--- title: "Hyperbaric oxygen therapy increases telomere length and…" description: "Hyperbaric oxygen therapy significantly increased telomere length and reduced senescent cell percentages in various immune cells in healthy older adults." url: "https://magellanlongevity.com/study/hbot_telomere.md" canonical: "https://magellanlongevity.com/study/hbot_telomere.html" html: "https://magellanlongevity.com/study/hbot_telomere.html" type: "study" study_key: "hbot_telomere" journal: "Aging (Albany NY)" year: 2020 pmid: "33206062" doi: "10.18632/aging.202188" citations: 1 updated: 2026-09-02 author: "Gabriel Radu, DO" author_credentials: "Physiatrist (PM&R). NY medical license 275110. NPI 1376861765." publisher: "Magellan Longevity" content_format: "markdown" --- # Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial [Home](https://magellanlongevity.com/) › [Research map](https://magellanlongevity.com/longevity-research-map.html) › Hyperbaric oxygen therapy increases telomere length and… **HTML version:** https://magellanlongevity.com/study/hbot_telomere.html · **In the Magellan app:** https://magellanlongevity.com/#/study/hbot_telomere ## Citation | Field | Value | | --- | --- | | Journal | Aging (Albany NY) | | Year | 2020 | | PMID | [33206062](https://pubmed.ncbi.nlm.nih.gov/33206062/) | | DOI | [10.18632/aging.202188](https://doi.org/10.18632/aging.202188) | | Study key | hbot_telomere | ## Takeaway Hyperbaric oxygen therapy significantly increased telomere length and reduced senescent cell percentages in various immune cells in healthy older adults. ## The question Does hyperbaric oxygen therapy (HBOT) affect telomere length and senescent cell concentrations in healthy aging adults? ## Hypothesis Repeated intermittent hyperoxic exposures, such as certain HBOT protocols, may induce regenerative effects that could impact telomere length and cellular senescence. ## Methods Thirty-five healthy adults, aged 64 and older, received 60 daily HBOT exposures. Whole blood samples were collected at baseline, after 30 and 60 sessions, and 1-2 weeks post-HBOT. Peripheral blood mononuclear cells (PBMCs) were analyzed for telomere length and senescence. ## Results Telomere length in T helper, T cytotoxic, natural killer, and B cells increased significantly by over 20% after HBOT. B cell telomere length showed the most significant increase, rising by 25.68% at session 30, 29.39% at session 60, and 37.63% post-HBOT. There was a significant decrease in senescent T helper cells by -37.30% post-HBOT and senescent T-cytotoxic cells by -10.96% post-HBOT. ## Conclusion Hyperbaric oxygen therapy (HBOT) may induce significant senolytic effects in aging populations, including increasing telomere length and clearing senescent cells. ## Limitations The study involved a specific HBOT protocol and a relatively small sample size of healthy, independently living adults, which may limit generalizability. ## Verbatim from the abstract > Telomere length of T helper, T cytotoxic, natural killer and B cells increased significantly by over 20% following HBOT... senescent T helper cells decreased by -37.30% post-HBOT. ## Change in B Cell Telomere Length Following HBOT | Measure | Percentage Increase (%) | | --- | --- | | 30 Sessions | 25.68 | | 60 Sessions | 29.39 | | Post-HBOT | 37.63 | *Percentage increase in B cell telomere length at different stages of hyperbaric oxygen therapy.* ## Reference 1. **Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial** Aging (Albany NY) 2020 · [PMID 33206062](https://pubmed.ncbi.nlm.nih.gov/33206062/) · [DOI 10.18632/aging.202188](https://doi.org/10.18632/aging.202188) > Telomere length of T helper, T cytotoxic, natural killer and B cells increased significantly by over 20% following HBOT... senescent T helper cells decreased by -37.30% post-HBOT. ## Structured data ```json {"@context":"https://schema.org","@graph":[{"@type":"MedicalWebPage","@id":"https://magellanlongevity.com/study/hbot_telomere.html#page","url":"https://magellanlongevity.com/study/hbot_telomere.html","name":"Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells:…","description":"Hyperbaric oxygen therapy significantly increased telomere length and reduced senescent cell percentages in various immune cells in healthy older adults.","inLanguage":"en","isPartOf":{"@type":"WebSite","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"author":{"@type":"Person","name":"Gabriel Radu, DO","jobTitle":"Physiatrist (PM&R)","identifier":[{"@type":"PropertyValue","name":"NPI","value":"1376861765"},{"@type":"PropertyValue","name":"NY medical license","value":"275110"}]},"publisher":{"@type":"Organization","name":"Magellan Longevity","url":"https://magellanlongevity.com/"},"encoding":{"@type":"MediaObject","encodingFormat":"text/markdown","contentUrl":"https://magellanlongevity.com/study/hbot_telomere.md"},"dateModified":"2026-09-02"},{"@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://magellanlongevity.com/"},{"@type":"ListItem","position":2,"name":"Research map","item":"https://magellanlongevity.com/longevity-research-map.html"},{"@type":"ListItem","position":3,"name":"Hyperbaric oxygen therapy increases telomere length and…","item":"https://magellanlongevity.com/study/hbot_telomere.html"}]},{"@type":"ScholarlyArticle","@id":"https://magellanlongevity.com/study/hbot_telomere.html#study","name":"Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial","headline":"Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells:…","datePublished":"2020","isPartOf":{"@type":"Periodical","name":"Aging (Albany NY)"},"identifier":"PMID:33206062","url":"https://pubmed.ncbi.nlm.nih.gov/33206062/","sameAs":"https://doi.org/10.18632/aging.202188","abstract":"Hyperbaric oxygen therapy significantly increased telomere length and reduced senescent cell percentages in various immune cells in healthy older adults."}]} ``` ## Related on Magellan Longevity - [Longevity research map](https://magellanlongevity.com/longevity-research-map.html) - [Evidence-based longevity supplements](https://magellanlongevity.com/longevity-supplements.md) ## Scope and disclosures Educational information, not medical advice. Nothing here is intended to diagnose, treat, cure, or prevent any disease. Talk to your physician before starting any supplement or device, especially if you are pregnant, nursing, or taking medication. Editorial firewall: evidence grades are assigned from the published research and are independent of any affiliate commission. As an Amazon Associate, Magellan Longevity earns from qualifying purchases. Reviewed for accuracy by a board-certified physician (DO).