--- title: "Elevated serum uric acid and risk of cardiovascular or all-cause…" description: "Higher serum uric acid levels are linked to a lower risk of cardiovascular death in hemodialysis patients." url: "https://magellanlongevity.com/study/d33485730.md" canonical: "https://magellanlongevity.com/study/d33485730.html" html: "https://magellanlongevity.com/study/d33485730.html" type: "study" study_key: "d33485730" journal: "Nutr Metab Cardiovasc Dis" year: 2020 pmid: "33485730" doi: "10.1016/j.numecd.2020.11.017" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # Elevated serum uric acid and risk of cardiovascular or all-cause mortality: a meta-analysis [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Elevated serum uric acid and risk of cardiovascular or… **HTML version:** https://magellanlongevity.com/study/d33485730.html · **In the Magellan app:** https://magellanlongevity.com/#/study/d33485730 ## Citation | Field | Value | | --- | --- | | Journal | Nutr Metab Cardiovasc Dis | | Year | 2020 | | PMID | [33485730](https://pubmed.ncbi.nlm.nih.gov/33485730/) | | DOI | [10.1016/j.numecd.2020.11.017](https://doi.org/10.1016/j.numecd.2020.11.017) | | Study key | d33485730 | ## Takeaway Higher serum uric acid levels are linked to a lower risk of cardiovascular death in hemodialysis patients. ## The question Does elevated serum uric acid (SUA) increase the risk of cardiovascular or all-cause mortality in maintenance hemodialysis patients? ## Hypothesis The meta-analysis aimed to determine if higher SUA values are a risk factor for cardiovascular or all-cause mortality in maintenance hemodialysis patients, given inconsistent results from previous studies. ## Methods A meta-analysis was conducted by searching Pubmed, Embase, and the Cochrane library up to August 31, 2020, for longitudinal studies investigating the association between elevated SUA and cardiovascular or all-cause mortality risk in maintenance hemodialysis patients. Pooled adjusted hazard ratios (HR) and 95% confidence intervals (CI) were calculated using a random-effects model. Ten studies with 264,571 hemodialysis patients were included. ## Results Patients with the highest SUA levels had a decreased risk of cardiovascular mortality (HR = 0.72, 95% CI 0.59-0.87) compared to those with the lowest SUA, after adjusting for confounders. For every 1 mg/dl increase in SUA, the overall risks of all-cause and cardiovascular mortality decreased by 6% (HR = 0.94, 95% CI 0.90-0.99) and 9% (HR = 0.91, 95% CI 0.89-0.94), respectively. ## Conclusion Elevated SUA levels are strongly and independently associated with a lower risk of cardiovascular mortality in maintenance hemodialysis patients. ## Limitations The study suggests that more designed studies, especially randomized controlled trials, are needed to definitively determine if high SUA levels are an independent risk factor for all-cause mortality in hemodialysis patients. ## Verbatim from the abstract > Elevated serum uric acid levels are strongly and independently associated with cardiovascular mortality risk ## Impact of 1 mg/dl Increase in Serum Uric Acid on Mortality Risk | Measure | Percentage Decrease in Risk | | --- | --- | | All-cause mortality risk decrease | 6 | | Cardiovascular mortality risk decrease | 9 | *For each 1 mg/dl increase in serum uric acid, the risk of all-cause mortality decreased by 6% and cardiovascular mortality decreased by 9%.* ## Reference 1. **Elevated serum uric acid and risk of cardiovascular or all-cause mortality: a meta-analysis** Nutr Metab Cardiovasc Dis 2020 · [PMID 33485730](https://pubmed.ncbi.nlm.nih.gov/33485730/) · [DOI 10.1016/j.numecd.2020.11.017](https://doi.org/10.1016/j.numecd.2020.11.017) > Elevated serum uric acid levels are strongly and independently associated with cardiovascular mortality risk ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/d33485730.html#page","url":"https://magellanlongevity.com/study/d33485730.html","name":"Elevated serum uric acid and risk of cardiovascular or all-cause mortality: a meta-analysis","description":"Higher serum uric acid levels are linked to a lower risk of cardiovascular death in hemodialysis patients.","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/d33485730.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"Elevated serum uric acid and risk of cardiovascular or…","item":"https://magellanlongevity.com/study/d33485730.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/d33485730.html#study","name":"Elevated serum uric acid and risk of cardiovascular or all-cause mortality: a meta-analysis","headline":"Elevated serum uric acid and risk of cardiovascular or all-cause mortality: a meta-analysis","datePublished":"2020","isPartOf":{"@type":"Periodical","name":"Nutr Metab Cardiovasc Dis"},"identifier":"PMID:33485730","url":"https://pubmed.ncbi.nlm.nih.gov/33485730/","sameAs":"https://doi.org/10.1016/j.numecd.2020.11.017","abstract":"Higher serum uric acid levels are linked to a lower risk of cardiovascular death in hemodialysis patients."}]} ``` ## Related on Magellan Longevity - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).