--- title: "Effects of Quercetin on Blood Pressure: A Systematic Review and…" description: "Quercetin supplementation, especially at doses of 500 mg/day or more, may help reduce both systolic and diastolic blood pressure." url: "https://magellanlongevity.com/study/d27405810.md" canonical: "https://magellanlongevity.com/study/d27405810.html" html: "https://magellanlongevity.com/study/d27405810.html" type: "study" study_key: "d27405810" journal: "J Am Heart Assoc" year: 2016 pmid: "27405810" doi: "10.1161/JAHA.115.002713" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Effects of Quercetin on Blood Pressure: A Systematic… **HTML version:** https://magellanlongevity.com/study/d27405810.html · **In the Magellan app:** https://magellanlongevity.com/#/study/d27405810 ## Citation | Field | Value | | --- | --- | | Journal | J Am Heart Assoc | | Year | 2016 | | PMID | [27405810](https://pubmed.ncbi.nlm.nih.gov/27405810/) | | DOI | [10.1161/JAHA.115.002713](https://doi.org/10.1161/JAHA.115.002713) | | Study key | d27405810 | ## Takeaway Quercetin supplementation, especially at doses of 500 mg/day or more, may help reduce both systolic and diastolic blood pressure. ## The question Does quercetin supplementation affect blood pressure? ## Hypothesis The evidence regarding quercetin's effects on blood pressure has been inconclusive, so this meta-analysis aims to assess its impact. ## Methods A systematic review and meta-analysis of placebo-controlled randomized controlled trials were conducted. Databases including PUBMED, Cochrane Library, Scopus, and EMBASE were searched up to January 31, 2015. Meta-analysis used either fixed-effects or random-effect models, with effect size expressed as weighted mean difference (WMD) and 95% CI. ## Results The meta-analysis included 7 trials with 9 treatment arms and 587 patients. Quercetin supplementation significantly reduced systolic BP (WMD: -3.04 mm Hg) and diastolic BP (WMD: -2.63 mm Hg). For doses ">="500 mg/day, significant reductions were observed in systolic BP (WMD: -4.45 mm Hg) and diastolic BP (WMD: -2.98 mm Hg). Doses "<"500 mg/day did not show a significant effect on either systolic BP (WMD: -1.59 mm Hg) or diastolic BP (WMD: -0.24 mm Hg), though indirect comparison tests between doses were not significant. ## Conclusion Quercetin supplementation has a statistically significant effect in reducing blood pressure, with this effect possibly limited to or greater with dosages of ">"500 mg/day. ## Limitations The abstract does not explicitly state limitations of the study, but it does call for further studies to investigate clinical relevance and potential application as an add-on therapy. ## Verbatim from the abstract > significant reductions both in systolic BP and diastolic BP following supplementation with quercetin ## Effect of Quercetin on Blood Pressure | Measure | WMD (mm Hg) | | --- | --- | | Overall Systolic BP Reduction | -3.04 | | Overall Diastolic BP Reduction | -2.63 | | Systolic BP Reduction (≥500 mg/day) | -4.45 | | Diastolic BP Reduction (≥500 mg/day) | -2.98 | | Systolic BP Reduction (<500 mg/day) | -1.59 | | Diastolic BP Reduction (<500 mg/day) | -0.24 | *Weighted mean difference (WMD) in blood pressure reduction (mm Hg) following quercetin supplementation, overall and by dose category.* ## Where this study is used on Magellan This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions. | Compound or device | Evidence grade | Graded pages | | --- | --- | --- | | Quercetin Capsules | Moderate evidence | [Quercetin Capsules](https://magellanlongevity.com/p/105.md) | ## Reference 1. **Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials** J Am Heart Assoc 2016 · [PMID 27405810](https://pubmed.ncbi.nlm.nih.gov/27405810/) · [DOI 10.1161/JAHA.115.002713](https://doi.org/10.1161/JAHA.115.002713) > significant reductions both in systolic BP and diastolic BP following supplementation with quercetin ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/d27405810.html#page","url":"https://magellanlongevity.com/study/d27405810.html","name":"Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","description":"Quercetin supplementation, especially at doses of 500 mg/day or more, may help reduce both systolic and diastolic blood pressure.","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/d27405810.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"Effects of Quercetin on Blood Pressure: A Systematic…","item":"https://magellanlongevity.com/study/d27405810.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/d27405810.html#study","name":"Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","headline":"Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","datePublished":"2016","isPartOf":{"@type":"Periodical","name":"J Am Heart Assoc"},"identifier":"PMID:27405810","url":"https://pubmed.ncbi.nlm.nih.gov/27405810/","sameAs":"https://doi.org/10.1161/JAHA.115.002713","abstract":"Quercetin supplementation, especially at doses of 500 mg/day or more, may help reduce both systolic and diastolic blood pressure."}]} ``` ## Related on Magellan Longevity - [Quercetin Capsules](https://magellanlongevity.com/p/105.md) — product graded on this and related evidence - [Evidence: lowers systolic/diastolic blood pressure](https://magellanlongevity.com/study/s105.md) - [Effect of quercetin supplementation on plasma lipid profiles, blood pressure, and…](https://magellanlongevity.com/study/d31940027.md) - [Senolytic drugs: from discovery to translation](https://magellanlongevity.com/study/d32686219.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).