---
title: "Antioxidant and anti-inflammatory effects of curcumin/turmeric…"
description: "Turmeric/curcumin supplementation can reduce inflammation and improve antioxidant status in adults."
url: "https://magellanlongevity.com/study/d36804260.md"
canonical: "https://magellanlongevity.com/study/d36804260.html"
html: "https://magellanlongevity.com/study/d36804260.html"
type: "study"
study_key: "d36804260"
journal: "Cytokine"
year: 2023
pmid: "36804260"
doi: "10.1016/j.cyto.2023.156144"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults: a meta-analysis of randomized controlled trials

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## Citation

| Field | Value |
| --- | --- |
| Journal | Cytokine |
| Year | 2023 |
| PMID | [36804260](https://pubmed.ncbi.nlm.nih.gov/36804260/) |
| DOI | [10.1016/j.cyto.2023.156144](https://doi.org/10.1016/j.cyto.2023.156144) |
| Study key | d36804260 |

## Takeaway

Turmeric/curcumin supplementation can reduce inflammation and improve antioxidant status in adults.

## The question

Does turmeric/curcumin supplementation impact inflammatory and oxidative balance in adults?

## Hypothesis

Turmeric and its bioactive compound, curcumin, may affect inflammatory and oxidative balance in the body.

## Methods

This systematic review and meta-analysis searched major databases (PubMed, Scopus, Web of Science, Cochrane Library, Google Scholar) up to October 2022 for randomized controlled trials (RCTs). The main outcomes included inflammatory markers (CRP, TNF-α, IL-6, IL-1β) and oxidative stress markers (TAC, MDA, SOD activity). Weighted mean differences (WMDs) were reported, with p-values < 0.05 considered significant. Sixty-six RCTs were included in the final analysis.

## Results

Turmeric/curcumin supplementation significantly reduced CRP (WMD: -0.58 mg/l), TNF-α (WMD: -3.48 pg/ml), and IL-6 (WMD: -1.31 pg/ml). No significant change was found for IL-1β (WMD: -0.46 pg/ml). Supplementation also significantly enhanced TAC (WMD = 0.21 mmol/l), reduced MDA levels (WMD = -0.33 µmol/l), and increased SOD activity (WMD = 20.51 u/l).

## Conclusion

Turmeric/curcumin supplementation significantly reduces several inflammatory markers and improves antioxidant activity.

## Limitations

The abstract does not explicitly state any limitations of the study.

## Verbatim from the abstract

> curcumin/turmeric supplementation significantly reduces CRP, TNF-alpha, and IL-6

## Impact of Turmeric/Curcumin on Inflammatory Markers

| Measure | WMD |
| --- | --- |
| CRP | -0.58 |
| TNF-α | -3.48 |
| IL-6 | -1.31 |
| IL-1β | -0.46 |

*Weighted mean differences (WMD) for inflammatory markers after turmeric/curcumin supplementation. Negative values indicate a reduction.*

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| High-Bioavailability Curcumin | Moderate evidence | [High-Bioavailability Curcumin](https://magellanlongevity.com/p/104.md) |

## Reference

1. **Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults: a meta-analysis of randomized controlled trials**
   Cytokine 2023 · [PMID 36804260](https://pubmed.ncbi.nlm.nih.gov/36804260/) · [DOI 10.1016/j.cyto.2023.156144](https://doi.org/10.1016/j.cyto.2023.156144)

   > curcumin/turmeric supplementation significantly reduces CRP, TNF-alpha, and IL-6

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## Related on Magellan Longevity

- [High-Bioavailability Curcumin](https://magellanlongevity.com/p/104.md) — product graded on this and related evidence
- [Evidence: lowers CRP, IL-6, TNF-alpha](https://magellanlongevity.com/study/s104.md)
- [Profiling Inflammatory Biomarkers following Curcumin Supplementation: An Umbrella…](https://magellanlongevity.com/study/d36700039.md)
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- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).