---
title: "Astaxanthin supplementation impact on insulin resistance, lipid…"
description: "Astaxanthin supplementation may improve insulin resistance, lipid profiles, and oxidative stress in infertile women with PCOS."
url: "https://magellanlongevity.com/study/d37874168.md"
canonical: "https://magellanlongevity.com/study/d37874168.html"
html: "https://magellanlongevity.com/study/d37874168.html"
type: "study"
study_key: "d37874168"
journal: "Phytother Res"
year: 2023
pmid: "37874168"
doi: "10.1002/ptr.8037"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Astaxanthin supplementation impact on insulin resistance, lipid profile, blood pressure, and oxidative stress: a triple-blind randomized clinical trial

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## Citation

| Field | Value |
| --- | --- |
| Journal | Phytother Res |
| Year | 2023 |
| PMID | [37874168](https://pubmed.ncbi.nlm.nih.gov/37874168/) |
| DOI | [10.1002/ptr.8037](https://doi.org/10.1002/ptr.8037) |
| Study key | d37874168 |

## Takeaway

Astaxanthin supplementation may improve insulin resistance, lipid profiles, and oxidative stress in infertile women with PCOS.

## The question

What is the effect of astaxanthin (ASX) supplementation on lipid profile, insulin resistance (IR), blood pressure (BP), and oxidative stress (OS) levels in infertile women with polycystic ovarian syndrome (PCOS)?

## Hypothesis

Astaxanthin (ASX) supplementation may have therapeutic benefits for polycystic ovarian syndrome (PCOS) patients, potentially improving lipid profile, insulin resistance, blood pressure, and oxidative stress.

## Methods

This was a triple-blind randomized clinical trial involving 58 infertile women with PCOS. Participants were randomly assigned to receive either a placebo or ASX (2 × 6 mg/day) for 8 weeks. Blood serum samples were collected before and after the intervention to evaluate fasting insulin (FI), fasting blood glucose (FBS), oxidative stress markers (malondialdehyde [MDA], superoxide dismutase [SOD], and total antioxidant capacity [TAC]), and lipid profiles. Insulin resistance indices were calculated, and blood pressure was assessed at the start and end of the study.

## Results

After 8 weeks, ASX consumption led to significant reductions in fasting blood sugar, HOMA-IR, FI, MDA, low-density lipoprotein-cholesterol, and TC/HDL-C. Conversely, ASX significantly increased TAC, HDL-C, and QUICKI. After adjusting for baseline values of age, BMI, and biochemical parameters, QUICKI and FI showed non-significant values, while other findings remained unchanged.

## Conclusion

Astaxanthin appears to be an effective and safe supplement that improves insulin metabolism, lipid profile parameters, and oxidative stress in infertile PCOS patients.

## Limitations

The abstract does not explicitly state any limitations of the study.

## Verbatim from the abstract

> ASX significantly increased TAC; significant reduction in MDA, alleviating oxidative stress

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| Astaxanthin Softgels | Moderate evidence | [Astaxanthin Softgels](https://magellanlongevity.com/p/107.md) |

## Reference

1. **Astaxanthin supplementation impact on insulin resistance, lipid profile, blood pressure, and oxidative stress: a triple-blind randomized clinical trial**
   Phytother Res 2023 · [PMID 37874168](https://pubmed.ncbi.nlm.nih.gov/37874168/) · [DOI 10.1002/ptr.8037](https://doi.org/10.1002/ptr.8037)

   > ASX significantly increased TAC; significant reduction in MDA, alleviating oxidative stress

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## Related on Magellan Longevity

- [Astaxanthin Softgels](https://magellanlongevity.com/p/107.md) — product graded on this and related evidence
- [Evidence: raises antioxidant capacity, lowers MDA](https://magellanlongevity.com/study/s107.md)
- [Effects of Astaxanthin Supplementation on Oxidative Stress](https://magellanlongevity.com/study/d30982442.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).