---
title: "Efficacy of Treatments in Reducing Inflammatory Lesion Count in…"
description: "Oral isotretinoin was the most effective treatment for reducing inflammatory lesions in rosacea, though several other topical and systemic therapies also…"
url: "https://magellanlongevity.com/study/d38807451.md"
canonical: "https://magellanlongevity.com/study/d38807451.html"
html: "https://magellanlongevity.com/study/d38807451.html"
type: "study"
study_key: "d38807451"
journal: "J Cutan Med Surg"
year: 2024
pmid: "38807451"
doi: "10.1177/12034754241253195"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Efficacy of Treatments in Reducing Inflammatory Lesion Count in Rosacea: A Systematic Review

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## Citation

| Field | Value |
| --- | --- |
| Journal | J Cutan Med Surg |
| Year | 2024 |
| PMID | [38807451](https://pubmed.ncbi.nlm.nih.gov/38807451/) |
| DOI | [10.1177/12034754241253195](https://doi.org/10.1177/12034754241253195) |
| Study key | d38807451 |

## Takeaway

Oral isotretinoin was the most effective treatment for reducing inflammatory lesions in rosacea, though several other topical and systemic therapies also showed efficacy.

## The question

What is the effectiveness of topical and systemic therapies in reducing inflammatory lesion count in rosacea patients?

## Hypothesis

The study aims to identify effective treatments for reducing inflammatory lesions in rosacea, which could alleviate the associated psychosocial burden.

## Methods

A systematic review was conducted by searching Medline, Embase, and Cochrane CENTRAL databases. The review included 43 clinical trials with a total of 18,347 rosacea patients.

## Results

The most studied treatments were ivermectin, metronidazole, azelaic acid, minocycline, and doxycycline. Oral isotretinoin was found to be the most effective treatment in reducing inflammatory lesions.

## Conclusion

Both topical and systemic therapies are effective in reducing inflammatory lesion count in rosacea patients, primarily by suppressing inflammation and killing mites. Oral isotretinoin is recommended for severe recalcitrant cases.

## Limitations

Additional research is needed to determine effective combination therapies for rosacea.

## Verbatim from the abstract

> the most well-studied treatments include ivermectin, metronidazole, and azelaic acid

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| Azelaic Acid Gel | Strong evidence | [Azelaic Acid Gel](https://magellanlongevity.com/p/182.md) |

## Reference

1. **Efficacy of Treatments in Reducing Inflammatory Lesion Count in Rosacea: A Systematic Review**
   J Cutan Med Surg 2024 · [PMID 38807451](https://pubmed.ncbi.nlm.nih.gov/38807451/) · [DOI 10.1177/12034754241253195](https://doi.org/10.1177/12034754241253195)

   > the most well-studied treatments include ivermectin, metronidazole, and azelaic acid

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## Related on Magellan Longevity

- [Azelaic Acid Gel](https://magellanlongevity.com/p/182.md) — product graded on this and related evidence
- [Evidence: anti-inflammatory, antioxidant](https://magellanlongevity.com/study/s182.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).