---
title: "Effects of Grape Seed Proanthocyanidin Extract on Vascular…"
description: "High-dose grape seed extract may help lower blood pressure and improve vascular elasticity in middle-aged Japanese adults with prehypertension,…"
url: "https://magellanlongevity.com/study/d31757033.md"
canonical: "https://magellanlongevity.com/study/d31757033.html"
html: "https://magellanlongevity.com/study/d31757033.html"
type: "study"
study_key: "d31757033"
journal: "Nutrients"
year: 2019
pmid: "31757033"
doi: "10.3390/nu11122844"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Effects of Grape Seed Proanthocyanidin Extract on Vascular Endothelial Function in Prehypertension: a Randomized Controlled Study

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## Citation

| Field | Value |
| --- | --- |
| Journal | Nutrients |
| Year | 2019 |
| PMID | [31757033](https://pubmed.ncbi.nlm.nih.gov/31757033/) |
| DOI | [10.3390/nu11122844](https://doi.org/10.3390/nu11122844) |
| Study key | d31757033 |

## Takeaway

High-dose grape seed extract may help lower blood pressure and improve vascular elasticity in middle-aged Japanese adults with prehypertension, especially non-smokers.

## The question

What are the effects of grape seed proanthocyanidin extract (GSPE) on blood pressure and vascular endothelial function in middle-aged Japanese adults with prehypertension?

## Hypothesis

The study hypothesized that GSPE consumption would improve blood pressure and vascular endothelial function in middle-aged Japanese adults with prehypertension.

## Methods

A randomized, double-blind, placebo-controlled study was conducted on 6 men and 24 women aged 40-64 years with prehypertension. Participants were randomized to receive either 200 mg/day GSPE, 400 mg/day GSPE, or placebo for 12 weeks. Blood pressure, brachial flow-mediated dilation (FMD), and other cardiovascular parameters were measured at baseline and after 4, 8, and 12 weeks.

## Results

After 12 weeks, the high-dose GSPE group (400 mg/day) showed a significant decrease in mean systolic blood pressure (SBP) by 13 mmHg. FMD did not change in any group. In a post-hoc analysis of non-smoking participants, the high-dose group also showed significant improvements in mean SBP, diastolic blood pressure (DBP), stiffness parameter β, distensibility, incremental elastic modulus (Einc), and pulse wave velocity (PWV) after 12 weeks. Changes in Einc and PWV from baseline to 12 weeks were significantly greater in the high-dose group compared to the placebo group.

## Conclusion

Consumption of high-dose GSPE (400 mg/day) may help maintain vascular elasticity and normal blood pressure in middle-aged Japanese adults with prehypertension, particularly in non-smokers.

## Limitations

The study's primary analysis did not find changes in FMD, and some significant findings were from an ad hoc analysis of a subgroup (non-smokers). The sample size was relatively small (30 participants).

## Verbatim from the abstract

> mean SBP in the high-dose group significantly decreased by 13 mmHg after 12 weeks

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| Grape Seed Extract | Moderate evidence | [Grape Seed Extract](https://magellanlongevity.com/p/111.md) |

## Reference

1. **Effects of Grape Seed Proanthocyanidin Extract on Vascular Endothelial Function in Prehypertension: a Randomized Controlled Study**
   Nutrients 2019 · [PMID 31757033](https://pubmed.ncbi.nlm.nih.gov/31757033/) · [DOI 10.3390/nu11122844](https://doi.org/10.3390/nu11122844)

   > mean SBP in the high-dose group significantly decreased by 13 mmHg after 12 weeks

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## Related on Magellan Longevity

- [Grape Seed Extract](https://magellanlongevity.com/p/111.md) — product graded on this and related evidence
- [Evidence: improves endothelial function, lowers BP](https://magellanlongevity.com/study/s111.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).