--- title: "Olive leaf extract effect on cardiometabolic profile among…" description: "Olive leaf extract may help reduce systolic blood pressure, LDL, and inflammatory markers, but more research is needed to confirm its overall…" url: "https://magellanlongevity.com/study/d33868820.md" canonical: "https://magellanlongevity.com/study/d33868820.html" html: "https://magellanlongevity.com/study/d33868820.html" type: "study" study_key: "d33868820" journal: "PeerJ" year: 2021 pmid: "33868820" doi: "10.7717/peerj.11173" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # Olive leaf extract effect on cardiometabolic profile among adults with prehypertension and hypertension: a meta-analysis [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Olive leaf extract effect on cardiometabolic profile among… **HTML version:** https://magellanlongevity.com/study/d33868820.html · **In the Magellan app:** https://magellanlongevity.com/#/study/d33868820 ## Citation | Field | Value | | --- | --- | | Journal | PeerJ | | Year | 2021 | | PMID | [33868820](https://pubmed.ncbi.nlm.nih.gov/33868820/) | | DOI | [10.7717/peerj.11173](https://doi.org/10.7717/peerj.11173) | | Study key | d33868820 | ## Takeaway Olive leaf extract may help reduce systolic blood pressure, LDL, and inflammatory markers, but more research is needed to confirm its overall cardiometabolic benefits. ## The question What is the effectiveness of olive leaf extract on cardiometabolic profiles among adults with prehypertension and hypertension? ## Hypothesis The study hypothesized that olive leaf extract would improve cardiometabolic profiles in prehypertensive and hypertensive individuals. ## Methods This systematic review and meta-analysis included five randomized clinical trials with 325 patients aged 18-80 years. Data from Cochrane, Medline, Embase, and trial registries were analyzed using random effects models to estimate mean differences and 95% confidence intervals for continuous outcomes. Primary outcomes were changes in systolic and diastolic blood pressure, while secondary outcomes included lipid profile, glucose metabolism, inflammatory markers, and kidney/liver functions. ## Results A daily dose of 500 mg of olive leaf extract significantly reduced systolic BP by -5.78 mmHg over at least 8 weeks compared to placebo, but had no significant effect on diastolic BP. A 1,000 mg daily dose of olive leaf extract versus captopril reduced LDL by -6.00 mg/dl. The 500 mg daily dose also reduced inflammatory markers IL-6 by -6.83 ng/L, IL-8 by -8.24 ng/L, and TNF-alpha by -7.40 ng/L compared to placebo. No significant changes in systolic or diastolic BP were found for 1,000 mg/day of a combined formulation or 1,000 mg/day of olive leaf extract alone versus placebo. ## Conclusion Olive leaf extract may reduce systolic blood pressure, LDL cholesterol, and inflammatory biomarkers. However, the limited number of participants in the included trials prevents a robust conclusion regarding its overall effects on cardiometabolic profiles. ## Limitations The main limitation is the small number of participants across the included trials, which may affect the robustness of the conclusions. ## Verbatim from the abstract > 500 mg olive leaf extract showed a significant reduction in systolic BP ## Impact of Olive Leaf Extract on Key Cardiometabolic Markers | Measure | Mean Difference | | --- | --- | | Systolic BP (500mg OLE vs Placebo) | -5.78 | | LDL (1000mg OLE vs Captopril) | -6 | | IL-6 (500mg OLE vs Placebo) | -6.83 | | IL-8 (500mg OLE vs Placebo) | -8.24 | | TNF-alpha (500mg OLE vs Placebo) | -7.4 | *Mean differences in mmHg for systolic BP and mg/dl or ng/L for other markers, showing reductions with olive leaf extract.* ## Where this study is used on Magellan This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions. | Compound or device | Evidence grade | Graded pages | | --- | --- | --- | | Olive Leaf Extract (Oleuropein) | Moderate evidence | [Olive Leaf Extract (Oleuropein)](https://magellanlongevity.com/p/109.md) | ## Reference 1. **Olive leaf extract effect on cardiometabolic profile among adults with prehypertension and hypertension: a meta-analysis** PeerJ 2021 · [PMID 33868820](https://pubmed.ncbi.nlm.nih.gov/33868820/) · [DOI 10.7717/peerj.11173](https://doi.org/10.7717/peerj.11173) > 500 mg olive leaf extract showed a significant reduction in systolic BP ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/d33868820.html#page","url":"https://magellanlongevity.com/study/d33868820.html","name":"Olive leaf extract effect on cardiometabolic profile among adults with prehypertension and hypertension: a…","description":"Olive leaf extract may help reduce systolic blood pressure, LDL, and inflammatory markers, but more research is needed to confirm its overall…","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/d33868820.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"Olive leaf extract effect on cardiometabolic profile among…","item":"https://magellanlongevity.com/study/d33868820.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/d33868820.html#study","name":"Olive leaf extract effect on cardiometabolic profile among adults with prehypertension and hypertension: a meta-analysis","headline":"Olive leaf extract effect on cardiometabolic profile among adults with prehypertension and hypertension: a…","datePublished":"2021","isPartOf":{"@type":"Periodical","name":"PeerJ"},"identifier":"PMID:33868820","url":"https://pubmed.ncbi.nlm.nih.gov/33868820/","sameAs":"https://doi.org/10.7717/peerj.11173","abstract":"Olive leaf extract may help reduce systolic blood pressure, LDL, and inflammatory markers, but more research is needed to confirm its overall cardiometabolic benefits."}]} ``` ## Related on Magellan Longevity - [Olive Leaf Extract (Oleuropein)](https://magellanlongevity.com/p/109.md) — product graded on this and related evidence - [Evidence: oleuropein lowers BP and LDL](https://magellanlongevity.com/study/s109.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).