---
title: "Associations of regular glucosamine use with all-cause and…"
description: "Regular glucosamine use is associated with a lower risk of death from all causes and specific diseases like cancer, CVD, respiratory, and digestive…"
url: "https://magellanlongevity.com/study/glu_biobank.md"
canonical: "https://magellanlongevity.com/study/glu_biobank.html"
html: "https://magellanlongevity.com/study/glu_biobank.html"
type: "study"
study_key: "glu_biobank"
journal: "Annals of the Rheumatic Diseases"
year: 2020
pmid: "32253185"
doi: "10.1136/annrheumdis-2020-217176"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# Associations of regular glucosamine use with all-cause and cause-specific mortality: a large prospective cohort study

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**HTML version:** https://magellanlongevity.com/study/glu_biobank.html · **In the Magellan app:** https://magellanlongevity.com/#/study/glu_biobank

## Citation

| Field | Value |
| --- | --- |
| Journal | Annals of the Rheumatic Diseases |
| Year | 2020 |
| PMID | [32253185](https://pubmed.ncbi.nlm.nih.gov/32253185/) |
| DOI | [10.1136/annrheumdis-2020-217176](https://doi.org/10.1136/annrheumdis-2020-217176) |
| Study key | glu_biobank |

## Takeaway

Regular glucosamine use is associated with a lower risk of death from all causes and specific diseases like cancer, CVD, respiratory, and digestive diseases.

## The question

What are the associations between regular glucosamine use and all-cause and cause-specific mortality?

## Hypothesis

The study aimed to evaluate the associations of regular glucosamine use with all-cause and cause-specific mortality.

## Methods

This population-based prospective cohort study included 495,077 participants from the UK Biobank, recruited from 2006 to 2010 and followed through 2018. Researchers calculated hazard ratios (HRs) and 95% CIs for all-cause and cause-specific mortality using Cox proportional hazards models, adjusting for potential confounding variables.

## Results

During a median follow-up of 8.9 years, 19,882 all-cause deaths were recorded. Regular glucosamine use was associated with lower all-cause mortality (HR 0.85), CVD mortality (HR 0.82), cancer mortality (HR 0.94), respiratory mortality (HR 0.73), and digestive mortality (HR 0.74). The inverse association with all-cause mortality appeared stronger in current smokers.

## Conclusion

Regular glucosamine supplementation was associated with lower mortality from all causes, cancer, cardiovascular disease, respiratory disease, and digestive diseases.

## Limitations

The abstract does not explicitly state limitations of the study.

## Verbatim from the abstract

> Regular glucosamine use was associated with significantly lower all-cause, cardiovascular, cancer, respiratory and digestive mortality (all-cause HR 0.73).

## Hazard Ratios for Mortality with Regular Glucosamine Use

| Measure | Hazard Ratio |
| --- | --- |
| All-cause mortality | 0.85 |
| CVD mortality | 0.82 |
| Cancer mortality | 0.94 |
| Respiratory mortality | 0.73 |
| Digestive mortality | 0.74 |

*Hazard ratios indicate the relative risk of mortality for regular glucosamine users compared to non-users, adjusted for confounding variables.*

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| D-Glucosamine | Moderate evidence | [D-Glucosamine Sulfate](https://magellanlongevity.com/p/197.md) |
| Osteo Bi-Flex (Triple Strength + Joint Shield) | Moderate evidence | [Osteo Bi-Flex Triple Strength (Glucosamine Chondroitin + Joint Shield)](https://magellanlongevity.com/p/217.md) |
| Glucosamine + Chondroitin (+ MSM) | Moderate evidence | [Glucosamine Chondroitin MSM (with OptiMSM)](https://magellanlongevity.com/p/218.md) |

## Reference

1. **Associations of regular glucosamine use with all-cause and cause-specific mortality: a large prospective cohort study**
   Annals of the Rheumatic Diseases 2020 · [PMID 32253185](https://pubmed.ncbi.nlm.nih.gov/32253185/) · [DOI 10.1136/annrheumdis-2020-217176](https://doi.org/10.1136/annrheumdis-2020-217176)

   > Regular glucosamine use was associated with significantly lower all-cause, cardiovascular, cancer, respiratory and digestive mortality (all-cause HR 0.73).

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## Related on Magellan Longevity

- [D-Glucosamine Sulfate](https://magellanlongevity.com/p/197.md) — product graded on this and related evidence
- [Osteo Bi-Flex Triple Strength (Glucosamine Chondroitin + Joint Shield)](https://magellanlongevity.com/p/217.md) — product graded on this and related evidence
- [Glucosamine Chondroitin MSM (with OptiMSM)](https://magellanlongevity.com/p/218.md) — product graded on this and related evidence
- [Genetically predicted glucosamine and longevity: A Mendelian randomization study](https://magellanlongevity.com/study/glu_mr.md)
- [Glucosamine/Chondroitin and Mortality in a US NHANES Cohort](https://magellanlongevity.com/study/glu_nhanes.md)
- [Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis](https://magellanlongevity.com/study/boswellia_oa.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).