--- title: "Disinfection By-Products in Drinking Water and Bladder Cancer" description: "Exposure to disinfection by-products in drinking water may interact with a specific genetic variant to increase bladder cancer risk." url: "https://magellanlongevity.com/study/d35536285.md" canonical: "https://magellanlongevity.com/study/d35536285.html" html: "https://magellanlongevity.com/study/d35536285.html" type: "study" study_key: "d35536285" journal: "Environ Health Perspect" year: 2022 pmid: "35536285" doi: "10.1289/EHP9895" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # Disinfection By-Products in Drinking Water and Bladder Cancer [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Disinfection By-Products in Drinking Water and Bladder… **HTML version:** https://magellanlongevity.com/study/d35536285.html · **In the Magellan app:** https://magellanlongevity.com/#/study/d35536285 ## Citation | Field | Value | | --- | --- | | Journal | Environ Health Perspect | | Year | 2022 | | PMID | [35536285](https://pubmed.ncbi.nlm.nih.gov/35536285/) | | DOI | [10.1289/EHP9895](https://doi.org/10.1289/EHP9895) | | Study key | d35536285 | ## Takeaway Exposure to disinfection by-products in drinking water may interact with a specific genetic variant to increase bladder cancer risk. ## The question Do total trihalomethanes (TTHMs) in drinking water interact with bladder cancer susceptibility genes to increase bladder cancer risk? ## Hypothesis The study hypothesized that there would be a combined effect on bladder cancer risk from TTHMs and bladder cancer susceptibility variants. ## Methods The study analyzed data from two case-control studies: the New England Bladder Cancer Study (1,162 controls) and the Spanish Bladder Cancer Study (772 controls). Adjusted logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CI) for TTHMs and genetic variants, with and without interaction terms. Results from both studies were then combined using meta-analysis. ## Results Of 16 loci, rs907611 at 11p15.5 showed the strongest association in the highest TTHM exposure category in both studies and in meta-analysis. For individuals with the rs907611-GG genotype in the highest exposure category, an odds ratio of 1.66 (95% CI: 1.17, 2.34) was observed. No other genetic variants showed consistent evidence of interaction. ## Conclusion The study found novel suggestive evidence for a multiplicative interaction between TTHMs and the rs907611-GG genotype, increasing bladder cancer risk. ## Limitations The study notes that further work is needed to replicate and extend this finding and to understand potential molecular mechanisms. ## Verbatim from the abstract > trihalomethanes, the most common class of disinfection by-products, have been linked to bladder cancer ## Where this study is used on Magellan This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions. | Compound or device | Evidence grade | Graded pages | | --- | --- | --- | | Water Purification (Reverse Osmosis & Ultrafiltration) | Emerging evidence | [SimPure Reverse Osmosis System](https://magellanlongevity.com/p/42.md), [Waterdrop Undersink Reverse Osmosis](https://magellanlongevity.com/p/44.md) | | Shower Dechlorination Filter | Emerging evidence | [Shower Dechlorination Filter](https://magellanlongevity.com/p/190.md) | ## Reference 1. **Disinfection By-Products in Drinking Water and Bladder Cancer** Environ Health Perspect 2022 · [PMID 35536285](https://pubmed.ncbi.nlm.nih.gov/35536285/) · [DOI 10.1289/EHP9895](https://doi.org/10.1289/EHP9895) > trihalomethanes, the most common class of disinfection by-products, have been linked to bladder cancer ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/d35536285.html#page","url":"https://magellanlongevity.com/study/d35536285.html","name":"Disinfection By-Products in Drinking Water and Bladder Cancer","description":"Exposure to disinfection by-products in drinking water may interact with a specific genetic variant to increase bladder cancer risk.","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/d35536285.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"Disinfection By-Products in Drinking Water and Bladder…","item":"https://magellanlongevity.com/study/d35536285.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/d35536285.html#study","name":"Disinfection By-Products in Drinking Water and Bladder Cancer","headline":"Disinfection By-Products in Drinking Water and Bladder Cancer","datePublished":"2022","isPartOf":{"@type":"Periodical","name":"Environ Health Perspect"},"identifier":"PMID:35536285","url":"https://pubmed.ncbi.nlm.nih.gov/35536285/","sameAs":"https://doi.org/10.1289/EHP9895","abstract":"Exposure to disinfection by-products in drinking water may interact with a specific genetic variant to increase bladder cancer risk."}]} ``` ## Related on Magellan Longevity - [Shower Dechlorination Filter](https://magellanlongevity.com/p/190.md) — product graded on this and related evidence - [SimPure Reverse Osmosis System](https://magellanlongevity.com/p/42.md) — product graded on this and related evidence - [Waterdrop Undersink Reverse Osmosis](https://magellanlongevity.com/p/44.md) — product graded on this and related evidence - [Prevalence of exposure of heavy metals and their impact on health consequences.](https://magellanlongevity.com/study/water_metals.md) - [Drinking water source and exposure to regulated water contaminants in the California…](https://magellanlongevity.com/study/x18.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).