---
title: "Efficacy of a Serum Combining Bakuchiol and Vanilla Tahitensis…"
description: "A serum with bakuchiol and vanilla tahitensis extract reduced signs of skin aging in lab tests and improved firmness and radiance in women."
url: "https://magellanlongevity.com/study/d32494181.md"
canonical: "https://magellanlongevity.com/study/d32494181.html"
html: "https://magellanlongevity.com/study/d32494181.html"
type: "study"
study_key: "d32494181"
journal: "Clin Cosmet Investig Dermatol"
year: 2020
pmid: "32494181"
doi: "10.2147/CCID.S235880"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Efficacy of a Serum Combining Bakuchiol and Vanilla Tahitensis Extract to Prevent Skin Photoaging

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## Citation

| Field | Value |
| --- | --- |
| Journal | Clin Cosmet Investig Dermatol |
| Year | 2020 |
| PMID | [32494181](https://pubmed.ncbi.nlm.nih.gov/32494181/) |
| DOI | [10.2147/CCID.S235880](https://doi.org/10.2147/CCID.S235880) |
| Study key | d32494181 |

## Takeaway

A serum with bakuchiol and vanilla tahitensis extract reduced signs of skin aging in lab tests and improved firmness and radiance in women.

## The question

Can a serum combining bakuchiol (BK) and vanilla tahitensis extract (VTE) prevent skin photoaging in vitro and improve clinical outcomes for naturally aged skin?

## Hypothesis

A combination of bakuchiol and vanilla tahitensis extract will have beneficial effects in preventing skin photoaging and improving clinical outcomes for naturally aged skin.

## Methods

In vitro, human dermal fibroblasts were treated with active compounds, exposed to UVA, and analyzed for actin network morphology, IL-8 (inflammation), and p16 (senescence). Human skin explants were used to evaluate chronic UVA-induced GAG loss and the effect of topical BK+VTE serum. An open-label clinical trial involved 43 women applying the serum twice daily for 56 days, assessing skin remodeling (FaceScan), firmness (Dynaskin and clinical scoring), and radiance (photographs).

## Results

UVA exposure increased IL-8 and p16 expression and altered fibroblast morphology. BK or VTE alone prevented actin network alteration and IL-8 upregulation. The BK+VTE combination showed synergistic protection against IL-8 and p16 overexpression. Serum application prevented GAG loss at the dermo-epidermal junction and increased dermal GAG in UVA-exposed skin explants. In the clinical trial, face ptosis was reduced by 11% (up to 23%) in 26 subjects, skin deformation depth was reduced by 24% (up to 30%) in 30 subjects, and radiance improved by 29% in 33 subjects. The serum was well-tolerated.

## Conclusion

The BK+VTE combination demonstrated anti-aging efficacy, potentially offering significant benefits for naturally aged skin in women due to synergistic effects on inflammaging and senescence.

## Limitations

The clinical trial was open-label, which may introduce bias. The study focused on naturally aged skin in women, limiting generalizability to other populations or skin types.

## Verbatim from the abstract

> the combination demonstrated anti-aging efficacy through a synergistic effect on inflammaging and senescence

## Clinical Improvements After 56 Days of Serum Application

| Measure | Average Improvement (%) |
| --- | --- |
| Face Ptosis Reduction | 11 |
| Skin Deformation Depth Reduction | 24 |
| Skin Radiance Improvement | 29 |

*Average percentage improvements observed in responsive subjects after 56 days of applying the bakuchiol and vanilla tahitensis extract serum.*

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| Bakuchiol Retinol-Alternative Cream | Moderate evidence | [Bakuchiol Retinol-Alternative Cream](https://magellanlongevity.com/p/181.md) |

## Reference

1. **Efficacy of a Serum Combining Bakuchiol and Vanilla Tahitensis Extract to Prevent Skin Photoaging**
   Clin Cosmet Investig Dermatol 2020 · [PMID 32494181](https://pubmed.ncbi.nlm.nih.gov/32494181/) · [DOI 10.2147/CCID.S235880](https://doi.org/10.2147/CCID.S235880)

   > the combination demonstrated anti-aging efficacy through a synergistic effect on inflammaging and senescence

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## Related on Magellan Longevity

- [Bakuchiol Retinol-Alternative Cream](https://magellanlongevity.com/p/181.md) — product graded on this and related evidence
- [Evidence: retinoid-mimicking gene expression](https://magellanlongevity.com/study/s181.md)
- [Clinical Evaluation of a Nature-Based Bakuchiol Anti-Aging Moisturizer for Sensitive Skin](https://magellanlongevity.com/study/d33346506.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).