---
title: "GlyNAC supplementation in mice increases length of life by…"
description: "GlyNAC supplementation extended the lifespan of mice by 24% and corrected several age-related cellular defects."
url: "https://magellanlongevity.com/study/glynac_mice.md"
canonical: "https://magellanlongevity.com/study/glynac_mice.html"
html: "https://magellanlongevity.com/study/glynac_mice.html"
type: "study"
study_key: "glynac_mice"
journal: "The Journals of Gerontology: Series A"
year: 2022
pmid: "35268089"
citations: 1
updated: 2026-09-02
author: "Gabriel Radu, DO"
author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765."
publisher: "Magellan Longevity"
content_format: "markdown"
---

# GlyNAC supplementation in mice increases length of life by correcting glutathione deficiency, oxidative stress, mitochondrial dysfunction, abnormalities in mitophagy and nutrient sensing, and genomic damage

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**HTML version:** https://magellanlongevity.com/study/glynac_mice.html · **In the Magellan app:** https://magellanlongevity.com/#/study/glynac_mice

## Citation

| Field | Value |
| --- | --- |
| Journal | The Journals of Gerontology: Series A |
| Year | 2022 |
| PMID | [35268089](https://pubmed.ncbi.nlm.nih.gov/35268089/) |
| DOI | — |
| Study key | glynac_mice |

## Takeaway

GlyNAC supplementation extended the lifespan of mice by 24% and corrected several age-related cellular defects.

## The question

Can GlyNAC supplementation increase lifespan and improve age-associated defects in mice?

## Hypothesis

GlyNAC supplementation will increase longevity by correcting glutathione deficiency, oxidative stress, and mitochondrial dysfunction.

## Methods

The study evaluated the effect of GlyNAC supplementation versus a placebo in C57BL/6J mice. Researchers measured the length of life and assessed age-associated glutathione deficiency, oxidative stress, mitochondrial dysfunction, abnormal mitophagy, nutrient-sensing, and genomic damage in the heart, liver, and kidneys.

## Results

Mice supplemented with GlyNAC lived 24% longer than control mice. GlyNAC supplementation also improved or corrected impaired glutathione synthesis, glutathione deficiency, oxidative stress, mitochondrial dysfunction, abnormal mitophagy, nutrient-sensing, and genomic damage.

## Conclusion

GlyNAC supplementation can increase lifespan and improve multiple age-associated defects in mice, providing a proof-of-concept for its potential as a nutritional supplement to enhance lifespan and healthspan.

## Limitations

This study was conducted in mice, and the findings may not directly translate to humans. Further investigation is warranted.

## Verbatim from the abstract

> GlyNAC supplementation increased length of life in mice by 24% while correcting glutathione deficiency and multiple defects of aging.

## Increase in Lifespan with GlyNAC Supplementation

| Measure | Relative Lifespan (%) |
| --- | --- |
| Control Mice | 100 |
| GlyNAC Supplemented Mice | 124 |

*Mice receiving GlyNAC supplementation lived 24% longer than control mice.*

## Where this study is used on Magellan

This paper is one of the citations behind the evidence grade on the pages below. Grades are assigned from the published research and are independent of affiliate commissions.

| Compound or device | Evidence grade | Graded pages |
| --- | --- | --- |
| GlyNAC (Glycine + N-Acetylcysteine) | Emerging evidence | [GlyNAC (Glycine + NAC)](https://magellanlongevity.com/p/198.md) |

## Reference

1. **GlyNAC supplementation in mice increases length of life by correcting glutathione deficiency, oxidative stress, mitochondrial dysfunction, abnormalities in mitophagy and nutrient sensing, and genomic damage**
   The Journals of Gerontology: Series A 2022 · [PMID 35268089](https://pubmed.ncbi.nlm.nih.gov/35268089/)

   > GlyNAC supplementation increased length of life in mice by 24% while correcting glutathione deficiency and multiple defects of aging.

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## Related on Magellan Longevity

- [GlyNAC (Glycine + NAC)](https://magellanlongevity.com/p/198.md) — product graded on this and related evidence
- [Glycine and N-Acetylcysteine (GlyNAC) supplementation in older adults improves…](https://magellanlongevity.com/study/glynac_rct.md)
- [Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione…](https://magellanlongevity.com/study/glutathione_glynac.md)
- [GlyNAC supplementation in older adults improves glutathione deficiency, oxidative…](https://magellanlongevity.com/study/x8.md)
- [Longevity research map](https://magellanlongevity.com/longevity-research-map.html)
- [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md)

## Scope and disclosures

Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication.

Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases.

Reviewed for accuracy by a board-certified physician (DO).