--- title: "Clinical Evaluation of a Nature-Based Bakuchiol Anti-Aging…" description: "A bakuchiol-based moisturizer improved skin moisture and anti-aging signs in people with sensitive skin." url: "https://magellanlongevity.com/study/d33346506.md" canonical: "https://magellanlongevity.com/study/d33346506.html" html: "https://magellanlongevity.com/study/d33346506.html" type: "study" study_key: "d33346506" journal: "J Drugs Dermatol" year: 2020 pmid: "33346506" doi: "10.36849/JDD.2020.5522" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # Clinical Evaluation of a Nature-Based Bakuchiol Anti-Aging Moisturizer for Sensitive Skin [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Clinical Evaluation of a Nature-Based Bakuchiol Anti-Aging… **HTML version:** https://magellanlongevity.com/study/d33346506.html · **In the Magellan app:** https://magellanlongevity.com/#/study/d33346506 ## Citation | Field | Value | | --- | --- | | Journal | J Drugs Dermatol | | Year | 2020 | | PMID | [33346506](https://pubmed.ncbi.nlm.nih.gov/33346506/) | | DOI | [10.36849/JDD.2020.5522](https://doi.org/10.36849/JDD.2020.5522) | | Study key | d33346506 | ## Takeaway A bakuchiol-based moisturizer improved skin moisture and anti-aging signs in people with sensitive skin. ## The question Can a nature-based bakuchiol-containing cleanser and moisturizer be tolerated and effective for anti-aging in individuals with sensitive skin? ## Hypothesis Bakuchiol, a meroterpene with retinol-like functionality, may provide anti-aging benefits without irritation for individuals with sensitive skin. ## Methods This 4-week study enrolled 60 female subjects aged 40-65 with Fitzpatrick skin types I-V and sensitive, mild to moderate photodamaged skin. The sensitive skin panel included subjects with eczema/atopic dermatitis, rosacea, or cosmetic intolerance syndrome. Subjects used a nature-based cleanser and moisturizer twice daily, with assessments for transepidermal water loss (TEWL), corneometry, tolerability, and efficacy at baseline, 5-10 minutes post-application, and week 4. ## Results The skin care products were well tolerated and efficacious (P<0.001) in improving visual smoothness, tactile smoothness, clarity, radiance, overall appearance, and global anti-aging, as assessed by investigators. Cheek corneometry measurements showed a statistically significant 16% increase in skin moisture content (P<0.001). ## Conclusion A bakuchiol nature-based anti-aging moisturizer is well tolerated and effective for individuals with sensitive skin. ## Limitations The study duration was 4 weeks, and the participant group was limited to females aged 40-65 with specific sensitive skin conditions and photodamage. ## Verbatim from the abstract > bakuchiol has retinol functionality through retinol-like regulation of gene expression ## Where this study is used on Magellan This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions. | Compound or device | Evidence grade | Graded pages | | --- | --- | --- | | Bakuchiol Retinol-Alternative Cream | Moderate evidence | [Bakuchiol Retinol-Alternative Cream](https://magellanlongevity.com/p/181.md) | ## Reference 1. **Clinical Evaluation of a Nature-Based Bakuchiol Anti-Aging Moisturizer for Sensitive Skin** J Drugs Dermatol 2020 · [PMID 33346506](https://pubmed.ncbi.nlm.nih.gov/33346506/) · [DOI 10.36849/JDD.2020.5522](https://doi.org/10.36849/JDD.2020.5522) > bakuchiol has retinol functionality through retinol-like regulation of gene expression ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/d33346506.html#page","url":"https://magellanlongevity.com/study/d33346506.html","name":"Clinical Evaluation of a Nature-Based Bakuchiol Anti-Aging Moisturizer for Sensitive Skin","description":"A bakuchiol-based moisturizer improved skin moisture and anti-aging signs in people with sensitive skin.","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/d33346506.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"Clinical Evaluation of a Nature-Based Bakuchiol Anti-Aging…","item":"https://magellanlongevity.com/study/d33346506.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/d33346506.html#study","name":"Clinical Evaluation of a Nature-Based Bakuchiol Anti-Aging Moisturizer for Sensitive Skin","headline":"Clinical Evaluation of a Nature-Based Bakuchiol Anti-Aging Moisturizer for Sensitive Skin","datePublished":"2020","isPartOf":{"@type":"Periodical","name":"J Drugs Dermatol"},"identifier":"PMID:33346506","url":"https://pubmed.ncbi.nlm.nih.gov/33346506/","sameAs":"https://doi.org/10.36849/JDD.2020.5522","abstract":"A bakuchiol-based moisturizer improved skin moisture and anti-aging signs in people with sensitive skin."}]} ``` ## Related on Magellan Longevity - [Bakuchiol Retinol-Alternative Cream](https://magellanlongevity.com/p/181.md) — product graded on this and related evidence - [Evidence: retinoid-mimicking gene expression](https://magellanlongevity.com/study/s181.md) - [Efficacy of a Serum Combining Bakuchiol and Vanilla Tahitensis Extract to Prevent Skin…](https://magellanlongevity.com/study/d32494181.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).