---
title: "A randomized controlled trial comparing myoinositol with…"
description: "Adding myoinositol to metformin improves menstrual regularity and quality of life in women with PCOS more than metformin alone, but other hormonal and…"
url: "https://magellanlongevity.com/study/d37265016.md"
canonical: "https://magellanlongevity.com/study/d37265016.html"
html: "https://magellanlongevity.com/study/d37265016.html"
type: "study"
study_key: "d37265016"
journal: "Clin Endocrinol (Oxf)"
year: 2023
pmid: "37265016"
doi: "10.1111/cen.14931"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# A randomized controlled trial comparing myoinositol with metformin versus metformin monotherapy in PCOS

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## Citation

| Field | Value |
| --- | --- |
| Journal | Clin Endocrinol (Oxf) |
| Year | 2023 |
| PMID | [37265016](https://pubmed.ncbi.nlm.nih.gov/37265016/) |
| DOI | [10.1111/cen.14931](https://doi.org/10.1111/cen.14931) |
| Study key | d37265016 |

## Takeaway

Adding myoinositol to metformin improves menstrual regularity and quality of life in women with PCOS more than metformin alone, but other hormonal and metabolic markers are not significantly different.

## The question

Does a combination of metformin with myoinositol and d-chiro-inositol offer superior benefits compared to metformin monotherapy in women with PCOS?

## Hypothesis

The study implicitly hypothesizes that the combination therapy will exert more beneficial effects in PCOS due to the insulin-sensitizing properties of myoinositol and d-chiro-inositol.

## Methods

This was a 6-month randomized controlled trial involving overweight and obese women with PCOS aged 18-35. Participants were randomized into two groups: 27 received metformin monotherapy, and 26 received metformin with myoinositol and d-chiro-inositol. Various parameters including menstrual cycle duration, anthropometric measures, hormonal profiles, metabolic markers, and quality of life scores were assessed at baseline and after 6 months.

## Results

Menstrual cycle regularity improved in both groups, with significantly greater improvement in the myoinositol combination group (p < .001). The PCOS Questionnaire (PCOSQ) score also showed significant improvement in the myoinositol-based therapy group (p < .001). Pregnancy rates were similar between both groups, and no statistically significant differences were observed in other hormonal or metabolic parameters.

## Conclusion

Adding myoinositol to metformin provides additional benefits in improving menstrual cycle regularity and quality of life for women with PCOS.

## Limitations

The abstract does not explicitly state limitations of the study.

## Verbatim from the abstract

> myoinositol acts as an insulin sensitizer and exerts beneficial effects in PCOS

## Improvement in Menstrual Cycle Regularity and PCOSQ Score

| Measure | Significant Improvement (1=Yes) |
| --- | --- |
| Menstrual Cycle Regularity (Myoinositol group) | 1 |
| PCOSQ Score (Myoinositol group) | 1 |

*The chart illustrates that the myoinositol combination group showed significant improvement in menstrual cycle regularity and PCOSQ score compared to the metformin monotherapy group. A value of 1 indicates significant improvement (p < .001).*

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| Myo-Inositol | Moderate evidence | [Myo-Inositol](https://magellanlongevity.com/p/131.md) |

## Reference

1. **A randomized controlled trial comparing myoinositol with metformin versus metformin monotherapy in PCOS**
   Clin Endocrinol (Oxf) 2023 · [PMID 37265016](https://pubmed.ncbi.nlm.nih.gov/37265016/) · [DOI 10.1111/cen.14931](https://doi.org/10.1111/cen.14931)

   > myoinositol acts as an insulin sensitizer and exerts beneficial effects in PCOS

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## Related on Magellan Longevity

- [Myo-Inositol](https://magellanlongevity.com/p/131.md) — product graded on this and related evidence
- [Evidence: insulin second-messenger](https://magellanlongevity.com/study/s131.md)
- [Comparison of two insulin sensitizers, metformin and myo-inositol, in women with PCOS](https://magellanlongevity.com/study/d27808588.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).