---
title: "Neuroprotective effects of flavone luteolin in neuroinflammation…"
description: "Luteolin, a natural compound, shows promise in protecting the brain by reducing inflammation and oxidative stress in various neurological conditions."
url: "https://magellanlongevity.com/study/d33098588.md"
canonical: "https://magellanlongevity.com/study/d33098588.html"
html: "https://magellanlongevity.com/study/d33098588.html"
type: "study"
study_key: "d33098588"
journal: "Biofactors"
year: 2020
pmid: "33098588"
doi: "10.1002/biof.1687"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma

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## Citation

| Field | Value |
| --- | --- |
| Journal | Biofactors |
| Year | 2020 |
| PMID | [33098588](https://pubmed.ncbi.nlm.nih.gov/33098588/) |
| DOI | [10.1002/biof.1687](https://doi.org/10.1002/biof.1687) |
| Study key | d33098588 |

## Takeaway

Luteolin, a natural compound, shows promise in protecting the brain by reducing inflammation and oxidative stress in various neurological conditions.

## The question

What are the neuroprotective effects of the flavone luteolin in neuroinflammation and neurotrauma?

## Hypothesis

The authors hypothesize that luteolin, a natural polyphenol, exhibits neuroprotective effects by suppressing neuroinflammatory responses and related mechanisms.

## Methods

This is a short review article. Data was collected from publications in PubMed using keywords such as 'luteolin and mast cells', 'neuroinflammation', 'neurodegenerative diseases', and 'TBI'.

## Results

Luteolin suppresses systemic and neuroinflammatory responses, including in COVID-19. It exhibits neuroprotective effects by suppressing immune cell activation (e.g., mast cells) and the release of inflammatory mediators. Luteolin also suppresses neuroinflammatory responses, activation of microglia and astrocytes, oxidative stress, and the severity of neuroinflammatory diseases like Alzheimer's, Parkinson's, multiple sclerosis, and TBI pathogenesis.

## Conclusion

Luteolin can improve cognitive decline and enhance neuroprotection in neurodegenerative diseases, TBI, and stroke.

## Limitations

This is a review article, summarizing existing research rather than presenting new experimental data. The specific limitations of the reviewed studies are not detailed.

## Verbatim from the abstract

> luteolin can suppress neuroinflammatory response, microglia activation, and oxidative stress

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| Luteolin Capsules | Emerging evidence | [Luteolin Capsules](https://magellanlongevity.com/p/115.md) |

## Reference

1. **Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma**
   Biofactors 2020 · [PMID 33098588](https://pubmed.ncbi.nlm.nih.gov/33098588/) · [DOI 10.1002/biof.1687](https://doi.org/10.1002/biof.1687)

   > luteolin can suppress neuroinflammatory response, microglia activation, and oxidative stress

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## Related on Magellan Longevity

- [Luteolin Capsules](https://magellanlongevity.com/p/115.md) — product graded on this and related evidence
- [Evidence: inhibits neuroinflammation, ER stress](https://magellanlongevity.com/study/s115.md)
- [Dietary Luteolin Reduces Proinflammatory Microglia in the Brain of Senescent Mice](https://magellanlongevity.com/study/d26918466.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).