---
title: "Profiling Inflammatory Biomarkers following Curcumin…"
description: "Curcumin supplementation significantly reduces key inflammatory biomarkers like CRP, IL-6, and TNF-."
url: "https://magellanlongevity.com/study/d36700039.md"
canonical: "https://magellanlongevity.com/study/d36700039.html"
html: "https://magellanlongevity.com/study/d36700039.html"
type: "study"
study_key: "d36700039"
journal: "Evid Based Complement Alternat Med"
year: 2023
pmid: "36700039"
doi: "10.1155/2023/4875636"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Profiling Inflammatory Biomarkers following Curcumin Supplementation: An Umbrella Meta-Analysis of Randomized Clinical Trials

[Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Profiling Inflammatory Biomarkers following Curcumin…

**HTML version:** https://magellanlongevity.com/study/d36700039.html · **In the Magellan app:** https://magellanlongevity.com/#/study/d36700039

## Citation

| Field | Value |
| --- | --- |
| Journal | Evid Based Complement Alternat Med |
| Year | 2023 |
| PMID | [36700039](https://pubmed.ncbi.nlm.nih.gov/36700039/) |
| DOI | [10.1155/2023/4875636](https://doi.org/10.1155/2023/4875636) |
| Study key | d36700039 |

## Takeaway

Curcumin supplementation significantly reduces key inflammatory biomarkers like CRP, IL-6, and TNF-.

## The question

What is the overall effect of curcumin supplementation on inflammatory biomarkers?

## Hypothesis

Curcumin supplementation will reduce inflammatory biomarkers, despite inconsistencies in previous meta-analyses.

## Methods

This umbrella meta-analysis systematically searched PubMed, Scopus, Embase, Web of Science, and Google Scholar until March 20, 2022. It included meta-analysis studies on curcumin's effects on inflammatory biomarkers with corresponding effect sizes and confidence intervals. A random-effects model was used, and the GRADE system evaluated evidence certainty.

## Results

A meta-analysis of ten studies with 5,870 participants showed significant decreases in C-reactive protein (CRP) (ES = -0.74), interleukin 6 (IL-6) (ES = -1.07), and tumour necrosis factor (TNF-) levels (ES = -1.92) after curcumin supplementation. Greater effects on CRP and TNF- were observed in trials with a mean age >45 years and a sample size >300 participants.

## Conclusion

Curcumin is a promising agent for reducing inflammation and may serve as an adjunctive therapeutic approach for diseases linked to elevated inflammatory biomarkers.

## Limitations

The abstract does not explicitly state limitations of the umbrella meta-analysis itself, beyond acknowledging previous inconsistencies in findings.

## Verbatim from the abstract

> significant decrease in CRP, interleukin 6, and tumour necrosis factor following curcumin supplementation

## Effect Sizes of Curcumin on Inflammatory Biomarkers

| Measure | Effect Size (ES) |
| --- | --- |
| C-reactive protein (CRP) | -0.74 |
| Interleukin 6 (IL-6) | -1.07 |
| Tumour necrosis factor (TNF-) | -1.92 |

*Effect sizes (ES) represent the magnitude of reduction in inflammatory biomarkers following curcumin supplementation.*

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| High-Bioavailability Curcumin | Moderate evidence | [High-Bioavailability Curcumin](https://magellanlongevity.com/p/104.md) |

## Reference

1. **Profiling Inflammatory Biomarkers following Curcumin Supplementation: An Umbrella Meta-Analysis of Randomized Clinical Trials**
   Evid Based Complement Alternat Med 2023 · [PMID 36700039](https://pubmed.ncbi.nlm.nih.gov/36700039/) · [DOI 10.1155/2023/4875636](https://doi.org/10.1155/2023/4875636)

   > significant decrease in CRP, interleukin 6, and tumour necrosis factor following curcumin supplementation

## Structured data

```json
{"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/d36700039.html#page","url":"https://magellanlongevity.com/study/d36700039.html","name":"Profiling Inflammatory Biomarkers following Curcumin Supplementation: An Umbrella Meta-Analysis of…","description":"Curcumin supplementation significantly reduces key inflammatory biomarkers like CRP, IL-6, and TNF-.","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/d36700039.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"Profiling Inflammatory Biomarkers following Curcumin…","item":"https://magellanlongevity.com/study/d36700039.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/d36700039.html#study","name":"Profiling Inflammatory Biomarkers following Curcumin Supplementation: An Umbrella Meta-Analysis of Randomized Clinical Trials","headline":"Profiling Inflammatory Biomarkers following Curcumin Supplementation: An Umbrella Meta-Analysis of…","datePublished":"2023","isPartOf":{"@type":"Periodical","name":"Evid Based Complement Alternat Med"},"identifier":"PMID:36700039","url":"https://pubmed.ncbi.nlm.nih.gov/36700039/","sameAs":"https://doi.org/10.1155/2023/4875636","abstract":"Curcumin supplementation significantly reduces key inflammatory biomarkers like CRP, IL-6, and TNF-."}]}
```

## Related on Magellan Longevity

- [High-Bioavailability Curcumin](https://magellanlongevity.com/p/104.md) — product graded on this and related evidence
- [Evidence: lowers CRP, IL-6, TNF-alpha](https://magellanlongevity.com/study/s104.md)
- [Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in…](https://magellanlongevity.com/study/d36804260.md)
- [Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis](https://magellanlongevity.com/study/boswellia_oa.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).