--- title: "Device and nondevice-guided slow breathing to reduce blood…" description: "Device-guided slow breathing did not significantly lower blood pressure in hypertensive patients compared to usual care." url: "https://magellanlongevity.com/study/d35601033.md" canonical: "https://magellanlongevity.com/study/d35601033.html" html: "https://magellanlongevity.com/study/d35601033.html" type: "study" study_key: "d35601033" journal: "Health Sci Rep" year: 2022 pmid: "35601033" doi: "10.1002/hsr2.636" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # Device and nondevice-guided slow breathing to reduce blood pressure in hypertensive patients: a meta-analysis [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Device and nondevice-guided slow breathing to reduce blood… **HTML version:** https://magellanlongevity.com/study/d35601033.html · **In the Magellan app:** https://magellanlongevity.com/#/study/d35601033 ## Citation | Field | Value | | --- | --- | | Journal | Health Sci Rep | | Year | 2022 | | PMID | [35601033](https://pubmed.ncbi.nlm.nih.gov/35601033/) | | DOI | [10.1002/hsr2.636](https://doi.org/10.1002/hsr2.636) | | Study key | d35601033 | ## Takeaway Device-guided slow breathing did not significantly lower blood pressure in hypertensive patients compared to usual care. ## The question What are the effects of device-guided slow breathing (DGSB) and nondevice-guided slow breathing (NDGSB) on blood pressure levels in patients with hypertension? ## Hypothesis The study aims to summarize the effects of DGSB and NDGSB on blood pressure levels, implying an investigation into whether these methods reduce blood pressure. ## Methods This systematic review and meta-analysis included randomized clinical trials involving hypertensive patients over 18 years old, of both sexes, with or without comorbidity or hypertensive medication. Studies compared groups performing DGSB and/or NDGSB with control conditions. The primary outcomes were systolic blood pressure (SBP) and diastolic blood pressure (DBP) values after interventions. A random effect model was used for quantitative analysis. ## Results Twenty-two studies with 17,214 participants were included. DGSB did not significantly reduce SBP or DBP compared to usual care. For SBP, the mean difference was -2.13 mmHg (288 individuals), and for DBP, it was -0.90 mmHg (288 individuals). SBP variations showed a mean difference of -2.42 (443 individuals), and DBP variations showed a mean difference of -1.67 (443 individuals). Considerable heterogeneity was observed across studies. ## Conclusion Device-guided slow breathing (DGSB) did not reduce blood pressure in hypertensive patients. Nondevice-guided slow breathing (NDGSB) is suggested as a potential future research direction. ## Limitations The abstract indicates considerable heterogeneity between the included studies, which may impact the generalizability of the findings. ## Verbatim from the abstract > effects of device-guided slow breathing on blood pressure of patients with hypertension ## Mean Difference in Blood Pressure Reduction with Device-Guided Slow Breathing vs. Usual Care | Measure | Mean Difference (mmHg) | | --- | --- | | SBP (mmHg) | -2.13 | | DBP (mmHg) | -0.9 | | SBP Variation (mmHg) | -2.42 | | DBP Variation (mmHg) | -1.67 | *Mean differences in SBP and DBP, and their variations, when comparing device-guided slow breathing to usual care. Negative values indicate a reduction.* ## Where this study is used on Magellan This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions. | Compound or device | Evidence grade | Graded pages | | --- | --- | --- | | Slow-Breathing Pacer Device | — | — | ## Reference 1. **Device and nondevice-guided slow breathing to reduce blood pressure in hypertensive patients: a meta-analysis** Health Sci Rep 2022 · [PMID 35601033](https://pubmed.ncbi.nlm.nih.gov/35601033/) · [DOI 10.1002/hsr2.636](https://doi.org/10.1002/hsr2.636) > effects of device-guided slow breathing on blood pressure of patients with hypertension ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/d35601033.html#page","url":"https://magellanlongevity.com/study/d35601033.html","name":"Device and nondevice-guided slow breathing to reduce blood pressure in hypertensive patients: a meta-analysis","description":"Device-guided slow breathing did not significantly lower blood pressure in hypertensive patients compared to usual care.","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/d35601033.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"Device and nondevice-guided slow breathing to reduce blood…","item":"https://magellanlongevity.com/study/d35601033.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/d35601033.html#study","name":"Device and nondevice-guided slow breathing to reduce blood pressure in hypertensive patients: a meta-analysis","headline":"Device and nondevice-guided slow breathing to reduce blood pressure in hypertensive patients: a meta-analysis","datePublished":"2022","isPartOf":{"@type":"Periodical","name":"Health Sci Rep"},"identifier":"PMID:35601033","url":"https://pubmed.ncbi.nlm.nih.gov/35601033/","sameAs":"https://doi.org/10.1002/hsr2.636","abstract":"Device-guided slow breathing did not significantly lower blood pressure in hypertensive patients compared to usual care."}]} ``` ## Related on Magellan Longevity - [Evidence: device-guided paced breathing](https://magellanlongevity.com/study/s166.md) - [Device-guided slow breathing reduces blood pressure and sympathetic activity in young…](https://magellanlongevity.com/study/d31436511.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).