---
title: "Resistance training and creatine supplementation on oxidative…"
description: "Resistance training improves antioxidant defense, muscle strength, and quality of life in older adults, and creatine supplementation further enhances…"
url: "https://magellanlongevity.com/study/d37206869.md"
canonical: "https://magellanlongevity.com/study/d37206869.html"
html: "https://magellanlongevity.com/study/d37206869.html"
type: "study"
study_key: "d37206869"
journal: "Front Public Health"
year: 2023
pmid: "37206869"
doi: "10.3389/fpubh.2023.1062832"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Resistance training and creatine supplementation on oxidative stress, muscle strength and quality of life in older adults

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## Citation

| Field | Value |
| --- | --- |
| Journal | Front Public Health |
| Year | 2023 |
| PMID | [37206869](https://pubmed.ncbi.nlm.nih.gov/37206869/) |
| DOI | [10.3389/fpubh.2023.1062832](https://doi.org/10.3389/fpubh.2023.1062832) |
| Study key | d37206869 |

## Takeaway

Resistance training improves antioxidant defense, muscle strength, and quality of life in older adults, and creatine supplementation further enhances muscle strength gains.

## The question

What is the effect of resistance training (RT) with creatine monohydrate supplementation (CS) on oxidative stress markers (8-OHdG, MDA, GPX, TAC), muscle strength, and quality of life in older adults?

## Hypothesis

The study hypothesized that RT with CS would improve oxidative stress markers, muscle strength, and quality of life in older adults.

## Methods

Forty-five non-athlete older men and women (mean age 68.1 ± 7.2 years) were randomly assigned to three groups: RT with creatine supplementation (RT + CS), RT with placebo (RT + P), and a control group. The RT protocol involved three sessions per week for 10 weeks. The RT + CS group received 0.1 g/kg body weight of creatine daily, while the RT + P group received an equivalent amount of starch. Fasting blood samples were collected before and after the 10-week intervention to measure oxidative stress markers. Muscle strength and quality of life were also assessed.

## Results

After 10 weeks, both training groups (RT + CS and RT + P) showed a significant decrease in MDA and 8-OHDG, and a significant increase in GPX and TAC (p = 0.001 for all). Creatinine levels increased in the RT + CS group (p = 0.014). Quality of life and muscle strength improved in both experimental groups (p = 0.001), with muscle strength changes being more pronounced in the RT + CS group compared to the RT + P group (p < 0.05).

## Conclusion

Regular resistance training is a suitable non-pharmacological method to enhance the antioxidant system, muscle strength, and quality of life in older adults. While the role of creatine on the antioxidant system and quality of life in older adults is not definitively established, creatine supplementation alongside RT can significantly increase muscle strength gains.

## Limitations

The study noted that there are no definite findings on the specific role of creatine on the antioxidant system and quality of life in older adults based on this research.

## Verbatim from the abstract

> muscle strength changes were more visible in the resistance training plus creatine group

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| Creatine Monohydrate | Strong evidence | [Creatine Monohydrate](https://magellanlongevity.com/p/123.md) |

## Reference

1. **Resistance training and creatine supplementation on oxidative stress, muscle strength and quality of life in older adults**
   Front Public Health 2023 · [PMID 37206869](https://pubmed.ncbi.nlm.nih.gov/37206869/) · [DOI 10.3389/fpubh.2023.1062832](https://doi.org/10.3389/fpubh.2023.1062832)

   > muscle strength changes were more visible in the resistance training plus creatine group

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## Related on Magellan Longevity

- [Creatine Monohydrate](https://magellanlongevity.com/p/123.md) — product graded on this and related evidence
- [Evidence: ATP/phosphocreatine energy buffer](https://magellanlongevity.com/study/s123.md)
- [The Additive Effects of Creatine Supplementation and Exercise Training in an Aging…](https://magellanlongevity.com/study/d30762623.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).