---
title: "Lutein and Zeaxanthin Supplementation Improves Dynamic Visual…"
description: "Lutein and zeaxanthin supplementation improved visual and cognitive function and reduced eye strain in children aged 5-12."
url: "https://magellanlongevity.com/study/d38363462.md"
canonical: "https://magellanlongevity.com/study/d38363462.html"
html: "https://magellanlongevity.com/study/d38363462.html"
type: "study"
study_key: "d38363462"
journal: "Adv Ther"
year: 2024
pmid: "38363462"
doi: "10.1007/s12325-024-02785-1"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Lutein and Zeaxanthin Supplementation Improves Dynamic Visual and Cognitive Performance

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## Citation

| Field | Value |
| --- | --- |
| Journal | Adv Ther |
| Year | 2024 |
| PMID | [38363462](https://pubmed.ncbi.nlm.nih.gov/38363462/) |
| DOI | [10.1007/s12325-024-02785-1](https://doi.org/10.1007/s12325-024-02785-1) |
| Study key | d38363462 |

## Takeaway

Lutein and zeaxanthin supplementation improved visual and cognitive function and reduced eye strain in children aged 5-12.

## The question

Can supplementation with lutein and zeaxanthin improve visual and cognitive performance in preadolescent children?

## Hypothesis

Supplementation with lutein and zeaxanthin will improve visual and cognitive outcomes in preadolescent children, similar to findings in adults.

## Methods

Sixty children (5-12 years old) were randomized in a 2:1 ratio to receive either gummies with 10 mg lutein and 2 mg zeaxanthin (LZ) or placebo for 180 days in a double-blind, placebo-controlled trial. Primary endpoint was macular pigment optical density (MPOD), with secondary endpoints including serum L and Z, BDNF, critical flicker fusion (CFF), eye strain/fatigue (VAS), sleep habits (CSHQ-A), and Creyos Health cognitive domains. Safety was monitored via physical exams, vital signs, lab tests, and adverse event tracking.

## Results

The LZ group showed significant increases in MPOD starting at day 42 and at all subsequent visits compared to placebo. Significant increases in serum lutein, reduced eye strain and fatigue, and improved cognitive performance (focus, episodic memory and learning, visuospatial working memory) were observed at days 90 and 180 in the LZ group. By day 180, the LZ group also showed significant increases in processing speed (CFF), attention, visuospatial processing, and serum Z and BDNF levels compared to placebo. No safety concerns were reported.

## Conclusion

Supplementation with lutein and zeaxanthin in preadolescent children increased MPOD, serum L, Z, and BDNF levels, which were associated with improved visual and cognitive performance and reduced eye strain and fatigue. The supplement was safe and well tolerated.

## Limitations

The abstract does not explicitly state any limitations of the study.

## Verbatim from the abstract

> improved cognitive performance (focus, episodic memory and learning, visuospatial working memory)

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| Lutein and Zeaxanthin | Strong evidence | [Lutein and Zeaxanthin](https://magellanlongevity.com/p/120.md) |

## Reference

1. **Lutein and Zeaxanthin Supplementation Improves Dynamic Visual and Cognitive Performance**
   Adv Ther 2024 · [PMID 38363462](https://pubmed.ncbi.nlm.nih.gov/38363462/) · [DOI 10.1007/s12325-024-02785-1](https://doi.org/10.1007/s12325-024-02785-1)

   > improved cognitive performance (focus, episodic memory and learning, visuospatial working memory)

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## Related on Magellan Longevity

- [Lutein and Zeaxanthin](https://magellanlongevity.com/p/120.md) — product graded on this and related evidence
- [Evidence: macular pigment, antioxidant](https://magellanlongevity.com/study/s120.md)
- [Effects of a Lutein and Zeaxanthin Intervention on Cognitive Function: A Randomized,…](https://magellanlongevity.com/study/d29135938.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).