--- title: "Genetically predicted glucosamine and longevity: A Mendelian…" description: "Genetically predicted higher glucosamine levels are associated with increased lifespan, particularly for mothers." url: "https://magellanlongevity.com/study/glu_mr.md" canonical: "https://magellanlongevity.com/study/glu_mr.html" html: "https://magellanlongevity.com/study/glu_mr.html" type: "study" study_key: "glu_mr" journal: "Mendelian Randomization Analysis" year: 2022 pmid: "35623867" doi: "10.1016/j.clnesp.2022.03.029" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # Genetically predicted glucosamine and longevity: A Mendelian randomization study [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Genetically predicted glucosamine and longevity: A… **HTML version:** https://magellanlongevity.com/study/glu_mr.html · **In the Magellan app:** https://magellanlongevity.com/#/study/glu_mr ## Citation | Field | Value | | --- | --- | | Journal | Mendelian Randomization Analysis | | Year | 2022 | | PMID | [35623867](https://pubmed.ncbi.nlm.nih.gov/35623867/) | | DOI | [10.1016/j.clnesp.2022.03.029](https://doi.org/10.1016/j.clnesp.2022.03.029) | | Study key | glu_mr | ## Takeaway Genetically predicted higher glucosamine levels are associated with increased lifespan, particularly for mothers. ## The question What is the effect of genetically predicted glucosamine on male and female lifespan? ## Hypothesis The study hypothesized that genetically predicted glucosamine would be associated with longevity. ## Methods A two-sample Mendelian randomization (MR) study was conducted using genetic data from the MRC-IEU consortium for 461,384 individuals. Five genetic variants were identified as instrumental variables for genetically predicted glucosamine. Genetic associations of these variants with parental longevity (combined parental age at death, mother's age at death, father's age at death) were obtained. The inverse-variance weighted method was used to estimate the effect of a 1-standard deviation (SD) increase in genetically predicted glucosamine on parental longevity. ## Results A 1-SD increase in genetically predicted glucosamine was associated with higher odds of combined parental age at death (odds ratio, 2.64) and maternal age at death (odds ratio, 1.73). No association was found with paternal age at death (odds ratio, 1.32). Sensitivity analyses did not find evidence of pleiotropic effects. ## Conclusion Lifelong higher levels of glucosamine may increase life expectancy, with positive effects specifically associated with maternal age at death. The sex-specific findings require further investigation. ## Limitations The abstract does not explicitly state limitations beyond suggesting further investigation for the sex-specific finding. ## Verbatim from the abstract > Higher genetically predicted glucosamine was associated with greater odds of extended parental lifespan, consistent with a causal effect on longevity. ## Odds Ratio of Longevity per 1-SD Increase in Genetically Predicted Glucosamine | Measure | Odds Ratio | | --- | --- | | Combined Parental Age at Death | 2.64 | | Maternal Age at Death | 1.73 | | Paternal Age at Death | 1.32 | *A 1-SD increase in genetically predicted glucosamine was associated with higher odds of combined parental age at death and maternal age at death, but not paternal age at death.* ## Where this study is used on Magellan This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions. | Compound or device | Evidence grade | Graded pages | | --- | --- | --- | | D-Glucosamine | Moderate evidence | [D-Glucosamine Sulfate](https://magellanlongevity.com/p/197.md) | ## Reference 1. **Genetically predicted glucosamine and longevity: A Mendelian randomization study** Mendelian Randomization Analysis 2022 · [PMID 35623867](https://pubmed.ncbi.nlm.nih.gov/35623867/) · [DOI 10.1016/j.clnesp.2022.03.029](https://doi.org/10.1016/j.clnesp.2022.03.029) > Higher genetically predicted glucosamine was associated with greater odds of extended parental lifespan, consistent with a causal effect on longevity. ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/glu_mr.html#page","url":"https://magellanlongevity.com/study/glu_mr.html","name":"Genetically predicted glucosamine and longevity: A Mendelian randomization study","description":"Genetically predicted higher glucosamine levels are associated with increased lifespan, particularly for mothers.","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/glu_mr.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"Genetically predicted glucosamine and longevity: A…","item":"https://magellanlongevity.com/study/glu_mr.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/glu_mr.html#study","name":"Genetically predicted glucosamine and longevity: A Mendelian randomization study","headline":"Genetically predicted glucosamine and longevity: A Mendelian randomization study","datePublished":"2022","isPartOf":{"@type":"Periodical","name":"Mendelian Randomization Analysis"},"identifier":"PMID:35623867","url":"https://pubmed.ncbi.nlm.nih.gov/35623867/","sameAs":"https://doi.org/10.1016/j.clnesp.2022.03.029","abstract":"Genetically predicted higher glucosamine levels are associated with increased lifespan, particularly for mothers."}]} ``` ## Related on Magellan Longevity - [D-Glucosamine Sulfate](https://magellanlongevity.com/p/197.md) — product graded on this and related evidence - [Associations of regular glucosamine use with all-cause and cause-specific mortality: a…](https://magellanlongevity.com/study/glu_biobank.md) - [Glucosamine/Chondroitin and Mortality in a US NHANES Cohort](https://magellanlongevity.com/study/glu_nhanes.md) - [Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis](https://magellanlongevity.com/study/boswellia_oa.md) - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).