---
title: "Thresholds of handgrip strength for all-cause, cancer, and…"
description: "Lower handgrip strength is linked to increased mortality risk, with the specific dose-response varying by cause of death."
url: "https://magellanlongevity.com/study/d36332759.md"
canonical: "https://magellanlongevity.com/study/d36332759.html"
html: "https://magellanlongevity.com/study/d36332759.html"
type: "study"
study_key: "d36332759"
journal: "Ageing Res Rev"
year: 2022
pmid: "36332759"
doi: "10.1016/j.arr.2022.101778"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Thresholds of handgrip strength for all-cause, cancer, and cardiovascular mortality: a meta-analysis

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## Citation

| Field | Value |
| --- | --- |
| Journal | Ageing Res Rev |
| Year | 2022 |
| PMID | [36332759](https://pubmed.ncbi.nlm.nih.gov/36332759/) |
| DOI | [10.1016/j.arr.2022.101778](https://doi.org/10.1016/j.arr.2022.101778) |
| Study key | d36332759 |

## Takeaway

Lower handgrip strength is linked to increased mortality risk, with the specific dose-response varying by cause of death.

## The question

Is the association between handgrip strength and all-cause, cancer, and cardiovascular mortality dose-dependent?

## Hypothesis

The study aimed to investigate the dose-response relationship of handgrip strength with all-cause, cancer, and cardiovascular mortality.

## Methods

A systematic review and meta-analysis were conducted using data from PubMed/MEDLINE, Web of Science, and Scopus up to February 8, 2022. Prospective cohort studies of healthy adults with objective handgrip strength measures were included. A random forest model and a two-stage random-effects hierarchical meta-regression model were used to analyze the dose-response relationship for all-cause, cancer, and cardiovascular mortality.

## Results

Forty-eight studies with 3,135,473 participants (49.6% women, aged 35-85 years) were included. Random forest models indicated a significant inverse association between handgrip strength and all-cause and cause-specific mortality. Dose-response meta-analyses showed that higher handgrip strength significantly reduced all-cause mortality risk within 26-50 kg in a close-to-linear inverse fashion. Cancer mortality showed a U-shaped association with significant risk reduction between 16 and 33 kg, while cardiovascular mortality displayed a close-to-linear inverse shape with significant risk reduction ranging from 24 to 40 kg.

## Conclusion

There is strong evidence that lower handgrip strength is associated with higher all-cause, cancer, and cardiovascular mortality risk. The dose-response relationship of handgrip strength varies substantially depending on the cause of mortality.

## Limitations

The abstract does not explicitly state limitations of the study.

## Verbatim from the abstract

> lower handgrip strength associated with higher all-cause, cancer, and cardiovascular mortality risk

## Handgrip Strength Ranges for Significant Mortality Risk Reduction

| Measure | Handgrip Strength (kg) |
| --- | --- |
| All-cause mortality | 38 |
| Cancer mortality | 24.5 |
| Cardiovascular mortality | 32 |

*The midpoint of the handgrip strength range associated with significant risk reduction for different mortality causes.*

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| Grip-Strength Dynamometer | Measurement tool | [Grip-Strength Dynamometer](https://magellanlongevity.com/p/153.md) |
| Hand Grip Dynamometer Pro | Strong evidence | [Hand Grip Dynamometer Pro](https://magellanlongevity.com/p/162.md) |

## Reference

1. **Thresholds of handgrip strength for all-cause, cancer, and cardiovascular mortality: a meta-analysis**
   Ageing Res Rev 2022 · [PMID 36332759](https://pubmed.ncbi.nlm.nih.gov/36332759/) · [DOI 10.1016/j.arr.2022.101778](https://doi.org/10.1016/j.arr.2022.101778)

   > lower handgrip strength associated with higher all-cause, cancer, and cardiovascular mortality risk

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## Related on Magellan Longevity

- [Grip-Strength Dynamometer](https://magellanlongevity.com/p/153.md) — product graded on this and related evidence
- [Hand Grip Dynamometer Pro](https://magellanlongevity.com/p/162.md) — product graded on this and related evidence
- [Evidence: Handgrip strength (muscle strength)](https://magellanlongevity.com/study/s153.md)
- [Association of Muscle Strength With All-Cause Mortality in the Oldest Old: a 28-country…](https://magellanlongevity.com/study/d39439054.md)
- [Evidence: quantifies handgrip-force biomarker](https://magellanlongevity.com/study/s162.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).