---
title: "Effects of high intensity inspiratory muscle training in…"
description: "High intensity inspiratory muscle training improves multiple health markers in patients with heart failure and reduced ejection fraction."
url: "https://magellanlongevity.com/study/d37285766.md"
canonical: "https://magellanlongevity.com/study/d37285766.html"
html: "https://magellanlongevity.com/study/d37285766.html"
type: "study"
study_key: "d37285766"
journal: "Heart Lung"
year: 2023
pmid: "37285766"
doi: "10.1016/j.hrtlng.2023.05.011"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Effects of high intensity inspiratory muscle training in patients with heart failure: a randomized controlled trial

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## Citation

| Field | Value |
| --- | --- |
| Journal | Heart Lung |
| Year | 2023 |
| PMID | [37285766](https://pubmed.ncbi.nlm.nih.gov/37285766/) |
| DOI | [10.1016/j.hrtlng.2023.05.011](https://doi.org/10.1016/j.hrtlng.2023.05.011) |
| Study key | d37285766 |

## Takeaway

High intensity inspiratory muscle training improves multiple health markers in patients with heart failure and reduced ejection fraction.

## The question

What are the effects of high intensity interval-based inspiratory muscle training (H-IMT) on cardiovascular, pulmonary, physical, and psychosocial functions in patients with heart failure and reduced ejection fraction (HFrEF)?

## Hypothesis

The study hypothesized that determining the most appropriate IMT protocol, specifically high intensity interval-based inspiratory muscle training, would optimize training benefits in patients with heart failure.

## Methods

Thirty-four HFrEF patients were randomized to either an H-IMT group or a control group for 8 weeks, 3 days/week. The H-IMT group trained at 70% of maximal inspiratory pressure, while the control group performed unloaded IMT. Each session involved 7 sets of 2-min training and 1-min interval, totaling 21 minutes. Various cardiovascular, pulmonary, physical, and psychosocial functions were assessed at baseline and after 8 weeks by blinded assessors.

## Results

Statistically significant between-group differences favoring the H-IMT group were observed in time domain parameters of heart rate variability, arterial stiffness, inspiratory and quadriceps muscle strength, respiratory muscle endurance, diaphragm thickness, functional capacity, frailty, dyspnea, fatigue, and disease-specific health-related quality of life.

## Conclusion

High intensity interval-based inspiratory muscle training (H-IMT) is an effective protocol for improving cardiac autonomic function, arterial stiffness, inspiratory and quadriceps muscle strength, respiratory muscle endurance, diaphragm thickness, functional capacity, frailty, dyspnea, fatigue, and disease-specific quality of life in patients with HFrEF.

## Limitations

The abstract does not explicitly state any limitations of the study.

## Verbatim from the abstract

> between-group differences in arterial stiffness and inspiratory muscle strength favored the training group

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| Inspiratory Muscle Strength Trainer | Moderate evidence | [Inspiratory Muscle Strength Trainer](https://magellanlongevity.com/p/165.md) |

## Reference

1. **Effects of high intensity inspiratory muscle training in patients with heart failure: a randomized controlled trial**
   Heart Lung 2023 · [PMID 37285766](https://pubmed.ncbi.nlm.nih.gov/37285766/) · [DOI 10.1016/j.hrtlng.2023.05.011](https://doi.org/10.1016/j.hrtlng.2023.05.011)

   > between-group differences in arterial stiffness and inspiratory muscle strength favored the training group

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## Related on Magellan Longevity

- [Inspiratory Muscle Strength Trainer](https://magellanlongevity.com/p/165.md) — product graded on this and related evidence
- [Evidence: high-resistance breath loading](https://magellanlongevity.com/study/s165.md)
- [Effects of inspiratory muscle training on blood pressure and sleep in obstructive sleep…](https://magellanlongevity.com/study/d36576599.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).