--- title: "Magnesium Supplementation and Blood Pressure: A Systematic…" description: "Magnesium supplementation can help lower blood pressure, especially in people with high blood pressure or low magnesium levels, but more research is…" url: "https://magellanlongevity.com/study/d41000008.md" canonical: "https://magellanlongevity.com/study/d41000008.html" html: "https://magellanlongevity.com/study/d41000008.html" type: "study" study_key: "d41000008" journal: "Hypertension" year: 2025 pmid: "41000008" doi: "10.1161/HYPERTENSIONAHA.125.25129" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # Magnesium Supplementation and Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Magnesium Supplementation and Blood Pressure: A Systematic… **HTML version:** https://magellanlongevity.com/study/d41000008.html · **In the Magellan app:** https://magellanlongevity.com/#/study/d41000008 ## Citation | Field | Value | | --- | --- | | Journal | Hypertension | | Year | 2025 | | PMID | [41000008](https://pubmed.ncbi.nlm.nih.gov/41000008/) | | DOI | [10.1161/HYPERTENSIONAHA.125.25129](https://doi.org/10.1161/HYPERTENSIONAHA.125.25129) | | Study key | d41000008 | ## Takeaway Magnesium supplementation can help lower blood pressure, especially in people with high blood pressure or low magnesium levels, but more research is needed due to study variability. ## The question What is the effect of magnesium supplementation on blood pressure in both hypertensive and normotensive populations? ## Hypothesis The study aimed to explore the relationship between magnesium supplementation and blood pressure. ## Methods A systematic review and meta-analysis of 38 randomized controlled trials, involving 2709 participants, was conducted. Studies had a duration of at least 4 weeks, with elemental magnesium doses ranging from 82.3 mg to 637 mg (median 365 mg) and a median intervention period of 12 weeks. Mean differences of changes in blood pressure were calculated using a random effects meta-analysis, and a cubic spline regression model was used for dose-response analysis. ## Results Magnesium supplementation reduced systolic blood pressure by -2.81 mm Hg and diastolic blood pressure by -2.05 mm Hg overall. Greater reductions in systolic blood pressure were observed in hypertensive individuals on BP-lowering medication (-7.68 mm Hg) and individuals with hypomagnesemia (-5.97 mm Hg). Diastolic blood pressure also saw greater reductions in these groups (-2.96 mm Hg and -4.75 mm Hg, respectively). No statistically significant effect was found in normotensive groups, and no dose-response relationship was identified. ## Conclusion Magnesium supplementation has a beneficial effect on reducing blood pressure, particularly in populations with hypertension and hypomagnesemia. However, the high heterogeneity across studies suggests that these effects should be interpreted with caution. ## Limitations The study identified high heterogeneity across the included trials. Further larger, well-designed studies are needed to assess higher magnesium doses and refine the dose-response relationship, as well as to identify optimal supplementation strategies for specific subpopulations. ## Verbatim from the abstract > Magnesium intake resulted in a reduction in systolic blood pressure ## Blood Pressure Reduction with Magnesium Supplementation | Measure | BP Reduction (mm Hg) | | --- | --- | | Overall Systolic BP Reduction | -2.81 | | Overall Diastolic BP Reduction | -2.05 | | Hypertensive Systolic BP Reduction | -7.68 | | Hypertensive Diastolic BP Reduction | -2.96 | | Hypomagnesemia Systolic BP Reduction | -5.97 | | Hypomagnesemia Diastolic BP Reduction | -4.75 | *Mean reductions in systolic and diastolic blood pressure (mm Hg) across different populations with magnesium supplementation.* ## Where this study is used on Magellan This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions. | Compound or device | Evidence grade | Graded pages | | --- | --- | --- | | Magnesium Glycinate | Moderate evidence | [Magnesium Glycinate](https://magellanlongevity.com/p/136.md) | ## Reference 1. **Magnesium Supplementation and Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials** Hypertension 2025 · [PMID 41000008](https://pubmed.ncbi.nlm.nih.gov/41000008/) · [DOI 10.1161/HYPERTENSIONAHA.125.25129](https://doi.org/10.1161/HYPERTENSIONAHA.125.25129) > Magnesium intake resulted in a reduction in systolic blood pressure ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/d41000008.html#page","url":"https://magellanlongevity.com/study/d41000008.html","name":"Magnesium Supplementation and Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled…","description":"Magnesium supplementation can help lower blood pressure, especially in people with high blood pressure or low magnesium levels, but more research is…","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/d41000008.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"Magnesium Supplementation and Blood Pressure: A Systematic…","item":"https://magellanlongevity.com/study/d41000008.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/d41000008.html#study","name":"Magnesium Supplementation and Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","headline":"Magnesium Supplementation and Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled…","datePublished":"2025","isPartOf":{"@type":"Periodical","name":"Hypertension"},"identifier":"PMID:41000008","url":"https://pubmed.ncbi.nlm.nih.gov/41000008/","sameAs":"https://doi.org/10.1161/HYPERTENSIONAHA.125.25129","abstract":"Magnesium supplementation can help lower blood pressure, especially in people with high blood pressure or low magnesium levels, but more research is needed due to study variability."}]} ``` ## Related on Magellan Longevity - [Magnesium Glycinate](https://magellanlongevity.com/p/136.md) — product graded on this and related evidence - [Evidence: enzymatic cofactor (300+ reactions)](https://magellanlongevity.com/study/s136.md) - [The Effects of Magnesium Supplementation on Blood Pressure Among Type 2 Diabetes…](https://magellanlongevity.com/study/d32385715.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).