---
title: "Effect of carnosine on lipid profile, fasting blood glucose,…"
description: "Carnosine supplementation may help lower HbA1C levels, but it does not appear to impact other markers of glucose metabolism or lipid profile."
url: "https://magellanlongevity.com/study/d31987255.md"
canonical: "https://magellanlongevity.com/study/d31987255.html"
html: "https://magellanlongevity.com/study/d31987255.html"
type: "study"
study_key: "d31987255"
journal: "Complement Ther Med"
year: 2019
pmid: "31987255"
doi: "10.1016/j.ctim.2019.102241"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Effect of carnosine on lipid profile, fasting blood glucose, HbA1C and insulin resistance: a meta-analysis of randomized controlled trials

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## Citation

| Field | Value |
| --- | --- |
| Journal | Complement Ther Med |
| Year | 2019 |
| PMID | [31987255](https://pubmed.ncbi.nlm.nih.gov/31987255/) |
| DOI | [10.1016/j.ctim.2019.102241](https://doi.org/10.1016/j.ctim.2019.102241) |
| Study key | d31987255 |

## Takeaway

Carnosine supplementation may help lower HbA1C levels, but it does not appear to impact other markers of glucose metabolism or lipid profile.

## The question

Does carnosine supplementation affect lipid profile, fasting blood glucose, HbA1C, and insulin resistance?

## Hypothesis

Carnosine supplementation may improve glucose disorders and dyslipidemia.

## Methods

A meta-analysis of randomized controlled trials (RCTs) was conducted by searching MEDLINE/PubMed, Scopus, and Web of Science up to June 2019. The search used Medical Subject Heading and keywords. Combined effect sizes were calculated as weighted mean difference (WMD) using a random-effects model, and heterogeneity was assessed with Cochran's Q test and I .

## Results

Four RCTs, involving 184 participants, were analyzed. Carnosine intervention significantly reduced HbA1C levels (WMD: -0.92 %, 95 % CI: -1.20, -0.63, I:69 %). However, combined results from four studies with 183 participants showed no significant reduction in triglycerides (WMD: -14.46 mg/dl, 95 % CI: -29.11, 0.19, I:94 %). No significant changes were observed for HOMA-IR, Cholesterol, fasting blood sugar, or HDL-C.

## Conclusion

Carnosine supplementation decreases HbA1C but does not significantly affect HOMA-IR, Cholesterol, fasting blood sugar, triglycerides, or HDL-C.

## Limitations

The study notes that future research with larger sample sizes, varied carnosine doses, and population-specific subgroups is needed to confirm and strengthen these findings.

## Verbatim from the abstract

> carnosine intervention reduced HbA1C levels in intervention vs control groups

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| Carnosine | Moderate evidence | [Carnosine](https://magellanlongevity.com/p/139.md) |

## Reference

1. **Effect of carnosine on lipid profile, fasting blood glucose, HbA1C and insulin resistance: a meta-analysis of randomized controlled trials**
   Complement Ther Med 2019 · [PMID 31987255](https://pubmed.ncbi.nlm.nih.gov/31987255/) · [DOI 10.1016/j.ctim.2019.102241](https://doi.org/10.1016/j.ctim.2019.102241)

   > carnosine intervention reduced HbA1C levels in intervention vs control groups

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- [Carnosine](https://magellanlongevity.com/p/139.md) — product graded on this and related evidence
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- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).