016/j.jtemb.2014.11.006) |
| Study key | d25511910 |

## Takeaway

Supplementing with selenium and coenzyme Q10 may improve cardiovascular outcomes in elderly individuals, potentially by enhancing antioxidant capacity.

## The question

What is the potential role of selenium deficiency and selenium intervention in atherosclerotic heart disease, and how does it interrelate with coenzyme Q10?

## Hypothesis

Selenium deficiency may lead to reduced anti-oxidative capacity, influencing the prognosis of atherosclerotic disease. Combining selenium and coenzyme Q10 may offer a theoretical advantage in intervention due to their anti-oxidative properties.

## Methods

This is a short review discussing the potential role of selenium deficiency and intervention trials in atherosclerotic heart disease. It also presents the interrelationship between selenium and coenzyme Q10 and discusses clinical results from an intervention study using both substances in an elderly population.

## Results

Selenium intake in Europe is often at the lower margin of recommendations, potentially leading to deficient anti-oxidative capacity in conditions like atherosclerotic disease. Increased oxidative stress is demonstrated in ischemic heart disease and heart failure. A clinical intervention study in an elderly population using both selenium and coenzyme Q10 showed a reduction in cardiovascular mortality, improved cardiac function by echocardiography, and lower NT-proBNP concentrations in the active treatment group compared to placebo.

## Conclusion

Selenium deficiency may contribute to atherosclerotic disease due to reduced anti-oxidative capacity. Supplementation with both selenium and coenzyme Q10 in an elderly population demonstrated benefits including reduced cardiovascular mortality, improved cardiac function, and lower myocardial wall tension.

## Limitations

The review does not specify the exact details, sample sizes, or statistical significance of the discussed intervention studies. It also does not quantify the observed reductions or improvements.

## Verbatim from the abstract

> reduction in cardiovascular mortality, a better cardiac function according to echocardiography

## Reference

1. **Selenium and coenzyme Q10 interrelationship in cardiovascular diseases**
   J Trace Elem Med Biol 2014 · [PMID 25511910](https://pubmed.ncbi.nlm.nih.gov/25511910/) · [DOI 10.1016/j.jtemb.2014.11.006](https://doi.org/10.1016/j.jtemb.2014.11.006)

   > reduction in cardiovascular mortality, a better cardiac function according to echocardiography

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## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).