--- title: "Long-term systolic blood pressure variability is associated with…" description: "Higher long-term systolic blood pressure variability is associated with increased risks of death and cardiovascular events, particularly stroke." url: "https://magellanlongevity.com/study/d38103812.md" canonical: "https://magellanlongevity.com/study/d38103812.html" html: "https://magellanlongevity.com/study/d38103812.html" type: "study" study_key: "d38103812" journal: "Curr Probl Cardiol" year: 2023 pmid: "38103812" doi: "10.1016/j.cpcardiol.2023.102343" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # Long-term systolic blood pressure variability is associated with mortality and cardiovascular events: a meta-analysis [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Long-term systolic blood pressure variability is… **HTML version:** https://magellanlongevity.com/study/d38103812.html · **In the Magellan app:** https://magellanlongevity.com/#/study/d38103812 ## Citation | Field | Value | | --- | --- | | Journal | Curr Probl Cardiol | | Year | 2023 | | PMID | [38103812](https://pubmed.ncbi.nlm.nih.gov/38103812/) | | DOI | [10.1016/j.cpcardiol.2023.102343](https://doi.org/10.1016/j.cpcardiol.2023.102343) | | Study key | d38103812 | ## Takeaway Higher long-term systolic blood pressure variability is associated with increased risks of death and cardiovascular events, particularly stroke. ## The question Is long-term systolic blood pressure variability (SBPV) associated with cardiovascular (CV) outcomes, even after adjusting for mean blood pressure? ## Hypothesis The study aims to evaluate the associations between mean blood pressure adjusted long-term SBPV and CV outcomes, suggesting a potential association. ## Methods A systematic review and meta-analysis was conducted by searching PubMed, Scopus, and Science Direct on January 4, 2023. The analysis included 43 studies with a total of 9,944,254 subjects. ## Results Long-term SBPV was associated with an increased risk of all-cause mortality (HR 1.21), CV mortality (HR 1.10), major adverse cardiovascular events (MACE) (HR 1.10), cerebrovascular stroke (HR 1.22), and myocardial infarction (HR 1.13). European populations showed a generally higher risk compared to other continents. ## Conclusion Long-term SBPV is associated with all-cause mortality, CV mortality, MACE, myocardial infarction, and stroke. Poor outcomes linked to long-term SBPV appear to be more driven by cerebrovascular events than coronary events. ## Limitations The abstract does not explicitly state limitations of the meta-analysis itself, but notes the questionability of the association after adjusting for mean BP, which the study aimed to address. ## Verbatim from the abstract > long-term systolic blood pressure variability is associated with all-cause and cardiovascular mortality ## Increased Risk Associated with Long-Term SBPV | Measure | Hazard Ratio | | --- | --- | | All-cause mortality | 1.21 | | Cerebrovascular stroke | 1.22 | | Myocardial infarction | 1.13 | | CV mortality | 1.1 | | MACE | 1.1 | *Hazard ratios indicate the increased risk of various outcomes associated with long-term systolic blood pressure variability.* ## Where this study is used on Magellan This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions. | Compound or device | Evidence grade | Graded pages | | --- | --- | --- | | 24h Ambulatory BP Monitor | Strong evidence | [24h Ambulatory BP Monitor](https://magellanlongevity.com/p/155.md) | ## Reference 1. **Long-term systolic blood pressure variability is associated with mortality and cardiovascular events: a meta-analysis** Curr Probl Cardiol 2023 · [PMID 38103812](https://pubmed.ncbi.nlm.nih.gov/38103812/) · [DOI 10.1016/j.cpcardiol.2023.102343](https://doi.org/10.1016/j.cpcardiol.2023.102343) > long-term systolic blood pressure variability is associated with all-cause and cardiovascular mortality ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/d38103812.html#page","url":"https://magellanlongevity.com/study/d38103812.html","name":"Long-term systolic blood pressure variability is associated with mortality and cardiovascular events: a…","description":"Higher long-term systolic blood pressure variability is associated with increased risks of death and cardiovascular events, particularly stroke.","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/d38103812.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"Long-term systolic blood pressure variability is…","item":"https://magellanlongevity.com/study/d38103812.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/d38103812.html#study","name":"Long-term systolic blood pressure variability is associated with mortality and cardiovascular events: a meta-analysis","headline":"Long-term systolic blood pressure variability is associated with mortality and cardiovascular events: a…","datePublished":"2023","isPartOf":{"@type":"Periodical","name":"Curr Probl Cardiol"},"identifier":"PMID:38103812","url":"https://pubmed.ncbi.nlm.nih.gov/38103812/","sameAs":"https://doi.org/10.1016/j.cpcardiol.2023.102343","abstract":"Higher long-term systolic blood pressure variability is associated with increased risks of death and cardiovascular events, particularly stroke."}]} ``` ## Related on Magellan Longevity - [24h Ambulatory BP Monitor](https://magellanlongevity.com/p/155.md) — product graded on this and related evidence - [Evidence: Blood pressure level and variability](https://magellanlongevity.com/study/s155.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).