---
title: "Sulforaphane Delays Fibroblast Senescence by Curbing Cellular…"
description: "Sulforaphane delays cell aging by reducing sugar uptake and metabolism, which lessens cellular damage."
url: "https://magellanlongevity.com/study/d30595796.md"
canonical: "https://magellanlongevity.com/study/d30595796.html"
html: "https://magellanlongevity.com/study/d30595796.html"
type: "study"
study_key: "d30595796"
journal: "Oxid Med Cell Longev"
year: 2018
pmid: "30595796"
doi: "10.1155/2018/5642148"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Sulforaphane Delays Fibroblast Senescence by Curbing Cellular Glucose Uptake, Increased Glycolysis, and Oxidative Damage

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## Citation

| Field | Value |
| --- | --- |
| Journal | Oxid Med Cell Longev |
| Year | 2018 |
| PMID | [30595796](https://pubmed.ncbi.nlm.nih.gov/30595796/) |
| DOI | [10.1155/2018/5642148](https://doi.org/10.1155/2018/5642148) |
| Study key | d30595796 |

## Takeaway

Sulforaphane delays cell aging by reducing sugar uptake and metabolism, which lessens cellular damage.

## The question

How does sulforaphane (SFN) delay fibroblast senescence, and what is the connection between Nrf2 activation, glucose metabolism, and oxidative damage in this process?

## Hypothesis

Sulforaphane (SFN) delays fibroblast senescence by activating Nrf2, which in turn curbs cellular glucose uptake and glycolysis, thereby reducing oxidative damage.

## Methods

The study investigated the effects of sulforaphane (SFN) on senescence in human MRC-5 and BJ fibroblasts. Researchers observed changes in glucose metabolism, hexokinase-2 expression, 6-phosphofructo-2-kinase, glucose-6-phosphate dehydrogenase, thioredoxin-interacting protein expression, and clearance of transglutaminase cross-linked proteins.

## Results

SFN activated Nrf2 and delayed senescence in human MRC-5 and BJ fibroblasts. Senescence was associated with increased glucose metabolism through glycolysis, leading to mitochondrial dysfunction and oxidative damage. SFN delayed senescence by decreasing glucose metabolism, exhibiting a caloric restriction mimetic-like activity, and reducing oxidative damage to cell protein and DNA. This was linked to increased thioredoxin-interacting protein, decreased hexokinase-2 and 6-phosphofructo-2-kinase, and increased glucose-6-phosphate dehydrogenase. SFN also enhanced the clearance of transglutaminase cross-linked proteins, which typically increase in senescence.

## Conclusion

Sulforaphane delays fibroblast senescence by curbing cellular glucose uptake and glycolysis, mimicking caloric restriction, and reducing oxidative damage. This mechanism involves the modulation of key enzymes and proteins involved in glucose metabolism and protein clearance.

## Limitations

The abstract does not explicitly state any limitations of the study.

## Verbatim from the abstract

> sulforaphane activates Nrf2 and delays senescence by decreasing glucose metabolism and oxidative damage

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| Broccoli Sprout Sulforaphane | Moderate evidence | [Broccoli Sprout Sulforaphane](https://magellanlongevity.com/p/103.md) |

## Reference

1. **Sulforaphane Delays Fibroblast Senescence by Curbing Cellular Glucose Uptake, Increased Glycolysis, and Oxidative Damage**
   Oxid Med Cell Longev 2018 · [PMID 30595796](https://pubmed.ncbi.nlm.nih.gov/30595796/) · [DOI 10.1155/2018/5642148](https://doi.org/10.1155/2018/5642148)

   > sulforaphane activates Nrf2 and delays senescence by decreasing glucose metabolism and oxidative damage

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## Related on Magellan Longevity

- [Broccoli Sprout Sulforaphane](https://magellanlongevity.com/p/103.md) — product graded on this and related evidence
- [Evidence: sulforaphane reduces hepatic gluconeogenesis](https://magellanlongevity.com/study/s103.md)
- [Sulforaphane reduces hepatic glucose production and improves glucose control in patients…](https://magellanlongevity.com/study/d28615356.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).