--- title: "Senolytic drugs: from discovery to translation" description: "Senolytic drugs, which clear aging cells, show promise in preclinical studies for treating many age-related diseases, with human trials currently underway." url: "https://magellanlongevity.com/study/d32686219.md" canonical: "https://magellanlongevity.com/study/d32686219.html" html: "https://magellanlongevity.com/study/d32686219.html" type: "study" study_key: "d32686219" journal: "J Intern Med" year: 2020 pmid: "32686219" doi: "10.1111/joim.13141" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # Senolytic drugs: from discovery to translation [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Senolytic drugs: from discovery to translation **HTML version:** https://magellanlongevity.com/study/d32686219.html · **In the Magellan app:** https://magellanlongevity.com/#/study/d32686219 ## Citation | Field | Value | | --- | --- | | Journal | J Intern Med | | Year | 2020 | | PMID | [32686219](https://pubmed.ncbi.nlm.nih.gov/32686219/) | | DOI | [10.1111/joim.13141](https://doi.org/10.1111/joim.13141) | | Study key | d32686219 | ## Takeaway Senolytic drugs, which clear aging cells, show promise in preclinical studies for treating many age-related diseases, with human trials currently underway. ## The question What are senolytic drugs and what is their potential for treating age-related dysfunction and diseases? ## Hypothesis Senolytic drugs, by selectively clearing senescent cells, can delay, prevent, or alleviate various age-related disorders and conditions. ## Methods This abstract reviews the discovery of senolytic drugs and summarizes findings from preclinical models and early pilot human trials. ## Results The first senolytic drugs (Dasatinib, Quercetin, Fisetin, Navitoclax) were discovered using a hypothesis-driven approach. In preclinical models, senolytics alleviated over 40 conditions, including frailty, cancers, and various organ system disorders. Early human pilot trials suggest senolytics decrease senescent cells, reduce inflammation, and alleviate frailty. ## Conclusion Senolytics show promise in preclinical models for treating numerous age-related conditions by targeting senescent cells. Early human trials are encouraging, but more extensive clinical trials are needed before widespread use. ## Limitations The abstract notes that it is too early for senolytics to be used outside of clinical trials, indicating that current human data are preliminary and further research is required. ## Verbatim from the abstract > The first senolytic drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis-driven approach ## Where this study is used on Magellan This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions. | Compound or device | Evidence grade | Graded pages | | --- | --- | --- | | All-in-One Longevity Formulation | Emerging evidence | [NOVOS Core All-In-One Sachets](https://magellanlongevity.com/p/12.md) | | Fisetin Senolytic Capsules | Emerging evidence | [Fisetin Senolytic Capsules](https://magellanlongevity.com/p/101.md) | | Quercetin Capsules | Moderate evidence | [Quercetin Capsules](https://magellanlongevity.com/p/105.md) | ## Reference 1. **Senolytic drugs: from discovery to translation** J Intern Med 2020 · [PMID 32686219](https://pubmed.ncbi.nlm.nih.gov/32686219/) · [DOI 10.1111/joim.13141](https://doi.org/10.1111/joim.13141) > The first senolytic drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis-driven approach ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/d32686219.html#page","url":"https://magellanlongevity.com/study/d32686219.html","name":"Senolytic drugs: from discovery to translation","description":"Senolytic drugs, which clear aging cells, show promise in preclinical studies for treating many age-related diseases, with human trials currently underway.","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/d32686219.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"Senolytic drugs: from discovery to translation","item":"https://magellanlongevity.com/study/d32686219.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/d32686219.html#study","name":"Senolytic drugs: from discovery to translation","headline":"Senolytic drugs: from discovery to translation","datePublished":"2020","isPartOf":{"@type":"Periodical","name":"J Intern Med"},"identifier":"PMID:32686219","url":"https://pubmed.ncbi.nlm.nih.gov/32686219/","sameAs":"https://doi.org/10.1111/joim.13141","abstract":"Senolytic drugs, which clear aging cells, show promise in preclinical studies for treating many age-related diseases, with human trials currently underway."}]} ``` ## Related on Magellan Longevity - [Quercetin Capsules](https://magellanlongevity.com/p/105.md) — product graded on this and related evidence - [Fisetin Senolytic Capsules](https://magellanlongevity.com/p/101.md) — product graded on this and related evidence - [NOVOS Core All-In-One Sachets](https://magellanlongevity.com/p/12.md) — product graded on this and related evidence - [The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in…](https://magellanlongevity.com/study/nmn_trial.md) - [Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging…](https://magellanlongevity.com/study/resv_sirt1.md) - [Induction of autophagy by spermidine promotes longevity.](https://magellanlongevity.com/study/spermidine_autophagy.md) - [Krebs cycle intermediates regulate DNA and histone methylation: epigenetic impact on the…](https://magellanlongevity.com/study/akg_krebs.md) - [Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione…](https://magellanlongevity.com/study/glutathione_glynac.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).