---
title: "NT-proBNP and mortality across the spectrum of glucose tolerance…"
description: "Higher NT-ProBNP levels are independently linked to increased risk of death from any cause and cardiovascular disease, regardless of blood sugar levels."
url: "https://magellanlongevity.com/study/d36344968.md"
canonical: "https://magellanlongevity.com/study/d36344968.html"
html: "https://magellanlongevity.com/study/d36344968.html"
type: "study"
study_key: "d36344968"
journal: "Cardiovasc Diabetol"
year: 2022
pmid: "36344968"
doi: "10.1186/s12933-022-01671-w"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# NT-proBNP and mortality across the spectrum of glucose tolerance in the general US population

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## Citation

| Field | Value |
| --- | --- |
| Journal | Cardiovasc Diabetol |
| Year | 2022 |
| PMID | [36344968](https://pubmed.ncbi.nlm.nih.gov/36344968/) |
| DOI | [10.1186/s12933-022-01671-w](https://doi.org/10.1186/s12933-022-01671-w) |
| Study key | d36344968 |

## Takeaway

Higher NT-ProBNP levels are independently linked to increased risk of death from any cause and cardiovascular disease, regardless of blood sugar levels.

## The question

Can N-terminal pro-B natriuretic peptide (NT-ProBNP) levels identify individuals at higher cardiovascular risk, independent of their blood glucose levels?

## Hypothesis

The study aims to evaluate if NT-ProBNP can help identify subjects at higher cardiovascular risk, independently of blood glucose levels.

## Methods

Serum NT-ProBNP levels were measured in 5502 participants aged 45-79 years without heart failure from the 1999-2004 National Health and Nutrition Examination Survey. Participants included 3380 with normoglycemia, 1125 with pre-diabetes, and 997 with diabetes. Cox and Fine Gray models, adjusted for cardiovascular risk factors, were used to assess the association between NT-ProBNP levels and all-cause and cardiovascular mortality through December 2015.

## Results

After a median follow-up of 13 years, 1509 participants died, with 330 deaths due to cardiovascular causes. Compared to participants with NT-ProBNP =" 300 pg/ml had an even higher incidence of all-cause mortality (HR 2.96) and cardiovascular mortality (HR 2.08). This association remained consistent across subgroups based on glycemic status, obesity, age, and sex.

## Conclusion

Elevated NT-ProBNP is independently associated with all-cause and cardiovascular mortality in the general population and may help identify patients at the highest risk.

## Limitations

The study design does not evaluate whether intensification of treatment based on biomarker data might lead to improvements in cardiovascular risk reduction.

## Verbatim from the abstract

> Elevated NT-proBNP is independently associated with all-cause and cardiovascular mortality

## Risk of Mortality by NT-ProBNP Levels

| Measure | Hazard Ratio |
| --- | --- |
| All-cause mortality (100-300 pg/ml) | 1.61 |
| All-cause mortality (">=" 300 pg/ml) | 2.96 |
| Cardiovascular mortality (100-300 pg/ml) | 1.57 |
| Cardiovascular mortality (">=" 300 pg/ml) | 2.08 |

*Hazard Ratios for all-cause and cardiovascular mortality compared to participants with NT-ProBNP < 100 pg/ml.*

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| NT-proBNP Cardiac Test | — | — |

## Reference

1. **NT-proBNP and mortality across the spectrum of glucose tolerance in the general US population**
   Cardiovasc Diabetol 2022 · [PMID 36344968](https://pubmed.ncbi.nlm.nih.gov/36344968/) · [DOI 10.1186/s12933-022-01671-w](https://doi.org/10.1186/s12933-022-01671-w)

   > Elevated NT-proBNP is independently associated with all-cause and cardiovascular mortality

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## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).